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Piriz, G. H., Gonzalez-Sprinberg, G. A., Ballester, F., & Vijande, J. (2024). Dosimetry of Large Field Valencia applicators for Cobalt-60-based brachytherapy. Med. Phys., 51, 5094–5098.
Abstract: BackgroundNon-melanoma skin cancer is one of the most common types of cancer and one of the main approaches is brachytherapy. For small lesions, the treatment of this cancer with brachytherapy can be done with two commercial applicators, one of these is the Large Field Valencia Applicators (LFVA).PurposeThe aim of this study is to test the capabilities of the LFVA to use clinically 60Co sources instead of the 192Ir ones. This study was designed for the same dwell positions and weights for both sources.MethodsThe Penelope Monte Carlo code was used to evaluate dose distribution in a water phantom when a 60Co source is considered. The LFVA design and the optimized dwell weights reported for the case of 192Ir are maintained with the only exception of the dwell weight of the central position, that was increased. 2D dose distributions, field flatness, symmetry and the leakage dose distribution around the applicator were calculated.ResultsWhen comparing the dose distributions of both sources, field flatness and symmetry remain unchanged. The only evident difference is an increase of the penumbra regions for all depths when using the 60Co source. Regarding leakage, the maximum dose within the air volume surrounding the applicator is in the order of 20% of the prescription dose for the 60Co source, but it decreases to less than 5% at about 1 cm distance.ConclusionsFlatness and symmetry remains unaltered as compared with 192Ir sources, while an increase in leakage has been observed. This proves the feasibility of using the LFVA in a larger range of clinical applications.
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Penas, J., Alejo, A., Bembibre, A., Apiñaniz, J. I., Garcia-Garcia, E., Guerrero, C., et al. (2024). Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source. Sci Rep, 14(1), 11448–12pp.
Abstract: Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the first time the use of a high-repetition rate, ultra-intense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10-14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} B(p,n) 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Significant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-the-art technology (10 Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range.
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Celestino-Ramirez, J. M., Escrihuela, F. J., Flores, L. J., & Miranda, O. G. (2024). Testing the nonunitarity of the leptonic mixing matrix at FASERv and FASERv2. Phys. Rev. D, 109(1), L011705–6pp.
Abstract: The FASERv experiment has detected the first neutrino events coming from LHC. Near future highstatistic neutrino samples will allow us to search for new physics within the neutrino sector. Motivated by the forthcoming promising FASERv neutrino data, and its successor, FASERv2, we study its potential for testing the unitarity of the neutrino lepton mixing matrix. Although it would be challenging for FASERv and FASERv2 to have strong constraints on this kind of new physics, we discuss its role in contributing to a future improved global analysis.
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Bernabeu, J., Sabulsky, D. O., Sanchez, F., & Segarra, A. (2024). Neutrino mass and nature through its mediation in atomic clock interference. AVS Quantum Sci., 6(1), 014410–8pp.
Abstract: The absolute mass of neutrinos and their nature are presently unknown. Aggregate matter has a coherent weak charge leading to a repulsive interaction mediated by a neutrino pair. The virtual neutrinos are non-relativistic at micron distances, giving a distinct behavior for Dirac versus Majorana mass terms. This effective potential allows for the disentanglement of the Dirac or Majorana nature of the neutrino via magnitude and distance dependence. We propose an experiment to search for this potential based on the concept that the density-dependent interaction of an atomic probe with a material source in one arm of an atomic clock interferometer generates a differential phase. The appropriate geometry of the device is selected using the saturation of the weak potential as a guide. The proposed experiment has the added benefit of being sensitive to gravity at micron distances. A strategy to suppress the competing Casimir-Polder interaction, depending on the electronic structure of the material source, as well as a way to compensate the gravitational interaction in the two arms of the interferometer is discussed.
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Araujo Filho, A. A. (2024). Analysis of a regular black hole in Verlinde's gravity. Class. Quantum Gravity, 41(1), 015003–30pp.
Abstract: This work focuses on the examination of a regular black hole within Verlinde's emergent gravity, specifically investigating the Hayward-like (modified) solution. The study reveals the existence of three horizons under certain conditions, i.e. an event horizon and two Cauchy horizons. Our results indicate regions which phase transitions occur based on the analysis of heat capacity and Hawking temperature. To compute the latter quantity, we utilize three distinct methods: the surface gravity approach, Hawking radiation, and the application of the first law of thermodynamics. In the case of the latter approach, it is imperative to introduce a correction to ensure the preservation of the Bekenstein-Hawking area law. Geodesic trajectories and critical orbits (photon spheres) are calculated, highlighting the presence of three light rings. Additionally, we investigate the black hole shadows. Furthermore, the quasinormal modes are explored using third- and sixth-order Wentzel-Kramers-Brillouin approximations. In particular, we observe stable and unstable oscillations for certain frequencies. Finally, in order to comprehend the phenomena of time-dependent scattering in this scenario, we provide an investigation of the time-domain solution.
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