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Author |
Baran, J. et al; Brzezinski, K. |
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Title |
Feasibility of the J-PET to monitor the range of therapeutic proton beams |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physica Medica |
Abbreviated Journal |
Phys. Medica |
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Volume |
118 |
Issue |
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Pages |
103301 - 9pp |
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Keywords |
PET; Range monitoring; J-PET; Monte Carlo simulations; Proton radiotherapy |
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Abstract |
Purpose: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J -PET) scanner for intra-treatment proton beam range monitoring. Methods: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J -PET scanner geometries. We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread -Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J -PET scanner prototype dedicated to the proton beam range assessment. Results: The investigations indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10-5 coincidences per primary proton, while the precision of the range assessment for both SPB and SOBP irradiation plans was found below 1 mm. Among the scanners with the same number of detector modules, the best results are found for the triple -layer dual -head geometry. The results indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for the clinical application, Conclusions: We performed simulation studies demonstrating that the feasibility of the J -PET detector for PET -based proton beam therapy range monitoring is possible with reasonable sensitivity and precision enabling its pre -clinical tests in the clinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double -layer cylindrical and triple -layer dual -head J -PET geometry configurations seem promising for future clinical application. |
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Address |
[Baran, Jakub; Silarski, Michal; Chug, Neha; Coussat, Aurelien; Czerwinski, Eryk; Dadgar, Meysam; Dulski, Kamil; Eliyan, Kavya, V; Gajos, Aleksander; Kacprzak, Krzysztof; Kaplon, Lukasz; Korcyl, Grzegorz; Kozik, Tomasz; Kumar, Deepak; Niedzwiecki, Szymon; Panek, Dominik; Parzych, Szymon; del Rio, Elena Perez; Simbarashe, Moyo; Sharma, Sushil; Shivani; Skurzok, Magdalena; Stepien, Ewa L.; Tayefi, Keyvan; Tayefi, Faranak; Moskal, Pawel] Jagiellonian Univ, Fac Phys Astron & Appl Comp Sci, 11 Lojasiewicza St, PL-30348 Krakow, Poland, Email: jakubbaran92@gmail.com |
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Publisher |
Elsevier Sci Ltd |
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English |
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ISSN |
1120-1797 |
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Conference |
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Notes |
WOS:001178648400001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5990 |
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Permanent link to this record |
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Author |
Etxebeste, A.; Barrio, J.; Bernabeu, J.; Lacasta, C.; Llosa, G.; Muñoz, E.; Ros, A.; Oliver, J.F. |
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Title |
Study of sensitivity and resolution for full ring PET prototypes based on continuous crystals and analytical modeling of the light distribution |
Type |
Journal Article |
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Year |
2019 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
64 |
Issue |
3 |
Pages |
035015 - 17pp |
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Keywords |
continuous crystals; NEMA NU 4-2008; positron emission tomography (PET); Monte Carlo simulations; image reconstruction; depth of interaction |
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Abstract |
Sensitivity and spatial resolution are the main parameters to maximize in the performance of a PET scanner. For this purpose, detectors consisting of a combination of continuous crystals optically coupled to segmented photodetectors have been employed. With the use of continuous crystals the sensitivity is increased with respect to the pixelated crystals. In addition, spatial resolution is no longer limited to the crystal size. The main drawback is the difficulty in determining the interaction position. In this work, we present the characterization of the performance of a full ring based on cuboid continuous crystals coupled to SiPMs. To this end, we have employed the simulations developed in a previous work for our experimental detector head. Sensitivity could be further enhanced by using tapered crystals. This enhancement is obtained by increasing the solid angle coverage, reducing the wedge-shaped gaps between contiguous detectors. The performance of the scanners based on both crystal geometries was characterized following NEMA NU 4-2008 standardized protocol in order to compare them. An average sensitivity gain over the entire axial field of view of 13.63% has been obtained with tapered geometry while similar performance of the spatial resolution has been proven with both scanners. The activity at which NECR and true peak occur is smaller and the peak value is greater for tapered crystals than for cuboid crystals. Moreover, a higher degree of homogeneity was obtained in the sensitivity map due to the tighter packing of the crystals, which reduces the gaps and results in a better recovery of homogeneous regions than for the cuboid configuration. Some of the results obtained, such as spatial resolution, depend on the interaction position estimation and may vary if other method is employed. |
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Address |
[Etxebeste, Ane; Barrio, John; Bernabeu, Jose; Lacasta, Carlos; Llosa, Gabriela; Munoz, Enrique; Ros, Ana; Oliver, Josef F.] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: ane.etxebeste@ific.uv.es |
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Publisher |
Iop Publishing Ltd |
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English |
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ISSN |
0031-9155 |
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Conference |
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Notes |
WOS:000457182500004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3897 |
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Permanent link to this record |
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Author |
Hornillos, M.B.G.; Gorlychev, V.; Caballero, R.; Cortes, G.; Poch, A.; Pretel, C.; Calvino, F.; Tain, J.L.; Algora, A.; Agramunt, J.; Cano-Ott, D.; Martinez, T.; Mendoza, E.; Rissanen, J.; Aysto, J.; Jokinen, A.; Eronen, T.; Moore, I.; Penttila, H. |
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Title |
Monte Carlo Simulations for the Study of a Moderated Neutron Detector |
Type |
Journal Article |
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Year |
2011 |
Publication |
Journal of the Korean Physical Society |
Abbreviated Journal |
J. Korean Phys. Soc. |
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Volume |
59 |
Issue |
2 |
Pages |
1573-1576 |
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Keywords |
Monte Carlo simulations; GEANT4; MCNPX; Beta delayed neutron emission; Neutron detector |
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Abstract |
This work presents the Monte Carlo simulations performed with the MCNPX and GEANT4 codes for the design of a BEta deLayEd Neutron detector, BELEN-20. This detector will be used for the study of beta delayed neutron emission and consists of a block of polyethylene with dimensions 90 x 90 x 80 cm(3) and 20 cylindrical (3)He gas counters. The results of these simulations have been validated experimentally with a (252)Cf source in the laboratory at UPC, Barcelona. Also the first experiment with this detector has been carried out in November 2009 in JYFL, Finland. In this experiment the neutron emission probability after beta decay of the fission products (88)Br, (94,95)Rb, and (138)I has been measured; this data is still under analysis. Simulations with MCNPX and GEANT4 have been performed in order to obtain the efficiency of the BELEN-20 detector for each of the above nuclei using the neutron energy distribution corresponding to each nucleus. |
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Address |
[Hornillos, MBG; Gorlychev, V; Caballero, R; Cortes, G; Poch, A; Pretel, C; Calvino, F] Univ Politecn Cataluna, Seccio Engn Nucl, E-08028 Barcelona, Spain, Email: belen.gomez@upc.edu |
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Publisher |
Korean Physical Soc |
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English |
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Original Title |
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Series Editor |
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Edition |
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ISSN |
0374-4884 |
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Notes |
WOS:000294080700028 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
733 |
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Permanent link to this record |
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Author |
Langer, C.; Algora, A.; Couture, A.; Csatlos, M.; Gulyas, J.; Heil, M.; Krasznahorkay, A.; O'Donnell, J.M.; Plag, R.; Reifarth, R.; Stuhl, L.; Sonnabend, K.; Tornyi, T.; Tovesson, F. |
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Title |
Simulations and developments of the Low Energy Neutron detector Array LENA |
Type |
Journal Article |
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Year |
2011 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
659 |
Issue |
1 |
Pages |
411-418 |
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Keywords |
Monte Carlo simulations; Charge-exchange reactions; Scintillation detectors; Neutron detector |
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Abstract |
Prototypes of the Low Energy Neutron detector Array (LENA) have been tested and compared with detailed GEANT simulations. LENA will consist of plastic scintillation bars with the dimensions 1000 x 45 x 10 mm(3). The tests have been performed with gamma-ray sources and neutrons originating from the neutron-induced fission of (235)U. The simulations agreed very well with the measured response and were therefore used to simulate the response to mono-energetic neutrons with different detection thresholds. LENA will be used to detect low-energy neutrons from (p,n)-type reactions with low momentum transfer foreseen at the R(3)B and EXL setups at FAIR, Darmstadt. |
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Address |
[Langer, C.; Heil, M.; Plag, R.; Reifarth, R.] GSI Helmholtzzentrum Schwerionenforsch GmbH, D-64291 Darmstadt, Germany, Email: c.langer@gsi.de |
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Corporate Author |
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Publisher |
Elsevier Science Bv |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Edition |
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ISSN |
0168-9002 |
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Notes |
WOS:000297826100057 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
833 |
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Permanent link to this record |
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Author |
Campanario, F.; Kubocz, M. |
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Title |
Higgs boson CP-properties of the gluonic contributions in Higgs plus three jet production via gluon fusion at the LHC |
Type |
Journal Article |
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Year |
2014 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
10 |
Issue |
10 |
Pages |
173 - 16pp |
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Keywords |
QCD Phenomenology; Monte Carlo Simulations |
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Abstract |
in high energy hadronic collisions, a general CP-violating Higgs boson Phi with accompanying jets can be efficiently produced via gluon fusion, which is mediated by heavy quark loops. In this article, we study the dominant sub-channel gg -> ggg Phi of the gluon fusion production process with triple real emission corrections at order alpha(5)(s). We go beyond the heavy top-quark approximation and include the full mass dependence of the top- and bottom-quark contributions. Furthermore, in a specific model we demonstrate the features of our program and show the impact of bottom-quark loop contributions in combination with large values of tan beta on differential distributions sensitive to CP-rneasurements of the Higgs boson. |
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Address |
[Campanario, Francisco] Univ Valencia CSIC, IFIC, Div Theory, E-46100 Valencia, Spain, Email: francisco.campanario@ific.uv.es; |
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Corporate Author |
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Thesis |
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Publisher |
Springer |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1029-8479 |
ISBN |
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Expedition |
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Conference |
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Notes |
WOS:000344652800003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2007 |
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Permanent link to this record |