|
Botella, F. J., Branco, G. C., Nebot, M., & Rebelo, M. N. (2016). Flavour-changing Higgs couplings in a class of two Higgs doublet models. Eur. Phys. J. C, 76(3), 161–17pp.
Abstract: We analyse various flavour-changing processes like t -> hu, hc, h -> t e, tau μas well as hadronic decays h -> bs, bd, in the framework of a class of two Higgs doublet models where there are flavour-changing neutral scalar currents at tree level. These models have the remarkable feature of having these flavour-violating couplings entirely determined by the CKM and PMNS matrices as well as tan beta. The flavour structure of these scalar currents results from a symmetry of the Lagrangian and therefore it is natural and stable under the renormalisation group. We show that in some of the models the rates of the above flavour-changing processes can reach the discovery level at the LHC at 13 TeV even taking into account the stringent bounds on low energy processes, in particular μ-> e gamma.
|
|
|
Botella, F. J., Branco, G. C., Nebot, M., Rebelo, M. N., & Silva-Marcos, J. I. (2017). Vector-like quarks at the origin of light quark masses and mixing. Eur. Phys. J. C, 77(6), 408–14pp.
Abstract: We show how a novel fine-tuning problem present in the Standard Model can be solved through the introduction of a Z(6) flavour symmetry, together with three Q = -1/3 quarks, three Q = 2/3 quarks, as well as a complex singlet scalar. The Z(6) symmetry is extended to the additional fields and it is an exact symmetry of the Lagrangian, only softly broken in the scalar potential, in order to avoid the domain-wall problem. Specific examples are given and a phenomenological analysis of the main features of the model is presented. It is shown that even for vector-like quarks with masses accessible at the LHC, one can have realistic quark masses and mixing, while respecting the strict constraints on processes arising from flavour changing neutral currents. The vector-like quark decay channels are also described.
|
|
|
Herrero-Garcia, J., Nebot, M., Rius, N., & Santamaria, A. (2014). The Zee-Babu model revisited in the light of new data. Nucl. Phys. B, 885, 542–570.
Abstract: We update previous analyses of the Zee-Babu model in the light of new data, e.g., the mixing angle On, the rare decay μ-> e gamma and the LHC results. We also analyze the possibility of accommodating the deviations in Gamma (H -> gamma gamma) hinted by the LHC experiments, and the stability of the scalar potential. We find that neutrino oscillation data and low energy constraints are still compatible with masses of the extra charged scalars accessible to LHC. Moreover, if any of them is discovered, the model can be falsified by combining the information on the singly and doubly charged scalar decay modes with neutrino data. Conversely, if the neutrino spectrum is found to be inverted and the CP phase delta is quite different from pi, the masses of the charged scalars will be well outside the LHC reach.
|
|
|
Alves, J. M., Botella, F. J., Branco, G. C., Cornet-Gomez, F., & Nebot, M. (2017). Controlled flavour changing neutral couplings in two Higgs Doublet models. Eur. Phys. J. C, 77(9), 585–18pp.
Abstract: We propose a class of two Higgs doublet models where there are flavour changing neutral currents (FCNC) at tree level, but under control due to the introduction of a discrete symmetry in the full Lagrangian. It is shown that in this class of models, one can have simultaneously FCNC in the up and down sectors, in contrast to the situation encountered in the renormalisable and minimal flavour violating 2HDM models put forward by Branco et al. (Phys Lett B 380: 119, 1996). The intensity of FCNC is analysed and it is shown that in this class of models one can respect all the strong constraints from experiment without unnatural fine-tuning. It is pointed out that the additional sources of flavour and CP violation are such that they can enhance significantly the generation of the Bbaryon asymmetry of the Universe, with respect to the standard model.
|
|
|
Peris, J. B., Davis, P., Cuevas, J. M., Nebot, M., & Sanjuan, R. (2010). Distribution of Fitness Effects Caused by Single-Nucleotide Substitutions in Bacteriophage f1. Genetics, 185(2), 603–U308.
Abstract: Empirical knowledge of the fitness effects of mutations is important for understanding many evolutionary processes, yet this knowledge is often hampered by several sources of measurement error and bias. Most of these problems can be solved using site-directed mutagenesis to engineer single mutations, an approach particularly suited for viruses due to their small genomes. Here, we used this technique to measure the fitness effect of 100 single-nucleotide substitutions in the bacteriophage f1, a filamentous single-strand DNA virus. We found that approximately one-fifth of all mutations are lethal. Viable ones reduced fitness by 11% on average and were accurately described by a log-normal distribution. More than 90% of synonymous substitutions were selectively neutral, while those affecting intergenic regions reduced fitness by 14% on average. Mutations leading to amino acid substitutions had an overall mean deleterious effect of 37%, which increased to 45% for those changing the amino acid polarity. Interestingly, mutations affecting early steps of the infection cycle tended to be more deleterious than those affecting late steps. Finally, we observed at least two beneficial mutations. Our results confirm that high mutational sensitivity is a general property of viruses with small genomes, including RNA and single-strand DNA viruses infecting animals, plants, and bacteria.
|
|