Abstract: Current cosmological tensions show that it is crucial to test the predictions from the canonical ACDM paradigm at different cosmic times. One very appealing test of structure formation in the Universe is the growth rate of structure in our universe f, usually parametrized via the growth index gamma, with f equivalent to Omega(m)(a)gamma and gamma similar or equal to 0.55 in the standard ACDM case. Recent studies have claimed a suppression of the growth of structure from a variety of cosmological observations, characterized by gamma > 0.55. By employing different self-consistent growth parametrizations schemes, we show here that gamma < 0.55, obtaining instead an enhanced growth of structure today. This preference reaches the 3 sigma significance using cosmic microwave background observations, supernova Ia and baryon acoustic oscillation measurements. The addition of cosmic microwave background lensing data relaxes such a preference to the 2 sigma level, since a larger lensing effect can always be compensated with a smaller structure growth, or, equivalently, with gamma > 0.55. We have also included the lensing amplitude AL as a free parameter in our data analysis, showing that the preference for AL > 1 still remains, except for some particular parametrizations when lensing observations are included. We also do not find any significant preference for an oscillatory dependence of AL, AL + Am sin l. To further reassess the effects of a nonstandard growth, we have computed by means of N-body simulations the dark matter density fields, the dark matter halo mass functions and the halo density profiles for different values of gamma. Future observations from the Square Kilometer Array, reducing by a factor of 3 the current errors on the gamma parameter, further confirm or refute with a strong statistical significance the deviation of the growth index from its standard value.

Abstract: Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the first time the use of a high-repetition rate, ultra-intense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10-14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} B(p,n) 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Significant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-the-art technology (10 Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range.