| Records |
| Author |
Lerendegui-Marco, J.; Balibrea-Correa, J.; Babiano-Suarez, V.; Ladarescu, I.; Domingo-Pardo, C. |
| Title |
Towards machine learning aided real-time range imaging in proton therapy |
Type |
Journal Article |
| Year |
2022 |
Publication |
Scientific Reports |
Abbreviated Journal |
Sci Rep |
| Volume |
12 |
Issue |
1 |
Pages |
2735 - 17pp |
| Keywords |
|
| Abstract |
Compton imaging represents a promising technique for range verification in proton therapy treatments. In this work, we report on the advantageous aspects of the i-TED detector for proton-range monitoring, based on the results of the first Monte Carlo study of its applicability to this field. i-TED is an array of Compton cameras, that have been specifically designed for neutron-capture nuclear physics experiments, which are characterized by gamma-ray energies spanning up to 5-6 MeV, rather low gamma-ray emission yields and very intense neutron induced gamma-ray backgrounds. Our developments to cope with these three aspects are concomitant with those required in the field of hadron therapy, especially in terms of high efficiency for real-time monitoring, low sensitivity to neutron backgrounds and reliable performance at the high gamma-ray energies. We find that signal-to-background ratios can be appreciably improved with i-TED thanks to its light-weight design and the low neutron-capture cross sections of its LaCl3 crystals, when compared to other similar systems based on LYSO, CdZnTe or LaBr3. Its high time-resolution (CRT similar to 500 ps) represents an additional advantage for background suppression when operated in pulsed HT mode. Each i-TED Compton module features two detection planes of very large LaCl3 monolithic crystals, thereby achieving a high efficiency in coincidence of 0.2% for a point-like 1 MeV gamma-ray source at 5 cm distance. This leads to sufficient statistics for reliable image reconstruction with an array of four i-TED detectors assuming clinical intensities of 10(8) protons per treatment point. The use of a two-plane design instead of three-planes has been preferred owing to the higher attainable efficiency for double time-coincidences than for threefold events. The loss of full-energy events for high energy gamma-rays is compensated by means of machine-learning based algorithms, which allow one to enhance the signal-to-total ratio up to a factor of 2. |
| Address |
[Lerendegui-Marco, Jorge; Balibrea-Correa, Javier; Babiano-Suarez, Victor; Ladarescu, Ion; Domingo-Pardo, Cesar] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: jorge.lerendegui@ific.uv.es |
| Corporate Author |
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Thesis |
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| Publisher |
Nature Portfolio |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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ISSN  |
2045-2322 |
ISBN |
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Medium |
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| Area |
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Expedition |
|
Conference |
|
| Notes |
WOS:000757537100018 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
no |
| Call Number |
IFIC @ pastor @ |
Serial |
5136 |
| Permanent link to this record |
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| Author |
Balibrea-Correa, J.; Lerendegui-Marco, J.; Ladarescu, I.; Guerrero, C.; Rodriguez-Gonzalez, T.; Jimenez-Ramos, M.C.; Fernandez-Martinez, B.; Domingo-Pardo, C. |
| Title |
Hybrid in-beam PET- and Compton prompt-gamma imaging aimed at enhanced proton-range verification |
Type |
Journal Article |
| Year |
2022 |
Publication |
European Physical Journal Plus |
Abbreviated Journal |
Eur. Phys. J. Plus |
| Volume |
137 |
Issue |
11 |
Pages |
1258 - 18pp |
| Keywords |
|
| Abstract |
We report on a hybrid in-beam PET and prompt-gamma Compton imaging system aimed at quasi real-time ion-range verification in proton-therapy treatments. Proof-of-concept experiments were carried out at the radiobiology beam line of the CNA cyclotron facility using a set of two synchronous Compton imagers and different target materials. The time structure of the 18 MeV proton beam was shaped with a series of beam-on and beam-off intervals, thereby mimicking a pulsed proton beam on a long time scale. During beam-on intervals, Compton imagingwas performed utilizing the high energy. -rays promptly emitted from the nuclear reactions occurring in the targets. In the course of the beam-off intervals in situ positron-emission tomography was accomplished with the same imagers using the beta+ decay of activated nuclei. The targets used were stacks of different materials covering also various proton ranges and energies. A systematic study on the performance of these two complementary imaging techniques is reported and the experimental results interpreted on the basis ofMonte Carlo calculations. The results demonstrate the possibility to combine both imaging techniques in a concomitant way, where high-efficiency prompt-gamma imaging is complemented with the high spatial accuracy of PET. Empowered by these results we suggest that a pulsed beam with a suitable duty cycle, in conjunction with in situ Compton- and PET-imaging may help to attain complementary information and quasi real-time range monitoring with high accuracy. |
| Address |
[Balibrea-Correa, J.; Lerendegui-Marco, J.; Ladarescu, I; Domingo-Pardo, C.] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: javier.balibrea@ific.uv.es |
| Corporate Author |
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Thesis |
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| Publisher |
Springer Heidelberg |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
2190-5444 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
|
| Notes |
WOS:000886327900002 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
no |
| Call Number |
IFIC @ pastor @ |
Serial |
5420 |
| Permanent link to this record |
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| Author |
n_TOF Collaboration (Patronis, N. et al); Babiano-Suarez, V.; Balibrea Correa, J.; Domingo-Pardo, C.; Ladarescu, I.; Lerendegui-Marco, J. |
| Title |
Status report of the n_TOF facility after the 2nd CERN long shutdown period |
Type |
Journal Article |
| Year |
2023 |
Publication |
EPJ Techniques and Instrumentation |
Abbreviated Journal |
EPJ Tech. Instrum. |
| Volume |
10 |
Issue |
1 |
Pages |
13 - 10pp |
| Keywords |
Neutron time of flight; Spallation target; Nuclear astrophysics; Neutron physics; Neutron induced fission; Neutron reactions |
| Abstract |
During the second long shutdown period of the CERN accelerator complex (LS2, 2019-2021), several upgrade activities took place at the nTOF facility. The most important have been the replacement of the spallation target with a next generation nitrogen-cooled lead target. Additionally, a new experimental area, at a very short distance from the target assembly (the NEAR Station) was established. In this paper, the core commissioning actions of the new installations are described. The improvement in the nTOF infrastructure was accompanied by several detector development projects. All these upgrade actions are discussed, focusing mostly on the future perspectives of the n_TOF facility. Furthermore, some indicative current and future measurements are briefly reported. |
| Address |
[Patronis, N.; Goula, S.; Eleme, Z.; Stamati, M. E.; Vagena, E.] Univ Ioannina, Ioannina, Greece, Email: nikolaos.patronis@cern.ch |
| Corporate Author |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
|
| ISSN |
2195-7045 |
ISBN |
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Medium |
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| Area |
|
Expedition |
|
Conference |
|
| Notes |
WOS:001008786600001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
5591 |
| Permanent link to this record |
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| Author |
Lerendegui-Marco, J.; Babiano-Suarez, V.; Balibrea-Correa, J.; Caballero, L.; Calvo, D.; Ladarescu, I.; Domingo-Pardo, C. |
| Title |
Simultaneous Gamma-Neutron Vision device: a portable and versatile tool for nuclear inspections |
Type |
Journal Article |
| Year |
2024 |
Publication |
EPJ Techniques and Instrumentation |
Abbreviated Journal |
EPJ Tech. Instrum. |
| Volume |
11 |
Issue |
1 |
Pages |
2 - 17pp |
| Keywords |
Gamma imaging; Neutron imaging; Nuclear inspections; Homeland security; Nuclear waste characterization |
| Abstract |
This work presents GN-Vision, a novel dual gamma-ray and neutron imaging system, which aims at simultaneously obtaining information about the spatial origin of gamma-ray and neutron sources. The proposed device is based on two position sensitive detection planes and exploits the Compton imaging technique for the imaging of gamma-rays. In addition, spatial distributions of slow- and thermal-neutron sources (<100 eV) are reconstructed by using a passive neutron pin-hole collimator attached to the first detection plane. The proposed gamma-neutron imaging device could be of prime interest for nuclear safety and security applications. The two main advantages of this imaging system are its high efficiency and portability, making it well suited for nuclear applications were compactness and real-time imaging is important. This work presents the working principle and conceptual design of the GN-Vision system and explores, on the basis of Monte Carlo simulations, its simultaneous gamma-ray and neutron detection and imaging capabilities for a realistic scenario where a Cf-252 source is hidden in a neutron moderating container. |
| Address |
[Lerendegui-Marco, Jorge; Babiano-Suarez, Victor; Balibrea-Correa, Javier; Caballero, Luis; Calvo, David; Ladarescu, Ion; Domingo-Pardo, Cesar] Univ Valencia, Inst Fis Corpuscular, CSIC, Valencia, Spain, Email: jorge.lerendegui@ific.uv.es |
| Corporate Author |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
2195-7045 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
WOS:001171512700001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
no |
| Call Number |
IFIC @ pastor @ |
Serial |
5975 |
| Permanent link to this record |
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| Author |
n_TOF Collaboration (Lerendegui-Marco, J. et al.); Domingo-Pardo, C.; Tain, J.L.; Tarifeño-Saldivia, A. |
| Title |
Radiative neutron capture on Pu-242 in the resonance region at the CERN n_TOF-EAR1 facility |
Type |
Journal Article |
| Year |
2018 |
Publication |
Physical Review C |
Abbreviated Journal |
Phys. Rev. C |
| Volume |
97 |
Issue |
2 |
Pages |
024605 - 21pp |
| Keywords |
|
| Abstract |
The spent fuel of current nuclear reactors contains fissile plutonium isotopes that can be combined with uranium to make mixed oxide (MOX) fuel. In this way the Pu from spent fuel is used in a new reactor cycle, contributing to the long-term sustainability of nuclear energy. However, an extensive use of MOX fuels, in particular in fast reactors, requires more accurate capture and fission cross sections for some Pu isotopes. In the case of Pu-242 there are sizable discrepancies among the existing capture cross-section measurements included in the evaluations (all from the 1970s) resulting in an uncertainty as high as 35% in the fast energy region. Moreover, postirradiation experiments evaluated with JEFF-3.1 indicate an overestimation of 14% in the capture cross section in the fast neutron energy region. In this context, the Nuclear Energy Agency (NEA) requested an accuracy of 8% in this cross section in the energy region between 500 meV and 500 keV. This paper presents a new time-of-flight capture measurement on Pu-242 carried out at nTOF-EAR1 (CERN), focusing on the analysis and statistical properties of the resonance region, below 4 keV. The Pu-242(n, gamma) reaction on a sample containing 95(4) mg enriched to 99.959% was measured with an array of four C6D6 detectors and applying the total energy detection technique. The high neutron energy resolution of nTOF-EAR1 and the good statistics accumulated have allowed us to extend the resonance analysis up to 4 keV, obtaining new individual and average resonance parameters from a capture cross section featuring a systematic uncertainty of 5%, fulfilling the request of the NEA. |
| Address |
[Lerendegui-Marco, J.; Guerrero, C.; Quesada, J. M.; Cortes-Giraldo, M. A.; Praena, J.; Sabate-Gilarte, M.] Univ Seville, Dept Fis Atom Mol & Nucl, E-41012 Seville, Spain, Email: cguerrero4@us.es |
| Corporate Author |
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Thesis |
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| Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
2469-9985 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
|
| Notes |
WOS:000424190700001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
3474 |
| Permanent link to this record |
