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Author |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
![goto web page (via DOI) doi](img/doi.gif)
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Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
Type |
Journal Article |
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Year |
2024 |
Publication |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
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Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
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Keywords |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
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Abstract |
In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
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Address |
[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
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Mdpi |
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WOS:001269841000001 |
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no |
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yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6204 |
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Author |
Barrientos, D.; Bellato, M.; Bazzacco, D.; Bortolato, D.; Cocconi, P.; Gadea, A.; Gonzalez, V.; Gulmini, M.; Isocrate, R.; Mengoni, D.; Pullia, A.; Recchia, F.; Rosso, D.; Sanchis, E.; Toniolo, N.; Ur, C.A.; Valiente-Dobon, J.J. |
![goto web page (via DOI) doi](img/doi.gif)
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Title |
Performance of the Fully Digital FPGA-Based Front-End Electronics for the GALILEO Array |
Type |
Journal Article |
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Year |
2015 |
Publication |
IEEE Transactions on Nuclear Science |
Abbreviated Journal |
IEEE Trans. Nucl. Sci. |
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Volume |
62 |
Issue |
6 |
Pages |
3134-3139 |
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Keywords |
FPGA; front-end electronics; gamma-ray spectroscopy; germanium detectors |
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Abstract |
In this work we present the architecture and results of a fully digital Front End Electronics (FEE) read out system developed for the GALILEO array. The FEE system, developed in collaboration with the Advanced Gamma Tracking Array (AGATA) collaboration, is composed of three main blocks: preamplifiers, digitizers and preprocessing electronics. The slow control system contains a custom Linux driver, a dynamic library and a server implementing network services. This work presents the first results of the digital FEE system coupled with a GALILEO germanium detector, which has demonstrated the capability to achieve an energy resolution of 1.53% at an energy of 1.33 MeV, similar to the one obtained with a conventional analog system. While keeping a good performance in terms of energy resolution, digital electronics will allow to instrument the full GALILEO array with a versatile system with high integration and low power consumption and costs. |
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Address |
[Barrientos, D.; Bortolato, D.; Cocconi, P.; Gulmini, M.; Rosso, D.; Toniolo, N.; Valiente-Dobon, J. J.] Ist Nazl Fis Nucl, Lab Nazl Legnaro, I-35020 Padua, Italy, Email: diego.barrientos@lnl.infn.it |
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Ieee-Inst Electrical Electronics Engineers Inc |
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English |
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ISSN ![sorted by ISSN field, ascending order (up)](img/sort_asc.gif) |
0018-9499 |
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Notes |
WOS:000372013500005 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2612 |
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Author |
Krzysiek, M. et al; Gadea, A.; Huyuk, T.; Barrientos, D. |
![find record details (via OpenURL) openurl](img/xref.gif)
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Title |
Study of the soft dipole modes in Ce-140 via inelastic scattering of O-17 |
Type |
Journal Article |
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Year |
2014 |
Publication |
Physica Scripta |
Abbreviated Journal |
Phys. Scr. |
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Volume |
89 |
Issue |
5 |
Pages |
054016 - 6pp |
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Keywords |
pygmy dipole resonances; inelastic scattering; AGATA detector; gamma spectroscopy |
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Abstract |
The main aim of this study was a deeper understanding of the nuclear structure properties of the soft dipole modes in Ce-140, excited via inelastic scattering of weakly bound O-17 projectiles. An important aim was to investigate the 'splitting' of the PDR into two parts: a low-energy isoscalar component dominated by neutron-skin oscillations and a higher-energy component lying on the tail of the giant dipole resonance of a rather isovector character. This was already observed for this nucleus, investigated in (alpha, alpha') and (gamma,gamma') experiments. The experiment was performed at Laboratori Nazionali di Legnaro, Italy. Inelastic scattering of O-17 ion beam at 20 MeV A(-1) was used to excite the resonance modes in the Ce-140 target. Gamma-rays were registered by five triple clusters of AGATA-Demonstrator and nine large volume scintillators (LaBr3). The scattered O-17 ions were identified by two Delta E – E Si telescopes of the TRACE array mounted inside the scattering chamber. The telescopes consisted of two segmented Si-pad detectors, each of 60 pixels. Very preliminary data have shown a strong domination of the E1 transitions in the 'pygmy' region with a character more similar to the one obtained in alpha scattering experiment. |
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Address |
[Krzysiek, M.; Kmiecik, M.; Maj, A.; Bednarczyk, P.; Ciemala, M.; Fornal, B.; Grebosz, J.; Mazurek, K.; Meczynski, W.; Zieblinski, M.] Polish Acad Sci, H Niewodniczanski Inst Nucl Phys, Krakow, Poland, Email: mateusz.krzysiek@ifj.edu.pl |
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Iop Publishing Ltd |
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English |
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ISSN ![sorted by ISSN field, ascending order (up)](img/sort_asc.gif) |
0031-8949 |
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Notes |
WOS:000335785300016 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1790 |
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Permanent link to this record |
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Author |
Pajtler, M.V. et al; Gadea, A. |
![find record details (via OpenURL) openurl](img/xref.gif)
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Title |
Excited states of Y-90,Y-92,Y-94 populated in Zr-90+Pb-208 multinucleon transfer reaction |
Type |
Journal Article |
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Year |
2021 |
Publication |
Physica Scripta |
Abbreviated Journal |
Phys. Scr. |
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Volume |
96 |
Issue |
3 |
Pages |
035305 - 7pp |
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Keywords |
multinucleon transfer reactions; gamma spectroscopy; magnetic spectrometers; gamma-ray spectrometers |
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Abstract |
Multinucleon transfer reactions in Zr-90+Pb-208 have been studied via fragment-gamma coincidences, employing the PRISMA magnetic spectrometer coupled to the CLARA gamma-array. An analysis on Y isotopes has been carried out incorporating spectroscopic as well as reaction mechanism aspects. New gamma transitions have been observed in Y-94, confirming the findings of recent studies where nuclei were produced via fission of uranium, and a comparison with near-by Y-90,Y-92 isotopes populated in the same reaction has been discussed. Experimental cross sections have been extracted and compared with the GRAZING calculations, showing a fair agreement along the neutron pick-up side. The results confirm how multinucleon transfer reactions are a suitable mechanism for the study of neutron-rich nuclei. |
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Address |
[Pajtler, M. Varga] Univ Osijek, Dept Phys, Osijek, Croatia, Email: Suzana.Szilner@irb.hr; |
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Iop Publishing Ltd |
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English |
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ISSN ![sorted by ISSN field, ascending order (up)](img/sort_asc.gif) |
0031-8949 |
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Notes |
WOS:000611517400001 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4694 |
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Permanent link to this record |
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Author |
Albaladejo, M.; Bibrzycki, L.; Dawid, S.M.; Fernandez-Ramirez, C.; Gonzalez-Solis, S.; Hiller Blin, A.N.; Jackura, A.W.; Mathieu, V.; Mikhasenko, M.; Make, V.I.; Passemar, E.; Pilloni, A.; Rodas, A.; Silva-Castro, J.A.; Smith, W.A.; Szczepaniak, A.P.; Winney, D. |
![goto web page (via DOI) doi](img/doi.gif)
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Title |
Novel approaches in hadron spectroscopy |
Type |
Journal Article |
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Year |
2022 |
Publication |
Progress in Particle and Nuclear Physics |
Abbreviated Journal |
Prog. Part. Nucl. Phys. |
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Volume |
127 |
Issue |
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Pages |
103981 - 75pp |
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Keywords |
Hadron spectroscopy; Exotic hadrons; Three-body scattering; Resonance production |
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Abstract |
The last two decades have witnessed the discovery of a myriad of new and unexpected hadrons. The future holds more surprises for us, thanks to new-generation experiments. Understanding the signals and determining the properties of the states requires a parallel theoretical effort. To make full use of available and forthcoming data, a careful amplitude modeling is required, together with a sound treatment of the statistical uncertainties, and a systematic survey of the model dependencies. We review the contributions made by the Joint Physics Analysis Center to the field of hadron spectroscopy. |
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Address |
[Albaladejo, Miguel; Blin, Astrid N. Hiller; Jackura, Andrew W.; Mokeev, Victor, I; Passemar, Emilie; Rodas, Arkaitz; Szczepaniak, Adam P.] Thomas Jefferson Natl Accelerator Facil, Theory Ctr & Phys Div, Newport News, VA 23606 USA, Email: alessandro.pilloni@unime.it |
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Publisher |
Elsevier |
Place of Publication |
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English |
Summary Language |
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ISSN ![sorted by ISSN field, ascending order (up)](img/sort_asc.gif) |
0146-6410 |
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Notes |
WOS:000883770300003 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5422 |
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Permanent link to this record |
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Author |
AGATA Collaboration; Doncel, M.; Recchia, F.; Quintana, B.; Gadea, A.; Farnea, E. |
![find record details (via OpenURL) openurl](img/xref.gif)
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Title |
Experimental test of the background rejection, through imaging capability, of a highly segmented AGATA germanium detector |
Type |
Journal Article |
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Year |
2010 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
622 |
Issue |
3 |
Pages |
614-618 |
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Keywords |
Gamma spectroscopy; Gamma tracking; Imaging; Position-sensitive germanium detectors |
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Abstract |
The development of highly segmented germanium detectors as well as the algorithms to identify the position of the interaction within the crystal opens the possibility to locate the gamma-ray source using Compton imaging algorithms. While the Compton-suppression shield, coupled to the germanium detector in conventional arrays, works also as an active filter against the gamma rays originated outside the target, the new generation of position sensitive gamma-ray detector arrays has to fully rely on tracking capabilities for this purpose. In specific experimental conditions, as the ones foreseen at radioactive beam facilities, the ability to discriminate background radiation improves the sensitivity of the gamma spectrometer. In this work we present the results of a measurement performed at the Laboratori Nazionali di Legnaro (LNL) aiming the evaluation of the AGATA detector capabilities to discriminate the origin of the gamma rays on an event-by-event basis. It will be shown that, exploiting the Compton scattering formula, it is possible to track back gamma rays coming from different positions, assigning them to specific emitting locations. These imaging capabilities are quantified for a single crystal AGATA detector. |
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Address |
[Doncel, M.; Quintana, B.] Univ Salamanca, Lab Radiac Ionizantes, E-37008 Salamanca, Spain, Email: doncel@usal.es |
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Publisher |
Elsevier Science Bv |
Place of Publication |
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English |
Summary Language |
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ISSN ![sorted by ISSN field, ascending order (up)](img/sort_asc.gif) |
0168-9002 |
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Notes |
ISI:000282562700017 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
257 |
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Permanent link to this record |
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Author |
AGATA Collaboration (Akkoyun, S. et al); Algora, A.; Barrientos, D.; Domingo-Pardo, C.; Egea, F.J.; Gadea, A.; Huyuk, T.; Kaci, M.; Mendez, V.; Rubio, B.; Salt, J.; Tain, J.L. |
![goto web page (via DOI) doi](img/doi.gif)
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Title |
AGATA-Advanced GAmma Tracking Array |
Type |
Journal Article |
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Year |
2012 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
668 |
Issue |
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Pages |
26-58 |
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Keywords |
AGATA; gamma-Ray spectroscopy; gamma-Ray tracking; HPGe detectors; Digital signal processing; Pulse-shape and gamma-ray tracking algorithms; Semiconductor detector performance and simulations |
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Abstract |
The Advanced GAmma Tracking Array (AGATA) is a European project to develop and operate the next generation gamma-ray spectrometer. AGATA is based on the technique of gamma-ray energy tracking in electrically segmented high-purity germanium crystals. This technique requires the accurate determination of the energy, time and position of every interaction as a gamma ray deposits its energy within the detector volume. Reconstruction of the full interaction path results in a detector with very high efficiency and excellent spectral response. The realisation of gamma-ray tracking and AGATA is a result of many technical advances. These include the development of encapsulated highly segmented germanium detectors assembled in a triple cluster detector cryostat, an electronics system with fast digital sampling and a data acquisition system to process the data at a high rate. The full characterisation of the crystals was measured and compared with detector-response simulations. This enabled pulse-shape analysis algorithms, to extract energy, time and position, to be employed. In addition, tracking algorithms for event reconstruction were developed. The first phase of AGATA is now complete and operational in its first physics campaign. In the future AGATA will be moved between laboratories in Europe and operated in a series of campaigns to take advantage of the different beams and facilities available to maximise its science output. The paper reviews all the achievements made in the AGATA project including all the necessary infrastructure to operate and support the spectrometer. |
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Address |
[Boston, A. J.; Boston, H. C.; Colosimo, S.; Cooper, R. J.; Cresswell, J. R.; Dimmock, M. R.; Filmer, F.; Grint, A. N.; Harkness, L. J.; Judson, D. S.; Mather, A. R.; Moon, S.; Nelson, L.; Nolan, P. J.; Norman, M.; Oxley, D. C.; Rigby, S.; Sampson, J.; Scraggs, D. P.; Seddon, D.; Slee, M.; Stanios, T.; Thornhill, J.; Unsworth, C.; Wells, D.] Univ Liverpool, Oliver Lodge Lab, Liverpool L69 7ZE, Merseyside, England, Email: a.j.boston@liverpool.ac.uk |
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Elsevier Science Bv |
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English |
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ISSN ![sorted by ISSN field, ascending order (up)](img/sort_asc.gif) |
0168-9002 |
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Notes |
WOS:000300864200005 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
923 |
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Permanent link to this record |
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Author |
AGATA Collaboration; Doncel, M.; Quintana, B.; Gadea, A.; Recchia, F.; Farnea, E. |
![find record details (via OpenURL) openurl](img/xref.gif)
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Title |
Background rejection capabilities of a Compton imaging telescope setup with a DSSD Ge planar detector and AGATA |
Type |
Journal Article |
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Year |
2011 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
648 |
Issue |
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Pages |
S131-S134 |
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Keywords |
gamma-Spectroscopy; Gamma tracking; Imaging; Position-sensitive germanium detectors |
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Abstract |
In this work, we show the first Monte Carlo results about the performance of the Ge array which we propose for the DESPEC experiment at FAIR, when the background algorithm developed for AGATA is applied. The main objective of our study is to characterize the capabilities of the gamma-spectroscopy system, made up of AGATA detectors in a semi-spherical distribution covering a 1 pi solid angle and a set of planar Ge detectors in a daisy configuration, to discriminate between gamma sources placed at different locations. |
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Address |
[Doncel, M.; Quintana, B.] Univ Salamanca, Lab Radiac Ionizantes, E-37008 Salamanca, Spain, Email: doncel@usal.es |
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Elsevier Science Bv |
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English |
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ISSN ![sorted by ISSN field, ascending order (up)](img/sort_asc.gif) |
0168-9002 |
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Notes |
WOS:000305376900035 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1071 |
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Permanent link to this record |
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Author |
Kowalska, M.; Naimi, S.; Agramunt, J.; Algora, A.; Beck, D.; Blank, B.; Blaum, K.; Bohm, C.; Borgmann, C.; Breitenfeldt, M.; Fraile, L.M.; George, S.; Herfurth, F.; Herlert, A.; Kreim, S.; Lunney, D.; Minaya-Ramirez, E.; Neidherr, D.; Rosenbusch, M.; Rubio, B.; Schweikhard, L.; Stanja, J.; Zuber, K. |
![find record details (via OpenURL) openurl](img/xref.gif)
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Title |
Trap-assisted decay spectroscopy with ISOLTRAP |
Type |
Journal Article |
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Year |
2012 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
689 |
Issue |
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Pages |
102-107 |
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Keywords |
Penning trap mass spectrometers; Trap-assisted decay spectroscopy; Studies at ISOL-type facilities |
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Abstract |
Penning traps are excellent high-precision mass spectrometers for radionuclides. The high-resolving power used for cleaning isobaric and even isomeric contaminants can be exploited to improve decay-spectroscopy studies by delivering purified samples. An apparatus allowing trap-assisted decay spectroscopy has been coupled to the ISOLTRAP mass spectrometer at ISOLDE/CERN. The results from studies with stable and radioactive ions show that the setup can be used to perform decay studies on purified short-lived nuclides and to assist mass measurements. |
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Address |
[Kowalska, M.; Herlert, A.] CERN, Dept Phys, CH-1211 Geneva 23, Switzerland, Email: kowalska@cern.ch |
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Elsevier Science Bv |
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English |
Summary Language |
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ISSN ![sorted by ISSN field, ascending order (up)](img/sort_asc.gif) |
0168-9002 |
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Notes |
WOS:000307797500016 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1134 |
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Permanent link to this record |
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Author |
AGATA Collaboration; Domingo-Pardo, C.; Bazzacco, D.; Doornenbal, P.; Farnea, E.; Gadea, A.; Gerl, J.; Wollersheim, H.J. |
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Title |
Conceptual design and performance study for the first implementation of AGATA at the in-flight RIB facility of GSI |
Type |
Journal Article |
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Year |
2012 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
694 |
Issue |
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Pages |
297-312 |
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Keywords |
gamma-Ray spectroscopy; Tracking; Monte Carlo |
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Abstract |
The main objective of the Advanced GAmma Tracking Array (AGATA) is the investigation of the structure of exotic nuclei at the new generation of RIB facilities. As part of the preparatory phase for FAIR-NUSTAR, AGATA is going to be installed at the FRS fragmentation facility of the GSI centre for an experimental campaign to be performed in 2012 and 2013. Owing to its gamma-ray tracking capabilities and the envisaged enhancement in resolving power, a series of in-flight gamma-ray spectroscopy experiments are being planned. The present work describes the conceptual design of this first implementation of AGATA at GSI-FRS, and provides information about the expected performance figures. According to the characteristics of each particular experiment, it is foreseen that the target-array distance is adjusted in order to achieve the optimum compromise between detection efficiency and energy resolution, or to cover an specific angular range of the emitted electromagnetic radiation. Thus, a comprehensive Monte Carlo study of the detection sensitivity in terms of photopeak efficiency, resolution and peak-to-total ratio, as a function of the target-array distance is presented. Several configurations have been investigated, and MC-calculations indicate that a remarkable enhancement in resolving power can be achieved when double-cluster AGATA detectors are developed and implemented. Several experimental effects are also investigated. This concerns the impact of passive materials between the target and the array, the angular distribution of the detection efficiency and the influence of target thickness effects and transition lifetimes in the attainable detection sensitivity. A short overview on half-life measurements via lineshape effects utilizing AGATA is also presented. (C) 2012 Elsevier B.V. All rights reserved. |
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Address |
[Domingo-Pardo, C.; Gadea, A.] Univ Valencia, CSIC, IFIC, Valencia, Spain, Email: domingo@ific.uv.es |
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Publisher |
Elsevier Science Bv |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN ![sorted by ISSN field, ascending order (up)](img/sort_asc.gif) |
0168-9002 |
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Conference |
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Notes |
WOS:000311020500041 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1240 |
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