Sanjuan, R., Nebot, M., Peris, J. B., & Alcami, J. (2013). Immune Activation Promotes Evolutionary Conservation of T-Cell Epitopes in HIV-1. PLoS. Biol., 11(4), e1001523–10pp.
Abstract: The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (T-H cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient level can promote either T-cell epitope conservation or escape. We predict greater conservation for epitopes contributing significantly to total immune activation levels (immunodominance), and when T-H cell infection is concomitant to epitope recognition (transinfection). We suggest that HIV-driven immune activation in the lymph nodes during the chronic stage of the disease may offer a favorable scenario for epitope conservation. Our results also support the view that some pathogens draw benefits from the immune response and suggest that vaccination strategies based on conserved T-H epitopes may be counterproductive.
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Nebot, M. (2020). Bounded masses in two Higgs doublets models, spontaneous CP violation and Z(2) symmetry. Phys. Rev. D, 102(11), 115002–16pp.
Abstract: In two Higgs doublet models (2HDMs) shaped by some unbroken symmetry, imposing perturbativity requirements on the quartic couplings can imply that the allowed masses of all the fundamental scalars are bounded from above. This important property is analyzed in detail for the only two realistic 2HDMs with an exact symmetry, the case with Z(2) symmetry and the case with CP symmetry. It is also noticeable that one exception arises in each case: when the vacuum is assumed to respect the imposed symmetry, a decoupling regime can nevertheless appear without violating perturbativity requirements. In both models with an exact symmetry and no decoupling regime, soft symmetry breaking terms can however lead to a decoupling regime: the possibility that this regime might be unnatural, since it requires some fine-tuning, is also analyzed.
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Bonilla, C., Nebot, M., Valle, J. W. F., & Srivastava, R. (2016). Flavor physics scenario for the 750 GeV diphoton anomaly. Phys. Rev. D, 93(7), 073009–5pp.
Abstract: A simple variant of a realistic flavor symmetry scheme for fermion masses and mixings provides a possible interpretation of the diphoton anomaly as an electroweak singlet “flavon.” The existence of TeV scale vectorlike T-quarks required to provide adequate values for Cabibbo-Kobayashi-Maskawa (CKM) parameters can also naturally account for the diphoton anomaly. Correlations between V-ub and V-cb with the vectorlike T-quark mass can be predicted. Should the diphoton anomaly survive in a future run, our proposed interpretation can also be tested in upcoming B and LHC studies.
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Bernabeu, J., Botella, F. J., Nebot, M., & Segarra, A. (2022). B-0 – (B)over-bar(0) entanglement for an ideal experiment for the direct CP violation phi(3)/gamma phase. Phys. Rev. D, 106(5), 054026–7pp.
Abstract: B-0-(B) over bar0 entanglement offers a conceptual alternative to the single charged B-decay asymmetry for the measurement of the direct CP-violating gamma/phi(3) phase. With f = J/Psi(L); J/Psi K-S and g = (pi pi)(0); (rho(L)rho(L))(0), the 16 time-ordered double-decay rate intensities to (f, g) depend on the relative phase between the f- and g-decay amplitudes given by gamma at tree level. Several constraining consistencies appear. An intrinsic accuracy of the method at the level of +/- 1 degrees could be achievable at Belle-II with an improved determination of the penguin amplitude to g channels from existing facilities.
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Morisi, S., Nebot, M., Patel, K. M., Peinado, E., & Valle, J. W. F. (2013). Quark-lepton mass relation and CKM mixing in an A(4) extension of the minimal supersymmetric standard model. Phys. Rev. D, 88(3), 036001–8pp.
Abstract: An interesting mass relation between down-type quarks and charged leptons has been recently predicted within a supersymmetric SU(3)(c) circle times SU(2)(L) circle times U(1)(Y) model based on the A(4) flavor symmetry. Here we propose a simple extension which provides an adequate full description of the quark sector. By adding a pair of vectorlike up quarks, we show how the CKM entries V-ub, V-cb, V-td and V-ts arise from deviations of the unitarity. We perform an analysis including the most relevant observables in the quark sector, such as oscillations and rare decays of kaons, B-d and B-s mesons. In the lepton sector, the model predicts an inverted hierarchy for the neutrino masses, leading to a potentially observable rate of neutrinoless double beta decay.
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