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Author |
Borys, D. et al; Brzezinski, K. |
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Title |
ProTheRaMon-a GATE simulation framework for proton therapy range monitoring using PET imaging |
Type |
Journal Article |
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Year |
2022 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
67 |
Issue |
22 |
Pages |
224002 - 15pp |
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Keywords |
proton therapy; GATE; Monte Carlo simulations; J-PET; medical imaging |
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Abstract |
Objective. This paper reports on the implementation and shows examples of the use of the ProTheRaMon framework for simulating the delivery of proton therapy treatment plans and range monitoring using positron emission tomography (PET). ProTheRaMon offers complete processing of proton therapy treatment plans, patient CT geometries, and intra-treatment PET imaging, taking into account therapy and imaging coordinate systems and activity decay during the PET imaging protocol specific to a given proton therapy facility. We present the ProTheRaMon framework and illustrate its potential use case and data processing steps for a patient treated at the Cyclotron Centre Bronowice (CCB) proton therapy center in Krakow, Poland. Approach. The ProTheRaMon framework is based on GATE Monte Carlo software, the CASToR reconstruction package and in-house developed Python and bash scripts. The framework consists of five separated simulation and data processing steps, that can be further optimized according to the user's needs and specific settings of a given proton therapy facility and PET scanner design. Main results. ProTheRaMon is presented using example data from a patient treated at CCB and the J-PET scanner to demonstrate the application of the framework for proton therapy range monitoring. The output of each simulation and data processing stage is described and visualized. Significance. We demonstrate that the ProTheRaMon simulation platform is a high-performance tool, capable of running on a computational cluster and suitable for multi-parameter studies, with databases consisting of large number of patients, as well as different PET scanner geometries and settings for range monitoring in a clinical environment. Due to its modular structure, the ProTheRaMon framework can be adjusted for different proton therapy centers and/or different PET detector geometries. It is available to the community via github (Borys et al 2022). |
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Address |
[Borys, Damian] Silesian Tech Univ, Dept Syst Biol & Engn, Gliwice, Poland, Email: damin.borys@polsl.pl |
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Publisher |
IOP Publishing Ltd |
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English |
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ISSN |
0031-9155 |
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Expedition |
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Conference |
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Notes |
WOS:000885248200001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration  |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5416 |
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Author |
Borja-Lloret, M.; Barrientos, L.; Bernabeu, J.; Lacasta, C.; Muñoz, E.; Ros, A.; Roser, J.; Viegas, R.; Llosa, G. |
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Title |
Influence of the background in Compton camera images for proton therapy treatment monitoring |
Type |
Journal Article |
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Year |
2023 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
68 |
Issue |
14 |
Pages |
144001 - 16pp |
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Keywords |
Compton imaging; Compton camera; proton therapy; treatment monitoring; Monte Carlo simulation; image reconstruction; background |
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Abstract |
Objective. Background events are one of the most relevant contributions to image degradation in Compton camera imaging for hadron therapy treatment monitoring. A study of the background and its contribution to image degradation is important to define future strategies to reduce the background in the system. Approach. In this simulation study, the percentage of different kinds of events and their contribution to the reconstructed image in a two-layer Compton camera have been evaluated. To this end, GATE v8.2 simulations of a proton beam impinging on a PMMA phantom have been carried out, for different proton beam energies and at different beam intensities. Main results. For a simulated Compton camera made of Lanthanum (III) Bromide monolithic crystals, coincidences caused by neutrons arriving from the phantom are the most common type of background produced by secondary radiations in the Compton camera, causing between 13% and 33% of the detected coincidences, depending on the beam energy. Results also show that random coincidences are a significant cause of image degradation at high beam intensities, and their influence in the reconstructed images is studied for values of the time coincidence windows from 500 ps to 100 ns. Significance. Results indicate the timing capabilities required to retrieve the fall-off position with good precision. Still, the noise observed in the image when no randoms are considered make us consider further background rejection methods. |
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Address |
[Borja-Lloret, M.; Barrientos, L.; Bernabeu, J.; Lacasta, C.; Munoz, E.; Ros, A.; Roser, J.; Viegas, R.; Llosa, G.] Inst Fis Corpuscular IFIC, CSIC UV, Valencia, Spain, Email: Marina.Borja@csic.es |
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Corporate Author |
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Publisher |
IOP Publishing Ltd |
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Language |
English |
Summary Language |
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Original Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0031-9155 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001022671300001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5571 |
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Author |
Lerendegui-Marco, J.; Babiano-Suarez, V.; Balibrea-Correa, J.; Caballero, L.; Calvo, D.; Ladarescu, I.; Domingo-Pardo, C. |
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Title |
Simultaneous Gamma-Neutron Vision device: a portable and versatile tool for nuclear inspections |
Type |
Journal Article |
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Year |
2024 |
Publication |
EPJ Techniques and Instrumentation |
Abbreviated Journal |
EPJ Tech. Instrum. |
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Volume |
11 |
Issue |
1 |
Pages |
2 - 17pp |
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Keywords |
Gamma imaging; Neutron imaging; Nuclear inspections; Homeland security; Nuclear waste characterization |
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Abstract |
This work presents GN-Vision, a novel dual gamma-ray and neutron imaging system, which aims at simultaneously obtaining information about the spatial origin of gamma-ray and neutron sources. The proposed device is based on two position sensitive detection planes and exploits the Compton imaging technique for the imaging of gamma-rays. In addition, spatial distributions of slow- and thermal-neutron sources (<100 eV) are reconstructed by using a passive neutron pin-hole collimator attached to the first detection plane. The proposed gamma-neutron imaging device could be of prime interest for nuclear safety and security applications. The two main advantages of this imaging system are its high efficiency and portability, making it well suited for nuclear applications were compactness and real-time imaging is important. This work presents the working principle and conceptual design of the GN-Vision system and explores, on the basis of Monte Carlo simulations, its simultaneous gamma-ray and neutron detection and imaging capabilities for a realistic scenario where a Cf-252 source is hidden in a neutron moderating container. |
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Address |
[Lerendegui-Marco, Jorge; Babiano-Suarez, Victor; Balibrea-Correa, Javier; Caballero, Luis; Calvo, David; Ladarescu, Ion; Domingo-Pardo, Cesar] Univ Valencia, Inst Fis Corpuscular, CSIC, Valencia, Spain, Email: jorge.lerendegui@ific.uv.es |
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Corporate Author |
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Thesis |
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Publisher |
Springer |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
2195-7045 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001171512700001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5975 |
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Author |
AGATA Collaboration; Doncel, M.; Recchia, F.; Quintana, B.; Gadea, A.; Farnea, E. |
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Title |
Experimental test of the background rejection, through imaging capability, of a highly segmented AGATA germanium detector |
Type |
Journal Article |
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Year |
2010 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
622 |
Issue |
3 |
Pages |
614-618 |
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Keywords |
Gamma spectroscopy; Gamma tracking; Imaging; Position-sensitive germanium detectors |
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Abstract |
The development of highly segmented germanium detectors as well as the algorithms to identify the position of the interaction within the crystal opens the possibility to locate the gamma-ray source using Compton imaging algorithms. While the Compton-suppression shield, coupled to the germanium detector in conventional arrays, works also as an active filter against the gamma rays originated outside the target, the new generation of position sensitive gamma-ray detector arrays has to fully rely on tracking capabilities for this purpose. In specific experimental conditions, as the ones foreseen at radioactive beam facilities, the ability to discriminate background radiation improves the sensitivity of the gamma spectrometer. In this work we present the results of a measurement performed at the Laboratori Nazionali di Legnaro (LNL) aiming the evaluation of the AGATA detector capabilities to discriminate the origin of the gamma rays on an event-by-event basis. It will be shown that, exploiting the Compton scattering formula, it is possible to track back gamma rays coming from different positions, assigning them to specific emitting locations. These imaging capabilities are quantified for a single crystal AGATA detector. |
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Address |
[Doncel, M.; Quintana, B.] Univ Salamanca, Lab Radiac Ionizantes, E-37008 Salamanca, Spain, Email: doncel@usal.es |
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Corporate Author |
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Publisher |
Elsevier Science Bv |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0168-9002 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
ISI:000282562700017 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
257 |
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Author |
Linhart, V.; Burdette, D.; Chessi, E.; Cindro, V.; Clinthorne, N.H.; Cochran, E.; Grosicar, B.; Honscheid, K.; Kagan, H.; Lacasta, C.; Llosa, G.; Mikuz, M.; Stankova, V.; Studen, A.; Weilhammer, P.; Zontar, D. |
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Title |
Spectroscopy study of imaging devices based on silicon Pixel Array Detector coupled to VATAGP7 read-out chips |
Type |
Journal Article |
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Year |
2011 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
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Volume |
6 |
Issue |
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Pages |
C01092 - 8pp |
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Keywords |
Gamma camera, SPECT, PET PET/CT, coronary CT angiography (CTA); Compton imaging |
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Abstract |
Spectroscopic and timing response studies have been conducted on a detector module consisting of a silicon Pixel Array Detector bonded on two VATAGP7 read-out chips manufactured by Gamma-Medica Ideas using laboratory gamma sources and the internal calibration facilities (the calibration system of the read-out chips). The performed tests have proven that the chips have (i) non-linear calibration curves which can be approximated by power functions, (ii) capability to measure the energy of photons with energy resolution better than 2 keV (exact range and resolution depend on experimental setup), (iii) the internal calibration facility which provides 6 out of 16 available internal calibration charges within our region of interest (spanning the Compton edge of 511 keV photons). The peaks induced by the internal calibration facility are suitable for a fit of the calibration curves. However, they are not suitable for measurements of equivalent noise charge because their full width at half maximum varies with their amplitude. These facts indicate that the VATAGP7 chips are useful and precise tools for a wide variety of spectroscopic devices. We have also explored time walk of the module and peaking time of the spectroscopy signals provided by the chips. We have observed that (iv) the time walk is caused partly by the peaking time of the signals provided by the fast shaper of the chips and partly by the timing uncertainty related to the varying position of the photon interaction, (v) the peaking time of the spectroscopy signals provided by the chips increases with increasing pulse height. |
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Address |
[Linhart, V.; Lacasta, C.; Llosa, G.; Stankova, V.] UVEG, CSIC, IFIC, Expt Phys Dept,Inst Fis Corpuscular, E-46071 Valencia, Spain, Email: Vladimir.Linhart@ific.uv.es |
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Corporate Author |
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Thesis |
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Publisher |
Iop Publishing Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1748-0221 |
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Conference |
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Notes |
ISI:000291345600097 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
645 |
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