Abstract: Proton therapy is a cancer treatment technique currently in growth since it offers advantages with respect to conventional X-ray and gamma-ray radiotherapy. In particular, better control of the dose deposition allowing to reach higher conformity in the treatments causing less secondary effects. However, in order to take full advantage of its potential, improvements in treatment planning and dose verification are required. A new prototype of proton computed tomography scanner is proposed to design more accurate and precise treatment plans for proton therapy. Our prototype is formed by double-sided silicon strip detectors and scintillators of LaBr3(Ce) with high energy resolution and fast response. Here, the results obtained from an experiment performed using a 100-MeV proton beam are presented. Proton radiographs of polymethyl methacrylate (PMMA) samples of 50-mm thickness with spatial patterns in aluminum were taken. Their properties were studied, including reproduction of the dimensions, spatial resolution, and sensitivity to different materials. Structures of up to 2 mm are well resolved and the sensitivity of the system was enough to distinguish the thicknesses of 10 mm of aluminum or PMMA. The spatial resolution of the images was 0.3 line pairs per mm (MTF-10%). This constitutes the first step to validate the device as a proton radiography scanner.

Abstract: Light sources that emit repetitive subnanosecond pulses are used in neutrino telescopes for time calibration. Optical pulses with an ultra-narrow (subnanosecond) width can replicate the light produced by neutrino interactions, and are an important calibration and test element. By measuring the time-of-flight of the light, it is possible to provide a relative time calibration for all the detector photomultipliers. This work presents the ultra-narrow time optical pulse emitter based on a laser (UNTOPEL), an instrument emitting ultra-short laser optical pulses with a duration of 500 ps, energies per pulse of four microjoules at a wavelength of 532 nm, and a timing precision of 400 ps. The UNTOPEL pulse intensity can be fine-tuned, which is a novelty and a significant advantage in those applications that need to illuminate light detectors located at different distances with the same light intensity. The UNTOPEL pulse intensity can be controlled remotely, allowing for its use in operating conditions where physical access is impossible or difficult. Moreover, it is easy to operate and can be easily controlled through an inter-integrated circuit bus. The UNTOPEL is a sound instrument used when subnanosecond pulses and variable energy emissions are needed.

Abstract: The charge-conjugation and parity-reversal (CP) symmetry of fundamental particles is a symmetry between matter and antimatter. Violation of this CP symmetry was first observed in 1964(1), and CP violation in the weak interactions of quarks was soon established(2). Sakharov proposed(3) that CP violation is necessary to explain the observed imbalance of matter and antimatter abundance in the Universe. However, CP violation in quarks is too small to support this explanation. So far, CP violation has not been observed in non-quark elementary particle systems. It has been shown that CP violation in leptons could generate the matter-antimatter disparity through a process called leptogenesis(4). Leptonic mixing, which appears in the standard model's charged current interactions(5,6), provides a potential source of CP violation through a complex phase dCP, which is required by some theoretical models of leptogenesis(7-9). This CP violation can be measured in muon neutrino to electron neutrino oscillations and the corresponding antineutrino oscillations, which are experimentally accessible using accelerator-produced beams as established by the Tokai-to-Kamioka (T2K) and NOvA experiments(10,11). Until now, the value of dCP has not been substantially constrained by neutrino oscillation experiments. Here we report a measurement using long-baseline neutrino and antineutrino oscillations observed by the T2K experiment that shows a large increase in the neutrino oscillation probability, excluding values of dCP that result in a large increase in the observed antineutrino oscillation probability at three standard deviations (3 sigma). The 3 sigma confidence interval for delta(CP), which is cyclic and repeats every 2p, is [-3.41, -0.03] for the so-called normal mass ordering and [-2.54, -0.32] for the inverted mass ordering. Our results indicate CP violation in leptons and our method enables sensitive searches for matter-antimatter asymmetry in neutrino oscillations using accelerator-produced neutrino beams. Future measurements with larger datasets will test whether leptonic CP violation is larger than the CP violation in quarks.

Abstract: Neutrinos exist in one of three types or 'flavours'-electron, muon and tau neutrinos-and oscillate from one flavour to another when propagating through space. This phenomena is one of the few that cannot be described using the standard model of particle physics (reviewed in ref. (1)), and so its experimental study can provide new insight into the nature of our Universe (reviewed in ref. (2)). Neutrinos oscillate as a function of their propagation distance (L) divided by their energy (E). Therefore, experiments extract oscillation parameters by measuring their energy distribution at different locations. As accelerator-based oscillation experiments cannot directly measure E, the interpretation of these experiments relies heavily on phenomenological models of neutrino-nucleus interactions to infer E. Here we exploit the similarity of electron-nucleus and neutrino-nucleus interactions, and use electron scattering data with known beam energies to test energy reconstruction methods and interaction models. We find that even in simple interactions where no pions are detected, only a small fraction of events reconstruct to the correct incident energy. More importantly, widely used interaction models reproduce the reconstructed energy distribution only qualitatively and the quality of the reproduction varies strongly with beam energy. This shows both the need and the pathway to improve current models to meet the requirements of next-generation, high-precision experiments such as Hyper-Kamiokande (Japan)(3) and DUNE (USA)(4). Electron scattering measurements are shown to reproduce only qualitatively state-of-the-art lepton-nucleus energy reconstruction models, indicating that improvements to these particle-interaction models are required to ensure the accuracy of future high-precision neutrino oscillation experiments.

Abstract: The standard model of particle physics(1-4) describes the known fundamental particles and forces that make up our Universe, with the exception of gravity. One of the central features of the standard model is a field that permeates all of space and interacts with fundamental particles(5-9). The quantum excitation of this field, known as the Higgs field, manifests itself as the Higgs boson, the only fundamental particle with no spin. In 2012, a particle with properties consistent with the Higgs boson of the standard model was observed by the ATLAS and CMS experiments at the Large Hadron Collider at CERN10,11. Since then, more than 30 times as many Higgs bosons have been recorded by the ATLAS experiment, enabling much more precise measurements and new tests of the theory. Here, on the basis of this larger dataset, we combine an unprecedented number of production and decay processes of the Higgs boson to scrutinize its interactions with elementary particles. Interactions with gluons, photons, and W and Z bosons-the carriers of the strong, electromagnetic and weak forces-are studied in detail. Interactions with three third-generation matter particles (bottom (b) and top (t) quarks, and tau leptons (tau)) are well measured and indications of interactions with a second-generation particle (muons, mu) are emerging. These tests reveal that the Higgs boson discovered ten years ago is remarkably consistent with the predictions of the theory and provide stringent constraints on many models of new phenomena beyond the standard model.