| Records |
| Author |
Borys, D. et al; Brzezinski, K. |
| Title |
ProTheRaMon-a GATE simulation framework for proton therapy range monitoring using PET imaging |
Type |
Journal Article |
| Year |
2022 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
| Volume |
67 |
Issue |
22 |
Pages |
224002 - 15pp |
| Keywords |
proton therapy; GATE; Monte Carlo simulations; J-PET; medical imaging |
| Abstract |
Objective. This paper reports on the implementation and shows examples of the use of the ProTheRaMon framework for simulating the delivery of proton therapy treatment plans and range monitoring using positron emission tomography (PET). ProTheRaMon offers complete processing of proton therapy treatment plans, patient CT geometries, and intra-treatment PET imaging, taking into account therapy and imaging coordinate systems and activity decay during the PET imaging protocol specific to a given proton therapy facility. We present the ProTheRaMon framework and illustrate its potential use case and data processing steps for a patient treated at the Cyclotron Centre Bronowice (CCB) proton therapy center in Krakow, Poland. Approach. The ProTheRaMon framework is based on GATE Monte Carlo software, the CASToR reconstruction package and in-house developed Python and bash scripts. The framework consists of five separated simulation and data processing steps, that can be further optimized according to the user's needs and specific settings of a given proton therapy facility and PET scanner design. Main results. ProTheRaMon is presented using example data from a patient treated at CCB and the J-PET scanner to demonstrate the application of the framework for proton therapy range monitoring. The output of each simulation and data processing stage is described and visualized. Significance. We demonstrate that the ProTheRaMon simulation platform is a high-performance tool, capable of running on a computational cluster and suitable for multi-parameter studies, with databases consisting of large number of patients, as well as different PET scanner geometries and settings for range monitoring in a clinical environment. Due to its modular structure, the ProTheRaMon framework can be adjusted for different proton therapy centers and/or different PET detector geometries. It is available to the community via github (Borys et al 2022). |
| Address |
[Borys, Damian] Silesian Tech Univ, Dept Syst Biol & Engn, Gliwice, Poland, Email: damin.borys@polsl.pl |
| Corporate Author |
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Thesis |
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| Publisher |
IOP Publishing Ltd |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0031-9155 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:000885248200001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration  |
no |
| Call Number |
IFIC @ pastor @ |
Serial |
5416 |
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| Author |
Balibrea-Correa, J.; Lerendegui-Marco, J.; Ladarescu, I.; Guerrero, C.; Rodriguez-Gonzalez, T.; Jimenez-Ramos, M.C.; Fernandez-Martinez, B.; Domingo-Pardo, C. |
| Title |
Hybrid in-beam PET- and Compton prompt-gamma imaging aimed at enhanced proton-range verification |
Type |
Journal Article |
| Year |
2022 |
Publication |
European Physical Journal Plus |
Abbreviated Journal |
Eur. Phys. J. Plus |
| Volume |
137 |
Issue |
11 |
Pages |
1258 - 18pp |
| Keywords |
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| Abstract |
We report on a hybrid in-beam PET and prompt-gamma Compton imaging system aimed at quasi real-time ion-range verification in proton-therapy treatments. Proof-of-concept experiments were carried out at the radiobiology beam line of the CNA cyclotron facility using a set of two synchronous Compton imagers and different target materials. The time structure of the 18 MeV proton beam was shaped with a series of beam-on and beam-off intervals, thereby mimicking a pulsed proton beam on a long time scale. During beam-on intervals, Compton imagingwas performed utilizing the high energy. -rays promptly emitted from the nuclear reactions occurring in the targets. In the course of the beam-off intervals in situ positron-emission tomography was accomplished with the same imagers using the beta+ decay of activated nuclei. The targets used were stacks of different materials covering also various proton ranges and energies. A systematic study on the performance of these two complementary imaging techniques is reported and the experimental results interpreted on the basis ofMonte Carlo calculations. The results demonstrate the possibility to combine both imaging techniques in a concomitant way, where high-efficiency prompt-gamma imaging is complemented with the high spatial accuracy of PET. Empowered by these results we suggest that a pulsed beam with a suitable duty cycle, in conjunction with in situ Compton- and PET-imaging may help to attain complementary information and quasi real-time range monitoring with high accuracy. |
| Address |
[Balibrea-Correa, J.; Lerendegui-Marco, J.; Ladarescu, I; Domingo-Pardo, C.] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: javier.balibrea@ific.uv.es |
| Corporate Author |
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Thesis |
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| Publisher |
Springer Heidelberg |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Series Issue |
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Edition |
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| ISSN |
2190-5444 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
WOS:000886327900002 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
no |
| Call Number |
IFIC @ pastor @ |
Serial |
5420 |
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| Author |
Hernandez, P.; Lopez-Pavon, J.; Rius, N.; Sandner, S. |
| Title |
Bounds on right-handed neutrino parameters from observable leptogenesis |
Type |
Journal Article |
| Year |
2022 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
| Volume |
12 |
Issue |
12 |
Pages |
012 - 58pp |
| Keywords |
Baryo-and Leptogenesis; Early Universe Particle Physics; Sterile or Heavy Neutrinos |
| Abstract |
We revisit the generation of a matter-antimatter asymmetry in the minimal extension of the Standard Model with two singlet heavy neutral leptons (HNL) that can explain neutrino masses. We derive an accurate analytical approximation to the solution of the complete linearized set of kinetic equations, which exposes the non-trivial parameter dependencies in the form of parameterization-independent CP invariants. The identification of various washout regimes relevant in different regions of parameter space sheds light on the relevance of the mass corrections in the interaction rates and clarifies the correlations of baryogenesis with other observables. In particular, by requiring that the measured baryon asymmetry is reproduced, we derive robust upper or lower bounds on the HNL mixings depending on their masses, and constraints on their flavour structure, as well as on the CP-violating phases of the PMNS mixing matrix, and the amplitude of neutrinoless double-beta decay. We also find certain correlations between low and high scale CP phases. Especially emphasizing the testable part of the parameter space we demonstrate that our findings are in very good agreement with numerical results. The methods developed in this work can help in exploring more complex scenarios. |
| Address |
[Hernandez, P.] Univ Valencia, Inst Fis Corpuscular, Edificio Inst Invest,Catedrat Jose Beltran 2, Paterna 46980, Spain, Email: m.pilar.hernandez@uv.es; |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1029-8479 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
WOS:000914640400003 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
no |
| Call Number |
IFIC @ pastor @ |
Serial |
5467 |
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| Author |
Aja, B. et al; Gimeno, B. |
| Title |
The Canfranc Axion Detection Experiment (CADEx): search for axions at 90 GHz with Kinetic Inductance Detectors |
Type |
Journal Article |
| Year |
2022 |
Publication |
Journal of Cosmology And Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
| Volume |
11 |
Issue |
11 |
Pages |
044 - 29pp |
| Keywords |
dark matter experiments; axions; dark matter detectors |
| Abstract |
We propose a novel experiment, the Canfranc Axion Detection Experiment (CADEx), to probe dark matter axions with masses in the range 330-460 μeV, within the W-band (80-110 GHz), an unexplored parameter space in the well-motivated dark matter window of Quantum ChromoDynamics (QCD) axions. The experimental design consists of a microwave resonant cavity haloscope in a high static magnetic field coupled to a highly sensitive detecting system based on Kinetic Inductance Detectors via optimized quasi-optics (horns and mirrors). The experiment is in preparation and will be installed in the dilution refrigerator of the Canfranc Underground Laboratory. Sensitivity forecasts for axion detection with CADEx, together with the potential of the experiment to search for dark photons, are presented. |
| Address |
[Aja, Beatriz; Artal, Eduardo; de la Fuente, Luisa; Pablo Pascual, Juan] Univ Cantabria, Dept Ingn Comunicac, Plaza Ciencia, Santander 39005, Spain, Email: ajab@unican.es; |
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Thesis |
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| Publisher |
IOP Publishing Ltd |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1475-7516 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:000934034600003 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
no |
| Call Number |
IFIC @ pastor @ |
Serial |
5478 |
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| Author |
Gariazzo, S.; de Salas, P.F.; Pisanti, O.; Consiglio, R. |
| Title |
PArthENoPE revolutions |
Type |
Journal Article |
| Year |
2022 |
Publication |
Computer Physics Communications |
Abbreviated Journal |
Comput. Phys. Commun. |
| Volume |
271 |
Issue |
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Pages |
108205 - 13pp |
| Keywords |
Primordial nucleosynthesis; Cosmology; Neutrino physics |
| Abstract |
This paper presents the main features of a new and updated version of the program PArthENoPE, which the community has been using for many years for computing the abundances of light elements produced during Big Bang Nucleosynthesis. This is the third release of the PArthENoPE code, after the 2008 and the 2018 ones, and will be distributed from the code's website, http://parthenope.na.infn.it. Apart from minor changes, the main improvements in this new version include a revisited implementation of the nuclear rates for the most important reactions of deuterium destruction, H-2(p,gamma) He-3, H-2(d, n)He-3 and H-2(d, p)H-3, and a re-designed GUI, which extends the functionality of the previous one. The new GUI, in particular, supersedes the previous tools for running over grids of parameters with a better management of parallel runs, and it offers a brand-new set of functions for plotting the results. Program summary Program title: PArthENoPE 3.0 CPC Library link to program files: https://doi.org/10.17632/wygr7d8yt9.2 Developer's repository link: http://parthenope.na.infn.it Licensing provisions: GPLv3 Programming language: Fortran 77 and Python Nature of problem: Computation of yields of light elements synthesized in the primordial universe Solution method: Livermore Solver for Ordinary Differential Equations (LSODE) for stiff and nonstiff systems, Python GUI for running and plotting Journal reference of previous version: Comput. Phys. Commun. 233 (2018) 237-242 Does the new version supersede the previous version?: Yes Reasons for the new version: Update of the physics and improvements in the GUI Summary of revisions: Update of the physics implemented in the Fortran code and improvements in the GUI functionalities, in particular new plotting functions. |
| Address |
[Gariazzo, S.] INFN, Sez Torino, Via P Giuria 1, I-10125 Turin, Italy, Email: pisanti@na.infn.it |
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Thesis |
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| Publisher |
Elsevier |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0010-4655 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:000720461800020 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
5027 |
| Permanent link to this record |
