Abstract: We report on a hybrid in-beam PET and prompt-gamma Compton imaging system aimed at quasi real-time ion-range verification in proton-therapy treatments. Proof-of-concept experiments were carried out at the radiobiology beam line of the CNA cyclotron facility using a set of two synchronous Compton imagers and different target materials. The time structure of the 18 MeV proton beam was shaped with a series of beam-on and beam-off intervals, thereby mimicking a pulsed proton beam on a long time scale. During beam-on intervals, Compton imagingwas performed utilizing the high energy. -rays promptly emitted from the nuclear reactions occurring in the targets. In the course of the beam-off intervals in situ positron-emission tomography was accomplished with the same imagers using the beta+ decay of activated nuclei. The targets used were stacks of different materials covering also various proton ranges and energies. A systematic study on the performance of these two complementary imaging techniques is reported and the experimental results interpreted on the basis ofMonte Carlo calculations. The results demonstrate the possibility to combine both imaging techniques in a concomitant way, where high-efficiency prompt-gamma imaging is complemented with the high spatial accuracy of PET. Empowered by these results we suggest that a pulsed beam with a suitable duty cycle, in conjunction with in situ Compton- and PET-imaging may help to attain complementary information and quasi real-time range monitoring with high accuracy.

Abstract: We study the energy loss of excited monopolium in an atomic medium. We perform a classical calculation in line with a similar calculation performed for charged particles which leads in the non-relativistic limit to the Bethe-Bloch formula except for the density dependence of the medium, which we do not consider in this paper. Our result shows that for maximally deformed Rydberg states, the ionization of monopolium in a light atomic medium is similar to that of light ions.

Abstract: Treatment planning systems at proton-therapy centres entirely use X-ray computed tomography (CT) as primary imaging technique to infer the proton treatment doses to tumour and healthy tissues. However, proton stopping powers in the body, as derived from X-ray images, suffer from important proton-range uncertainties. In order to reduce this uncertainty in range, one could use proton-CT images instead. The main goal of this work is to test the capabilities of a newly-developed proton-CT scanner, based on the use of a set of tracking detectors and a high energy resolution scintillator for the residual energy of the protons. Different custom-made phantoms were positioned at the field of view of the scanner and were irradiated with protons at the CCB proton-therapy center in Krakow. We measured with the phantoms at different angles and produced sinograms that were used to obtain reconstructed images by Filtered Back-Projection. The obtained images were used to determine the capabilities of our scanner in terms of spatial resolution and proton Relative Stopping Power (RSP) mapping and validate its use as proton-CT scanner. The results show that the scanner can produce medium-high quality images, with spatial resolution better than 2 mm in radiography, below 3 mm in tomography and resolving power in the RSP comparable to other state-of-the-art pCT scanners.

Abstract: The beam aperture of a particle accelerator defines the clearance available for the circulating beams and is a parameter of paramount importance for the accelerator performance. At the CERN Large Hadron Collider (LHC), the knowledge and control of the available aperture is crucial because the nominal proton beams carry an energy of 362 MJ stored in a superconducting environment. Even a tiny fraction of beam losses could quench the superconducting magnets or cause severe material damage. Furthermore, in a circular collider, the performance in terms of peak luminosity depends to a large extent on the aperture of the inner triplet quadrupoles, which are used to focus the beams at the interaction points. In the LHC, this aperture represents the smallest aperture at top-energy with squeezed beams and determines the maximum potential reach of the peak luminosity. Beam-based aperture measurements in these conditions are difficult and challenging. In this paper, we present different methods that have been developed over the years for precise beam-based aperture measurements in the LHC, highlighting applications and results that contributed to boost the operational LHC performance in Run 1 (2010-2013) and Run 2 (2015-2018)

Abstract: This work deals with lump-like structures in models described by a single real scalar field in two-dimensional spacetime. We start with a model that supports lump-like configurations and use the deformation procedure to construct scalar field theories that support both lumps and kinks, with the corresponding stability investigation giving rise to new physical systems. Very interestingly, we find models that support stable topological solutions, with the stability potential being able to support a tower of non-negative bound states, generating distinct families of potentials of current interest to quantum mechanics. We also describe models where the lump-like solutions give rise to stability potentials that have the shape of a double well.