|
Record |
Links |
|
Author |
Koolen, B.B.; Vidal-Sicart, S.; Benlloch, J.M.; Olmos, R.A.V. |
![find record details (via OpenURL) openurl](img/xref.gif)
|
|
Title |
Evaluating heterogeneity of primary tumor 18 F-FDG uptake in breast cancer with a dedicated breast PET ( MAMMI): a feasibility study based on correlation with PET/CT |
Type |
Journal Article |
|
Year |
2014 |
Publication |
Nuclear Medicine Communications |
Abbreviated Journal |
Nucl. Med. Commun. |
|
|
Volume |
35 |
Issue |
5 |
Pages |
446-452 |
|
|
Keywords |
breast cancer; F-18-FDG; heterogeneity; MAMMI; PET |
|
|
Abstract |
PurposeThe aim of the study was to evaluate the heterogeneity of primary tumor F-18-fluorodeoxyglucose (F-18-FDG) uptake in breast cancer patients using a dedicated breast PET.Patients and methodsA positron emission tomography/computed tomography (PET/CT) of the thorax was performed 60 min after administration of 180-240 MBq of F-18-FDG in patients with breast cancer. Subsequently, 110 min after injection, a scan was taken with a dedicated high-resolution breast PET [MAMmography with Molecular Imaging (MAMMI)]. Both procedures were performed with the patients in the prone position. Four-point scores were used to compare the intensity (0: none; 1: mild; 2: moderate; 3: high) and heterogeneity (0: none; 1: mild; 2: moderate; 3: high) of F-18-FDG uptake between PET/CT and MAMMI images.ResultsThirty-five patients in whom the primary tumor was visualized on both scans were included in this analysis. The mean primary tumor size was 35.1 mm (range 10-108 mm). The mean intensity score was similar on both devices (2.4 for PET/CT and 2.3 for MAMMI; P=0.439), but the mean heterogeneity score on MAMMI images was significantly higher (PET/CT 1.9 vs. MAMMI 2.3; P=0.005). MAMMI showed a higher heterogeneity score in 11 (31%) of 35 patients, especially in tumors with moderate or high intensity. Significantly higher heterogeneity scores on both PET/CT and MAMMI were seen in large tumors (P=0.005 and 0.014, respectively) and in tumors with high intensity scores (P=0.012 and P<0.001, respectively).ConclusionHeterogeneous tumor F-18-FDG uptake in breast cancer is frequently observed, particularly in large tumors with intense F-18-FDG uptake. It is more often seen on MAMMI PET than on conventional PET/CT. Although the observed heterogeneity should be proven histopathologically, this finding offers a rationale for F-18-FDG-guided biopsies. |
|
|
Address |
[Koolen, Bas B.; Vidal-Sicart, Sergi; Olmos, Renato A. Valdes] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Nucl Med, NL-1066 CX Amsterdam, Netherlands, Email: b.koolen@nki.nl |
|
|
Corporate Author |
|
Thesis |
|
|
|
Publisher |
Lippincott Williams & Wilkins |
Place of Publication |
|
Editor |
|
|
|
Language |
English |
Summary Language |
|
Original Title |
|
|
|
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
|
Series Volume |
|
Series Issue |
|
Edition |
|
|
|
ISSN |
0143-3636 |
ISBN |
|
Medium |
|
|
|
Area |
|
Expedition |
|
Conference |
|
|
|
Notes |
WOS:000334103800002 |
Approved |
no |
|
|
Is ISI |
yes |
International Collaboration ![sorted by International Collaboration field, descending order (down)](img/sort_desc.gif) |
yes |
|
|
Call Number |
IFIC @ pastor @ |
Serial |
1763 |
|
Permanent link to this record |