|
|
Sanjuan, R., Nebot, M., Peris, J. B., & Alcami, J. (2013). Immune Activation Promotes Evolutionary Conservation of T-Cell Epitopes in HIV-1. PLoS. Biol., 11(4), e1001523–10pp.
Abstract: The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (T-H cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient level can promote either T-cell epitope conservation or escape. We predict greater conservation for epitopes contributing significantly to total immune activation levels (immunodominance), and when T-H cell infection is concomitant to epitope recognition (transinfection). We suggest that HIV-driven immune activation in the lymph nodes during the chronic stage of the disease may offer a favorable scenario for epitope conservation. Our results also support the view that some pathogens draw benefits from the immune response and suggest that vaccination strategies based on conserved T-H epitopes may be counterproductive.
|
|
|
|
Morfin, J. G., Nieves, J., & Sobczyk, J. T. (2012). Recent Developments in Neutrino/Antineutrino-Nucleus Interactions. Adv. High. Energy Phys., 2012, 934597–35pp.
Abstract: Recent experimental results and developments in the theoretical treatment of neutrino-nucleus interactions in the energy range of 1-10 GeV are discussed. Difficulties in extracting neutrino-nucleon cross sections from neutrino-nucleus scattering data are explained and significance of understanding nuclear effects for neutrino oscillation experiments is stressed. Detailed discussions of the status of two-body current contribution in the kinematic region dominated by quasielastic scattering and specific features of partonic nuclear effects in weak DIS scattering are presented.
|
|
|
|
NEXT Collaboration(Gomez-Cadenas, J. J. et al), Alvarez, V., Carcel, S., Cervera-Villanueva, A., Diaz, J., Ferrario, P., et al. (2014). Present Status and Future Perspectives of the NEXT Experiment. Adv. High. Energy Phys., 2014, 907067–22pp.
Abstract: NEXT is an experiment dedicated to neutrinoless double beta decay searches in xenon. The detector is a TPC, holding 100 kg of high-pressure xenon enriched in the Xe-136 isotope. It is under construction in the Laboratorio Subterraneo de Canfranc in Spain, and it will begin operations in 2015. The NEXT detector concept provides an energy resolutionbetter than 1% FWHM and a topological signal that can be used to reduce the background. Furthermore, the NEXT technology can be extrapolated to a 1 ton-scale experiment.
|
|
|
|
Bonilla, J. et al, & Vos, M. (2022). Jets and Jet Substructure at Future Colliders. Front. Physics, 10, 897719–17pp.
Abstract: Even though jet substructure was not an original design consideration for the Large Hadron Collider (LHC) experiments, it has emerged as an essential tool for the current physics program. We examine the role of jet substructure on the motivation for and design of future energy Frontier colliders. In particular, we discuss the need for a vibrant theory and experimental research and development program to extend jet substructure physics into the new regimes probed by future colliders. Jet substructure has organically evolved with a close connection between theorists and experimentalists and has catalyzed exciting innovations in both communities. We expect such developments will play an important role in the future energy Frontier physics program.
|
|
|
|
Boucenna, M. S., Morisi, S., & Valle, J. W. F. (2014). The Low-Scale Approach to Neutrino Masses. Adv. High. Energy Phys., 2014, 831598–15pp.
Abstract: In this short review we revisit the broad landscape of low-scale SU(3)(C) circle times SU(2)(L) circle times U(1)(Y) models of neutrino mass generation, with view on their phenomenological potential. This includes signatures associated to direct neutrino mass messenger production at the LHC, as well as messenger-induced lepton flavor violation processes. We also briefly comment on the presence of WIMP cold dark matter candidates.
|
|
