Abstract: Intraoperative radiotherapy using mobile linear accelerators is used for a wide variety of malignancies. However, when large fields are used in combination with high energies, a deterioration of the flatness dose profile is measured with respect to smaller fields and lower energies. Indeed, for the LIAC HWL of Sordina, this deterioration is observed for the 12 MeV beam combined with 10 cm (or larger) diameter applicator. Aimed to solve this problem, a flattening filter has been designed and validated evaluating the feasibility of its usage at the upper part of the applicator. The design of the filter was based on Monte Carlo simulations because of its accuracy in modeling components of clinical devices, among other purposes. The LIAC 10 cm diameter applicator was modeled and simulated independently by two different research groups using two different MC codes, reproducing the heterogeneity of the 12 MeV energy beam. Then, an iterative process of filter design was carried out. Finally, the MC designed conical filter with the optimal size and height to obtain the desired flattened beam was built in-house using a 3D printer. During the experimental validation of the applicator-filter, percentage depth dose, beam profiles, absolute and peripheral dose measurements were performed to demonstrate the effectiveness of the filter addition in the applicator. These measurements conclude that the beam has been flattened, from 5.9% with the standard configuration to 1.6% for the configuration with the filter, without significant increase of the peripheral dose. Consequently, the new filter-applicator LIAC configuration can be used also in a conventional surgery room. A reduction of 16% of the output dose and a reduction of 1.1 mm in the D50 of the percentage depth dose was measured with respect to the original configuration. This work is a proof-of-concept that demonstrates that it is possible to add a filter able to flatten the beam delivered by the Sordina LIAC HWL. Future studies will focus on more refined technical solutions fully compatible with the integrity of the applicator, including its sterilization, to be safely introduced in the clinical practice.

Abstract: One of the basic propositions of quantum field theory is Lorentz invariance. The spontaneous breaking of Lorentz symmetry at a high energy scale can be studied at low energy extensions like the Standard model in a model-independent way through effective field theory (EFT). The present and future Long-baseline neutrino experiments can give a scope to observe such a Planck-suppressed physics of Lorentz invariance violation (LIV). A proposed long baseline experiment, Protvino to ORCA (dubbed “P2O”) with a baseline of 2595 km, is expected to provide good sensitivities to unresolved issues, especially neutrino mass ordering. P2O can offer good statistics even with a moderate beam power and runtime, owing to the very large (similar to 6 Mt) detector volume at KM3NeT/ ORCA. Here we discuss in detail, how the individual LIV parameters affect neutrino oscillations at P2O and DUNE baselines at the level of probability and derive analytical expressions to understand interesting degeneracies and other features. We estimate increment Delta chi(2) sensitivities to the LIV parameters, analyzing their correlations among each other, and also with the standard oscillation parameters. We calculate these results for P2O alone and also carry out a combined analysis of P2O with DUNE. We point out crucial features in the sensitivity contours and explain them qualitatively with the help of the relevant probability expressions derived here. Finally we estimate constraints on the individual LIV parameters at 95% confidence level (C.L.) intervals stemming from the combined analysis of P2O and DUNE datasets, and highlight the improvement over the existing constraints. We also find out that the additional degeneracy induced by the LIV parameter a(ee) around -22 x 10(-23) GeV is lifted by the combined analysis at 95% C.L.

Abstract: A thorough study of the J(PC )= 1(++) elastic D0 & macr;D*(0) and D+D*(-) scattering, where the form of the meson-meson interaction is inferred from lattice QCD calculations of string breaking, is carried out for center-of-mass energies up to 4 GeV. We show that the presence of chi c1(3872), which can be naturally assigned to either a bound or virtual charmoniumlike state close below the D0 & macr;D*0 threshold, can overshadow a quasiconventional charmoniumlike resonance lying above threshold. This makes difficult the experimental detection of this resonance through the D0 & macr;D*(0) and D+D*(-) channels, despite being its expected main decay modes. We analyze alternative strong and electromagnetic decay modes. Comparison with existing data shows that this resonance may have already been observed through its decay to omega J/psi.