Abstract: We present a study of the decays B-0,B-+ -> J/psi pi(+)pi(-)pi K-0(0,+), using 467 x 106 B (B) over bar pairs recorded with the BABAR detector. We present evidence for the decay mode X(3872) -> J/psi omega, with product branching fractions B(B+ -> X(3872K(+)) x B(X(3872) -> J/psi omega) = [0.6 +/- 0.2(stat) +/- 0.1(syst)] x 10(-5), and B(B-0 -> X(3872)K-0) x B(X(3872) -> J/psi omega) = [0.6 +/- 0.3(stat) +/- 0.1(syst)] x 10(-5). A detailed study of the pi(+) pi(-) pi(0) mass distribution from X(3872) decay favors a negative-parity assignment.

Abstract: Accurate estimates of virus mutation rates are important to understand the evolution of the viruses and to combat them. However, methods of estimation are varied and often complex. Here, we critically review over 40 original studies and establish criteria to facilitate comparative analyses. The mutation rates of 23 viruses are presented as substitutions per nucleotide per cell infection (s/n/c) and corrected for selection bias where necessary, using a new statistical method. The resulting rates range from 10(-8) to 10(-6) s/n/c for DNA viruses and from 10(-6) to 10(-4) s/n/c for RNA viruses. Similar to what has been shown previously for DNA viruses, there appears to be a negative correlation between mutation rate and genome size among RNA viruses, but this result requires further experimental testing. Contrary to some suggestions, the mutation rate of retroviruses is not lower than that of other RNA viruses. We also show that nucleotide substitutions are on average four times more common than insertions/deletions (indels). Finally, we provide estimates of the mutation rate per nucleotide per strand copying, which tends to be lower than that per cell infection because some viruses undergo several rounds of copying per cell, particularly double-stranded DNA viruses. A regularly updated virus mutation rate data set will be available at www.uv.es/rsanjuan/virmut.

Abstract: Charged particle therapy, or so-called hadrontherapy, is developing very rapidly. There is large pressure on the scientific community to deliver dedicated accelerators, providing the best possible treatment modalities at the lowest cost. In this context, the Italian research Foundation TERA is developing fast-cycling accelerators, dubbed 'cyclinacs'. These are a combination of a cyclotron (accelerating ions to a fixed initial energy) followed by a high gradient linac boosting the ions energy up to the maximum needed for medical therapy. The linac is powered by many independently controlled klystrons to vary the beam energy from one pulse to the next. This accelerator is best suited to treat moving organs with a 4D multipainting spot scanning technique. A dual proton/carbon ion cyclinac is here presented. It consists of an Electron Beam Ion Source, a superconducting isochronous cyclotron and a high-gradient linac. All these machines are pulsed at high repetition rate (100-400 Hz). The source should deliver both C6+ and H-2(+) ions in short pulses (1.5 μs flat-top) and with sufficient intensity (at least 10(8) fully stripped carbon ions per pulse at 300 Hz). The cyclotron accelerates the ions to 120 MeV/u. It features a compact design (with superconducting coils) and a low power consumption. The linac has a novel C-band high-gradient structure and accelerates the ions to variable energies up to 400 MeV/u. High RF frequencies lead to power consumptions which are much lower than the ones of synchrotrons for the same ion extraction energy. This work is part of a collaboration with the CLIC group, which is working at CERN on high-gradient electron-positron colliders.