Abstract: In the development of prototype systems for positron emission tomography a valid and robust image reconstruction algorithm is required. However, prototypes often employ novel detector and system geometries which may change rapidly under optimization. In addition, developing systems generally produce highly granular, or possibly continuous detection domains which require some level of on-the-fly calculation for retention of measurement precision. In this investigation a new method of on-the-fly system matrix calculation is proposed that provides advantages in application to such list-mode systems in terms of flexibility in system modeling. The new method is easily adaptable to complicated system geometries and available computational resources. Detection uncertainty models are used as random number generators to produce ensembles of possible photon trajectories at image reconstruction time for each datum in the measurement list. However, the result of this approach is that the system matrix elements change at each iteration in a non-repetitive manner. The resulting algorithm is considered the simulation of a one-pass list (SOPL) which is generated and the list traversed during image reconstruction. SOPL alters the system matrix in use at each iteration and so behavior within the maximum likelihood-expectation maximization algorithm was investigated. A two-pixel system and a small two dimensional imaging model are used to illustrate the process and quantify aspects of the algorithm. The two-dimensional imaging system showed that, while incurring a penalty in image resolution, in comparison to a non-random equal-computation counterpart, SOPL provides much enhanced noise properties. In addition, enhancement in system matrix quality is straightforward (by increasing the number of samples in the ensemble) so that the resolution penalty can be recovered when desired while retaining improvement in noise properties. Finally the approach is tested and validated against a standard (highly accurate) system matrix using experimental data from a prototype system-the AX-PET.

Abstract: Here we review the current status of global fits to neutrino oscillation data within the three-flavour framework. In our analysis we include the most recent data from solar and atmospheric neutrino experiments as well as the latest results from the long-baseline accelerator neutrino experiments and the recent measurements of reactor neutrino disappearance reported by Double Chooz, Daya Bay and RENO. We present updated determinations for the two neutrino mass splittings and the three mixing angles responsible for neutrino oscillations that, for the first time, have all been measured with 1 sigma accuracies ranging from 3 to 15%. A weak sensitivity for the CP violating phase is also reported from the global analysis.

Abstract: In a recent paper the authors make a study on the determination of the S-matrix elements for scattering of particles in the infinite volume from the energy levels in a finite box for the case of multiple channels. The study is done with a toy model in 1+1 dimension and the authors find that there is some ambiguity in the sign of nondiagonal matrix elements, casting doubts on whether the needed observables in the infinite volume can be obtained from the energy levels of the box. In this paper I present an easy derivation, confirming the ambiguity of the sign and argue that this, however, does not put restrictions in the determination of observables.

Abstract: We present a strategy to extract the position of the two Lambda(1405) poles from experimental photoproduction data measured recently at different energies in the gamma p -> K+pi(0)Sigma(0) reaction at Jefferson Laboratory. By means of a chiral dynamics motivated potential with free parameters, we solve the Bethe-Salpeter equation in the coupled channels (K) over barN and pi Sigma in isospin I = 0 and parametrize the amplitude for the photonuclear reaction in terms of a linear combination of the pi Sigma -> pi Sigma and (K) over barN -> pi Sigma scattering amplitudes in I = 0, with a different linear combination for each energy. Good fits to the data are obtained with some sets of parameters, by means of which one can also predict the cross section for the K- p -> pi(0)Sigma(0) reaction. These later results help us decide among the possible solutions. The result is that the different solutions lead to two poles similar to those found in the chiral unitary approach. With the best result we find the two Lambda(1405) poles at 1385 – 68i MeV and 1419 – 22i MeV.

Abstract: The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (T-H cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient level can promote either T-cell epitope conservation or escape. We predict greater conservation for epitopes contributing significantly to total immune activation levels (immunodominance), and when T-H cell infection is concomitant to epitope recognition (transinfection). We suggest that HIV-driven immune activation in the lymph nodes during the chronic stage of the disease may offer a favorable scenario for epitope conservation. Our results also support the view that some pathogens draw benefits from the immune response and suggest that vaccination strategies based on conserved T-H epitopes may be counterproductive.