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Assam, I., Vijande, J., Ballester, F., Perez-Calatayud, J., Poppe, B., & Siebert, F. A. (2022). Evaluation of dosimetric effects of metallic artifact reduction and tissue assignment on Monte Carlo dose calculations for I-125 prostate implants. Med. Phys., 49, 6195–6208.
Abstract: Purpose Monte Carlo (MC) simulation studies, aimed at evaluating the magnitude of tissue heterogeneity in I-125 prostate permanent seed implant brachytherapy (BT), customarily use clinical post-implant CT images to generate a virtual representation of a realistic patient model (virtual patient model). Metallic artifact reduction (MAR) techniques and tissue assignment schemes (TAS) are implemented on the post-implant CT images to mollify metallic artifacts due to BT seeds and to assign tissue types to the voxels corresponding to the bright seed spots and streaking artifacts, respectively. The objective of this study is to assess the combined influence of MAR and TAS on MC absorbed dose calculations in post-implant CT-based phantoms. The virtual patient models used for I-125 prostate implant MC absorbed dose calculations in this study are derived from the CT images of an external radiotherapy prostate patient without BT seeds and prostatic calcifications, thus averting the need to implement MAR and TAS. Methods The geometry of the IsoSeed I25.S17plus source is validated by comparing the MC calculated results of the TG-43 parameters for the line source approximation with the TG-43U1S2 consensus data. Four MC absorbed dose calculations are performed in two virtual patient models using the egs_brachy MC code: (1) TG-43-based D-w,w-TG(43), (2) D-w,D-w-MBDC that accounts for interseed scattering and attenuation (ISA), (3) D-m,D-m that examines ISA and tissue heterogeneity by scoring absorbed dose in tissue, and (4) D-w,D-m that unlike D-m,D-m scores absorbed dose in water. The MC absorbed doses (1) and (2) are simulated in a TG-43 patient phantom derived by assigning the densities of every voxel to 1.00 g cm(-3) (water), whereas MC absorbed doses (3) and (4) are scored in the TG-186 patient phantom generated by mapping the mass density of each voxel to tissue according to a CT calibration curve. The MC absorbed doses calculated in this study are compared with VariSeed v8.0 calculated absorbed doses. To evaluate the dosimetric effect of MAR and TAS, the MC absorbed doses of this work (independent of MAR and TAS) are compared to the MC absorbed doses of different I-125 source models from previous studies that were calculated with different MC codes using post-implant CT-based phantoms generated by implementing MAR and TAS on post-implant CT images. Results The very good agreement of TG-43 parameters of this study and the published consensus data within 3% validates the geometry of the IsoSeed I25.S17plus source. For the clinical studies, the TG-43-based calculations show a D-90 overestimation of more than 4% compared to the more realistic MC methods due to ISA and tissue composition. The results of this work generally show few discrepancies with the post-implant CT-based dosimetry studies with respect to the D-90 absorbed dose metric parameter. These discrepancies are mainly Type B uncertainties due to the different I-125 source models and MC codes. Conclusions The implementation of MAR and TAS on post-implant CT images have no dosimetric effect on the I-125 prostate MC absorbed dose calculation in post-implant CT-based phantoms.
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Andricek, L., Boronat, M., Fuster, J., Garcia, I., Gomis, P., Marinas, C., et al. (2016). Integrated cooling channels in position-sensitive silicon detectors. J. Instrum., 11, P06018–15pp.
Abstract: We present an approach to construct position-sensitive silicon detectors with an integrated cooling circuit. Tests on samples demonstrate that a very modest liquid flow very effectively cool the devices up to a power dissipation of over 10 W/cm(2). The liquid flow is found to have a negligible impact on the mechanical stability. A finite-element simulation predicts the cooling performance to an accuracy of approximately 10%.
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Aplin, S., Boronat, M., Dannheim, D., Duarte, J., Gaede, F., Ruiz-Jimeno, A., et al. (2013). Forward tracking at the next e(+)e(-) collider part II: experimental challenges and detector design. J. Instrum., 8, T06001–26pp.
Abstract: We present the second in a series of studies into the forward tracking system for a future linear e(+)e(-) collider with a center-of-mass energy in the range from 250 GeV to 3 TeV. In this note a number of specific challenges are investigated, which have caused a degradation of the tracking and vertexing performance in the forward region in previous experiments. We perform a quantitative analysis of the dependence of the tracking performance on detector design parameters and identify several ways to mitigate the performance loss for charged particles emitted at shallow angle.
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ANTARES Collaboration(Albert, A. et al), Colomer, M., Gozzini, R., Hernandez-Rey, J. J., Illuminati, G., Khan-Chowdhury, N. R., et al. (2021). Constraining the contribution of Gamma-Ray Bursts to the high-energy diffuse neutrino flux with 10 yr of ANTARES data. Mon. Not. Roy. Astron. Soc., 500(4), 5614–5628.
Abstract: Addressing the origin of the astrophysical neutrino flux observed by IceCube is of paramount importance. Gamma-Ray Bursts (GRBs) are among the few astrophysical sources capable of achieving the required energy to contribute to such neutrino flux through p gamma interactions. In this work, ANTARFS data have been used to search for upward going muon neutrinos in spatial and temporal coincidence with 784 GRBs occurred from 2007 to 2017. For each GRB, the expected neutrino flux has been calculated in the framework of the internal shock model and the impact of the lack of knowledge on the majority of source redshifts and on other intrinsic parameters of the emission mechanism has been quantified. It is found that the model parameters that set the radial distance where shock collisions occur have the largest impact on neutrino flux expectations. In particular, the bulk Lorentz factor of the source ejecta and the minimum variability time-scale are found to contribute significantly to the GRB-neutrino flux uncertainty. For the selected sources, ANTARES data have been analysed by maximizing the discovery probability of the stacking sample through an extended maximum-likelihood strategy. Since no neutrino event passed the quality cuts set by the optimization procedure, 90 per cent confidence level upper limits (with their uncertainty) on the total expected diffuse neutrino flux have been derived, according to the model. The GRB contribution to the observed diffuse astrophysical neutrino flux around 100 TeV is constrained to be less than 10 percent.
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KM3NeT Collaboration(Aiello, S. et al), Barrios-Marti, J., Calvo, D., Coleiro, A., Colomer, M., Gozzini, S. R., et al. (2018). Characterisation of the Hamamatsu photomultipliers for the KM3NeT Neutrino Telescope. J. Instrum., 13, P05035–17pp.
Abstract: The Hamamatsu R12199-023-inch photomultiplier tube is the photodetector chosen for the first phase of the KM3NeT neutrino telescope. About 7000 photomultipliers have been characterised for dark count rate, timing spread and spurious pulses. The quantum efficiency, the gain and the peak-to-valley ratio have also been measured for a sub-sample in order to determine parameter values needed as input to numerical simulations of the detector.
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Kuehn, S. et al, Bernabeu, J., Lacasta, C., Marco-Hernandez, R., Santoyo, D., Solaz, C., et al. (2017). Prototyping of hybrids and modules for the forward silicon strip tracking detector for the ATLAS Phase-II upgrade. J. Instrum., 12, P05015–26pp.
Abstract: For the High-Luminosity upgrade of the Large Hadron Collider an increased instantaneous luminosity of up to 7.5 . 10(34) cm(-2) s(-1), leading to a total integrated luminosity of up to 3000 fb(-1), is foreseen. The current silicon and transition radiation tracking detectors of the ATLAS experiment will be unable to cope with the increased track densities and radiation levels, and will need to be replaced. The new tracking detector will consist entirely of silicon pixel and strip detectors. In this paper, results on the development and tests of prototype components for the new silicon strip detector in the forward regions (end-caps) of the ATLAS detector are presented. Flex-printed readout boards with fast readout chips, referred to as hybrids, and silicon detector modules are investigated. The modules consist of a hybrid glued onto a silicon strip sensor. The channels on both are connected via wire-bonds for readout and powering. Measurements of important performance parameters and a comparison of two possible readout schemes are presented. In addition, the assembly procedure is described and recommendations for further prototyping are derived.
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LHCb Collaboration(Aaij, R. et al), Martinez-Vidal, F., Oyanguren, A., Ruiz Valls, P., & Sanchez Mayordomo, C. (2016). A new algorithm for identifying the flavour of B-s(0) mesons at LHCb. J. Instrum., 11, P05010–23pp.
Abstract: A new algorithm for the determination of the initial flavour of B-s(0) mesons is presented. The algorithm is based on two neural networks and exploits the b hadron production mechanism at a hadron collider. The first network is trained to select charged kaons produced in association with the B-s(0) meson. The second network combines the kaon charges to assign the B-s(0) flavour and estimates the probability of a wrong assignment. The algorithm is calibrated using data corresponding to an integrated luminosity of 3 fb(-1) collected by the LHCb experiment in proton-proton collisions at 7 and 8 TeV centre-of-mass energies. The calibration is performed in two ways: by resolving the B-s(0)-B-s(0) flavour oscillations in B-s(0) -> D-s(-)pi(+) decays, and by analysing flavour-specific B-s2*(5840)(0) -> B+K- decays. The tagging power measured in B-s(0) -> D-s(-)pi(+) decays is found to be (1.80 +/- 0.19 ( stat) +/- 0.18 (syst))%, which is an improvement of about 50% compared to a similar algorithm previously used in the LHCb experiment.
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Oliveira, C. A. B., Sorel, M., Martin-Albo, J., Gomez-Cadenas, J. J., Ferreira, A. L., & Veloso, J. F. C. A. (2011). Energy resolution studies for NEXT. J. Instrum., 6, P05007–13pp.
Abstract: This work aims to present the current state of simulations of electroluminescence (EL) produced in gas-based detectors with special interest for NEXT – Neutrino Experiment with a Xenon TPC. NEXT is a neutrinoless double beta decay experiment, thus needs outstanding energy resolution which can be achieved by using electroluminescence. The process of light production is reviewed and properties such as EL yield and associated fluctuations, excitation and electroluminescence efficiencies, and energy resolution, are calculated. An EL production region with a 5 mm width gap between two infinite parallel planes is considered, where a uniform electric field is produced. The pressure and temperature considered are 10 bar and 293 K, respectively. The results show that, even for low values of VUV photon detection efficiency, good energy resolution can be achieved: below 0.4% (FWHM) at Q(beta beta) = 2.458 MeV.
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NEXT Collaboration(Cebrian, S. et al), Alvarez, V., Carcel, S., Cervera-Villanueva, A., Diaz, J., Ferrario, P., et al. (2015). Radiopurity assessment of the tracking readout for the NEXT double beta decay experiment. J. Instrum., 10, P05006–16pp.
Abstract: The “Neutrino Experiment with a Xenon Time-Projection Chamber” (NEXT) is intended to investigate the neutrinoless double beta decay of Xe-136, which requires a severe suppression of potential backgrounds; therefore, an extensive screening and selection process is underway to control the radiopurity levels of the materials to be used in the experimental set-up of NEXT. The detector design combines the measurement of the topological signature of the event for background discrimination with the energy resolution optimization. Separate energy and tracking readout planes are based on different sensors: photomultiplier tubes for calorimetry and silicon multi-pixel photon counters for tracking. The design of a radiopure tracking plane, in direct contact with the gas detector medium, was specially challenging since the needed components like printed circuit boards, connectors, sensors or capacitors have typically, according to available information in databases and in the literature, activities too large for experiments requiring ultra-low background conditions. Here, the radiopurity assessment of tracking readout components based on gamma-ray spectroscopy using ultra-low background germanium detectors at the Laboratorio Subterraneo de Canfranc (Spain) is described. According to the obtained results, radiopure enough printed circuit boards made of kapton and copper, silicon photomultipliers and other required components, fulfilling the requirement of an overall background level in the region of interest of at most 8 x 10(-4) counts keV(-1) kg(-1) y(-1), have been identified.
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NEXT Collaboration(Alvarez, V. et al), Ball, M., Carcel, S., Cervera-Villanueva, A., Diaz, J., Ferrario, P., et al. (2013). Design and characterization of the SiPM tracking system of NEXT-DEMO, a demonstrator prototype of the NEXT-100 experiment. J. Instrum., 8, T05002–18pp.
Abstract: NEXT-100 experiment aims at searching the neutrinoless double-beta decay of the Xe-136 isotope using a TPC filled with a 100 kg of high-pressure gaseous xenon, with 90% isotopic enrichment. The experiment will take place at the Laboratorio Subterraneo de Canfranc (LSC), Spain. NEXT-100 uses electroluminescence (EL) technology for energy measurement with a resolution better than 1% FWHM. The gaseous xenon in the TPC additionally allows the tracks of the two beta particles to be recorded, which are expected to have a length of up to 30 cm at 10 bar pressure. The ability to record the topological signature of the beta beta 0 nu events provides a powerful background rejection factor for the beta beta experiment. In this paper, we present a novel 3D imaging concept using SiPMs coated with tetraphenyl butadiene (TPB) for the EL read out and its first implementation in NEXT-DEMO, a large-scale prototype of the NEXT-100 experiment. The design and the first characterization measurements of the NEXT-DEMO SiPM tracking system are presented. The SiPM response uniformity over the tracking plane drawn from its gain map is shown to be better than 4%. An automated active control system for the stabilization of the SiPMs gain was developed, based on the voltage supply compensation of the gain drifts. The gain is shown to be stabilized within 0.2% relative variation around its nominal value, provided by Hamamatsu, in a temperature range of 10 degrees C. The noise level from the electronics and the SiPM dark noise is shown to lay typically below the level of 10 photoelectrons (pe) in the ADC. Hence, a detection threshold at 10 pe is set for the acquisition of the tracking signals. The ADC full dynamic range (4096 channels) is shown to be adequate for signal levels of up to 200 pe/mu s, which enables recording most of the tracking signals.
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