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Author |
Cabello, J.; Wells, K. |
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Title |
The spatial resolution of silicon-based electron detectors in beta-autoradiography |
Type |
Journal Article |
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Year |
2010 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
55 |
Issue |
6 |
Pages  |
1677-1699 |
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Keywords |
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Abstract |
Thin tissue autoradiography is an imaging modality where ex-vivo tissue sections are placed in direct contact with autoradiographic film. These tissue sections contain a radiolabelled ligand bound to a specific biomolecule under study. This radioligand emits beta- or beta+ particles ionizing silver halide crystals in the film. High spatial resolution autoradiograms are obtained using low energy radioisotopes, such as H-3 where an intrinsic 0.1-1 μm spatial resolution can be achieved. Several digital alternatives have been presented over the past few years to replace conventional film but their spatial resolution has yet to equal film, although silicon-based imaging technologies have demonstrated higher sensitivity compared to conventional film. It will be shown in this work how pixel size is a critical parameter for achieving high spatial resolution for low energy uncollimated beta imaging. In this work we also examine the confounding factors impeding silicon-based technologies with respect to spatial resolution. The study considers charge diffusion in silicon and detector noise, and this is applied to a range of radioisotopes typically used in autoradiography. Finally an optimal detector geometry to obtain the best possible spatial resolution for a specific technology and a specific radioisotope is suggested. |
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Address |
[Cabello, Jorge; Wells, Kevin] Univ Surrey, Fac Elect & Phys Sci, Ctr Vis Speech & Signal Proc, Surrey GU2 7XH, England, Email: jcabello@ific.uv.es |
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Publisher |
Iop Publishing Ltd |
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English |
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ISSN |
0031-9155 |
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Notes |
ISI:000275120300010 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
489 |
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Author |
Blume, M.; Martinez-Moller, A.; Keil, A.; Navab, N.; Rafecas, M. |
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Title |
Joint Reconstruction of Image and Motion in Gated Positron Emission Tomography |
Type |
Journal Article |
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Year |
2010 |
Publication |
IEEE Transactions on Medical Imaging |
Abbreviated Journal |
IEEE Trans. Med. Imaging |
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Volume |
29 |
Issue |
11 |
Pages |
1892-1906 |
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Keywords |
Gating; motion compensation; positron emission tomography (PET); reconstruction |
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Abstract |
We present a novel intrinsic method for joint reconstruction of both image and motion in positron emission tomography (PET). Intrinsic motion compensation methods exclusively work on the measured data, without any external motion measurements. Most of these methods separate image from motion estimation: They use deformable image registration/optical flow techniques in order to estimate the motion from individually reconstructed gates. Then, the image is estimated based on this motion information. With these methods, a main problem lies in the motion estimation step, which is based on the noisy gated frames. The more noise is present, the more inaccurate the image registration becomes. As we show both visually and quantitatively, joint reconstruction using a simple deformation field motion model can compete with state-of-the-art image registration methods which use robust multilevel B-spline motion models. |
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Address |
[Blume, Moritz; Rafecas, Magdalena] Univ Valencia, CSIC, IFIC, E-46071 Valencia, Spain, Email: moritz.blume@cs.tum.edu |
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Publisher |
Ieee-Inst Electrical Electronics Engineers Inc |
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Language |
English |
Summary Language |
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ISSN |
0278-0062 |
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Notes |
ISI:000283941800007 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
340 |
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Author |
Colonna, N.; Belloni, F.; Berthoumieux, E.; Calviani, M.; Domingo-Pardo, C.; Guerrero, C.; Karadimos, D.; Lederer, C.; Massimi, C.; Paradela, C.; Plag, R.; Praena, J.; Sarmento, R. |
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Title |
Advanced nuclear energy systems and the need of accurate nuclear data: the n_TOF project at CERN |
Type |
Journal Article |
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Year |
2010 |
Publication |
Energy & Environmental Science |
Abbreviated Journal |
Energy Environ. Sci. |
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Volume |
3 |
Issue |
12 |
Pages |
1910-1917 |
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Keywords |
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Abstract |
To satisfy the world's constantly increasing demand for energy, a suitable mix of different energy sources has to be devised. In this scenario, an important role could be played by nuclear energy, provided that major safety, waste and proliferation issues affecting current nuclear reactors are satisfactorily addressed. To this purpose, a large effort has been under way for a few years towards the development of advanced nuclear systems with the aim of closing the fuel cycle. Generation IV reactors, with full or partial waste recycling capability, accelerator driven systems, as well as new fuel cycles are the main options being investigated. The design of advanced systems requires improvements in basic nuclear data, such as cross-sections for neutron-induced reactions on actinides. In this paper, the main concepts of advanced reactor systems are described, together with the related needs of new and accurate nuclear data. The present activity in this field at the neutron facility n_TOF at CERN is discussed. |
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Address |
[Colonna, N.] Ist Nazl Fis Nucl, Sez Bari, I-70126 Bari, Italy, Email: nicola.colonna@ba.infn.it |
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Publisher |
Royal Soc Chemistry |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Volume |
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Edition |
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ISSN |
1754-5692 |
ISBN |
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Notes |
ISI:000284590900007 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
319 |
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Author |
Balbinot, R.; Carusotto, I.; Fabbri, A.; Recati, A. |
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Title |
Testing Hawking Particle Creation By Black Holes Through Correlation Measurements |
Type |
Journal Article |
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Year |
2010 |
Publication |
International Journal of Modern Physics D |
Abbreviated Journal |
Int. J. Mod. Phys. D |
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Volume |
19 |
Issue |
14 |
Pages |
2371-2377 |
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Abstract |
Hawking's prediction of thermal radiation by black holes has been shown by Unruh to be expected also in condensed matter systems. We show here that in a black hole-like configuration realized in a BEC this particle-creation does indeed take place and can be unambiguously identified via a characteristic pattern in the density-density correlations. This opens the concrete possibility of the experimental verification of this effect. |
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Address |
[Balbinot, R.] Univ Bologna, Dipartimento Fis, I-40126 Bologna, Italy, Email: balbinot@bo.infn.it |
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Publisher |
World Scientific Publ Co Pte Ltd |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0218-2718 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
ISI:000286112000022 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
534 |
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| Permanent link to this record |
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Author |
Belver, D.; Cabanelas, P.; Castro, E.; Garzon, J.A.; Gil, A.; Gonzalez-Diaz, D.; Koenig, W.; Traxler, M. |
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Title |
Performance of the Low-Jitter High-Gain/Bandwidth Front-End Electronics of the HADES tRPC Wall |
Type |
Journal Article |
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Year |
2010 |
Publication |
IEEE Transactions on Nuclear Science |
Abbreviated Journal |
IEEE Trans. Nucl. Sci. |
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Volume |
57 |
Issue |
5 |
Pages |
2848-2856 |
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Keywords |
Charge to width algorithm; fast amplifying and digitizing electronics; front-end electronics; HADES; time of flight; timing RPC |
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Abstract |
A front-end electronics (FEE) chain for accurate time measurements has been developed for the new Resistive Plate Chamber (RPC)-based Time-of-Flight (TOF) wall of the High Acceptance Di-Electron Spectrometer (HADES). The wall covers an area of around 8 m(2) divided in 6 sectors. In total, 1122 4-gap timing RPC cells are read-out by 2244 time and charge sensitive channels. The FEE chain consists of 2 custom-made boards: a 4-channel Daughter BOard(DBO) and a 32-channel MotherBOard (MBO). The DBO uses a fast 2 GHz amplifier feeding a dual high-speed discriminator. The time and charge information are encoded, respectively, in the leading edge and the width of an LVDS signal. Each MBO houses up to 8 DBOs providing them regulated voltage supply, threshold values via DACs, test signals and, additionally, routing out a signal proportional to the channel multiplicity needed for a 1st level trigger decision. The MBO delivers LVDS signals to a multi-purpose Trigger Readout Board (TRB) for data acquisition. The FEE allows achieving a system resolution around 75 ps fulfilling comfortably the requirements of the HADES upgrade [1]. The commissioning of the whole RPC wall is finished and the 6 sectors are already mounted in their final position in the HADES spectrometer and ready to take data during the beam-times foreseen for 2010. |
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Address |
[Belver, Daniel; Cabanelas, P.; Castro, E.; Garzon, J. A.] Univ Santiago Compostela, LabCAF, Santiago De Compostela 15782, Spain, Email: daniel.belver@usc.es |
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Corporate Author |
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Thesis |
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Publisher |
Ieee-Inst Electrical Electronics Engineers Inc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0018-9499 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
ISI:000283440400007 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
349 |
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