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Valdes-Cortez, C., Mansour, I., Rivard, M. J., Ballester, F., Mainegra-Hing, E., Thomson, R. M., et al. (2021). A study of Type B uncertainties associated with the photoelectric effect in low-energy Monte Carlo simulations. Phys. Med. Biol., 66(10), 105014–14pp.
Abstract: Purpose. To estimate Type B uncertainties in absorbed-dose calculations arising from the different implementations in current state-of-the-art Monte Carlo (MC) codes of low-energy photon cross-sections (<200 keV). Methods. MC simulations are carried out using three codes widely used in the low-energy domain: PENELOPE-2018, EGSnrc, and MCNP. Three dosimetry-relevant quantities are considered: mass energy-absorption coefficients for water, air, graphite, and their respective ratios; absorbed dose; and photon-fluence spectra. The absorbed dose and the photon-fluence spectra are scored in a spherical water phantom of 15 cm radius. Benchmark simulations using similar cross-sections have been performed. The differences observed between these quantities when different cross-sections are considered are taken to be a good estimator for the corresponding Type B uncertainties. Results. A conservative Type B uncertainty for the absorbed dose (k = 2) of 1.2%-1.7% (<50 keV), 0.6%-1.2% (50-100 keV), and 0.3% (100-200 keV) is estimated. The photon-fluence spectrum does not present clinically relevant differences that merit considering additional Type B uncertainties except for energies below 25 keV, where a Type B uncertainty of 0.5% is obtained. Below 30 keV, mass energy-absorption coefficients show Type B uncertainties (k = 2) of about 1.5% (water and air), and 2% (graphite), diminishing in all materials for larger energies and reaching values about 1% (40-50 keV) and 0.5% (50-75 keV). With respect to their ratios, the only significant Type B uncertainties are observed in the case of the water-to-graphite ratio for energies below 30 keV, being about 0.7% (k = 2). Conclusions. In contrast with the intermediate (about 500 keV) or high (about 1 MeV) energy domains, Type B uncertainties due to the different cross-sections implementation cannot be considered subdominant with respect to Type A uncertainties or even to other sources of Type B uncertainties (tally volume averaging, manufacturing tolerances, etc). Therefore, the values reported here should be accommodated within the uncertainty budget in low-energy photon dosimetry studies.
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Oliver, S., Vijande, J., Tejedor-Aguilar, N., Miro, R., Rovira-Escutia, J. J., Ballester, F., et al. (2023). Monte Carlo flattening filter design to high energy intraoperative electron beam homogenization. Radiat. Phys. Chem., 212, 111102–6pp.
Abstract: Intraoperative radiotherapy using mobile linear accelerators is used for a wide variety of malignancies. However, when large fields are used in combination with high energies, a deterioration of the flatness dose profile is measured with respect to smaller fields and lower energies. Indeed, for the LIAC HWL of Sordina, this deterioration is observed for the 12 MeV beam combined with 10 cm (or larger) diameter applicator. Aimed to solve this problem, a flattening filter has been designed and validated evaluating the feasibility of its usage at the upper part of the applicator. The design of the filter was based on Monte Carlo simulations because of its accuracy in modeling components of clinical devices, among other purposes. The LIAC 10 cm diameter applicator was modeled and simulated independently by two different research groups using two different MC codes, reproducing the heterogeneity of the 12 MeV energy beam. Then, an iterative process of filter design was carried out. Finally, the MC designed conical filter with the optimal size and height to obtain the desired flattened beam was built in-house using a 3D printer. During the experimental validation of the applicator-filter, percentage depth dose, beam profiles, absolute and peripheral dose measurements were performed to demonstrate the effectiveness of the filter addition in the applicator. These measurements conclude that the beam has been flattened, from 5.9% with the standard configuration to 1.6% for the configuration with the filter, without significant increase of the peripheral dose. Consequently, the new filter-applicator LIAC configuration can be used also in a conventional surgery room. A reduction of 16% of the output dose and a reduction of 1.1 mm in the D50 of the percentage depth dose was measured with respect to the original configuration. This work is a proof-of-concept that demonstrates that it is possible to add a filter able to flatten the beam delivered by the Sordina LIAC HWL. Future studies will focus on more refined technical solutions fully compatible with the integrity of the applicator, including its sterilization, to be safely introduced in the clinical practice.
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Carames, T. F., Fontoura, C. E., Krein, G., Vijande, J., & Valcarce, A. (2018). Charmed baryons in nuclear matter. Phys. Rev. D, 98(11), 114019–9pp.
Abstract: We study the temperature and baryon density dependence of the masses of the lightest charmed baryons Lambda(c), Sigma(c) and Sigma(c)*. We also look at the effects of the temperature and baryon density on the binding energies of the Lambda N-c and Lambda(c)Lambda(c) systems. Baryon masses and baryon-baryon interactions are evaluated within a chiral constituent quark model. Medium effects are incorporated in those parameters of the model related to the dynamical breaking of chiral symmetry, which are the masses of the constituent quarks, the sigma and pi meson masses, and quark-meson couplings. We find that while the in-medium Lambda(c) mass decreases monotonically with temperature, those of Sigma(c) and Sigma(c)* have a nonmonotonic dependence. These features can be understood in terms of a simple group theory analysis regarding the one-gluon exchange interaction in those hadrons. The in-medium Lambda N-c and Lambda(c)Lambda(c) interactions are governed by a delicate balance involving a stronger attraction due to the decrease of the sigma meson mass, suppression of coupled-channel effects and lower thresholds, leading to shallow bound states with binding energies of a few MeV. The Lambda(c) baryon could possibly be bound to a large nucleus, in qualitative agreement with results based on relativistic mean field models or QCD sum rules. Ongoing experiments at RHIC or LHCb or the planned ones at FAIR and J-PARC may take advantage of the present results.
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Gimenez-Alventosa, V., Gimenez, V., Ballester, F., Vijande, J., & Andreo, P. (2018). Correction factors for ionization chamber measurements with the 'Valencia' and 'large field Valencia' brachytherapy applicators. Phys. Med. Biol., 63(12), 125004–10pp.
Abstract: Treatment of small skin lesions using HDR brachytherapy applicators is a widely used technique. The shielded applicators currently available in clinical practice are based on a tungsten-alloy cup that collimates the source-emitted radiation into a small region, hence protecting nearby tissues. The goal of this manuscript is to evaluate the correction factors required for dose measurements with a plane-parallel ionization chamber typically used in clinical brachytherapy for the 'Valencia' and 'large field Valencia' shielded applicators. Monte Carlo simulations have been performed using the PENELOPE-2014 system to determine the absorbed dose deposited in a water phantom and in the chamber active volume with a Type A uncertainty of the order of 0.1%. The average energies of the photon spectra arriving at the surface of the water phantom differ by approximately 10%, being 384 keV for the 'Valencia' and 343 keV for the 'large field Valencia'. The ionization chamber correction factors have been obtained for both applicators using three methods, their values depending on the applicator being considered. Using a depth-independent global chamber perturbation correction factor and no shift of the effective point of measurement yields depth-dose differences of up to 1% for the 'Valencia' applicator. Calculations using a depth-dependent global perturbation factor, or a shift of the effective point of measurement combined with a constant partial perturbation factor, result in differences of about 0.1% for both applicators. The results emphasize the relevance of carrying out detailed Monte Carlo studies for each shielded brachytherapy applicator and ionization chamber.
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Hernandez, E., Vijande, J., Valcarce, A., & Richard, J. M. (2020). Spectroscopy, lifetime and decay modes of the T-bb(-) tetraquark. Phys. Lett. B, 800, 135073–9pp.
Abstract: We present the first full-fledged study of the flavor-exotic isoscalar T-bb(-) equivalent to bb (u) over bar(d) over bar tetraquark with spin and parity J(P) = 1(+). We report accurate solutions of the four-body problem in a quark model, characterizing the structure of the state as a function of the ratio M-Q/m(q) of the heavy to light quark masses. For such a standard constituent model, T-bb(-) lies approximately 150 MeV below the strong decay threshold B- (B) over bar*(0) and 105 MeV below the electromagnetic decay threshold B- (B) over bar (0)gamma. We evaluate the lifetime of T-bb(-), identifying the promising decay modes where the tetraquark might be looked for in future experiments. Its total decay width is Gamma approximate to 87 x 10(-15) GeV and therefore its lifetime tau approximate to 7.6 ps. The promising final states are B*(-) D*(+) l (v) over bar (l) and (B) over bar*(0) l (v) over bar (l) among the semileptonic decays, and B*(-) D*(+) D-s*(-), (B) over bar*(0) D*(0) D-s*(-), and B*(-) D*(+) rho(-) among the nonleptonic ones. The semileptonic decay to the isoscalar J(P) = 0(+) tetraquark T-bc(0) is also relevant but it is not found to be dominant. There is a broad consensus about the existence of this tetraquark, and its detection will validate our understanding of the low-energy realizations of Quantum Chromodynamics (QCD) in the multiquark sector.
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