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Roser, J., Muñoz, E., Barrientos, L., Barrio, J., Bernabeu, J., Borja-Lloret, M., et al. (2020). Image reconstruction for a multi-layer Compton telescope: an analytical model for three interaction events. Phys. Med. Biol., 65(14), 145005–17pp.
Abstract: Compton Cameras are electronically collimated photon imagers suitable for sub-MeV to few MeV gamma-ray detection. Such features are desirable to enablein vivorange verification in hadron therapy, through the detection of secondary Prompt Gammas. A major concern with this technique is the poor image quality obtained when the incoming gamma-ray energy is unknown. Compton Cameras with more than two detector planes (multi-layer Compton Cameras) have been proposed as a solution, given that these devices incorporate more signal sequences of interactions to the conventional two interaction events. In particular, three interaction events convey more spectral information as they allow inferring directly the incident gamma-ray energy. A three-layer Compton Telescope based on continuous Lanthanum (III) Bromide crystals coupled to Silicon Photomultipliers is being developed at the IRIS group of IFIC-Valencia. In a previous work we proposed a spectral reconstruction algorithm for two interaction events based on an analytical model for the formation of the signal. To fully exploit the capabilities of our prototype, we present here an extension of the model for three interaction events. Analytical expressions of the sensitivity and the System Matrix are derived and validated against Monte Carlo simulations. Implemented in a List Mode Maximum Likelihood Expectation Maximization algorithm, the proposed model allows us to obtain four-dimensional (energy and position) images by using exclusively three interaction events. We are able to recover the correct spectrum and spatial distribution of gamma-ray sources when ideal data are employed. However, the uncertainties associated to experimental measurements result in a degradation when real data from complex structures are employed. Incorrect estimation of the incident gamma-ray interaction positions, and missing deposited energy associated with escaping secondaries, have been identified as the causes of such degradation by means of a detailed Monte Carlo study. As expected, our current experimental resolution and efficiency to three interaction events prevents us from correctly recovering complex structures of radioactive sources. However, given the better spectral information conveyed by three interaction events, we expect an improvement of the image quality of conventional Compton imaging when including such events. In this regard, future development includes the incorporation of the model assessed in this work to the two interaction events model in order to allow using simultaneously two and three interaction events in the image reconstruction.
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Bernabeu, J. (2020). Symmetries and Their Breaking in the Fundamental Laws of Physics. Symmetry-Basel, 12(8), 1316–27pp.
Abstract: Symmetries in the Physical Laws of Nature lead to observable effects. Beyond the regularities and conserved magnitudes, the last few decades in particle physics have seen the identification of symmetries, and their well-defined breaking, as the guiding principle for the elementary constituents of matter and their interactions. Flavour SU(3) symmetry of hadrons led to the Quark Model and the antisymmetric requirement under exchange of identical fermions led to the colour degree of freedom. Colour became the generating charge for flavour-independent strong interactions of quarks and gluons in the exact colour SU(3) local gauge symmetry. Parity Violation in weak interactions led us to consider the chiral fields of fermions as the objects with definite transformation properties under the weak isospin SU(2) gauge group of the Unifying Electro-Weak SU(2) x U(1) symmetry, which predicted novel weak neutral current interactions. CP-Violation led to three families of quarks opening the field of Flavour Physics. Time-reversal violation has recently been observed with entangled neutral mesons, compatible with CPT-invariance. The cancellation of gauge anomalies, which would invalidate the gauge symmetry of the quantum field theory, led to Quark-Lepton Symmetry. Neutrinos were postulated in order to save the conservation laws of energy and angular momentum in nuclear beta decay. After the ups and downs of their mass, neutrino oscillations were discovered in 1998, opening a new era about their origin of mass, mixing, discrete symmetries and the possibility of global lepton-number violation through Majorana mass terms and Leptogenesis as the source of the matter-antimatter asymmetry in the universe. The experimental discovery of quarks and leptons and the mediators of their interactions, with physical observables in spectacular agreement with this Standard Theory, is the triumph of Symmetries. The gauge symmetry is exact only when the particles are massless. One needs a subtle breaking of the symmetry, providing the origin of mass without affecting the excellent description of the interactions. This is the Brout-Englert-Higgs Mechanism, which produces the Higgs Boson as a remnant, discovered at CERN in 2012. Open present problems are addressed with by searching the New Physics Beyond-the-Standard-Model.
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Gimenez-Alventosa, V., Gimenez, V., Ballester, F., Vijande, J., & Andreo, P. (2020). Monte Carlo calculation of beam quality correction factors for PTW cylindrical ionization chambers in photon beams. Phys. Med. Biol., 65(20), 205005–11pp.
Abstract: The beam quality correction factork(Q)for megavoltage photon beams has been calculated for eight PTW (Freiburg, Germany) ionization chambers (Farmer chambers PTW30010, PTW30011, PTW30012, and PTW30013, Semiflex 3D chambers PTW31021, PTW31010, and PTW31013, and the PinPoint 3D chamber PTW31016). Simulations performed on the widely used NE-2571 ionization chamber have been used to benchmark the results. The Monte Carlo code PENELOPE/penEasy was used to calculate the absorbed dose to a point in water and the absorbed dose to the active air volume of the chambers for photon beams in the range 4 to 24 MV. Of the nine ionization chambers analysed, only five are included in the current version of the International Code of Practice for dosimetry based on standards of absorbed dose to water (IAEA TRS 398). The values reported in this work agree with those in the literature within the uncertainty estimates and are to be included in the average values of the data obtained by different working groups for the forthcoming update of TRS 398.
Keywords: TRS 398; Monte Carlo; dosimetry; ionization chambers; MV photon beams
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Ros Garcia, A., Barrio, J., Etxebeste, A., Garcia-Lopez, J., Jimenez-Ramos, M. C., Lacasta, C., et al. (2020). MACACO II test-beam with high energy photons. Phys. Med. Biol., 65(24), 245027–12pp.
Abstract: The IRIS group at IFIC Valencia is developing a three-layer Compton camera for treatment monitoring in proton therapy. The system is composed of three detector planes, each made of a LaBr3<i monolithic crystal coupled to a SiPM array. Having obtained successful results with the first prototype (MACACO) that demonstrated the feasibility of the proposed technology, a second prototype (MACACO II) with improved performance has been developed, and is the subject of this work. The new system has an enhanced detector energy resolution which translates into a higher spatial resolution of the telescope. The image reconstruction method has also been improved with an accurate model of the sensitivity matrix. The device has been tested with high energy photons at the National Accelerator Centre (CNA, Seville). The tests involved a proton beam of 18 MeV impinging on a graphite target, to produce 4.4 MeV photons. Data were taken at different system positions of the telescope with the first detector at 65 and 160 mm from the target, and at different beam intensities. The measurements allowed successful reconstruction of the photon emission distribution at two target positions separated by 5 mm in different telescope configurations. This result was obtained both with data recorded in the first and second telescope planes (two interaction events) and, for the first time in beam experiments, with data recorded in the three planes (three interaction events).
Keywords: Compton imaging; Compton camera; proton therapy; LaBr3; test-beam; image reconstruction
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Balibrea-Correa, J., Lerendegui-Marco, J., Babiano-Suarez, V., Caballero, L., Calvo, D., Ladarescu, I., et al. (2021). Machine Learning aided 3D-position reconstruction in large LaCl3 crystals. Nucl. Instrum. Methods Phys. Res. A, 1001, 165249–17pp.
Abstract: We investigate five different models to reconstruct the 3D gamma-ray hit coordinates in five large LaCl3(Ce) monolithic crystals optically coupled to pixelated silicon photomultipliers. These scintillators have a base surface of 50 x 50 mm(2) and five different thicknesses, from 10 mm to 30 mm. Four of these models are analytical prescriptions and one is based on a Convolutional Neural Network. Average resolutions close to 1-2 mm fwhm are obtained in the transverse crystal plane for crystal thicknesses between 10 mm and 20 mm using analytical models. For thicker crystals average resolutions of about 3-5 mm fwhm are obtained. Depth of interaction resolutions between 1 mm and 4 mm are achieved depending on the distance of the interaction point to the photosensor surface. We propose a Machine Learning algorithm to correct for linearity distortions and pin-cushion effects. The latter allows one to keep a large field of view of about 70%-80% of the crystal surface, regardless of crystal thickness. This work is aimed at optimizing the performance of the so-called Total Energy Detector with Compton imaging capability (i-TED) for time-of-flight neutron capture cross-section measurements.
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