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Pich, A. (2021). Precision physics with inclusive QCD processes. Prog. Part. Nucl. Phys., 117, 103846–41pp.
Abstract: The inclusive production of hadrons through electroweak currents can be rigorously analysed with short-distance theoretical tools. The associated observables are insensitive to the involved infrared behaviour of the strong interaction, allowing for very precise tests of Quantum Chromodynamics. The theoretical predictions for sigma(e(+)e(-) -> hadrons) and the hadronic decay widths of the tau lepton and the Z, W and Higgs bosons have reached an impressive accuracy of O(alpha(4)(s)). Precise experimental measurements of the Z and tau hadronic widths have made possible the accurate determination of the strong coupling at two very different energy scales, providing a highly significant experimental verification of asymptotic freedom. A detailed discussion of the theoretical description of these processes and their current phenomenological status is presented. The most precise determinations of alpha(s) from other sources are also briefly reviewed and compared with the fully-inclusive results.
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Carrasco-Ribelles, L. A., Pardo-Mas, J. R., Tortajada, S., Saez, C., Valdivieso, B., & Garcia-Gomez, J. M. (2021). Predicting morbidity by local similarities in multi-scale patient trajectories. J. Biomed. Inform., 120, 103837–9pp.
Abstract: Patient Trajectories (PTs) are a method of representing the temporal evolution of patients. They can include information from different sources and be used in socio-medical or clinical domains. PTs have generally been used to generate and study the most common trajectories in, for instance, the development of a disease. On the other hand, healthcare predictive models generally rely on static snapshots of patient information. Only a few works about prediction in healthcare have been found that use PTs, and therefore benefit from their temporal dimension. All of them, however, have used PTs created from single-source information. Therefore, the use of longitudinal multi-scale data to build PTs and use them to obtain predictions about health conditions is yet to be explored. Our hypothesis is that local similarities on small chunks of PTs can identify similar patients concerning their future morbidities. The objectives of this work are (1) to develop a methodology to identify local similarities between PTs before the occurrence of morbidities to predict these on new query individuals; and (2) to validate this methodology on risk prediction of cardiovascular diseases (CVD) occurrence in patients with diabetes. We have proposed a novel formal definition of PTs based on sequences of longitudinal multi-scale data. Moreover, a dynamic programming methodology to identify local alignments on PTs for predicting future morbidities is proposed. Both the proposed methodology for PT definition and the alignment algorithm are generic to be applied on any clinical domain. We validated this solution for predicting CVD in patients with diabetes and we achieved a precision of 0.33, a recall of 0.72 and a specificity of 0.38. Therefore, the proposed solution in the diabetes use case can result of utmost utility to secondary screening.
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Giare, W., Mena, O., & Di Valentino, E. (2023). Lensing impact on cosmic relics and tensions. Phys. Rev. D, 108(10), 103539–9pp.
Abstract: Cosmological bounds on neutrinos and additional hypothetical light thermal relics, such as QCD axions, are currently among the most restrictive ones. These limits mainly rely on cosmic microwave background temperature anisotropies. Nonetheless, one of the largest cosmological signatures of thermal relics is that on gravitational lensing, due to their free-streaming behavior before their nonrelativistic period. We investigate late-time only hot-relic mass constraints, primarily based on recently released lensing data from the Atacama Cosmology Telescope, both alone and in combination with lensing data from the Planck satellite. Additionally, we consider other local probes, such as baryon acoustic oscillations measurements, shear-shear, galaxy-galaxy, and galaxy-shear correlation functions from the dark energy survey, and distance moduli measurements from Type-Ia Supernovae. The tightest bounds we find are Sigma m(v) < 0.43 eV and m(a) < 1.1 eV, both at 95% CL Interestingly, these limits are still much stronger than those found on e.g., laboratory neutrino mass searches, reassessing the robustness of the extraction of thermal relic properties via cosmological observations. In addition, when considering lensing-only data, the significance of the Hubble constant tension is considerably reduced, while the clustering parameter sigma 8 controversy is completely absent.
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Servant, G., & Simakachorn, P. (2024). Ultrahigh frequency primordial gravitational waves beyond the kHz: The case of cosmic strings. Phys. Rev. D, 109(10), 103538–24pp.
Abstract: We investigate gravitational -wave backgrounds (GWBs) of primordial origin that would manifest only at ultrahigh frequencies, from kilohertz to 100 gigahertz, and leave no signal at LIGO, the Einstein Telescope, the Cosmic Explorer, LISA, or pulsar -timing arrays. We focus on GWBs produced by cosmic strings and make predictions for the GW spectra scanning over high-energy scale (beyond 10 10 GeV) particle physics parameters. Signals from local string networks can easily be as large as the big bang nucleosynthesis/ cosmic microwave background bounds, with a characteristic strain as high as 10 – 26 in the 10 kHz band, offering prospects to probe grand unification physics in the 10 14 -10 17 GeV energy range. In comparison, GWB from axionic strings is suppressed (with maximal characteristic strain similar to 10 – 31 ) due to the early matter era induced by the associated heavy axions. We estimate the needed reach of hypothetical futuristic GW detectors to probe such GWB and, therefore, the corresponding high-energy physics processes. Beyond the information of the symmetry -breaking scale, the high -frequency spectrum encodes the microscopic structure of the strings through the position of the UV cutoffs associated with cusps and kinks, as well as potential information about friction forces on the string. The IR slope, on the other hand, reflects the physics responsible for the decay of the string network. We discuss possible strategies for reconstructing the scalar potential, particularly the scalar self -coupling, from the measurement of the UV cutoff of the GW spectrum.
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Caputo, A., Liu, H. W., Mishra-Sharma, S., & Ruderman, J. T. (2020). Modeling dark photon oscillations in our inhomogeneous Universe. Phys. Rev. D, 102(10), 103533–26pp.
Abstract: A dark photon may kinetically mix with the Standard Model photon, leading to observable cosmological signatures. The mixing is resonantly enhanced when the dark photon mass matches the primordial plasma frequency, which depends sensitively on the underlying spatial distribution of electrons. Crucially, inhomogeneities in this distribution can have a significant impact on the nature of resonant conversions. We develop and describe, for the first time, a general analytic formalism to treat resonant oscillations in the presence of inhomogeneities. Our formalism follows from the theory of level crossings of random fields and only requires knowledge of the one-point probability density function (PDF) of the underlying electron number density fluctuations. We validate our formalism using simulations and illustrate the photon-to-dark photon conversion probability for several different choices of PDFs that are used to characterize the low-redshift Universe.
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Di Valentino, E., Gariazzo, S., Giare, W., Melchiorri, A., Mena, O., & Renzi, F. (2023). Novel model-marginalized cosmological bound on the QCD axion mass. Phys. Rev. D, 107(10), 103528–16pp.
Abstract: We present model-marginalized limits on mixed hot dark matter scenarios, which consider both thermal neutrinos and thermal QCD axions. A novel aspect of our analyses is the inclusion of small-scale cosmic microwave background (CMB) observations from the Atacama Cosmology Telescope (ACT) and the South Pole Telescope (SPT), together with those from the Planck satellite and baryon acoustic oscillation (BAO) data. After marginalizing over a number of well-motivated nonminimal background cosmologies, the tightest 95% Confidential Level (CL) upper bound we obtain is 0.21 eV, both for P m nu and ma, from the combination of ACT, Planck and BAO measurements. Restricting the analyses to the standard ?CDM picture, we find P m nu < 0.16 eV and ma < 0.18 eV, both at 95% CL Interestingly, the best background cosmology is never found within the minimal ?CDM plus hot relics, regardless of the datasets exploited in the analyses. The combination of Planck with either BAO, SPT or ACT prefers a universe with a nonzero value of the running in the primordial power spectrum with strong evidence. Small-scale CMB probes, both alone and combined with BAO, either prefer, with substantial evidence, nonflat universes (as in the case of SPT) or a model with a time varying dark energy component (as in the case of ACT).
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Figueroa, D. G., Hindmarsh, M., Lizarraga, J., & Urrestilla, J. (2020). Irreducible background of gravitational waves from a cosmic defect network: Update and comparison of numerical techniques. Phys. Rev. D, 102(10), 103516–25pp.
Abstract: Cosmological phase transitions in the early Universe may produce relics in the form of a network of cosmic defects. Independently of the order of a phase transition, topology of the defects, and their global or gauge nature, the defects are expected to emit gravitational waves (GWs) as the network energy-momentum tensor adapts itself to maintaining scaling. We show that the evolution of any defect network (and for that matter any scaling source) emits a GW background with spectrum Omega(GW) proportional to f(3) for f << f(0), Omega(GW) proportional to 1/f(2) for f(0) less than or similar to f less than or similar to feq, and Omega(GW) proportional to const (i.e., exactly scale invariant) for f >> f(eq), where f(0) and f(eq) denote respectively the frequencies corresponding to the present and matter-radiation equality horizons. This background represents an irreducible emission of GWs from any scaling network of cosmic defects, with its amplitude characterized only by the symmetry-breaking scale and the nature of the defects. Using classical lattice simulations we calculate the GW signal emitted by defects created after the breaking of a global symmetry O(N) -> O(N – 1). We obtain the GW spectrum for N between 2 and 20 with two different techniques: integrating over unequal-time correlators of the energy-momentum tensor, updating our previous work on smaller lattices, and for the first time, comparing the result with the real-time evolution of the tensor perturbations sourced by the same defects. Our results validate the equivalence of the two techniques. Using cosmic microwave background upper bounds on the defects' energy scale, we discuss the difficulty of detecting this GW background in the case of global defects.
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Di Valentino, E., Gariazzo, S., Giunti, C., Mena, O., Pan, S., & Yang, W. Q. (2022). Minimal dark energy: Key to sterile neutrino and Hubble constant tensions? Phys. Rev. D, 105(10), 103511–15pp.
Abstract: Minimal dark energy models, described by the same number of free parameters of the standard cosmological model with cold dark matter plus a cosmological constant to parametrize the dark energy component, constitute very appealing scenarios which may solve long-standing, pending tensions. On the one hand, they alleviate significantly the tension between cosmological observations and the presence of one sterile neutrino motivated by the short-baseline anomalies: we obtain a 95% CL cosmological bound on the mass of a fully thermalized fourth sterile neutrino (N-eff = 4) equal to m(s) < 0.65(1.3) eV within the Phenomenologically Emergent Dark Energy (PEDE) and Vacuum Metamorphosis (VM) scenarios under consideration. Interestingly, these limits are in agreement with the observations at short-baseline experiments, and the PEDE scenario is favored with respect to the Lambda CDM case when the full data combination is considered. On the other hand, the Hubble tension is satisfactorily solved in almost all the minimal dark energy schemes explored here. These phenomenological scenarios may therefore shed light on differences arising from near and far Universe probes, and also on discrepancies between cosmological and laboratory sterile neutrino searches.
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Baran, J. et al, & Brzezinski, K. (2024). Feasibility of the J-PET to monitor the range of therapeutic proton beams. Phys. Medica, 118, 103301–9pp.
Abstract: Purpose: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J -PET) scanner for intra-treatment proton beam range monitoring. Methods: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J -PET scanner geometries. We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread -Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J -PET scanner prototype dedicated to the proton beam range assessment. Results: The investigations indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10-5 coincidences per primary proton, while the precision of the range assessment for both SPB and SOBP irradiation plans was found below 1 mm. Among the scanners with the same number of detector modules, the best results are found for the triple -layer dual -head geometry. The results indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for the clinical application, Conclusions: We performed simulation studies demonstrating that the feasibility of the J -PET detector for PET -based proton beam therapy range monitoring is possible with reasonable sensitivity and precision enabling its pre -clinical tests in the clinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double -layer cylindrical and triple -layer dual -head J -PET geometry configurations seem promising for future clinical application.
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Barrientos, L., Borja-Lloret, M., Casaña, J. V., Dendooven, P., Garcia Lopez, J. G., Hueso-Gonzalez, F., et al. (2024). Gamma-ray sources imaging and test-beam results with MACACO III Compton camera. Phys. Medica, 117, 103199–10pp.
Abstract: Hadron therapy is a radiotherapy modality which offers a precise energy deposition to the tumors and a dose reduction to healthy tissue as compared to conventional methods. However, methods for real-time monitoring are required to ensure that the radiation dose is deposited on the target. The IRIS group of IFIC-Valencia developed a Compton camera prototype for this purpose, intending to image the Prompt Gammas emitted by the tissue during irradiation. The system detectors are composed of Lanthanum (III) bromide scintillator crystals coupled to silicon photomultipliers. After an initial characterization in the laboratory, in order to assess the system capabilities for future experiments in proton therapy centers, different tests were carried out in two facilities: PARTREC (Groningen, The Netherlands) and the CNA cyclotron (Sevilla, Spain). Characterization studies performed at PARTREC indicated that the detectors linearity was improved with respect to the previous version and an energy resolution of 5.2 % FWHM at 511 keV was achieved. Moreover, the imaging capabilities of the system were evaluated with a line source of 68Ge and a point-like source of 241Am-9Be. Images at 4.439 MeV were obtained from irradiation of a graphite target with an 18 MeV proton beam at CNA, to perform a study of the system potential to detect shifts at different intensities. In this sense, the system was able to distinguish 1 mm variations in the target position at different beam current intensities for measurement times of 1800 and 600 s.
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