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Amaldi, U., Bonomi, R., Braccini, S., Crescenti, M., Degiovanni, A., Garlasche, M., et al. (2010). Accelerators for hadrontherapy: From Lawrence cyclotrons to linacs. Nucl. Instrum. Methods Phys. Res. A, 620(2-3), 563–577.
Abstract: Hadrontherapy with protons and carbon ions is a fast developing methodology in radiation oncology. The accelerators used and planned for this purpose are reviewed starting from the cyclotrons used in the thirties. As discussed in the first part of this paper, normal and superconducting cyclotrons are still employed, together with synchrotrons, for proton therapy while for carbon ion therapy synchrotrons have been till now the only option. The latest developments concern a superconducting cyclotron for carbon ion therapy, fast-cycling high frequency linacs and 'single room' proton therapy facilities. These issues are discussed in the second part of the paper by underlining the present challenges, in particular the treatment of moving organs.
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Llosa, G., Barrio, J., Cabello, J., Crespo, A., Lacasta, C., Rafecas, M., et al. (2012). Detector characterization and first coincidence tests of a Compton telescope based on LaBr3 crystals and SiPMs. Nucl. Instrum. Methods Phys. Res. A, 695, 105–108.
Abstract: A Compton telescope for dose monitoring in hadron therapy consisting of several layers of continuous LaBr3 crystals coupled to silicon photomultiplier (SiPM) arrays is under development within the ENVISION project. In order to test the possibility of employing such detectors for the telescope, a detector head consisting of a continuous 16 mm x 18 mm x 5 mm LaBr3 crystal coupled to a SiPM array has been assembled and characterized, employing the SPIROC1 ASIC as readout electronics. The best energy resolution obtained at 511 key is 6.5% FWHM and the timing resolution is 3.1 ns FWHM. A position determination method for continuous crystals is being tested, with promising results. In addition, the detector has been operated in time coincidence with a second detector layer, to determine the coincidence capabilities of the system. The first tests are satisfactory, and encourage the development of larger detectors that will compose the telescope prototype.
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Degiovanni, A., Amaldi, U., Bonomi, R., Garlasche, M., Garonna, A., Verdu-Andres, S., et al. (2011). TERA high gradient test program of RF cavities for medical linear accelerators. Nucl. Instrum. Methods Phys. Res. A, 657(1), 55–58.
Abstract: The scientific community and the medical industries are putting a considerable effort into the design of compact, reliable and cheap accelerators for hadrontherapy. Up to now only circular accelerators are used to deliver beams with energies suitable for the treatment of deep seated tumors. The TERA Foundation has proposed and designed a hadrontherapy facility based on the cyclinac concept: a high gradient linear accelerator placed downstream of a cyclotron used as an injector. The overall length of the linac, and therefore its final cost, is almost inversely proportional to the average accelerating gradient achieved in the linac. TERA, in collaboration with the CLIC RF group, has started a high gradient test program. The main goal is to study the high gradient behavior of prototype cavities and to determine the appropriate linac operating frequency considering important issues such as machine reliability and availability of distributed power sources. A preliminary test of a 3 GHz cavity has been carried out at the beginning of 2010, giving encouraging results. Further investigations are planned before the end of 2011. A set of 5.7 GHz cavities is under production and will be tested in a near future. The construction and test of a multi-cell structure is also foreseen.
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Llosa, G., Barrio, J., Lacasta, C., Callier, S., Raux, L., & de La Taille, C. (2011). First tests in the application of silicon photomultiplier arrays to dose monitoring in hadron therapy. Nucl. Instrum. Methods Phys. Res. A, 648, S96–S99.
Abstract: A detector head composed of a continuous LaBr3 crystal coupled to a silicon photomultiplier array has been mounted and tested, for its use in a Compton telescope for dose monitoring in hadron therapy. The LaBr3 crystal has 16 mm x 18 mm x 5 mm size, and it is surrounded with reflecting material in five faces. The SiPM array has 16 (4 x 4) elements of 3 mm x 3 mm size. The SPIROC1 ASIC has been employed as readout electronics. The detector shows a linear behavior up to 1275 keV. The energy resolution obtained at 511 keV is 7% FWHM, and it varies as one over the square root of the energy up to the energies tested. The variations among the detector channels are within 12%. A preliminary measurement of the timing resolution gives 7 ns FWHM. The spatial resolution obtained with the center of gravity method is 1.2 mm FWHM. The tests performed confirm the correct functioning of the detector.
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Llosa, G. (2015). Recent developments in photodetection for medical applications. Nucl. Instrum. Methods Phys. Res. A, 787, 353–357.
Abstract: The use of the most advanced technology in medical imaging results in the development of high performance detectors that can significantly improve the performance of the medical devices employed in hospitals. Scintillator crystals coupled to photodetectors remain to be essential detectors in terms of performance and cost for medical imaging applications in different imaging modalities. Recent advances in photodetectors result in an increase of the performance of the medical scanners. Solid state detectors can provide substantial performance improvement, but are more complex to integrate into clinical detectors due mainly to their higher cost. Solid state photodetectors (APDs, SiPMs) have made new detector concepts possible and have led to improvements in different imaging modalities. Recent advances in detectors for medical imaging are revised.
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Barrientos, L., Borja-Lloret, M., Etxebeste, A., Muñoz, E., Oliver, J. F., Ros, A., et al. (2021). Performance evaluation of MACACO II Compton camera. Nucl. Instrum. Methods Phys. Res. A, 1014, 165702–7pp.
Abstract: The IRIS group at IFIC-Valencia has developed a second version of a Compton camera prototype for hadron therapy treatment monitoring, with the aim of improving the performance with respect to its predecessor. The system is composed of three Lanthanum (III) bromide (LaBr3) crystals coupled to silicon photomultipliers (SiPMs). The detector energy resolution has been improved to 5.6% FWHM at 511 keV and an angular resolution of 8.0 degrees has been obtained. Images of a Na-22 point-like source have been reconstructed selecting two and three interaction events. Moreover, the experimental data have been reproduced with Monte Carlo simulations using a Compton camera module (CCMod) in GATE v8.2 obtaining a good correlation.
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Andreev, Y. M. et al, Molina Bueno, L., & Tuzi, M. (2023). Measurement of the intrinsic hadronic contamination in the NA64-e high-purity e+/e- beam at CERN. Nucl. Instrum. Methods Phys. Res. A, 1057, 168776–8pp.
Abstract: We present the measurement of the intrinsic hadronic contamination at the CERN SPS H4 beamline configured to transport electrons and positrons at 100 GeV/c. The analysis, performed using data collected by the NA64-e experiment in 2022, is based on calorimetric measurements, exploiting the different interaction mechanisms of electrons and hadrons in the NA64 detector. We determined the contamination by comparing the results obtained using the nominal electron/positron beamline configuration with those from a dedicated setup, in which only hadrons impinged on the detector. We also obtained an estimate of the relative protons, antiprotons and pions yield by exploiting the different absorption probabilities of these particles in matter. We cross-checked our results with a dedicated Monte Carlo simulation for the hadron production at the primary T2 target, finding a good agreement with the experimental measurements.
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Mitsou, V. A. (2013). Shedding light on dark matter at colliders. Int. J. Mod. Phys. A, 28(31), 1330052–34pp.
Abstract: Dark matter remains one of the most puzzling mysteries in Fundamental Physics of our times. Experiments at high-energy physics colliders are expected to shed light to its nature and determine its properties. This review focuses on recent searches for dark matter signatures at the Large Hadron Collider, also discussing related prospects in future e(+)e(-) colliders.
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Flores, M. M., Kim, J. S., Rolbiecki, K., & Ruiz de Austri, R. (2023). Updated LHC bounds on MUED after run 2. Int. J. Mod. Phys. A, 38(1), 2350002–14pp.
Abstract: We present updated LHC limits on the minimal universal extra dimensions (MUEDs) model from the Run 2 searches. We scan the parameter space against a number of searches implemented in the public code CheckMATE and derive up-to-date limits on the MUED parameter space from 13TeV searches. The strongest constraints come from a search dedicated to squarks and gluinos with one isolated lepton, jets and missing transverse energy. In the procedure, we take into account initial state radiation and stress its importance in the MUED searches, which is not always appreciated.
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Vijande, J., Valcarce, A., Carames, T. F., & Garcilazo, H. (2013). Heavy Hadron Spectroscopy: A Quark Model Perspective. Int. J. Mod. Phys. E, 22(5), 1330011–25pp.
Abstract: We present recent results of hadron spectroscopy and hadron hadron interaction from the perspective of constituent quark models. We pay special attention to the role played by higher-order hock space components in the hadron spectra and the connection of this extension with the hadron-hadron interaction. The main goal of our description is to obtain a coherent understanding of the low-energy hadron phenomenology without enforcing any particular model, to constrain its characteristics and learn about the low-energy realization of the theory.
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