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Author |
Penas, J.; Alejo, A.; Bembibre, A.; Apiñaniz, J.I.; Garcia-Garcia, E.; Guerrero, C.; Henares, J.L.; Hernandez-Palmero, I.; Mendez, C.; Millan-Callado, M.A.; Puyuelo-Valdes, P.; Seimetz, M.; Benlliure, J. |
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Title |
Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source |
Type |
Journal Article |
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Year |
2024 |
Publication |
Scientific Reports |
Abbreviated Journal |
Sci Rep |
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Volume |
14 |
Issue |
1 |
Pages |
11448 - 12pp |
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Keywords |
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Abstract |
Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the first time the use of a high-repetition rate, ultra-intense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10-14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} B(p,n) 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Significant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-the-art technology (10 Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range. |
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Address |
[Penas, Juan; Alejo, Aaron; Bembibre, Adrian; Benlliure, Jose] Univ Santiago de Compostela, Inst Galego Fis Altas Enerxias IGFAE, Santiago De Compostela 15782, Spain, Email: j.benlliure@usc.es |
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Nature Portfolio |
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English |
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ISSN |
2045-2322 |
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Conference |
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Notes |
WOS:001228252900017 |
Approved |
no |
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Is ISI |
yes |
International Collaboration  |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
6143 |
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Author |
Navarro, P.; Gimeno, B.; Monzo-Cabrera, J.; Diaz-Morcillo, A.; Blas, D. |
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Title |
Study of a cubic cavity resonator for gravitational waves detection in the microwave frequency range |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
109 |
Issue |
10 |
Pages |
104048 - 19pp |
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Abstract |
The direct detection of gravitational waves (GWs) of frequencies above MHz has recently received considerable attention. In this work, we present a precise study of the reach of a cubic cavity resonator to GWs in the microwave range, using for the first time tools allowing to perform realistic simulations. Concretely, the boundary integral -resonant mode expansion (BI-RME) 3D method, which allows us to obtain not only the detected power but also the detected voltage (magnitude and phase), is used here. After analyzing three cubic cavities for different frequencies and working simultaneously with three different degenerate modes at each cavity, we conclude that the sensitivity of the experiment is strongly dependent on the polarization and incidence angle of the GW. The presented experiment can reach sensitivities up to 1 x 10 – 19 at 100 MHz, 2 x 10 – 20 at 1 GHz, and 6 x 10 – 19 at 10 GHz for optimal angles and polarizations, and where in all cases we assumed an integration time of Delta t 1 / 4 1 ms. These results provide a strong case for further developing the use of cavities to detect GWs. Moreover, the possibility of analyzing the detected voltage (magnitude and phase) opens a new interferometric detection scheme based on the combination of the detected signals from multiple cavities. |
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Address |
[Navarro, Pablo; Monzo-Cabrera, Juan; Diaz-Morcillo, Alejandro] Univ Politecn Cartagena, Dept Tecnol Informac & Comunicac, Plaza Hosp 1, Cartagena 30302, Spain, Email: pablonm.ct.94@gmail.com; |
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Publisher |
Amer Physical Soc |
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English |
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ISSN |
2470-0010 |
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Conference |
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Notes |
WOS:001239272400007 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
6152 |
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Author |
Pavao, R.; Gubler, P.; Fernandez-Soler, P.; Nieves, J.; Oka, M.; Takahashi, T.T. |
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Title |
The negative-parity spin-1/2 A baryon spectrum from lattice QCD and effective theory |
Type |
Journal Article |
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Year |
2021 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
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Volume |
820 |
Issue |
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Pages |
136473 - 8pp |
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Keywords |
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Abstract |
The spectrum of the negative-parity spin-1/2 Lambda baryons is studied using lattice QCD and hadronic effective theory in a unitarized coupled-channel framework. A direct comparison between the two approaches is possible by considering the hadronic effective theory in a finite volume and with hadron masses and mesonic decay constants that correspond to the situation studied on the lattice. Comparing the energy level spectrum and SU(3) flavor decompositions of the individual states, it is found that the lowest two states extracted from lattice QCD can be associated with one of the two Lambda(1405)-poles and the Lambda(1670) resonance. The quark mass dependences of these two lattice QCD levels are in good agreement with their effective theory counterparts. However, as current lattice QCD studies still rely on three-quark operators to generate the physical states, clear signals corresponding to the meson-baryon scattering states, that appear in the finite volume effective theory calculation, are not yet seen. |
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Address |
[Pavao, Rafael; Fernandez-Soler, Pedro; Nieves, Juan] Univ Valencia, CSIC, Inst Invest Paterna, Inst Fis Corpuscular IFIC,Ctr Mixto, Apartado 22085, E-46071 Valencia, Spain, Email: gubler@post.j-parc.jp |
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Publisher |
Elsevier |
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Language |
English |
Summary Language |
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Original Title |
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Series Volume |
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Edition |
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ISSN |
0370-2693 |
ISBN |
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Area |
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Conference |
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Notes |
WOS:000713101800041 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5022 |
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Author |
Ilner, A.; Blair, J.; Cabrera, D.; Markert, C.; Bratkovskaya, E. |
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Title |
Probing hot and dense nuclear matter with K*, (K)over-bar* vector mesons |
Type |
Journal Article |
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Year |
2019 |
Publication |
Physical Review C |
Abbreviated Journal |
Phys. Rev. C |
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Volume |
99 |
Issue |
2 |
Pages |
024914 - 22pp |
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Keywords |
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Abstract |
We investigate the possibility of probing the hot and dense nuclear matter-created in relativistic heavyion collisions (HICs)-with strange vector mesons (K*, (K) over bar*). Our analysis is based on the nonequilibrium parton-hadron-string dynamics (PHSD) transport approach which incorporates partonic and hadronic degrees of freedom and describes the full dynamics of HIC on a microscopic level-starting from the primary nucleon-nucleon collisions to the formation of the strongly interacting quark gluon plasma (QGP), followed by dynamical hadronization of (anti)quarks as well as final hadronic elastic and inelastic interactions. This allows us to study the K* and (K) over bar* meson formation from the QGP as well as the in-medium effects related to the modification of their spectral properties during the propagation through the dense and hot hadronic environment in the expansion phase. We employ relativistic Breit-Wigner spectral functions for the K*, (K) over bar* mesons with self-energies obtained from a self-consistent coupled-channel G-matrix approach to study the role of in-medium effects on the K* and (K) over bar* meson dynamics in heavy-ion collisions from FAIR/NICA to LHC energies. According to our analysis most of the final K* /(K) over bar*'s, that can be observed experimentally by reconstruction of the invariant mass of pi + K((K) over bar) pairs, are produced during the late hadronic phase and originate dominantly from the K((K) over bar) + pi -> K*( (K) over bar*) formation channel. The amount of K*/ (K) over bar*'s, originating from the QGP channel is comparatively small even at LHC energies and those K* /(K) over bar*'s can hardly be reconstructed experimentally due to the rescattering of final pions and (anti)kaons. This mirrors the results from our previous study on the strange vector-meson production in heavy-ion collisions at RHIC energies. We demonstrate that K* /(K) over bar* in-medium effects should be visible at FAIR/NICA and BES RHIC energies, where the production of K* /(K) over bar*'s occurs at larger net-baryon densities. Finally, we present the experimental procedures to extract the information on the resonance masses and widths by fitting the final mass spectra at LHC energies. |
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Address |
[Ilner, Andrej; Bratkovskaya, Elena] Johann Wolfgang Goethe Univ Frankfurt Main, Inst Theoret Phys, D-60438 Frankfurt, Germany, Email: ilner@fias.uni-frankfurt.de |
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Publisher |
Amer Physical Soc |
Place of Publication |
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English |
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ISSN |
2469-9985 |
ISBN |
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Conference |
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Notes |
WOS:000459905400005 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3925 |
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Author |
BABAR Collaboration (Lees, J.P. et al); Martinez-Vidal, F.; Oyanguren, A. |
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Title |
Observation of the Decay D-0 -> K- pi(+) e(+) e(-) |
Type |
Journal Article |
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Year |
2019 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
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Volume |
122 |
Issue |
8 |
Pages |
081802 - 8pp |
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Keywords |
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Abstract |
We report the observation of the rare charm decay D-0 -> K-pi(+)e(+)e(-), based on 468 fb(-1) of e(+)e(-) annihilation data collected at or close to the center-of-mass energy of the (sic)(4S) resonance with the BABAR detector at the SLAC National Accelerator Laboratory. We find the branching fraction in the invariant mass range 0.675 < m(e(+)e(-)) < 0.875 GeV/c(2) of the electron-positron pair to be B(D-0 -> K-pi(+)e(+)e(-)) = (4.0 +/- 0.5 +/- 0.2 +/- 0.1) x 10(-6), where the first uncertainty is statistical, the second systematic, and the third due to the uncertainty in the branching fraction of the decay D-0 -> K-pi(+)pi(+)pi(-) used as a normalization mode. The significance of the observation corresponds to 9.7 standard deviations including systematic uncertainties. This result is consistent with the recently reported D-0 -> K-pi(+)mu(+)mu(-) branching fraction, measured in the same invariant mass range, and with the value expected in the standard model. In a set of regions of m(e(+)e(-)), where long-distance effects are potentially small, we determine a 90% confidence level upper limit on the branching fraction B(D-0 -> K-pi(+)e(+)e(-)) < 3.1 x 10(-6). |
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Address |
[Lees, J. P.; Poireau, V.; Tisserand, V.] Univ Savoie, CNRS, IN2P3, Lab Annecy Le Vieux Phys Particules LAPP, F-74941 Annecy Le Vieux, France |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0031-9007 |
ISBN |
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Area |
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Conference |
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Notes |
WOS:000459920400005 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3926 |
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