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Author |
Penas, J.; Alejo, A.; Bembibre, A.; Apiñaniz, J.I.; Garcia-Garcia, E.; Guerrero, C.; Henares, J.L.; Hernandez-Palmero, I.; Mendez, C.; Millan-Callado, M.A.; Puyuelo-Valdes, P.; Seimetz, M.; Benlliure, J. |
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Title |
Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source |
Type |
Journal Article |
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Year |
2024 |
Publication |
Scientific Reports |
Abbreviated Journal |
Sci Rep |
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Volume |
14 |
Issue |
1 |
Pages  |
11448 - 12pp |
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Keywords |
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Abstract |
Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the first time the use of a high-repetition rate, ultra-intense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10-14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} B(p,n) 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Significant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-the-art technology (10 Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range. |
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Address |
[Penas, Juan; Alejo, Aaron; Bembibre, Adrian; Benlliure, Jose] Univ Santiago de Compostela, Inst Galego Fis Altas Enerxias IGFAE, Santiago De Compostela 15782, Spain, Email: j.benlliure@usc.es |
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Publisher |
Nature Portfolio |
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English |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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ISSN |
2045-2322 |
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Expedition |
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Conference |
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Notes |
WOS:001228252900017 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
6143 |
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Author |
Garcia, A.R.; Martinez, T.; Cano-Ott, D.; Castilla, J.; Guerrero, C.; Marin, J.; Martinez, G.; Mendoza, E.; Ovejero, M.C.; Reillo, E.M.; Santos, C.; Tera, F.J.; Villamarin, D.; Nolte, R.; Agramunt, J.; Algora, A.; Tain, J.L.; Banerjee, K.; Bhattacharya, C.; Pentilla, H.; Rinta-Antila, S.; Gorelov, D. |
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Title |
MONSTER: a time of flight spectrometer for beta-delayed neutron emission measurements |
Type |
Journal Article |
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Year |
2012 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
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Volume |
7 |
Issue |
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Pages |
C05012 - 12pp |
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Keywords |
Scintillators, scintillation and light emission processes (solid, gas and liquid scintillators); Instrumentation and methods for time-of-flight (TOF) spectroscopy; Neutron detectors (cold, thermal, fast neutrons) |
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Abstract |
The knowledge of the beta-decay properties of nuclei contributes decisively to our understanding of nuclear phenomena: the beta-delayed neutron emission of neutron rich nuclei plays an important role in the nucleosynthesis r-process and constitutes a probe for nuclear structure of very neutron rich nuclei providing information about the high energy part of the full beta strength (S-beta) function. In addition, beta-delayed neutrons are essential for the control and safety of nuclear reactors. In order to determine the neutron energy spectra and emission probabilities from neutron precursors a MOdular Neutron time-of-flight SpectromeTER (MONSTER) has been proposed for the DESPEC experiment at the future FAIR facility. The design of MONSTER and status of its construction are reported in this work. |
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Address |
[Garcia, A. R.; Martinez, T.; Cano-Ott, D.; Castilla, J.; Guerrero, C.; Marin, J.; Martinez, G.; Mendoza, E.; Ovejero, M. C.; Reillo, E. M.; Santos, C.; Tera, F. J.; Villamarin, D.] Ctr Invest Energet MedioAmbientales & Tecnol CIEM, E-28040 Madrid, Spain, Email: trino.martinez@ciemat.es |
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Publisher |
Iop Publishing Ltd |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1748-0221 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000305419700013 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1084 |
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Author |
Colonna, N.; Belloni, F.; Berthoumieux, E.; Calviani, M.; Domingo-Pardo, C.; Guerrero, C.; Karadimos, D.; Lederer, C.; Massimi, C.; Paradela, C.; Plag, R.; Praena, J.; Sarmento, R. |
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Title |
Advanced nuclear energy systems and the need of accurate nuclear data: the n_TOF project at CERN |
Type |
Journal Article |
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Year |
2010 |
Publication |
Energy & Environmental Science |
Abbreviated Journal |
Energy Environ. Sci. |
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Volume |
3 |
Issue |
12 |
Pages |
1910-1917 |
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Keywords |
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Abstract |
To satisfy the world's constantly increasing demand for energy, a suitable mix of different energy sources has to be devised. In this scenario, an important role could be played by nuclear energy, provided that major safety, waste and proliferation issues affecting current nuclear reactors are satisfactorily addressed. To this purpose, a large effort has been under way for a few years towards the development of advanced nuclear systems with the aim of closing the fuel cycle. Generation IV reactors, with full or partial waste recycling capability, accelerator driven systems, as well as new fuel cycles are the main options being investigated. The design of advanced systems requires improvements in basic nuclear data, such as cross-sections for neutron-induced reactions on actinides. In this paper, the main concepts of advanced reactor systems are described, together with the related needs of new and accurate nuclear data. The present activity in this field at the neutron facility n_TOF at CERN is discussed. |
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Address |
[Colonna, N.] Ist Nazl Fis Nucl, Sez Bari, I-70126 Bari, Italy, Email: nicola.colonna@ba.infn.it |
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Publisher |
Royal Soc Chemistry |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1754-5692 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
ISI:000284590900007 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
319 |
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Author |
n_TOF Collaboration (Guerrero, C. et al); Giubrone, G.; Tain, J.L. |
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Title |
Characterization of the New n_TOF Neutron Beam: Fluence, Profile and Resolution |
Type |
Journal Article |
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Year |
2011 |
Publication |
Journal of the Korean Physical Society |
Abbreviated Journal |
J. Korean Phys. Soc. |
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Volume |
59 |
Issue |
2 |
Pages |
1624-1627 |
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Keywords |
n_TOF; Time-of-flight; Neutron beam; Nuclear data; Cross sections |
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Abstract |
After a halt of four years, the nTOF spallation neutron facility at CERN has resumed operation in November 2008 with a new spallation target characterized by an improved safety and engineering design, resulting in a more robust overall performance and efficient cooling. The first measurement during the 2009 run has aimed at the full characterization of the neutron beam. Several detectors, such as calibrated fission chambers, the nTOF Silicon Monitor, a MicroMegas detector with (10)B and (235)U samples, as well as liquid and solid scintillators have been used in order to characterize the properties of the neutron fluence. The spatial profile of the beam has been studied with a specially designed “X-Y” MicroMegas which provided a 2D image of the beam as a function of neutron energy. Both properties have been compared with simulations performed. with the FLUKA code. The characterization of the resolution function is based on results from simulations which have been verified by the study of narrow capture resonances. of (56)Fe, which were measured as part of a new campaign of (n,gamma) measurements on Fe and Ni isotopes. |
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Address |
[Guerrero, C; Becares, V; Cano-Ott, D; Fernandez-Ordonez, M; Gonzalez-Romero, E; Martin-Fuertes, F; Martinez, T; Mendoza, E; Pina, G; Quinones, J; Vlachoudis, V] Ctr Invest Energet Medioambientales & Tecnol, Madrid 28040, Spain, Email: carlos.guerrero@ciemat.es |
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Corporate Author |
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Thesis |
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Publisher |
Korean Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0374-4884 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000294080700041 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
735 |
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Author |
n_TOF Collaboration (Guerrero, C. et al); Domingo-Pardo, C.; Tain, J.L. |
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Title |
Study of Photon Strength Function of Actinides: the Case of (235)U, (238)Np and (241)Pu |
Type |
Journal Article |
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Year |
2011 |
Publication |
Journal of the Korean Physical Society |
Abbreviated Journal |
J. Korean Phys. Soc. |
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Volume |
59 |
Issue |
2 |
Pages |
1510-1513 |
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Keywords |
Photon/Gamma strength functions; Pygmy; Scissor mode; n_TOF; Total absorption calorimeter; TAC; Neutron capture |
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Abstract |
The decay from excited levels in medium and heavy nuclei can be described in a statistical approach by means of Photon Strength Functions and Level Density distributions. The study of electromagnetic cascades following neutron capture based on the use of high efficiency detectors has been shown to be well suited for probing the properties of the Photon Strength Function of heavy (high level density) and/or radioactive (high background) nuclei. In this work we have investigated for the first time the validity of the recommended PSF of actinides, in particular (235)U, (238)Np and (241)Pu. Our study includes the search for resonance structures in the PSF below S(n) and draws conclusions regarding their existence and their characteristics in terms of energy, width and electromagnetic nature. |
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Address |
[Guerrero, C; Alvarez-Velarde, F; Ano-Ott, DC; Martinez, T; Mendoza, E; Villamarin, D] Ctr Invest Energet Medioambientales & Technol CIE, Madrid, Spain, Email: carlos.guerrero@ciemat.es |
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Corporate Author |
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Thesis |
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Publisher |
Korean Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0374-4884 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000294080700013 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
731 |
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| Permanent link to this record |
