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Carrasco-Ribelles, L. A., Pardo-Mas, J. R., Tortajada, S., Saez, C., Valdivieso, B., & Garcia-Gomez, J. M. (2021). Predicting morbidity by local similarities in multi-scale patient trajectories. J. Biomed. Inform., 120, 103837–9pp.
Abstract: Patient Trajectories (PTs) are a method of representing the temporal evolution of patients. They can include information from different sources and be used in socio-medical or clinical domains. PTs have generally been used to generate and study the most common trajectories in, for instance, the development of a disease. On the other hand, healthcare predictive models generally rely on static snapshots of patient information. Only a few works about prediction in healthcare have been found that use PTs, and therefore benefit from their temporal dimension. All of them, however, have used PTs created from single-source information. Therefore, the use of longitudinal multi-scale data to build PTs and use them to obtain predictions about health conditions is yet to be explored. Our hypothesis is that local similarities on small chunks of PTs can identify similar patients concerning their future morbidities. The objectives of this work are (1) to develop a methodology to identify local similarities between PTs before the occurrence of morbidities to predict these on new query individuals; and (2) to validate this methodology on risk prediction of cardiovascular diseases (CVD) occurrence in patients with diabetes. We have proposed a novel formal definition of PTs based on sequences of longitudinal multi-scale data. Moreover, a dynamic programming methodology to identify local alignments on PTs for predicting future morbidities is proposed. Both the proposed methodology for PT definition and the alignment algorithm are generic to be applied on any clinical domain. We validated this solution for predicting CVD in patients with diabetes and we achieved a precision of 0.33, a recall of 0.72 and a specificity of 0.38. Therefore, the proposed solution in the diabetes use case can result of utmost utility to secondary screening.
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Baran, J. et al, & Brzezinski, K. (2024). Feasibility of the J-PET to monitor the range of therapeutic proton beams. Phys. Medica, 118, 103301–9pp.
Abstract: Purpose: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J -PET) scanner for intra-treatment proton beam range monitoring. Methods: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J -PET scanner geometries. We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread -Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J -PET scanner prototype dedicated to the proton beam range assessment. Results: The investigations indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10-5 coincidences per primary proton, while the precision of the range assessment for both SPB and SOBP irradiation plans was found below 1 mm. Among the scanners with the same number of detector modules, the best results are found for the triple -layer dual -head geometry. The results indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for the clinical application, Conclusions: We performed simulation studies demonstrating that the feasibility of the J -PET detector for PET -based proton beam therapy range monitoring is possible with reasonable sensitivity and precision enabling its pre -clinical tests in the clinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double -layer cylindrical and triple -layer dual -head J -PET geometry configurations seem promising for future clinical application.
Keywords: PET; Range monitoring; J-PET; Monte Carlo simulations; Proton radiotherapy
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Barrientos, L., Borja-Lloret, M., Casaña, J. V., Dendooven, P., Garcia Lopez, J. G., Hueso-Gonzalez, F., et al. (2024). Gamma-ray sources imaging and test-beam results with MACACO III Compton camera. Phys. Medica, 117, 103199–10pp.
Abstract: Hadron therapy is a radiotherapy modality which offers a precise energy deposition to the tumors and a dose reduction to healthy tissue as compared to conventional methods. However, methods for real-time monitoring are required to ensure that the radiation dose is deposited on the target. The IRIS group of IFIC-Valencia developed a Compton camera prototype for this purpose, intending to image the Prompt Gammas emitted by the tissue during irradiation. The system detectors are composed of Lanthanum (III) bromide scintillator crystals coupled to silicon photomultipliers. After an initial characterization in the laboratory, in order to assess the system capabilities for future experiments in proton therapy centers, different tests were carried out in two facilities: PARTREC (Groningen, The Netherlands) and the CNA cyclotron (Sevilla, Spain). Characterization studies performed at PARTREC indicated that the detectors linearity was improved with respect to the previous version and an energy resolution of 5.2 % FWHM at 511 keV was achieved. Moreover, the imaging capabilities of the system were evaluated with a line source of 68Ge and a point-like source of 241Am-9Be. Images at 4.439 MeV were obtained from irradiation of a graphite target with an 18 MeV proton beam at CNA, to perform a study of the system potential to detect shifts at different intensities. In this sense, the system was able to distinguish 1 mm variations in the target position at different beam current intensities for measurement times of 1800 and 600 s.
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Linowski, T., Schlichtholz, K., Sorelli, G., Gessner, M., Walschaers, M., Treps, N., et al. (2023). Application range of crosstalk-affected spatial demultiplexing for resolving separations between unbalanced sources. New J. Phys., 25(10), 103050–13pp.
Abstract: Super resolution is one of the key issues at the crossroads of contemporary quantum optics and metrology. Recently, it was shown that for an idealized case of two balanced sources, spatial mode demultiplexing (SPADE) achieves resolution better than direct imaging even in the presence of measurement crosstalk (Gessner et al 2020 Phys. Rev. Lett. 125 100501). In this work, we consider arbitrarily unbalanced sources and provide a systematic analysis of the impact of crosstalk on the resolution obtained from SPADE. As we dissect, in this generalized scenario, SPADE's effectiveness depends non-trivially on the strength of crosstalk, relative brightness and the separation between the sources. In particular, for any source imbalance, SPADE performs worse than ideal direct imaging in the asymptotic limit of vanishing source separations. Nonetheless, for realistic values of crosstalk strength, SPADE is still the superior method for several orders of magnitude of source separations.
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Di Molfetta, G., & Perez, A. (2016). Quantum walks as simulators of neutrino oscillations in a vacuum and matter. New J. Phys., 18, 103038–8pp.
Abstract: We analyze the simulation of Dirac neutrino oscillations using quantum walks, both in a vacuum and in matter. We show that this simulation, in the continuum limit, reproduces a set of coupled Dirac equations that describe neutrino flavor oscillations, and we make use of this to establish a connection with neutrino phenomenology, thus allowing one to fix the parameters of the simulation for a given neutrino experiment. We also analyze how matter effects for neutrino propagation can be simulated in the quantum walk. In this way, important features, such as the MSW effect, can be incorporated. Thus, the simulation of neutrino oscillations with the help of quantum walks might be useful to illustrate these effects in extreme conditions, such as the solar interior or supernovae.
Keywords: quantum walks; neutrino oscillations; quantum simulation
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Plaza, J., Martinez, T., Becares, V., Cano-Ott, D., Villamarin, D., de Rada, A. P., et al. (2023). Thermal neutron background at Laboratorio Subterraneo de Canfranc (LSC). Astropart Phys., 146, 102793–9pp.
Abstract: The thermal neutron background at Laboratorio Subterraneo de Canfranc (LSC) has been determined using several He-3 proportional counter detectors. Bare and Cd shielded counters were used in a series of long measurements. Pulse shape discrimination techniques were applied to discriminate between neutron and gamma signals as well as other intrinsic contributions. Montecarlo simulations allowed us to estimate the sensitivity of the detectors and calculate values for the background flux of thermal neutrons inside Hall-A of LSC. The obtained value is (3.5 +/- 0.8)x10(-6) n/cm(2)s, and is within an order of magnitude compared to similar facilities.
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Weber, M. et al, & Esperante, D. (2024). DONES EVO: Risk mitigation for the IFMIF-DONES facility. Nucl. Mater. Energy, 38, 101622–5pp.
Abstract: The International Fusion Materials Irradiation Facility- DEMO Oriented Neutron Source (IFMIF-DONES) is a scientific infrastructure aimed to provide an intense neutron source for the qualification of materials to be used in future fusion power reactors. Its implementation is critical for the construction of the fusion DEMOnstration Power Plant (DEMO). IFMIF-DONES is a unique facility requiring a broad set of technologies. Although most of the necessary technologies have already been validated, there are still some aspects that introduce risks in the evolution of the project. In order to mitigate these risks, a consortium of companies, with the support of research centres and the funding of the CDTI (Centre for the Development of Industrial Technology and Innovation), has launched the DONES EVO Programme, which comprises six lines of research: center dot Improvement of signal transmission and integrity (planning and integration risks) center dot Optimisation of RF conditioning processes (planning and reliability risks) center dot Development of a reliable beam extraction device (reliability risks) center dot Development of technologies for the production of medical isotopes (reliability risks) center dot Improvement of critical parts of the lithium purification system (safety and reliability risks) center dot Validation of the manufacture of critical components with special materials (reliability risk). DONES EVO will focus on developing the appropriate response to the risks identified in the IFMIFDONES project through research and prototyping around the associated technologies.
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Heidari, N., Hassanabadi, H., Araujo Filho, A. A., Kriz, J., Zare, S., & Porfirio, P. J. (2024). Gravitational signatures of a non-commutative stable black hole. Phys. Dark Universe, 43, 101382–13pp.
Abstract: This work investigates several key aspects of a non-commutative theory with mass deformation. We calculate thermodynamic properties of the system and compare our results with recent literature. We examine the quasinormal modes of massless scalar perturbations using two approaches: the WKB approximation and the Poschl-Teller fitting method. Our results indicate that stronger non-commutative parameters lead to slower damping oscillations of gravitational waves and higher partial absorption cross sections. Furthermore, we study the geodesics of massless and massive particles, highlighting that the non-commutative parameter (R) significantly impacts the paths of light and event horizons. Also, we calculate the shadows, which show that larger values of (R) correspond to larger shadow radii, and provide some constraints on (R) applying the observation of Sgr A* from the Event Horizon Telescope. Finally, we explore the deflection angle in this context.
Keywords: Non-commutativity; Black hole; Shadows; Geodesics
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Gerbino, M. et al, Martinez-Mirave, P., Mena, O., Tortola, M., & Valle, J. W.. (2023). Synergy between cosmological and laboratory searches in neutrino physics. Phys. Dark Universe, 42, 101333–36pp.
Abstract: The intersection of the cosmic and neutrino frontiers is a rich field where much discovery space still remains. Neutrinos play a pivotal role in the hot big bang cosmology, influencing the dynamics of the universe over numerous decades in cosmological history. Recent studies have made tremendous progress in understanding some properties of cosmological neutrinos, primarily their energy density. Upcoming cosmological probes will measure the energy density of relativistic particles with higher precision, but could also start probing other properties of the neutrino spectra. When convolved with results from terrestrial experiments, cosmology can become even more acute at probing new physics related to neutrinos or even Beyond the Standard Model (BSM). Any discordance between laboratory and cosmological data sets may reveal new BSM physics and/or suggest alternative models of cosmology. We give examples of the intersection between terrestrial and cosmological probes in the neutrino sector, and briefly discuss the possibilities of what different laboratory experiments may see in conjunction with cosmological observatories.
Keywords: Neutrinos; Cosmology; Neutrino phenomenology
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Araujo Filho, A. A., Furtado, J., Hassanabadi, H., & Reis, J. A. A. S. (2023). Thermal analysis of photon-like particles in rainbow gravity. Phys. Dark Universe, 42, 101310–8pp.
Abstract: This work is devoted to study the thermodynamic behavior of photon-like particles within the rainbow gravity formalism. To to do this, we chose two particular ansatzs to accomplish our calculations. First, we consider a dispersion relation which avoids UV divergences, getting a positive effective cosmological constant. We provide numerical analysis for the thermodynamic functions of the system and bounds are estimated. Furthermore, a phase transition is also expected for this model. Second, we consider a dispersion relation employed in the context of Gamma Ray Bursts. Remarkably, for this latter case, the thermodynamic properties are calculated in an analytical manner and they turn out to depend on the harmonic series Hn, gamma & UGamma; (z), polygamma & psi;n(z) and zeta Riemann functions & zeta;(z).
Keywords: Rainbow gravity; Thermodynamics; Bounds
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