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Author |
Koolen, B.B.; Vidal-Sicart, S.; Benlloch, J.M.; Olmos, R.A.V. |
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Title |
Evaluating heterogeneity of primary tumor 18 F-FDG uptake in breast cancer with a dedicated breast PET ( MAMMI): a feasibility study based on correlation with PET/CT |
Type |
Journal Article |
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Year |
2014 |
Publication |
Nuclear Medicine Communications |
Abbreviated Journal |
Nucl. Med. Commun. |
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Volume |
35 |
Issue |
5 |
Pages  |
446-452 |
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Keywords |
breast cancer; F-18-FDG; heterogeneity; MAMMI; PET |
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Abstract |
PurposeThe aim of the study was to evaluate the heterogeneity of primary tumor F-18-fluorodeoxyglucose (F-18-FDG) uptake in breast cancer patients using a dedicated breast PET.Patients and methodsA positron emission tomography/computed tomography (PET/CT) of the thorax was performed 60 min after administration of 180-240 MBq of F-18-FDG in patients with breast cancer. Subsequently, 110 min after injection, a scan was taken with a dedicated high-resolution breast PET [MAMmography with Molecular Imaging (MAMMI)]. Both procedures were performed with the patients in the prone position. Four-point scores were used to compare the intensity (0: none; 1: mild; 2: moderate; 3: high) and heterogeneity (0: none; 1: mild; 2: moderate; 3: high) of F-18-FDG uptake between PET/CT and MAMMI images.ResultsThirty-five patients in whom the primary tumor was visualized on both scans were included in this analysis. The mean primary tumor size was 35.1 mm (range 10-108 mm). The mean intensity score was similar on both devices (2.4 for PET/CT and 2.3 for MAMMI; P=0.439), but the mean heterogeneity score on MAMMI images was significantly higher (PET/CT 1.9 vs. MAMMI 2.3; P=0.005). MAMMI showed a higher heterogeneity score in 11 (31%) of 35 patients, especially in tumors with moderate or high intensity. Significantly higher heterogeneity scores on both PET/CT and MAMMI were seen in large tumors (P=0.005 and 0.014, respectively) and in tumors with high intensity scores (P=0.012 and P<0.001, respectively).ConclusionHeterogeneous tumor F-18-FDG uptake in breast cancer is frequently observed, particularly in large tumors with intense F-18-FDG uptake. It is more often seen on MAMMI PET than on conventional PET/CT. Although the observed heterogeneity should be proven histopathologically, this finding offers a rationale for F-18-FDG-guided biopsies. |
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Address |
[Koolen, Bas B.; Vidal-Sicart, Sergi; Olmos, Renato A. Valdes] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Nucl Med, NL-1066 CX Amsterdam, Netherlands, Email: b.koolen@nki.nl |
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Lippincott Williams & Wilkins |
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English |
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ISSN |
0143-3636 |
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Notes |
WOS:000334103800002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1763 |
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Author |
Oset, E.; Martinez Torres, A.; Khemchandani, K.P.; Roca, L.; Yamagata-Sekihara, J. |
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Title |
Two, three, many body systems involving mesons |
Type |
Journal Article |
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Year |
2012 |
Publication |
Progress in Particle and Nuclear Physics |
Abbreviated Journal |
Prog. Part. Nucl. Phys. |
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Volume |
67 |
Issue |
2 |
Pages |
455-460 |
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Keywords |
Meson many body; Chiral dynamics; Dynamically generated resonances |
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Abstract |
In this talk we show recent developments on few body systems involving mesons. We report on an approach to Faddeev equations using chiral unitary dynamics, where an explicit cancellation of the two body off shell amplitude with three body forces stemming from the same chiral Lagrangians takes place. This removal of the unphysical off shell part of the amplitudes is most welcome and renders the approach unambiguous, showing that only on shell two body amplitudes need to be used. Within this approach, systems of two mesons and one baryon are studied, reproducing properties of the low lying 1/2(+) states. On the other hand we also report on multirho and K* multirho states which can be associated to known meson resonances of high spin. |
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Address |
[Oset, E.; Yamagata, J.] Ctr Mixto CSIC UV, Inst Fis Corpuscular, Inst Invest Paterna, Valencia 46071, Spain, Email: oset@ific.uv.es |
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Elsevier Science Bv |
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English |
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ISSN |
0146-6410 |
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Notes |
WOS:000303282200060 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
998 |
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Author |
Tolos, L.; Cabrera, D.; Garcia-Recio, C.; Molina, R.; Nieves, J.; Oset, E.; Ramos, A.; Romanets, O.; Salcedo, L.L. |
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Title |
Strangeness and charm in nuclear matter |
Type |
Journal Article |
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Year |
2013 |
Publication |
Nuclear Physics A |
Abbreviated Journal |
Nucl. Phys. A |
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Volume |
914 |
Issue |
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Pages |
461-471 |
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Keywords |
Strange mesons; Transparency ratio; Dynamically-generated baryon resonances; Open charm in matter; D-mesic nuclei |
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Abstract |
The properties of strange (K, (K) over bar and (K) over bar*) and open-charm (D, (D) over bar and D*) mesons in dense matter are studied using a unitary approach in coupled channels for meson-baryon scattering. In the strangeness sector, the interaction with nucleons always comes through vector-meson exchange, which is evaluated by chiral and hidden gauge Lagrangians. For the interaction of charmed mesons with nucleons we extend the SU(3) Weinberg-Tomozawa Lagrangian to incorporate spin-flavor symmetry and implement a suitable flavor symmetry breaking. The in-medium solution for the scattering amplitude accounts for Pauli blocking effects and meson self-energies. On one hand, we obtain the K, (K) over bar and (K) over bar* spectral functions in the nuclear medium and study their behaviour at finite density, temperature and momentum. We also make an estimate of the transparency ratio of the gamma A -> K+ K*(-) A' reaction, which we propose as a tool to detect in-medium modifications of the (K) over bar* meson. On the other hand, in the charm sector, several resonances with negative parity are generated dynamically by the s-wave interaction between pseudoscalar and vector meson multiplets with 1/2(+) and 3/2(+) baryons. The properties of these states in matter are analyzed and their influence on the open-charm meson spectral functions is studied. We finally discuss the possible formation of D-mesic nuclei at FAIR energies. |
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Address |
[Tolos, Laura] Fac Ciencies, Inst Ciencias Espacio IEEC CSIC, E-08193 Bellaterra, Barcelona, Spain, Email: tolos@ice.csic.es |
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Elsevier Science Bv |
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English |
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Edition |
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ISSN |
0375-9474 |
ISBN |
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Notes |
WOS:000324847700066 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1598 |
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Author |
Romanets, O.; Tolos, L.; Garcia-Recio, C.; Nieves, J.; Salcedo, L.L.; Timmermans, R. |
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Title |
Heavy-quark spin symmetry for charmed and strange baryon resonances |
Type |
Journal Article |
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Year |
2013 |
Publication |
Nuclear Physics A |
Abbreviated Journal |
Nucl. Phys. A |
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Volume |
914 |
Issue |
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Pages |
488-493 |
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Keywords |
Charm; Heavy-quark spin symmetry; Dynamically generated baryon resonances |
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Abstract |
We study charmed and strange odd-parity baryon resonances that are generated dynamically by a unitary baryon-meson coupled-channels model which incorporates heavy-quark spin symmetry. This is accomplished by extending the SU(3) Weinberg-Tomozawa chiral Lagrangian to SU(8) spin-flavor symmetry plus a suitable symmetry breaking. The model generates resonances with negative parity from the s-wave interaction of pseudoscalar and vector mesons with 1/2(+) and 3/2(+) baryons in all the isospin, spin, and strange sectors with one, two, and three charm units. Some of our results can be identified with experimental data from several facilities, such as the CLEO, Belle, or BaBar Collaborations, as well as with other theoretical models, whereas others do not have a straightforward identification and require the compilation of more data and also a refinement of the model. (c) 2013 Elsevier B.V. All rights reserved. |
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Address |
[Romanets, Olena; Timmermans, Rob] Univ Groningen, Theory Grp, KVI, NL-9747 AA Groningen, Netherlands, Email: o.romanets@rug.nl |
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Elsevier Science Bv |
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English |
Summary Language |
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0375-9474 |
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Conference |
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Notes |
WOS:000324847700069 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1601 |
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Author |
Candela-Juan, C.; Ballester, F.; Perez-Calatayud, J.; Vijande, J. |
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Title |
Assaying multiple I-125 seeds with the well-ionization chamber SourceCheck(4 Pi) 33005 and a new insert |
Type |
Journal Article |
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Year |
2015 |
Publication |
Journal of Contemporary Brachytherapy |
Abbreviated Journal |
J. Contemp. Brachytherapy |
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Volume |
7 |
Issue |
6 |
Pages |
492-496 |
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Keywords |
brachytherapy; insert; quality assurance; prostate; seeds; well chamber |
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Abstract |
Purpose: To provide a practical solution that can be adopted in clinical routine to fulfill the AAPM-ESTRO recommendations regarding quality assurance of seeds used in prostate permanent brachytherapy. The aim is to design a new insert for the well-ionization chamber SourceCheck(4 Pi) 33005 (PTW, Germany) that allows evaluating the mean air-kerma strength of up to ten I-125 seeds with one single measurement instead of measuring each seed individually. Material and methods: The material required is: a) the SourceCheck(4 Pi) 33005 well-ionization chamber provided with a PTW insert to measure the air-kerma strength S-K of one single seed at a time; b) a newly designed insert that accommodates ten seeds in one column, which allows measuring the mean S-K of the ten seeds in one single measurement; and c) a container with ten seeds from the same batch and class of the seeds used for the patient implant, and a set of nine non-radioactive seeds.The new insert is characterized by determining its calibration coefficient, used to convert the reading of the well-chamber when ten seeds are measured to their mean S-K. The proposed method is validated by comparing the mean S-K of the ten seeds obtained from the new insert with the individual measurement of S-K of each seed, evaluated with the PTW insert. Results: The ratio between the calibration coefficient of the new insert and the calibration coefficient of the PTW insert for the SourceCheck(4 Pi) 33005 is 1.135 +/- 0.007 (k = 1). The mean S-K of a set of ten seeds evaluated with this new system is in agreement with the mean value obtained from measuring independently the S-K of each seed. Conclusions: The new insert and procedure allow evaluating the mean S-K of ten seeds prior to the implant in a single measurement. The method is faster and more efficient from radiation protection point of view than measuring the individual S-K of each seed. |
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Address |
[Candela-Juan, Cristian; Perez-Calatayud, Jose] La Fe Univ, Dept Radiat Oncol, Phys Sect, E-46026 Valencia, Spain, Email: ccanjuan@gmail.com |
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Publisher |
Termedia Publishing House Ltd |
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English |
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ISSN |
1689-832x |
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Notes |
WOS:000368381300010 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
2533 |
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