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Author Linhart, V.; Burdette, D.; Chessi, E.; Cindro, V.; Clinthorne, N.H.; Cochran, E.; Grosicar, B.; Honscheid, K.; Kagan, H.; Lacasta, C.; Llosa, G.; Mikuz, M.; Stankova, V.; Studen, A.; Weilhammer, P.; Zontar, D.
Title Spectroscopy study of imaging devices based on silicon Pixel Array Detector coupled to VATAGP7 read-out chips Type Journal Article
Year 2011 Publication Journal of Instrumentation Abbreviated Journal J. Instrum.
Volume 6 Issue Pages C01092 - 8pp
Keywords Gamma camera, SPECT, PET PET/CT, coronary CT angiography (CTA); Compton imaging
Abstract Spectroscopic and timing response studies have been conducted on a detector module consisting of a silicon Pixel Array Detector bonded on two VATAGP7 read-out chips manufactured by Gamma-Medica Ideas using laboratory gamma sources and the internal calibration facilities (the calibration system of the read-out chips). The performed tests have proven that the chips have (i) non-linear calibration curves which can be approximated by power functions, (ii) capability to measure the energy of photons with energy resolution better than 2 keV (exact range and resolution depend on experimental setup), (iii) the internal calibration facility which provides 6 out of 16 available internal calibration charges within our region of interest (spanning the Compton edge of 511 keV photons). The peaks induced by the internal calibration facility are suitable for a fit of the calibration curves. However, they are not suitable for measurements of equivalent noise charge because their full width at half maximum varies with their amplitude. These facts indicate that the VATAGP7 chips are useful and precise tools for a wide variety of spectroscopic devices. We have also explored time walk of the module and peaking time of the spectroscopy signals provided by the chips. We have observed that (iv) the time walk is caused partly by the peaking time of the signals provided by the fast shaper of the chips and partly by the timing uncertainty related to the varying position of the photon interaction, (v) the peaking time of the spectroscopy signals provided by the chips increases with increasing pulse height.
Address [Linhart, V.; Lacasta, C.; Llosa, G.; Stankova, V.] UVEG, CSIC, IFIC, Expt Phys Dept,Inst Fis Corpuscular, E-46071 Valencia, Spain, Email: Vladimir.Linhart@ific.uv.es
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (down) 1748-0221 ISBN Medium
Area Expedition Conference
Notes ISI:000291345600097 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ elepoucu @ Serial 645
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Author Ros, A.; Lerche, C.W.; Sebastia, A.; Sanchez, F.; Benlloch, J.M.
Title Retroreflector arrays for better light collection efficiency of gamma-ray imaging detectors with continuous scintillation crystals without DOI misestimation Type Journal Article
Year 2014 Publication Journal of Instrumentation Abbreviated Journal J. Instrum.
Volume 9 Issue Pages P04009 - 14pp
Keywords Gamma detectors (scintillators, CZT, HPG, HgI etc); Interaction of radiation with matter; Gamma camera, SPECT, PET PET/CT, coronary CT angiography (CTA); Detector design and construction technologies and materials
Abstract A method to improve light collection efficiency of gamma-ray imaging detectors by using retroreflector arrays has been tested, simulations of the behaviour of the scintillation light illuminating the retroreflector surface have been made. Measurements including retroreflector arrays in the setup have also been taken. For the measurements, positron emission tomography (PET) detectors with continuous scintillation crystals have been used. Each detector module consists of a continuous LSO-scintillator of dimensions 49x49x10 mm(3) and a H8500 position-sensitive photo-multiplier (PSPMT) from Hamamatsu. By using a continuous scintillation crystal, the scintillation light distribution has not been destroyed and the energy, the centroids along the x- and y-direction and the depth of interaction (DOI) can be estimated. Simulations have also been run taking into account the use of continuous scintillation crystals. Due to the geometry of the continuous scintillation crystals in comparison with pixelated crystals, a good light collection efficiency is necessary to correctly reconstruct the impact point of the gamma-ray. The aim of this study is to investigate whether micro-machine retro-reflectors improve light yield without misestimation of the impact point. The results shows an improvement on the energy and centroid resolutions without worsening the depth of interaction resolution. Therefore it can be concluded that using retroreflector arrays at the entrance side of the scintillation crystal improves light collection efficiency without worsening the impact point estimation.
Address [Ros, A.] Inst Fis Corpuscular IFIC, Valencia 46980, Spain, Email: anrogar2@i3m.upv.es
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (down) 1748-0221 ISBN Medium
Area Expedition Conference
Notes WOS:000336123800049 Approved no
Is ISI yes International Collaboration no
Call Number IFIC @ pastor @ Serial 1798
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Author Brzezinski, K.; Oliver, J.F.; Gillam, J.; Rafecas, M.; Studen, A.; Grkovski, M.; Kagan, H.; Smith, S.; Llosa, G.; Lacasta, C.; Clinthorne, N.H.
Title Experimental evaluation of the resolution improvement provided by a silicon PET probe Type Journal Article
Year 2016 Publication Journal of Instrumentation Abbreviated Journal J. Instrum.
Volume 11 Issue Pages P09016 - 13pp
Keywords Gamma camera; SPECT; PET PET/CT; coronary CT angiography (CTA); Medical-image reconstruction methods and algorithms; computer-aided software
Abstract A high-resolution PET system, which incorporates a silicon detector probe into a conventional PET scanner, has been proposed to obtain increased image quality in a limited region of interest. Detailed simulation studies have previously shown that the additional probe information improves the spatial resolution of the reconstructed image and increases lesion detectability, with no cost to other image quality measures. The current study expands on the previous work by using a laboratory prototype of the silicon PET-probe system to examine the resolution improvement in an experimental setting. Two different versions of the probe prototype were assessed, both consisting of a back-to-back pair of 1-mm thick silicon pad detectors, one arranged in 32 x 16 arrays of 1.4mm x 1.4mm pixels and the other in 40 x 26 arrays of 1.0mm x 1.0mm pixels. Each detector was read out by a set of VATAGP7 ASICs and a custom-designed data acquisition board which allowed trigger and data interfacing with the PET scanner, itself consisting of BGO block detectors segmented into 8 x 6 arrays of 6mm x 12mm x 30mm crystals. Limited-angle probe data was acquired from a group of Na-22 point-like sources in order to observe the maximum resolution achievable using the probe system. Data from a Derenzo-like resolution phantom was acquired, then scaled to obtain similar statistical quality as that of previous simulation studies. In this case, images were reconstructed using measurements of the PET ring alone and with the inclusion of the probe data. Images of the Na-22 source demonstrated a resolution of 1.5mm FWHM in the probe data, the PET ring resolution being approximately 6 mm. Profiles taken through the image of the Derenzo-like phantom showed a clear increase in spatial resolution. Improvements in peak-to-valley ratios of 50% and 38%, in the 4.8mm and 4.0mm phantom features respectively, were observed, while previously unresolvable 3.2mm features were brought to light by the addition of the probe. These results support the possibility of improving the image resolution of a clinical PET scanner using the silicon PET-probe.
Address [Brzezinski, K.; Oliver, J. F.; Gillam, J.; Rafecas, M.; Llosa, G.; Lacasta, C.] Univ Valencia, CSIC, Inst Fis Corpuscular, C Catedrat Jose Beltran 2, Valencia, Spain, Email: k.w.brzezinski@rug.nl
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (down) 1748-0221 ISBN Medium
Area Expedition Conference
Notes WOS:000387862300016 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 2865
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Author Gomez-Cadenas, J.J.; Benlloch-Rodriguez, J.M.; Ferrario, P.; Monrabal, F.; Rodriguez, J.; Toledo, J.F.
Title Investigation of the coincidence resolving time performance of a PET scanner based on liquid xenon: a Monte Carlo study Type Journal Article
Year 2016 Publication Journal of Instrumentation Abbreviated Journal J. Instrum.
Volume 11 Issue Pages P09011 - 18pp
Keywords Gamma camera; SPECT; PET PET/CT; coronary CT angiography (CTA); Instrumentation and methods for time-of-flight (TOF) spectroscopy; Noble liquid detectors (scintillation ionization, double-phase); Scintillators; scintillation and light emission processes (solid, gas and liquid scintillators)
Abstract The measurement of the time of flight of the two 511 keV gammas recorded in coincidence in a PET scanner provides an effective way of reducing the random background and therefore increases the scanner sensitivity, provided that the coincidence resolving time (CRT) of the gammas is sufficiently good. The best commercial PET-TOF system today (based in LYSO crystals and digital SiPMs), is the VEREOS of Philips, boasting a CRT of 316 ps (FWHM). In this paper we present a Monte Carlo investigation of the CRT performance of a PET scanner exploiting the scintillating properties of liquid xenon. We find that an excellent CRT of 70 ps (depending on the PDE of the sensor) can be obtained if the scanner is instrumented with silicon photomultipliers (SiPMs) sensitive to the ultraviolet light emitted by xenon. Alternatively, a CRT of 160 ps can be obtained instrumenting the scanner with (much cheaper) blue-sensitive SiPMs coated with a suitable wavelength shifter. These results show the excellent time of flight capabilities of a PET device based in liquid xenon.
Address [Gomez-Cadenas, J. J.; Benlloch-Rodriguez, J. M.; Ferrario, P.; Rodriguez, J.] CSIC, Inst Fis Corpuscular IFIC, Calle Catedrat Jose Beltran 2, Valencia 46980, Spain, Email: paola.ferrario@ific.uv.es
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (down) 1748-0221 ISBN Medium
Area Expedition Conference
Notes WOS:000387862300011 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 2866
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Author Gomez-Cadenas, J.J.; Benlloch-Rodriguez, J.M.; Ferrario, P.
Title Monte Carlo study of the coincidence resolving time of a liquid xenon PET scanner, using Cherenkov radiation Type Journal Article
Year 2017 Publication Journal of Instrumentation Abbreviated Journal J. Instrum.
Volume 12 Issue Pages P08023 - 13pp
Keywords Cherenkov and transition radiation; Gamma camera; SPECT; PET PET/CT; coronary CT angiography (CTA); Noble liquid detectors (scintillation, ionization, double-phase); Photon detectors for UV; visible and IR photons (solid-state) (PIN diodes, APDs, Si-PMTs, G-APDs, CCDs, EBCCDs, EMCCDs etc)
Abstract In this paper we use detailed Monte Carlo simulations to demonstrate that liquid xenon (LXe) can be used to build a Cherenkov-based TOF-PET, with an intrinsic coincidence resolving time (CRT) in the vicinity of 10 ps. This extraordinary performance is due to three facts: a) the abundant emission of Cherenkov photons by liquid xenon; b) the fact that LXe is transparent to Cherenkov light; and c) the fact that the fastest photons in LXe have wavelengths higher than 300 nm, therefore making it possible to separate the detection of scintillation and Cherenkov light. The CRT in a Cherenkov LXe TOF-PET detector is, therefore, dominated by the resolution (time jitter) introduced by the photosensors and the electronics. However, we show that for sufficiently fast photosensors (e.g, an overall 40 ps jitter, which can be achieved by current micro-channel plate photomultipliers) the overall CRT varies between 30 and 55 ps, depending on the detection efficiency. This is still one order of magnitude better than commercial CRT devices and improves by a factor 3 the best CRT obtained with small laboratory prototypes.
Address [Ferrario, P.] CSIC, Inst Fis Corpuscular IFIC, Calle Catedrat Jose Beltran 2, Valencia 46980, Spain, Email: paola.ferrario@ific.uv.es
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (down) 1748-0221 ISBN Medium
Area Expedition Conference
Notes WOS:000414160300006 Approved no
Is ISI yes International Collaboration no
Call Number IFIC @ pastor @ Serial 3347
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Author Renner, J. et al; Romo-Luque, C.; Carrion, J.V.; Diaz, J.; Martinez, A.; Querol, M.; Rodriguez-Ponce, J.; Teruel-Pardo, S.
Title Monte Carlo characterization of PETALO, a full-body liquid xenon-based PET detector Type Journal Article
Year 2022 Publication Journal of Instrumentation Abbreviated Journal J. Instrum.
Volume 17 Issue 5 Pages P05044 - 17pp
Keywords Cryogenic detectors; Gamma camera; SPECT; PET PET; CT; coronary CT angiography (CTA); Liquid detectors
Abstract New detector approaches in Positron Emission Tomography imaging will play an important role in reducing costs, lowering administered radiation doses, and improving overall performance. PETALO employs liquid xenon as the active scintillating medium and UV-sensitive silicon photomultipliers for scintillation readout. The scintillation time in liquid xenon is fast enough to register time-of-flight information for each detected coincidence, and sufficient scintillation is produced with low enough fluctuations to obtain good energy resolution. The present simulation study examines a full-body-sized PETALO detector and evaluates its potential performance in PET image reconstruction.
Address [Romo-Luque, C.; Carrion, J. V.; Diaz, J.; Martinez, A.; Querol, M.; Rodriguez-Ponce, J.; Teruel-Pardo, S.] CSIC, Inst Fis Corpuscular IFIC, Calle Catedrat Jose Beltran 2, E-46980 Valencia, Spain, Email: paola.ferrario@dipc.org
Corporate Author Thesis
Publisher IOP Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (down) 1748-0221 ISBN Medium
Area Expedition Conference
Notes WOS:000811102400010 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 5264
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Author Baran, J. et al; Brzezinski, K.
Title Feasibility of the J-PET to monitor the range of therapeutic proton beams Type Journal Article
Year 2024 Publication Physica Medica Abbreviated Journal Phys. Medica
Volume 118 Issue Pages 103301 - 9pp
Keywords PET; Range monitoring; J-PET; Monte Carlo simulations; Proton radiotherapy
Abstract Purpose: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J -PET) scanner for intra-treatment proton beam range monitoring. Methods: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J -PET scanner geometries. We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread -Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J -PET scanner prototype dedicated to the proton beam range assessment. Results: The investigations indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10-5 coincidences per primary proton, while the precision of the range assessment for both SPB and SOBP irradiation plans was found below 1 mm. Among the scanners with the same number of detector modules, the best results are found for the triple -layer dual -head geometry. The results indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for the clinical application, Conclusions: We performed simulation studies demonstrating that the feasibility of the J -PET detector for PET -based proton beam therapy range monitoring is possible with reasonable sensitivity and precision enabling its pre -clinical tests in the clinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double -layer cylindrical and triple -layer dual -head J -PET geometry configurations seem promising for future clinical application.
Address [Baran, Jakub; Silarski, Michal; Chug, Neha; Coussat, Aurelien; Czerwinski, Eryk; Dadgar, Meysam; Dulski, Kamil; Eliyan, Kavya, V; Gajos, Aleksander; Kacprzak, Krzysztof; Kaplon, Lukasz; Korcyl, Grzegorz; Kozik, Tomasz; Kumar, Deepak; Niedzwiecki, Szymon; Panek, Dominik; Parzych, Szymon; del Rio, Elena Perez; Simbarashe, Moyo; Sharma, Sushil; Shivani; Skurzok, Magdalena; Stepien, Ewa L.; Tayefi, Keyvan; Tayefi, Faranak; Moskal, Pawel] Jagiellonian Univ, Fac Phys Astron & Appl Comp Sci, 11 Lojasiewicza St, PL-30348 Krakow, Poland, Email: jakubbaran92@gmail.com
Corporate Author Thesis
Publisher Elsevier Sci Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (down) 1120-1797 ISBN Medium
Area Expedition Conference
Notes WOS:001178648400001 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 5990
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Author Viegas, R.; Roser, J.; Barrientos, L.; Borja-Lloret, M.; Casaña, J.V.; Lopez, J.G.; Jimenez-Ramos, M.C.; Hueso-Gonzalez, F.; Ros, A.; Llosa, G.
Title Characterization of a Compton camera based on the TOFPET2 ASIC Type Journal Article
Year 2023 Publication Radiation Physics and Chemistry Abbreviated Journal Radiat. Phys. Chem.
Volume 202 Issue Pages 110507 - 11pp
Keywords Compton camera; Hadron therapy; LaBr3; PETsys TOFPET2; Silicon photomultipliers
Abstract The use of Compton cameras for medical imaging and its interest as a hadron therapy treatment monitoring has increased in the last decade with the development of silicon photomultipliers. MACACOp is a Compton camera prototype designed and assembled at the IRIS group of IFIC-Valencia. This Compton camera is based on monolithic Lanthanum (III) Bromide crystals and silicon photomultipliers, and employs the novel TOFPET2 ASIC as readout electronics. This system emerged as an alternative to MACACO II prototype, with the aim of improving its limited time resolution. To test the performance of the ASIC in a Compton camera setup, the prototype was characterized, both in laboratory and in-beam. A time resolution of 1.5 ns was obtained after time corrections, which improves greatly the performance of the MACACO II. Moreover, the results obtained at high photon energies demonstrate the ability of the system to obtain 1 mm displacements of the reconstructed spots. The results reinforce the potential of the system as a monitoring device for hadron therapy.
Address [Viegas, R.; Roser, J.; Barrientos, L.; Borja-Lloret, M.; Casana, J., V; Hueso-Gonzalez, F.; Ros, A.; Llosa, G.] CSIC UV, Inst Fis Corpuscular IFIC, Valencia, Spain, Email: Rita.Viegas@ific.uv.es
Corporate Author Thesis
Publisher Pergamon-Elsevier Science Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (down) 0969-806x ISBN Medium
Area Expedition Conference
Notes WOS:000870840600006 Approved no
Is ISI yes International Collaboration no
Call Number IFIC @ pastor @ Serial 5392
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Author Tarifeño-Saldivia, A.; Soto, L.
Title Effects of gas chamber geometry and gas flow on the neutron production in a fast plasma focus neutron source Type Journal Article
Year 2014 Publication Plasma Physics and Controlled Fusion Abbreviated Journal Plasma Phys. Control. Fusion
Volume 56 Issue 12 Pages 125013 - 5pp
Keywords pulsed neutron source; repetitive plasma focus; neutron yield measurement; fast plasma focus
Abstract This work reports that gas chamber geometry and gas flow management substantially affect the neutron production of a repetitive fast plasma focus. The gas flow rate is the most sensitive parameter. An appropriate design of the gas chamber combined with a suitable flow-rate management can lead to improvements in the neutron production of one order of magnitude working in a fast repetitive mode.
Address [Tarifeno-Saldivia, Ariel; Soto, Leopoldo] Comis Chilena Energia Nucl CCHEN, Santiago, Chile, Email: atarisal@gmail.com;
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (down) 0741-3335 ISBN Medium
Area Expedition Conference
Notes WOS:000346926300024 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 2070
Permanent link to this record
 

 
Author Gomez-Cadenas, J.J.; Benlloch-Rodriguez, J.M.; Ferrario, P.
Title Application of scintillating properties of liquid xenon and silicon photomultiplier technology to medical imaging Type Journal Article
Year 2016 Publication Spectrochimica Acta Part B Abbreviated Journal Spectroc. Acta Pt. B
Volume 118 Issue Pages 6-13
Keywords PET; TOF; Liquid xenon; Energy resolution; High sensitivity; Coincidence resolution time (CRT); SiPMs
Abstract We describe a new positron emission time-of-flight apparatus using liquid xenon. The detector is based in a liquid xenon scintillating cell. The cell shape and dimensions can be optimized depending on the intended application. In its simplest form, the liquid xenon scintillating cell is a box in which two faces are covered by silicon photomultipliers and the others by a reflecting material such as Teflon. It is a compact, homogenous and highly efficient detector which shares many of the desirable properties of monolithic crystals, with the added advantage of high yield and fast scintillation offered by liquid xenon. Our initial studies suggest that good energy and spatial resolution comparable with that achieved by lutetium oxyorthosilicate crystals can be obtained with a detector based in liquid xenon scintillating cells. In addition, the system can potentially achieve an excellent coincidence resolving time of better than 100 ps.
Address [Gomez-Cadenas, J. J.; Benlloch-Rodriguez, J. M.; Ferrario, Paola] Univ Valencia, CSIC, IFIC, E-46003 Valencia, Spain, Email: gomez@mail.cern.ch
Corporate Author Thesis
Publisher Pergamon-Elsevier Science Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (down) 0584-8547 ISBN Medium
Area Expedition Conference
Notes WOS:000374073300002 Approved no
Is ISI yes International Collaboration no
Call Number IFIC @ pastor @ Serial 2631
Permanent link to this record