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Author |
Brzezinski, K. et al |
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Title |
Detection of range shifts in proton beam therapy using the J-PET scanner: a patient simulation study |
Type |
Journal Article |
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Year |
2023 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
68 |
Issue |
14 |
Pages  |
145016 - 17pp |
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Keywords |
proton therapy; positron emission tomography; in vivo range verification; J-PET; Monte Carlo |
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Abstract |
Objective. The Jagiellonian positron emission tomography (J-PET) technology, based on plastic scintillators, has been proposed as a cost effective tool for detecting range deviations during proton therapy. This study investigates the feasibility of using J-PET for range monitoring by means of a detailed Monte Carlo simulation study of 95 patients who underwent proton therapy at the Cyclotron Centre Bronowice (CCB) in Krakow, Poland. Approach. Discrepancies between prescribed and delivered treatments were artificially introduced in the simulations by means of shifts in patient positioning and in the Hounsfield unit to the relative proton stopping power calibration curve. A dual-layer, cylindrical J-PET geometry was simulated in an in-room monitoring scenario and a triple-layer, dual-head geometry in an in-beam protocol. The distribution of range shifts in reconstructed PET activity was visualized in the beam's eye view. Linear prediction models were constructed from all patients in the cohort, using the mean shift in reconstructed PET activity as a predictor of the mean proton range deviation. Main results. Maps of deviations in the range of reconstructed PET distributions showed agreement with those of deviations in dose range in most patients. The linear prediction model showed a good fit, with coefficient of determination r (2) = 0.84 (in-room) and 0.75 (in-beam). Residual standard error was below 1 mm: 0.33 mm (in-room) and 0.23 mm (in-beam). Significance. The precision of the proposed prediction models shows the sensitivity of the proposed J-PET scanners to shifts in proton range for a wide range of clinical treatment plans. Furthermore, it motivates the use of such models as a tool for predicting proton range deviations and opens up new prospects for investigations into the use of intra-treatment PET images for predicting clinical metrics that aid in the assessment of the quality of delivered treatment. |
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Address |
[Brzezinski, Karol; Gajewski, Jan; Kopec, Renata; Olko, Pawel; Stasica, Paulina; Rucinski, Antoni] Polish Acad Sci, Inst Nucl Phys, Krakow, Poland, Email: karol.brzezinski@ific.uv.es |
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IOP Publishing Ltd |
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English |
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0031-9155 |
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Notes |
WOS:001026535700001 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5616 |
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Author |
Borja, E.F.; Garay, I.; Strobel, E. |
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Title |
Revisiting the quantum scalar field in spherically symmetric quantum gravity |
Type |
Journal Article |
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Year |
2012 |
Publication |
Classical and Quantum Gravity |
Abbreviated Journal |
Class. Quantum Gravity |
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Volume |
29 |
Issue |
14 |
Pages |
145012 - 19pp |
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Abstract |
We extend previous results in spherically symmetric gravitational systems coupled with a massless scalar field within the loop quantum gravity framework. As a starting point, we take the Schwarzschild spacetime. The results presented here rely on the uniform discretization method. We are able to minimize the associated discrete master constraint using a variational method. The trial state for the vacuum consists of a direct product of a Fock vacuum for the matter part and a Gaussian centered around the classical Schwarzschild solution. This paper follows the line of research presented by Gambini et al (2009 Class. Quantum Grav. 26 215011 (arXiv: 0906.1774v1)) and a comparison between their result and the one given in this work is made. |
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Address |
[Borja, Enrique F.; Garay, Inaki; Strobel, Eckhard] Univ Erlangen Nurnberg, Inst Theoret Phys 3, D-91058 Erlangen, Germany, Email: eckhard@bebsdb.dnsalias.net |
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Iop Publishing Ltd |
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English |
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0264-9381 |
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Notes |
WOS:000305810600013 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1087 |
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Author |
Roser, J.; Muñoz, E.; Barrientos, L.; Barrio, J.; Bernabeu, J.; Borja-Lloret, M.; Etxebeste, A.; Llosa, G.; Ros, A.; Viegas, R.; Oliver, J.F. |
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Title |
Image reconstruction for a multi-layer Compton telescope: an analytical model for three interaction events |
Type |
Journal Article |
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Year |
2020 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
65 |
Issue |
14 |
Pages |
145005 - 17pp |
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Keywords |
Compton camera; Compton imaging; hadron therapy; image reconstruction; lm-mlem; monte carlo simulations; multi-layer Compton telescope |
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Abstract |
Compton Cameras are electronically collimated photon imagers suitable for sub-MeV to few MeV gamma-ray detection. Such features are desirable to enablein vivorange verification in hadron therapy, through the detection of secondary Prompt Gammas. A major concern with this technique is the poor image quality obtained when the incoming gamma-ray energy is unknown. Compton Cameras with more than two detector planes (multi-layer Compton Cameras) have been proposed as a solution, given that these devices incorporate more signal sequences of interactions to the conventional two interaction events. In particular, three interaction events convey more spectral information as they allow inferring directly the incident gamma-ray energy. A three-layer Compton Telescope based on continuous Lanthanum (III) Bromide crystals coupled to Silicon Photomultipliers is being developed at the IRIS group of IFIC-Valencia. In a previous work we proposed a spectral reconstruction algorithm for two interaction events based on an analytical model for the formation of the signal. To fully exploit the capabilities of our prototype, we present here an extension of the model for three interaction events. Analytical expressions of the sensitivity and the System Matrix are derived and validated against Monte Carlo simulations. Implemented in a List Mode Maximum Likelihood Expectation Maximization algorithm, the proposed model allows us to obtain four-dimensional (energy and position) images by using exclusively three interaction events. We are able to recover the correct spectrum and spatial distribution of gamma-ray sources when ideal data are employed. However, the uncertainties associated to experimental measurements result in a degradation when real data from complex structures are employed. Incorrect estimation of the incident gamma-ray interaction positions, and missing deposited energy associated with escaping secondaries, have been identified as the causes of such degradation by means of a detailed Monte Carlo study. As expected, our current experimental resolution and efficiency to three interaction events prevents us from correctly recovering complex structures of radioactive sources. However, given the better spectral information conveyed by three interaction events, we expect an improvement of the image quality of conventional Compton imaging when including such events. In this regard, future development includes the incorporation of the model assessed in this work to the two interaction events model in order to allow using simultaneously two and three interaction events in the image reconstruction. |
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Address |
[Roser, J.; Munoz, E.; Barrientos, L.; Barrio, J.; Bernabeu, J.; Borja-Lloret, M.; Etxebeste, A.; Llosa, G.; Ros, A.; Viegas, R.; Oliver, J. F.] Inst Fis Corpuscular IFIC CSIC UVEG, Valencia, Spain, Email: Jorge.Roser@ific.uv.es |
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Iop Publishing Ltd |
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English |
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ISSN |
0031-9155 |
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Conference |
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Notes |
WOS:000552701600001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
4481 |
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Author |
Borja-Lloret, M.; Barrientos, L.; Bernabeu, J.; Lacasta, C.; Muñoz, E.; Ros, A.; Roser, J.; Viegas, R.; Llosa, G. |
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Title |
Influence of the background in Compton camera images for proton therapy treatment monitoring |
Type |
Journal Article |
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Year |
2023 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
68 |
Issue |
14 |
Pages |
144001 - 16pp |
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Keywords |
Compton imaging; Compton camera; proton therapy; treatment monitoring; Monte Carlo simulation; image reconstruction; background |
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Abstract |
Objective. Background events are one of the most relevant contributions to image degradation in Compton camera imaging for hadron therapy treatment monitoring. A study of the background and its contribution to image degradation is important to define future strategies to reduce the background in the system. Approach. In this simulation study, the percentage of different kinds of events and their contribution to the reconstructed image in a two-layer Compton camera have been evaluated. To this end, GATE v8.2 simulations of a proton beam impinging on a PMMA phantom have been carried out, for different proton beam energies and at different beam intensities. Main results. For a simulated Compton camera made of Lanthanum (III) Bromide monolithic crystals, coincidences caused by neutrons arriving from the phantom are the most common type of background produced by secondary radiations in the Compton camera, causing between 13% and 33% of the detected coincidences, depending on the beam energy. Results also show that random coincidences are a significant cause of image degradation at high beam intensities, and their influence in the reconstructed images is studied for values of the time coincidence windows from 500 ps to 100 ns. Significance. Results indicate the timing capabilities required to retrieve the fall-off position with good precision. Still, the noise observed in the image when no randoms are considered make us consider further background rejection methods. |
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Address |
[Borja-Lloret, M.; Barrientos, L.; Bernabeu, J.; Lacasta, C.; Munoz, E.; Ros, A.; Roser, J.; Viegas, R.; Llosa, G.] Inst Fis Corpuscular IFIC, CSIC UV, Valencia, Spain, Email: Marina.Borja@csic.es |
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Publisher |
IOP Publishing Ltd |
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English |
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ISSN |
0031-9155 |
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Conference |
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Notes |
WOS:001022671300001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5571 |
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Author |
n_TOF Collaboration (Guerrero, C. et al); Domingo-Pardo, C.; Tain, J.L. |
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Title |
Neutron Capture on the s-Process Branching Point Tm-171 via Time-of-Flight and Activation |
Type |
Journal Article |
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Year |
2020 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
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Volume |
125 |
Issue |
14 |
Pages |
142701 - 8pp |
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Keywords |
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Abstract |
The neutron capture cross sections of several unstable nuclides acting as branching points in the s process are crucial for stellar nucleosynthesis studies. The unstable Tm-171 (t(1/2) = 1.92 yr) is part of the branching around mass A similar to 170 but its neutron capture cross section as a function of the neutron energy is not known to date. In this work, following the production for the first time of more than 5 mg of Tm-171 at the high-flux reactor Institut Laue-Langevin in France, a sample was produced at the Paul Scherrer Institute in Switzerland. Two complementary experiments were carried out at the neutron time-of-flight facility (nTOF) at CERN in Switzerland and at the SARAF liquid lithium target facility at Soreq Nuclear Research Center in Israel by time of flight and activation, respectively. The result of the time -of-flight experiment consists of the first ever set of resonance parameters and the corresponding average resonance parameters, allowing us to make an estimation of the Maxwellian-averaged cross sections (MACS) by extrapolation. The activation measurement provides a direct and more precise measurement of the MACS at 30 keV: 384 (40) mb, with which the estimation from the nTOF data agree at the limit of 1 standard deviation. This value is 2.6 times lower than the JEFF-3.3 and ENDF/B-VIII evaluations, 25% lower than that of the Bao et al. compilation, and 1.6 times larger than the value recommended in the KAlloNiS (v1) database, based on the only previous experiment. Our result affects the nucleosynthesis at the A similar to 170 branching, namely, the Yb-171 abundance increases in the material lost by asymptotic giant branch stars, providing a better match to the available pre-solar SiC grain measurements compared to the calculations based on the current JEFF-3.3 model-based evaluation. |
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Address |
[Guerrero, C.; Lerendegui-Marco, J.; Quesada, J. M.; Cortes-Giraldo, M. A.; Millan-Callado, M. A.; Praena, J.; Rodriguez-Gonzalez, T.; Sabate-Gilarte, M.] Univ Seville, Seville, Spain, Email: cguerrero4@us.es |
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Publisher |
Amer Physical Soc |
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English |
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ISSN |
0031-9007 |
ISBN |
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Conference |
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Notes |
WOS:000574781200004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4551 |
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Author |
LHCb Collaboration (Aaij, R. et al); Jashal, B.K.; Martinez-Vidal, F.; Oyanguren, A.; Remon Alepuz, C.; Ruiz Vidal, J. |
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Title |
Measurement of the Nuclear Modification Factor and Prompt Charged Particle Production in p-Pb and pp Collisions at root s(NN )=5 TeV |
Type |
Journal Article |
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Year |
2022 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
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Volume |
128 |
Issue |
14 |
Pages |
142004 - 12pp |
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Keywords |
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Abstract |
The production of prompt charged particles in proton-lead collisions and in proton-proton collisions at the nucleon-nucleon center-of-mass energy root s(NN) = 5 TeV is studied at LHCb as a function of pseudorapidity (eta) and transverse momentum (p(T) ) with respect to the proton beam direction. The nuclear modification factor for charged particles is determined as a function of eta between -4.8 < eta < -2.5 (backward region) and 2.0 < eta < 4.8 (forward region), and p(T) between 0.2 < p(T) < 8.0 GeV/c. The results show a suppression of charged particle production in proton-lead collisions relative to proton-proton collisions in the forward region and an enhancement in the backward region for p(T) larger than 1.5 GeV/c. This measurement constrains nuclear PDFs and saturation models at previously unexplored values of the parton momentum fraction down to 10(-6). |
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Address |
[Leite, J. Baptista; Bediaga, I; Torres, M. Cruz; De Miranda, J. M.; dos Reis, A. C.; Gomes, A.; Massafferri, A.; Machado, D. Torres] Ctr Brasileiro Pesquisas Fis CBPF, Rio De Janeiro, Brazil |
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Amer Physical Soc |
Place of Publication |
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English |
Summary Language |
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0031-9007 |
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Conference |
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Notes |
WOS:000792795000003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5233 |
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Author |
ATLAS Collaboration (Aad, G. et al); Cabrera Urban, S.; Castillo Gimenez, V.; Costa, M.J.; Fernandez Martinez, P.; Ferrer, A.; Fiorini, L.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gonzalez de la Hoz, S.; Hernandez Jimenez, Y.; Higon-Rodriguez, E.; Irles Quiles, A.; Kaci, M.; King, M.; Lacasta, C.; Lacuesta, V.R.; Marti-Garcia, S.; Mitsou, V.A.; Moles-Valls, R.; Oliver Garcia, E.; Pedraza Lopez, S.; Perez Garcia-Estañ, M.T.; Romero Adam, E.; Ros, E.; Salt, J.; Sanchez Martinez, V.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valladolid Gallego, E.; Valls Ferrer, J.A.; Vos, M. |
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Title |
Measurement of Spin Correlation in Top-Antitop Quark Events and Search for Top Squark Pair Production in pp Collisions at root s=8 TeV Using the ATLAS Detector |
Type |
Journal Article |
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Year |
2015 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
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Volume |
114 |
Issue |
14 |
Pages |
142001 - 19pp |
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Abstract |
A measurement of spin correlation in t (t) over bar production is presented using data collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of 8 TeV, corresponding to an integrated luminosity of 20.3 fb(-1). The correlation between the top and antitop quark spins is extracted from dilepton t (t) over bar events by using the difference in the azimuthal angle between the two charged leptons in the laboratory frame. In the helicity basis the measured degree of correlation corresponds to A(helicity) = 0.38 +/- 0.04, in agreement with the standard model prediction. A search is performed for pair production of top squarks with masses close to the top quark mass decaying to predominantly right-handed top quarks and a light neutralino, the lightest supersymmetric particle. Top squarks with masses between the top quark mass and 191 GeV are excluded at the 95% confidence level. |
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Address |
[Jackson, P.; Lee, L.; Soni, N.; White, M. J.] Univ Adelaide, Dept Phys, Adelaide, SA, Australia |
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Amer Physical Soc |
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English |
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0031-9007 |
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Notes |
WOS:000352350000006 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2190 |
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Author |
ATLAS Collaboration (Aad, G. et al); Cabrera Urban, S.; Castillo Gimenez, V.; Costa, M.J.; Fassi, F.; Ferrer, A.; Fiorini, L.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gonzalez de la Hoz, S.; Hernandez Jimenez, Y.; Higon-Rodriguez, E.; Irles Quiles, A.; Kaci, M.; King, M.; Lacasta, C.; Lacuesta, V.R.; March, L.; Marti-Garcia, S.; Mitsou, V.A.; Moles-Valls, R.; Oliver Garcia, E.; Pedraza Lopez, S.; Perez Garcia-Estañ, M.T.; Romero Adam, E.; Ros, E.; Salt, J.; Sanchez Martinez, V.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valladolid Gallego, E.; Valls Ferrer, J.A.; Vos, M. |
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Title |
Evidence for Electroweak Production of W(+/-) W(+/-) jj in pp Collisions at root s=8 TeV with the ATLAS Detector |
Type |
Journal Article |
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Year |
2014 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
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Volume |
113 |
Issue |
14 |
Pages |
141803 - 19pp |
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Abstract |
This Letter presents the first study of W(+/-)W(+/-)jj, same-electric-charge diboson production in association with two jets, using 20.3 fb(-1) of proton-proton collision data at root s = 8 TeV recorded by the ATLAS detector at the Large Hadron Collider. Events with two reconstructed same-charge leptons (e(+/-)e(+/-), e(+/-)mu(+/-), and mu(+/-)mu(+/-)) and two or more jets are analyzed. Production cross sections are measured in two fiducial regions, with different sensitivities to the electroweak and strong production mechanisms. First evidence for W(+/-)W(+/-)jj production and electroweak-only W(+/-)W(+/-)jj production is observed with a significance of 4.5 and 3.6 standard deviations, respectively. The measured production cross sections are in agreement with standard model predictions. Limits at 95% confidence level are set on anomalous quartic gauge couplings. |
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Address |
[Jackson, P.; Soni, N.; White, M. J.] Univ Adelaide, Dept Phys, Adelaide, SA, Australia |
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Amer Physical Soc |
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English |
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ISSN |
0031-9007 |
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Conference |
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Notes |
WOS:000344031200004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2000 |
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Author |
CDF Collaboration (Aaltonen, T. et al); Cabrera, S. |
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Title |
Search for the Higgs Boson Using Neural Networks in Events with Missing Energy and b-Quark Jets in p(p)over-bar Collisions at root s=1.96 TeV |
Type |
Journal Article |
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Year |
2010 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
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Volume |
104 |
Issue |
14 |
Pages |
141801 - 7pp |
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Abstract |
We report on a search for the standard model Higgs boson produced in association with a W or Z boson in p (p) over bar collisions at root s = 1.96 TeV recorded by the CDF II experiment at the Tevatron in a data sample corresponding to an integrated luminosity of 2.1 fb(-1). We consider events which have no identified charged leptons, an imbalance in transverse momentum, and two or three jets where at least one jet is consistent with originating from the decay of a b hadron. We find good agreement between data and background predictions. We place 95% confidence level upper limits on the production cross section for several Higgs boson masses ranging from 110 GeV/c(2) to 150 GeV/c(2). For a mass of 115 GeV/c(2) the observed (expected) limit is 6.9 (5.6) times the standard model prediction. |
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Address |
[Aaltonen, T.; Mehtala, P.; Orava, R.; Osterberg, K.; Saarikko, H.; van Remortel, N.] Univ Helsinki, Dept Phys, Div High Energy Phys, FIN-00014 Helsinki, Finland |
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Amer Physical Soc |
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English |
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ISSN |
0031-9007 |
ISBN |
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Notes |
ISI:000276541900011 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
288 |
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Author |
LHCb Collaboration (Aaij, R. et al); Martinez-Vidal, F.; Oyanguren, A.; Ruiz Valls, P.; Sanchez Mayordomo, C. |
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Title |
Evidence for CP Violation in B+ -> p(p)over-barK(+) Decays |
Type |
Journal Article |
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Year |
2014 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
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Volume |
113 |
Issue |
14 |
Pages |
141801 - 9pp |
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Abstract |
Three-body B+ -> p (p) over barK(+) and B+ -> p (p) over bar pi(+) decays are studied using a data sample corresponding to an integrated luminosity of 3.0 fb(-1) collected by the LHCb experiment in proton-proton collisions at center-of-mass energies of 7 and 8 TeV. Evidence of CP violation in the B+ -> p (p) over barK(+) decay is found in regions of the phase space, representing the first measurement of this kind for a final state containing baryons. Measurements of the forward-backward asymmetry of the light meson in the p (p) over bar rest frame yield A(FB)(p (p) over barK(+), m(p (p) over bar) < 2.85 GeV/c(2)) = 0.495 +/- 0.012 (stat) +/- 0.007 (syst) and A(FB)(p<(p)over bar>pi(+), m(p (p) over bar) < 2.85 GeV/c(2)) = -0.409 +/- 0.033 (stat) +/- 0.006 (syst). In addition, the branching fraction of the decay B+ -> <(Lambda)over bar>(1520)p is measured to be B(B+ -> (Lambda) over bar (1520)p) = (3.15 +/- 0.48 (stat) +/- 0.07 (syst) +/- 0.26 (BF)) x 10(-7), where BF denotes the uncertainty on secondary branching fractions. |
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Address |
[Bediaga, I.; De Miranda, J. M.; Rodrigues, F. Ferreira; Gomes, A.; Hicheur, A.; Kucewicz, W.; Massafferri, A.; dos Reis, A. C.; Rodrigues, A. B.] Ctr Brasileiro Pesquisas Fis, Rio De Janeiro, Brazil |
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Publisher |
Amer Physical Soc |
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Language |
English |
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Original Title |
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ISSN |
0031-9007 |
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Notes |
WOS:000346502900005 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2044 |
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| Permanent link to this record |
