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Muñoz, E., Ros, A., Borja-Lloret, M., Barrio, J., Dendooven, P., Oliver, J. F., et al. (2021). Proton range verification with MACACO II Compton camera enhanced by a neural network for event selection. Sci Rep, 11(1), 9325–12pp.
Abstract: The applicability extent of hadron therapy for tumor treatment is currently limited by the lack of reliable online monitoring techniques. An active topic of investigation is the research of monitoring systems based on the detection of secondary radiation produced during treatment. MACACO, a multi-layer Compton camera based on LaBr3 scintillator crystals and SiPMs, is being developed at IFIC-Valencia for this purpose. This work reports the results obtained from measurements of a 150 MeV proton beam impinging on a PMMA target. A neural network trained on Monte Carlo simulations is used for event selection, increasing the signal to background ratio before image reconstruction. Images of the measured prompt gamma distributions are reconstructed by means of a spectral reconstruction code, through which the 4.439 MeV spectral line is resolved. Images of the emission distribution at this energy are reconstructed, allowing calculation of the distal fall-off and identification of target displacements of 3 mm.
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Hatifi, M., Di Molfetta, G., Debbasch, F., & Brachet, M. (2019). Quantum walk hydrodynamics. Sci Rep, 9, 2989–7pp.
Abstract: A simple Discrete-Time Quantum Walk (DTQW) on the line is revisited and given an hydrodynamic interpretation through a novel relativistic generalization of the Madelung transform. Numerical results show that suitable initial conditions indeed produce hydrodynamical shocks and that the coherence achieved in current experiments is robust enough to simulate quantum hydrodynamical phenomena through DTQWs. An analytical computation of the asymptotic quantum shock structure is presented. The non-relativistic limit is explored in the Supplementary Material (SM).
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Lerendegui-Marco, J., Balibrea-Correa, J., Babiano-Suarez, V., Ladarescu, I., & Domingo-Pardo, C. (2022). Towards machine learning aided real-time range imaging in proton therapy. Sci Rep, 12(1), 2735–17pp.
Abstract: Compton imaging represents a promising technique for range verification in proton therapy treatments. In this work, we report on the advantageous aspects of the i-TED detector for proton-range monitoring, based on the results of the first Monte Carlo study of its applicability to this field. i-TED is an array of Compton cameras, that have been specifically designed for neutron-capture nuclear physics experiments, which are characterized by gamma-ray energies spanning up to 5-6 MeV, rather low gamma-ray emission yields and very intense neutron induced gamma-ray backgrounds. Our developments to cope with these three aspects are concomitant with those required in the field of hadron therapy, especially in terms of high efficiency for real-time monitoring, low sensitivity to neutron backgrounds and reliable performance at the high gamma-ray energies. We find that signal-to-background ratios can be appreciably improved with i-TED thanks to its light-weight design and the low neutron-capture cross sections of its LaCl3 crystals, when compared to other similar systems based on LYSO, CdZnTe or LaBr3. Its high time-resolution (CRT similar to 500 ps) represents an additional advantage for background suppression when operated in pulsed HT mode. Each i-TED Compton module features two detection planes of very large LaCl3 monolithic crystals, thereby achieving a high efficiency in coincidence of 0.2% for a point-like 1 MeV gamma-ray source at 5 cm distance. This leads to sufficient statistics for reliable image reconstruction with an array of four i-TED detectors assuming clinical intensities of 10(8) protons per treatment point. The use of a two-plane design instead of three-planes has been preferred owing to the higher attainable efficiency for double time-coincidences than for threefold events. The loss of full-energy events for high energy gamma-rays is compensated by means of machine-learning based algorithms, which allow one to enhance the signal-to-total ratio up to a factor of 2.
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Angles-Castillo, A., & Perez, A. (2022). A quantum walk simulation of extra dimensions with warped geometry. Sci Rep, 12(1), 1926–12pp.
Abstract: We investigate the properties of a quantum walk which can simulate the behavior of a spin 1/2 particle in a model with an ordinary spatial dimension, and one extra dimension with warped geometry between two branes. Such a setup constitutes a 1+ 1 dimensional version of the Randall-Sundrum model, which plays an important role in high energy physics. In the continuum spacetime limit, the quantum walk reproduces the Dirac equation corresponding to the model, which allows to anticipate some of the properties that can be reproduced by the quantum walk. In particular, we observe that the probability distribution becomes, at large time steps, concentrated near the “low energy” brane, and can be approximated as the lowest eigenstate of the continuum Hamiltonian that is compatible with the symmetries of the model. In this way, we obtain a localization effect whose strength is controlled by a warp coefficient. In other words, here localization arises from the geometry of the model, at variance with the usual effect that is originated from random irregularities, as in Anderson localization. In summary, we establish an interesting correspondence between a high energy physics model and localization in quantum walks.
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Masud, M., Bishai, M., & Mehta, P. (2019). Extricating New Physics Scenarios at DUNE with Higher Energy Beams. Sci Rep, 9, 352–9pp.
Abstract: The proposed Deep Underground Neutrino Experiment (DUNE) utilizes a wide-band on-axis tunable muon-(anti) neutrino beam with a baseline of 1300 km to search for CP violation with high precision. Given the long baseline, DUNE is also sensitive to effects due to matter induced non-standard neutrino interactions (NSI) which can interfere with the standard three-flavor oscillation paradigm. Hence it is desirable to design strategies to disentangle effects due to NSI from standard oscillations. In this article, we exploit the tunability of the DUNE neutrino beam over a wide-range of energies to devise an experimental strategy for separating oscillation effects due to NSI from the standard three-flavor oscillation scenario. Using chi(2) analysis, we obtain an optimal combination of beam tunes and distribution of run times in neutrino and anti-neutrino modes that would enable DUNE to isolate new physics scenarios from the standard. We can distinguish scenarios at 3 sigma (5 sigma) level for almost all (similar to 50%) values of delta. To the best of our knowledge, our strategy is entirely new and has not been reported elsewhere.
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