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Author |
Assam, I.; Vijande, J.; Ballester, F.; Perez-Calatayud, J.; Poppe, B.; Siebert, F.A. |
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Title |
Evaluation of dosimetric effects of metallic artifact reduction and tissue assignment on Monte Carlo dose calculations for I-125 prostate implants |
Type |
Journal Article |
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Year |
2022 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
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Volume |
49 |
Issue |
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Pages |
6195-6208 |
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Keywords |
metallic artifact reduction; Monte Carlo dosimetry; post-implant CT; prostate brachytherapy; tissue assignment schemes; voxelized virtual patient model |
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Abstract |
Purpose Monte Carlo (MC) simulation studies, aimed at evaluating the magnitude of tissue heterogeneity in I-125 prostate permanent seed implant brachytherapy (BT), customarily use clinical post-implant CT images to generate a virtual representation of a realistic patient model (virtual patient model). Metallic artifact reduction (MAR) techniques and tissue assignment schemes (TAS) are implemented on the post-implant CT images to mollify metallic artifacts due to BT seeds and to assign tissue types to the voxels corresponding to the bright seed spots and streaking artifacts, respectively. The objective of this study is to assess the combined influence of MAR and TAS on MC absorbed dose calculations in post-implant CT-based phantoms. The virtual patient models used for I-125 prostate implant MC absorbed dose calculations in this study are derived from the CT images of an external radiotherapy prostate patient without BT seeds and prostatic calcifications, thus averting the need to implement MAR and TAS. Methods The geometry of the IsoSeed I25.S17plus source is validated by comparing the MC calculated results of the TG-43 parameters for the line source approximation with the TG-43U1S2 consensus data. Four MC absorbed dose calculations are performed in two virtual patient models using the egs_brachy MC code: (1) TG-43-based D-w,w-TG(43), (2) D-w,D-w-MBDC that accounts for interseed scattering and attenuation (ISA), (3) D-m,D-m that examines ISA and tissue heterogeneity by scoring absorbed dose in tissue, and (4) D-w,D-m that unlike D-m,D-m scores absorbed dose in water. The MC absorbed doses (1) and (2) are simulated in a TG-43 patient phantom derived by assigning the densities of every voxel to 1.00 g cm(-3) (water), whereas MC absorbed doses (3) and (4) are scored in the TG-186 patient phantom generated by mapping the mass density of each voxel to tissue according to a CT calibration curve. The MC absorbed doses calculated in this study are compared with VariSeed v8.0 calculated absorbed doses. To evaluate the dosimetric effect of MAR and TAS, the MC absorbed doses of this work (independent of MAR and TAS) are compared to the MC absorbed doses of different I-125 source models from previous studies that were calculated with different MC codes using post-implant CT-based phantoms generated by implementing MAR and TAS on post-implant CT images. Results The very good agreement of TG-43 parameters of this study and the published consensus data within 3% validates the geometry of the IsoSeed I25.S17plus source. For the clinical studies, the TG-43-based calculations show a D-90 overestimation of more than 4% compared to the more realistic MC methods due to ISA and tissue composition. The results of this work generally show few discrepancies with the post-implant CT-based dosimetry studies with respect to the D-90 absorbed dose metric parameter. These discrepancies are mainly Type B uncertainties due to the different I-125 source models and MC codes. Conclusions The implementation of MAR and TAS on post-implant CT images have no dosimetric effect on the I-125 prostate MC absorbed dose calculation in post-implant CT-based phantoms. |
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[Assam, Isong; Siebert, Frank-Andre] UKSH, Clin Radiotherapy Radiooncol, Campus Kiel, Kiel, Germany, Email: Isong.Assam@uksh.de |
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Wiley |
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English |
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0094-2405 |
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WOS:000835807200001 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5321 |
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Author |
Peppa, V.; Thomson, R.M.; Enger, S.A.; Fonseca, G.P.; Lee, C.N.; Lucero, J.N.E.; Mourtada, F.; Siebert, F.A.; Vijande, J.; Papagiannis, P. |
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Title |
A MC-based anthropomorphic test case for commissioning model-based dose calculation in interstitial breast 192-Ir HDR brachytherapy |
Type |
Journal Article |
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Year |
2023 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
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Volume |
50 |
Issue |
7 |
Pages |
4675-4687 |
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Keywords |
anthropomorphic phantom; commissioning; HDR brachytherapy; model based dose calculation algorithms; Monte Carlo |
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Abstract |
PurposeTo provide the first clinical test case for commissioning of Ir-192 brachytherapy model-based dose calculation algorithms (MBDCAs) according to the AAPM TG-186 report workflow. Acquisition and Validation MethodsA computational patient phantom model was generated from a clinical multi-catheter Ir-192 HDR breast brachytherapy case. Regions of interest (ROIs) were contoured and digitized on the patient CT images and the model was written to a series of DICOM CT images using MATLAB. The model was imported into two commercial treatment planning systems (TPSs) currently incorporating an MBDCA. Identical treatment plans were prepared using a generic Ir-192 HDR source and the TG-43-based algorithm of each TPS. This was followed by dose to medium in medium calculations using the MBDCA option of each TPS. Monte Carlo (MC) simulation was performed in the model using three different codes and information parsed from the treatment plan exported in DICOM radiation therapy (RT) format. Results were found to agree within statistical uncertainty and the dataset with the lowest uncertainty was assigned as the reference MC dose distribution. Data Format and Usage NotesThe dataset is available online at ,. Files include the treatment plan for each TPS in DICOM RT format, reference MC dose data in RT Dose format, as well as a guide for database users and all files necessary to repeat the MC simulations. Potential ApplicationsThe dataset facilitates the commissioning of brachytherapy MBDCAs using TPS embedded tools and establishes a methodology for the development of future clinical test cases. It is also useful to non-MBDCA adopters for intercomparing MBDCAs and exploring their benefits and limitations, as well as to brachytherapy researchers in need of a dosimetric and/or a DICOM RT information parsing benchmark. Limitations include specificity in terms of radionuclide, source model, clinical scenario, and MBDCA version used for its preparation. |
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Address |
[Peppa, Vasiliki; Papagiannis, Panagiotis] Natl & Kapodistrian Univ Athens, Med Sch, Med Phys Lab, Athens, Greece, Email: ppapagi@med.uoa.gr |
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Wiley |
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English |
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0094-2405 |
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Notes |
WOS:000989616100001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5529 |
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Author |
Beaulieu, L.; Ballester, F.; Granero, D.; Tedgren, A.C.; Haworth, A.; Lowenstein, J.R.; Ma, Y.Z.; Mourtada, F.; Papagiannis, P.; Rivard, M.J.; Siebert, F.A.; Sloboda, R.S.; Smith, R.L.; Thomson, R.M.; Verhaegen, F.; Fonseca, G.; Vijande, J. |
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Title |
AAPM WGDCAB Report 372: A joint AAPM, ESTRO, ABG, and ABS report on commissioning of model-based dose calculation algorithms in brachytherapy |
Type |
Journal Article |
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Year |
2023 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
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Volume |
50 |
Issue |
8 |
Pages |
e946–e960 |
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Keywords |
brachytherapy; commissioning; dose calculation; model-based dose calculation; Monte Carlo; TG-186 |
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Abstract |
The introduction of model-based dose calculation algorithms (MBDCAs) in brachytherapy provides an opportunity for a more accurate dose calculation and opens the possibility for novel, innovative treatment modalities. The joint AAPM, ESTRO, and ABG Task Group 186 (TG-186) report provided guidance to early adopters. However, the commissioning aspect of these algorithms was described only in general terms with no quantitative goals. This report, from the Working Group on Model-Based Dose Calculation Algorithms in Brachytherapy, introduced a field-tested approach to MBDCA commissioning. It is based on a set of well-characterized test cases for which reference Monte Carlo (MC) and vendor-specific MBDCA dose distributions are available in a Digital Imaging and Communications in Medicine-Radiotherapy (DICOM-RT) format to the clinical users. The key elements of the TG-186 commissioning workflow are now described in detail, and quantitative goals are provided. This approach leverages the well-known Brachytherapy Source Registry jointly managed by the AAPM and the Imaging and Radiation Oncology Core (IROC) Houston Quality Assurance Center (with associated links at ESTRO) to provide open access to test cases as well as step-by-step user guides. While the current report is limited to the two most widely commercially available MBDCAs and only for Ir-192-based afterloading brachytherapy at this time, this report establishes a general framework that can easily be extended to other brachytherapy MBDCAs and brachytherapy sources. The AAPM, ESTRO, ABG, and ABS recommend that clinical medical physicists implement the workflow presented in this report to validate both the basic and the advanced dose calculation features of their commercial MBDCAs. Recommendations are also given to vendors to integrate advanced analysis tools into their brachytherapy treatment planning system to facilitate extensive dose comparisons. The use of the test cases for research and educational purposes is further encouraged. |
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Address |
[Beaulieu, Luc; Ma, Yunzhi] CHU Quebec Univ Laval, Serv Phys Med & Radioprotect, Quebec City, PQ, Canada, Email: beaulieu@phy.ulaval.ca |
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Wiley |
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English |
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0094-2405 |
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Notes |
WOS:001026540300001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5579 |
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Author |
Fletcher, E.M.; Ballester, F.; Beaulieu, L.; Morrison, H.; Poher, A.; Rivard, M.J.; Sloboda, R.S.; Vijande, J.; Thomson, R.M. |
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Title |
Generation and comparison of 3D dosimetric reference datasets for COMS eye plaque brachytherapy using model-based dose calculations |
Type |
Journal Article |
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Year |
2024 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
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Volume |
51 |
Issue |
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Pages |
694-706 |
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Keywords |
Monte Carlo; ocular brachytherapy; treatment planning |
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Abstract |
PurposeA joint Working Group of the American Association of Physicists in Medicine (AAPM), the European Society for Radiotherapy and Oncology (ESTRO), and the Australasian Brachytherapy Group (ABG) was created to aid in the transition from the AAPM TG-43 dose calculation formalism, the current standard, to model-based dose calculations. This work establishes the first test cases for low-energy photon-emitting brachytherapy using model-based dose calculation algorithms (MBDCAs).Acquisition and Validation MethodsFive test cases are developed: (1) a single model 6711 125I brachytherapy seed in water, 13 seeds (2) individually and (3) in combination in water, (4) the full Collaborative Ocular Melanoma Study (COMS) 16-mm eye plaque in water, and (5) the full plaque in a realistic eye phantom. Calculations are done with four Monte Carlo (MC) codes and a research version of a commercial treatment planning system (TPS). For all test cases, local agreement of MC codes was within & SIM;2.5% and global agreement was & SIM;2% (4% for test case 5). MC agreement was within expected uncertainties. Local agreement of TPS with MC was within 5% for test case 1 and & SIM;20% for test cases 4 and 5, and global agreement was within 0.4% for test case 1 and 10% for test cases 4 and 5.Data Format and Usage NotesDose distributions for each set of MC and TPS calculations are available online () along with input files and all other information necessary to repeat the calculations.Potential ApplicationsThese data can be used to support commissioning of MBDCAs for low-energy brachytherapy as recommended by TGs 186 and 221 and AAPM Report 372. This work additionally lays out a sample framework for the development of test cases that can be extended to other applications beyond eye plaque brachytherapy. |
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Address |
[Fletcher, Elizabeth M.; Thomson, Rowan M.] Carleton Univ, Phys Dept, Carleton Lab Radiotherapy Phys, Ottawa, ON, Canada, Email: rthomson@physics.carleton.ca |
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Wiley |
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English |
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0094-2405 |
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Notes |
WOS:001058112300001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5632 |
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Author |
Fanchiotti, H.; Garcia Canal, C.A.; Mayosky, M.; Veiga, A.; Vento, V. |
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Title |
The Geometric Phase in Classical Systems and in the Equivalent Quantum Hermitian and Non-Hermitian PT-Symmetric Systems |
Type |
Journal Article |
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Year |
2023 |
Publication |
Brazilian Journal of Physics |
Abbreviated Journal |
Braz. J. Phys. |
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Volume |
53 |
Issue |
6 |
Pages |
143 - 11pp |
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Keywords |
Geometrical phases; Decomplexification; Resonat circuit; Gyrator |
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Abstract |
The decomplexification procedure allows one to show mathematically (stricto sensu) the equivalence (isomorphism) between the quantum dynamics of a system with a finite number of basis states and a classical dynamics system. This unique way of connecting different dynamics was used in the past to analyze the relationship between the well-known geometric phase present in the quantum evolution discovered by Berry and its generalizations, with their analogs, the Hannay phases, in the classical domain. In here, this analysis is carried out for several quantum hermitian and non-hermitian PT-symmetric Hamiltonians and compared with the Hannay phase analysis in their classical isomorphic equivalent systems. As the equivalence ends in the classical domain with oscillator dynamics, we exploit the analogy to propose resonant electric circuits coupled with a gyrator, to reproduce the geometric phase coming from the theoretical solutions, in simulated laboratory experiments. |
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Address |
[Fanchiotti, H.; Canal, C. A. Garcia] Univ Nacl La Plata, FLP CONICET, RA-1900 La Plata, Argentina, Email: vicente.vento@uv.es |
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Springer |
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English |
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0103-9733 |
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Notes |
WOS:001058597300001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5627 |
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Author |
Garcia Canal, C.A.; Tarutina, T.; Vento, V. |
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Title |
Analysis of Nuclear Effects in Structure Functions and Their Connection with the Binding Energy of Nuclei |
Type |
Journal Article |
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Year |
2023 |
Publication |
Brazilian Journal of Physics |
Abbreviated Journal |
Braz. J. Phys. |
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Volume |
53 |
Issue |
6 |
Pages |
161 - 8pp |
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Keywords |
Structure functions; Deep inelastic scattering; EMC effect; Nuclear dynamics |
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Abstract |
We describe nuclear effects in structure functions of nuclei in DIS by means of a multiplicative factor beta(A)(x) which differentiates the structure function of the bound nucleons from that of the free nucleons. Our analysis determines that beta(A)(x) establishes a relation between the quark-gluon dynamics expressed by the bound nucleon structure functions and the nuclear dynamics as described by the well-known semi-empirical Bethe-Weizsacker mass formula. This relation corroborates a connection between the underlying quark-gluon dynamics and the phenomenological nuclear dynamics. |
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Address |
[Canal, C. A. Garcia] Univ La Plata, Dept Phys, Cc 67, RA-1900 La Plata, Argentina, Email: ttarutina@gmail.com |
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Springer |
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English |
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0103-9733 |
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Notes |
WOS:001087936700001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5766 |
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Author |
Fujita, Y.; Rubio, B.; Gelletly, W. |
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Title |
Spin-isospin excitations probed by strong, weak and electro-magnetic interactions |
Type |
Journal Article |
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Year |
2011 |
Publication |
Progress in Particle and Nuclear Physics |
Abbreviated Journal |
Prog. Part. Nucl. Phys. |
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Volume |
66 |
Issue |
3 |
Pages |
549-606 |
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Keywords |
Gamow-Teller transitions; beta decay; Charge-exchange reactions; Isospin symmetry; High resolution; Proton-rich nuclei |
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Abstract |
Gamow-Teller (GT) transitions are the most common weak interaction processes of spin-isospin (sigma tau) type in atomic nuclei. They are of interest not only in nuclear physics but also in astrophysics; they play an important role in supernovae explosions and nucleosynthesis. The direct study of weak decay processes, however, gives relatively limited information about GT transitions and the states excited via GT transitions (GT states); beta decay can only access states at excitation energies lower than the decay Q-value, and neutrino-induced reactions have very small cross-sections. However, one should note that beta decay has a direct access to the absolute GT transition strengths B(GT) from a study of half-lives, Q(beta)-values and branching ratios. They also provide information on GT transitions in nuclei far-from-stability. Studies of M1 gamma transitions provide similar information. In contrast, the complementary charge-exchange (CE) reactions, such as the (p, n) or ((3)He, t) reactions at intermediate beam energies and 0 degrees, can selectively excite GT states up to high excitation energies in the final nucleus. It has been found empirically that there is a close proportionality between the cross-sections at 0 degrees and the transition strengths B(GT) in these CE reactions. Therefore, CE reactions are useful tools to study the relative values of B(GT) strengths up to high excitation energies. In recent ((3)He, t) measurements, one order-of-magnitude improvement in the energy resolution has been achieved. This has made it possible to make one-to-one comparisons of GT transitions studied in CE reactions and beta decays. Thus GT strengths in ((3)He, t) reactions can be normalised by the beta-decay values. In addition, comparisons with closely related M1 transitions studied in gamma decay or electron inelastic scattering [(e, e')1, and furthermore with “spin” M I transitions that can be studied by proton inelastic scattering [(p, p')[ have now been made possible. In these comparisons, the isospin quantum number T and associated symmetry structure in the same mass A nuclei (isobars) play a key role. Isospin symmetry can extend our scope even to the structures of unstable nuclei that are far from reach at present unstable beam factories. |
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Address |
[Fujita, Y] Osaka Univ, Dept Phys, Osaka 5600043, Japan, Email: fujita@rcnp.osaka-u.ac.jp |
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Elsevier Science Bv |
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English |
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ISSN |
0146-6410 |
ISBN |
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Notes |
WOS:000292473100003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
692 |
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Author |
Alvarez-Ruso, L. et al; Nieves, J. |
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Title |
NuSTEC White Paper: Status and challenges of neutrino-nucleus scattering |
Type |
Journal Article |
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Year |
2018 |
Publication |
Progress in Particle and Nuclear Physics |
Abbreviated Journal |
Prog. Part. Nucl. Phys. |
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Volume |
100 |
Issue |
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Pages |
1-68 |
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Keywords |
Neutrino; Nucleus; Scattering; Nuclear; Model; Oscillations |
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Abstract |
The precise measurement of neutrino properties is among the highest priorities in fundamental particle physics, involving many experiments worldwide. Since the experiments rely on the interactions of neutrinos with bound nucleons inside atomic nuclei, the planned advances in the scope and precision of these experiments require a commensurate effort in the understanding and modeling of the hadronic and nuclear physics of these interactions, which is incorporated as a nuclear model in neutrino event generators. This model is essential to every phase of experimental analyses and its theoretical uncertainties play an important role in interpreting every result. In this White Paper we discuss in detail the impact of neutrino-nucleus interactions, especially the nuclear effects, on the measurement of neutrino properties using the determination of oscillation parameters as a central example. After an Executive Summary and a concise Overview of the issues, we explain how the neutrino event generators work, what can be learned from electron-nucleus interactions and how each underlying physics process – from quasi-elastic to deep inelastic scattering – is understood today. We then emphasize how our understanding must improve to meet the demands of future experiments. With every topic we find that the challenges can be met only with the active support and collaboration among specialists in strong interactions and electroweak physics that include theorists and experimentalists from both the nuclear and high energy physics communities. |
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Address |
[Alvarez-Ruso, L.; Nieves, J.] Univ Valencia, Ctr Mixto CSIC, Inst Fis Corpuscular IFIC, E-46071 Valencia, Spain, Email: morfin@fnal.gov |
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Elsevier Science Bv |
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English |
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ISSN |
0146-6410 |
ISBN |
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Conference |
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Notes |
WOS:000430618800001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3569 |
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Author |
PTOLEMY Collaboration (Betti, M.G. et al); de Salas, P.F.; Gariazzo, S.; Pastor, S. |
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Title |
A design for an electromagnetic filter for precision energy measurements at the tritium endpoint |
Type |
Journal Article |
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Year |
2019 |
Publication |
Progress in Particle and Nuclear Physics |
Abbreviated Journal |
Prog. Part. Nucl. Phys. |
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Volume |
106 |
Issue |
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Pages |
120-131 |
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Keywords |
PTOLEMY; Relic neutrino; Cosmic Neutrino Background; CNB; Neutrino mass; Transverse drift filter |
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Abstract |
We present a detailed description of the electromagnetic filter for the PTOLEMY project to directly detect the Cosmic Neutrino Background (CNB). Starting with an initial estimate for the orbital magnetic moment, the higher-order drift process of E x B is configured to balance the gradient-B drift motion of the electron in such a way as to guide the trajectory into the standing voltage potential along the mid-plane of the filter. As a function of drift distance along the length of the filter, the filter zooms in with exponentially increasing precision on the transverse velocity component of the electron kinetic energy. This yields a linear dimension for the total filter length that is exceptionally compact compared to previous techniques for electromagnetic filtering. The parallel velocity component of the electron kinetic energy oscillates in an electrostatic harmonic trap as the electron drifts along the length of the filter. An analysis of the phase-space volume conservation validates the expected behavior of the filter from the adiabatic invariance of the orbital magnetic moment and energy conservation following Liouville's theorem for Hamiltonian systems. (C) 2019 Elsevier B.V. All rights reserved. |
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Address |
[Hochberg, Y.] Hebrew Univ Jerusalem, Racah Inst Phys, Jerusalem, Israel, Email: cgtully@Princeton.EDU |
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Elsevier Science Bv |
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English |
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ISSN |
0146-6410 |
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WOS:000464490900003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3978 |
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Author |
Davesne, D.; Pastore, A.; Navarro, J. |
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Title |
Linear response theory with finite-range interactions |
Type |
Journal Article |
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Year |
2021 |
Publication |
Progress in Particle and Nuclear Physics |
Abbreviated Journal |
Prog. Part. Nucl. Phys. |
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Volume |
120 |
Issue |
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Pages |
103870 - 55pp |
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Keywords |
Linear response theory; Finite-range interactions; Gogny and Nakada interactions; Finite size instabilities; Continued fraction approximation; Multipolar expansion |
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Abstract |
This review focuses on the calculation of infinite nuclear matter response functions using phenomenological finite-range interactions, equipped or not with tensor terms. These include Gogny and Nakada families, which are commonly used in the literature. Because of the finite-range, the main technical difficulty stems from the exchange terms of the particle-hole interaction. We first present results based on the so-called Landau and Landau-like approximations of the particle-hole interaction. Then, we review two methods which in principle provide numerically exact response functions. The first one is based on a multipolar expansion of both the particle-hole interaction and the particle-hole propagator and the second one consists in a continued fraction expansion of the response function. The numerical precision can be pushed to any degree of accuracy, but it is actually shown that two or three terms suffice to get converged results. Finally, we apply the formalism to the determination of possible finite-size instabilities induced by a finite-range interaction. |
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Address |
[Davesne, D.] Univ Lyon, F-69003 Lyon, France, Email: alessandro.pastore@york.ac.uk |
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Publisher |
Elsevier |
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English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0146-6410 |
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Conference |
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Notes |
WOS:000674530100008 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4910 |
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