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Bordes, J., Chan, H. M., & Tsun, T. S. (2010). Possible anomalies in Higgs decay: charm-suppression and flavour-violation. Eur. Phys. J. C, 65(3-4), 537–542.
Abstract: It is suggested that the Higgs boson may have a branching ratio into the c (c) over bar c mode suppressed by several orders of magnitude compared with conventional predictions and in addition some small but detectable flavour-violating modes such as b (s) over bar and tau(mu) over bar. The suggestion is based on a scheme proposed and tested earlier for explaining the mixing pattern and mass hierarchy of fermions in terms of a rotating mass matrix. If confirmed, the effects would cast new light on the geometric origin of fermion generations and of the Higgs field itself.
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Amaldi, U., Bonomi, R., Braccini, S., Crescenti, M., Degiovanni, A., Garlasche, M., et al. (2010). Accelerators for hadrontherapy: From Lawrence cyclotrons to linacs. Nucl. Instrum. Methods Phys. Res. A, 620(2-3), 563–577.
Abstract: Hadrontherapy with protons and carbon ions is a fast developing methodology in radiation oncology. The accelerators used and planned for this purpose are reviewed starting from the cyclotrons used in the thirties. As discussed in the first part of this paper, normal and superconducting cyclotrons are still employed, together with synchrotrons, for proton therapy while for carbon ion therapy synchrotrons have been till now the only option. The latest developments concern a superconducting cyclotron for carbon ion therapy, fast-cycling high frequency linacs and 'single room' proton therapy facilities. These issues are discussed in the second part of the paper by underlining the present challenges, in particular the treatment of moving organs.
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Actis, S. et al, & Rodrigo, G. (2010). Quest for precision in hadronic cross sections at low energy: Monte Carlo tools vs. experimental data. Eur. Phys. J. C, 66(3-4), 585–686.
Abstract: We present the achievements of the last years of the experimental and theoretical groups working on hadronic cross section measurements at the low-energy e (+) e (-) colliders in Beijing, Frascati, Ithaca, Novosibirsk, Stanford and Tsukuba and on tau decays. We sketch the prospects in these fields for the years to come. We emphasise the status and the precision of the Monte Carlo generators used to analyse the hadronic cross section measurements obtained as well with energy scans as with radiative return, to determine luminosities and tau decays. The radiative corrections fully or approximately implemented in the various codes and the contribution of the vacuum polarisation are discussed.
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Cervera-Villanueva, A., Laing, A., Martin-Albo, J., & Soler, F. J. P. (2010). Performance of the MIND detector at a Neutrino Factory using realistic muon reconstruction. Nucl. Instrum. Methods Phys. Res. A, 624(3), 601–614.
Abstract: A Neutrino Factory producing an intense beam composed of v(e)((v) over bar (e)) and (v) over bar (mu)(v(mu)) from muon decays has been shown to have the greatest sensitivity to the two currently unmeasured neutrino mixing parameters theta(13) and delta(CP) Using the wrong-sign muon signal to measure v(e)-> v(mu)((v) over bar (e) ->(v) over bar (mu)) oscillations in a 50kt Magnetised Iron Neutrino Detector (MIND) sensitivity to delta(CP) could be maintained down to small values of theta(13) However the detector efficiencies used in these previous studies were calculated assuming perfect pattern recognition In this paper MIND is reassessed taking into account for the first time a realistic pattern recognition for the muon candidate Reoptimisation of the analysis utilises a combination of methods including a multivariate analysis similar to the one used in MINOS to maintain high efficiency while suppressing backgrounds ensuring that the signal selection efficiency and the background levels are comparable or better than the ones in previous analyses As a result MIND remains the most sensitive future facility for the discovery of CP violation from neutrino oscillations.
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Peris, J. B., Davis, P., Cuevas, J. M., Nebot, M., & Sanjuan, R. (2010). Distribution of Fitness Effects Caused by Single-Nucleotide Substitutions in Bacteriophage f1. Genetics, 185(2), 603–U308.
Abstract: Empirical knowledge of the fitness effects of mutations is important for understanding many evolutionary processes, yet this knowledge is often hampered by several sources of measurement error and bias. Most of these problems can be solved using site-directed mutagenesis to engineer single mutations, an approach particularly suited for viruses due to their small genomes. Here, we used this technique to measure the fitness effect of 100 single-nucleotide substitutions in the bacteriophage f1, a filamentous single-strand DNA virus. We found that approximately one-fifth of all mutations are lethal. Viable ones reduced fitness by 11% on average and were accurately described by a log-normal distribution. More than 90% of synonymous substitutions were selectively neutral, while those affecting intergenic regions reduced fitness by 14% on average. Mutations leading to amino acid substitutions had an overall mean deleterious effect of 37%, which increased to 45% for those changing the amino acid polarity. Interestingly, mutations affecting early steps of the infection cycle tended to be more deleterious than those affecting late steps. Finally, we observed at least two beneficial mutations. Our results confirm that high mutational sensitivity is a general property of viruses with small genomes, including RNA and single-strand DNA viruses infecting animals, plants, and bacteria.
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