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Sanjuan, R., Nebot, M., Peris, J. B., & Alcami, J. (2013). Immune Activation Promotes Evolutionary Conservation of T-Cell Epitopes in HIV-1. PLoS. Biol., 11(4), e1001523–10pp.
Abstract: The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (T-H cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient level can promote either T-cell epitope conservation or escape. We predict greater conservation for epitopes contributing significantly to total immune activation levels (immunodominance), and when T-H cell infection is concomitant to epitope recognition (transinfection). We suggest that HIV-driven immune activation in the lymph nodes during the chronic stage of the disease may offer a favorable scenario for epitope conservation. Our results also support the view that some pathogens draw benefits from the immune response and suggest that vaccination strategies based on conserved T-H epitopes may be counterproductive.
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Morfin, J. G., Nieves, J., & Sobczyk, J. T. (2012). Recent Developments in Neutrino/Antineutrino-Nucleus Interactions. Adv. High. Energy Phys., 2012, 934597–35pp.
Abstract: Recent experimental results and developments in the theoretical treatment of neutrino-nucleus interactions in the energy range of 1-10 GeV are discussed. Difficulties in extracting neutrino-nucleon cross sections from neutrino-nucleus scattering data are explained and significance of understanding nuclear effects for neutrino oscillation experiments is stressed. Detailed discussions of the status of two-body current contribution in the kinematic region dominated by quasielastic scattering and specific features of partonic nuclear effects in weak DIS scattering are presented.
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NEXT Collaboration(Gomez-Cadenas, J. J. et al), Alvarez, V., Carcel, S., Cervera-Villanueva, A., Diaz, J., Ferrario, P., et al. (2014). Present Status and Future Perspectives of the NEXT Experiment. Adv. High. Energy Phys., 2014, 907067–22pp.
Abstract: NEXT is an experiment dedicated to neutrinoless double beta decay searches in xenon. The detector is a TPC, holding 100 kg of high-pressure xenon enriched in the Xe-136 isotope. It is under construction in the Laboratorio Subterraneo de Canfranc in Spain, and it will begin operations in 2015. The NEXT detector concept provides an energy resolutionbetter than 1% FWHM and a topological signal that can be used to reduce the background. Furthermore, the NEXT technology can be extrapolated to a 1 ton-scale experiment.
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Bonilla, J. et al, & Vos, M. (2022). Jets and Jet Substructure at Future Colliders. Front. Physics, 10, 897719–17pp.
Abstract: Even though jet substructure was not an original design consideration for the Large Hadron Collider (LHC) experiments, it has emerged as an essential tool for the current physics program. We examine the role of jet substructure on the motivation for and design of future energy Frontier colliders. In particular, we discuss the need for a vibrant theory and experimental research and development program to extend jet substructure physics into the new regimes probed by future colliders. Jet substructure has organically evolved with a close connection between theorists and experimentalists and has catalyzed exciting innovations in both communities. We expect such developments will play an important role in the future energy Frontier physics program.
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Boucenna, M. S., Morisi, S., & Valle, J. W. F. (2014). The Low-Scale Approach to Neutrino Masses. Adv. High. Energy Phys., 2014, 831598–15pp.
Abstract: In this short review we revisit the broad landscape of low-scale SU(3)(C) circle times SU(2)(L) circle times U(1)(Y) models of neutrino mass generation, with view on their phenomenological potential. This includes signatures associated to direct neutrino mass messenger production at the LHC, as well as messenger-induced lepton flavor violation processes. We also briefly comment on the presence of WIMP cold dark matter candidates.
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Barenboim, G. (2022). Some Aspects About Pushing the CPT and Lorentz Invariance Frontier With Neutrinos. Front. Physics, 10, 813753–7pp.
Abstract: The CPT symmetry, which combines Charge Conjugation, Parity, and Time Reversal, is a cornerstone of our model-building method, and its probable violation will endanger the most extended tool we presently utilize to explain physics, namely local relativistic quantum fields. However, the kaon system's conservation constraints appear to be rather severe. We will show in this paper that neutrino oscillation experiments can enhance this limit by many orders of magnitude, making them an excellent instrument for investigating the basis of our understanding of Nature. As a result, verifying CPT invariance does not evaluate a specific model, but rather the entire paradigm. Therefore, as the CPT's status in the neutrino sector, linked or not to Lorentz invariance violation, will be assessed at an unprecedented level by current and future long baseline experiments, distinguishing it from comparable experimental fingerprints coming from non-standard interactions is critical. Whether the entire paradigm or simply the conventional model of neutrinos is at jeopardy is significantly dependent on this.
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Asai, M., Cortes-Giraldo, M. A., Gimenez-Alventosa, V., Gimenez, V., & Salvat, F. (2021). The PENELOPE Physics Models and Transport Mechanics. Implementation into Geant4. Front. Physics, 9, 738735–20pp.
Abstract: A translation of the penelope physics subroutines to C++, designed as an extension of the Geant4 toolkit, is presented. The Fortran code system penelope performs Monte Carlo simulation of coupled electron-photon transport in arbitrary materials for a wide energy range, nominally from 50 eV up to 1 GeV. Penelope implements the most reliable interaction models that are currently available, limited only by the required generality of the code. In addition, the transport of electrons and positrons is simulated by means of an elaborate class II scheme in which hard interactions (involving deflection angles or energy transfers larger than pre-defined cutoffs) are simulated from the associated restricted differential cross sections. After a brief description of the interaction models adopted for photons and electrons/positrons, we describe the details of the class-II algorithm used for tracking electrons and positrons. The C++ classes are adapted to the specific code structure of Geant4. They provide a complete description of the interactions and transport mechanics of electrons/positrons and photons in arbitrary materials, which can be activated from the G4ProcessManager to produce simulation results equivalent to those from the original penelope programs. The combined code, named PenG4, benefits from the multi-threading capabilities and advanced geometry and statistical tools of Geant4.
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Balbinot, R., & Fabbri, A. (2014). Amplifying the Hawking Signal in BECs. Adv. High. Energy Phys., 2014, 713574–8pp.
Abstract: We consider simple models of Bosep-Einstein condensates to study analog pairp-creation effects, namely, the Hawking effect from acoustic black holes and the dynamical Casimir effect in rapidly timep-dependent backgrounds. We also focus on a proposal by Cornell to amplify the Hawking signal in density-density correlators by reducing the atoms' interactions shortly before measurements are made.
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Pierre Auger Collaboration(Abreu, P. et al), & Pastor, S. (2013). Ultrahigh Energy Neutrinos at the Pierre Auger Observatory. Adv. High. Energy Phys., 2013, 708680–18pp.
Abstract: The observation of ultrahigh energy neutrinos (UHE nu s) has become a priority in experimental astroparticle physics. UHE nu s can be detected with a variety of techniques. In particular, neutrinos can interact in the atmosphere (downward-going nu) or in the Earth crust (Earth-skimming nu), producing air showers that can be observed with arrays of detectors at the ground. With the surface detector array of the Pierre Auger Observatory we can detect these types of cascades. The distinguishing signature for neutrino events is the presence of very inclined showers produced close to the ground (i.e., after having traversed a large amount of atmosphere). In this work we review the procedure and criteria established to search for UHE nu s in the data collected with the ground array of the Pierre Auger Observatory. This includes Earth-skimming as well as downward-going neutrinos. No neutrino candidates have been found, which allows us to place competitive limits to the diffuse flux of UHE nu s in the EeV range and above.
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Vicente, A. (2015). Lepton Flavor Violation beyond the MSSM. Adv. High. Energy Phys., 2015, 686572–22pp.
Abstract: Most extensions of the Standard Model lepton sector predict large lepton flavor violating rates. Given the promising experimental perspectives for lepton flavor violation in the next few years, this generic expectation might offer a powerful indirect probe to look for new physics. In this review we will cover several aspects of lepton flavor violation in supersymmetric models beyond the Minimal Supersymmetric Standard Model. In particular, we will concentrate on three different scenarios: high-scale and low-scale seesaw models as well as models with R-parity violation. We will see that in some cases the LFV phenomenology can have characteristic features for specific scenarios, implying that dedicated studies must be performed in order to correctly understand the phenomenology in nonminimal supersymmetric models.
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