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Author Balibrea-Correa, J.; Lerendegui-Marco, J.; Ladarescu, I.; Guerrero, C.; Rodriguez-Gonzalez, T.; Jimenez-Ramos, M.C.; Fernandez-Martinez, B.; Domingo-Pardo, C.
Title Hybrid in-beam PET- and Compton prompt-gamma imaging aimed at enhanced proton-range verification Type Journal Article
Year 2022 Publication European Physical Journal Plus Abbreviated Journal Eur. Phys. J. Plus
Volume 137 Issue 11 Pages (up) 1258 - 18pp
Keywords
Abstract We report on a hybrid in-beam PET and prompt-gamma Compton imaging system aimed at quasi real-time ion-range verification in proton-therapy treatments. Proof-of-concept experiments were carried out at the radiobiology beam line of the CNA cyclotron facility using a set of two synchronous Compton imagers and different target materials. The time structure of the 18 MeV proton beam was shaped with a series of beam-on and beam-off intervals, thereby mimicking a pulsed proton beam on a long time scale. During beam-on intervals, Compton imagingwas performed utilizing the high energy. -rays promptly emitted from the nuclear reactions occurring in the targets. In the course of the beam-off intervals in situ positron-emission tomography was accomplished with the same imagers using the beta+ decay of activated nuclei. The targets used were stacks of different materials covering also various proton ranges and energies. A systematic study on the performance of these two complementary imaging techniques is reported and the experimental results interpreted on the basis ofMonte Carlo calculations. The results demonstrate the possibility to combine both imaging techniques in a concomitant way, where high-efficiency prompt-gamma imaging is complemented with the high spatial accuracy of PET. Empowered by these results we suggest that a pulsed beam with a suitable duty cycle, in conjunction with in situ Compton- and PET-imaging may help to attain complementary information and quasi real-time range monitoring with high accuracy.
Address [Balibrea-Correa, J.; Lerendegui-Marco, J.; Ladarescu, I; Domingo-Pardo, C.] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: javier.balibrea@ific.uv.es
Corporate Author Thesis
Publisher Springer Heidelberg Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2190-5444 ISBN Medium
Area Expedition Conference
Notes WOS:000886327900002 Approved no
Is ISI yes International Collaboration no
Call Number IFIC @ pastor @ Serial 5420
Permanent link to this record
 
 
Author Lerendegui-Marco, J.; Balibrea-Correa, J.; Babiano-Suarez, V.; Ladarescu, I.; Domingo-Pardo, C.
Title Towards machine learning aided real-time range imaging in proton therapy Type Journal Article
Year 2022 Publication Scientific Reports Abbreviated Journal Sci Rep
Volume 12 Issue 1 Pages (up) 2735 - 17pp
Keywords
Abstract Compton imaging represents a promising technique for range verification in proton therapy treatments. In this work, we report on the advantageous aspects of the i-TED detector for proton-range monitoring, based on the results of the first Monte Carlo study of its applicability to this field. i-TED is an array of Compton cameras, that have been specifically designed for neutron-capture nuclear physics experiments, which are characterized by gamma-ray energies spanning up to 5-6 MeV, rather low gamma-ray emission yields and very intense neutron induced gamma-ray backgrounds. Our developments to cope with these three aspects are concomitant with those required in the field of hadron therapy, especially in terms of high efficiency for real-time monitoring, low sensitivity to neutron backgrounds and reliable performance at the high gamma-ray energies. We find that signal-to-background ratios can be appreciably improved with i-TED thanks to its light-weight design and the low neutron-capture cross sections of its LaCl3 crystals, when compared to other similar systems based on LYSO, CdZnTe or LaBr3. Its high time-resolution (CRT similar to 500 ps) represents an additional advantage for background suppression when operated in pulsed HT mode. Each i-TED Compton module features two detection planes of very large LaCl3 monolithic crystals, thereby achieving a high efficiency in coincidence of 0.2% for a point-like 1 MeV gamma-ray source at 5 cm distance. This leads to sufficient statistics for reliable image reconstruction with an array of four i-TED detectors assuming clinical intensities of 10(8) protons per treatment point. The use of a two-plane design instead of three-planes has been preferred owing to the higher attainable efficiency for double time-coincidences than for threefold events. The loss of full-energy events for high energy gamma-rays is compensated by means of machine-learning based algorithms, which allow one to enhance the signal-to-total ratio up to a factor of 2.
Address [Lerendegui-Marco, Jorge; Balibrea-Correa, Javier; Babiano-Suarez, Victor; Ladarescu, Ion; Domingo-Pardo, Cesar] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: jorge.lerendegui@ific.uv.es
Corporate Author Thesis
Publisher Nature Portfolio Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2045-2322 ISBN Medium
Area Expedition Conference
Notes WOS:000757537100018 Approved no
Is ISI yes International Collaboration no
Call Number IFIC @ pastor @ Serial 5136
Permanent link to this record
 
 
Author n_TOF Collaboration (Balibrea-Correa, J. et al); Domingo-Pardo, C.; Giubrone, G.; Tain, J.L.; Tarifeño-Saldivia, A.
Title Measurement of the alpha ratio and (n, gamma) cross section of U-235 from 0.2 to 200 eV at n_TOF Type Journal Article
Year 2020 Publication Physical Review C Abbreviated Journal Phys. Rev. C
Volume 102 Issue 4 Pages (up) 044615 - 18pp
Keywords
Abstract We measured the neutron capture-to-fission cross-section ratio (alpha ratio) and the capture cross section of U-235 between 0.2 and 200 eV at the nTOF facility at CERN. The simultaneous measurement of neutron-induced capture and fission rates was performed by means of the nTOF BaF2 Total Absorption Calorimeter (TAC), used for detection of gamma rays, in combination with a set of micromegas detectors used as fission tagging detectors. The energy dependence of the capture cross section was obtained with help of the Li-6(n, t) standard reaction determining the n_TOF neutron fluence; the well-known integral of the U-235(n, f) cross section between 7.8 and 11 eV was then used for its absolute normalization. The alpha ratio, obtained with slightly higher statistical fluctuations, was determined directly, without need for any reference cross section. To perform the analysis of this measurement we developed a new methodology to correct the experimentally observed effect that the probabilities of detecting a fission reaction in the TAC and the micromegas detectors are not independent. The results of this work have been used in a new evaluation of U-235 performed within the scope of the Collaborative International Evaluated Library Organisation (CIELO) Project, and are consistent with the ENDF/B-VIII.0 and JEFF-3.3 capture cross sections below 4 eV and above 100 eV. However, the measured capture cross section is on average 10% larger between 4 and 100 eV.
Address [Balibrea-Correa, J.; Mendoza, E.; Cano-Ott, D.] Ctr Invest Energet Medioambientales & Tecnol, CIEMAT, Madrid, Spain, Email: emilio.mendoza@ciemat.es
Corporate Author Thesis
Publisher Amer Physical Soc Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0556-2813 ISBN Medium
Area Expedition Conference
Notes WOS:000579839000003 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 4575
Permanent link to this record
 
 
Author Plaza, J.; Martinez, T.; Becares, V.; Cano-Ott, D.; Villamarin, D.; de Rada, A.P.; Mendoza, E.; Pesudo, V.; Santorelli, R.; Pena, C.; Balibrea-Correa, J.; Boeltzig, A.
Title Thermal neutron background at Laboratorio Subterraneo de Canfranc (LSC) Type Journal Article
Year 2023 Publication Astroparticle Physics Abbreviated Journal Astropart Phys.
Volume 146 Issue Pages (up) 102793 - 9pp
Keywords Underground neutron background; Thermal neutron flux; He-3 proportional counter; Pulse shape discrimination
Abstract The thermal neutron background at Laboratorio Subterraneo de Canfranc (LSC) has been determined using several He-3 proportional counter detectors. Bare and Cd shielded counters were used in a series of long measurements. Pulse shape discrimination techniques were applied to discriminate between neutron and gamma signals as well as other intrinsic contributions. Montecarlo simulations allowed us to estimate the sensitivity of the detectors and calculate values for the background flux of thermal neutrons inside Hall-A of LSC. The obtained value is (3.5 +/- 0.8)x10(-6) n/cm(2)s, and is within an order of magnitude compared to similar facilities.
Address [Plaza, J.; Martinez, T.; Becares, V; Cano-Ott, D.; Villamarin, D.; Perez de Rada, A.; Mendoza, E.; Pesudo, V; Santorelli, R.] Ctr Invest Energet Medioambientales & Tecnol CIEM, Ave Complutense 40, Madrid 28040, Spain, Email: julio.plaza@ciemat.es
Corporate Author Thesis
Publisher Elsevier Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0927-6505 ISBN Medium
Area Expedition Conference
Notes WOS:000928281600001 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 5482
Permanent link to this record
 
 
Author Balibrea-Correa, J.; Lerendegui-Marco, J.; Calvo, D.; Caballero, L.; Babiano, V.; Ladarescu, I.; Redondo, M.L.; Tain, J.L.; Tolosa, A.; Domingo-Pardo, C.; Calvino, F.; Casanovas, A.; Tarifeño-Saldivia, A.; Alcayne, V.; Cano-Ott, D.; Martinez, T.; Guerrero, C.; Barbagallo, M.; Macina, D.; Bacak, M.
Title A first prototype of C6D6 total-energy detector with SiPM readout for neutron capture time-of-flight experiments Type Journal Article
Year 2021 Publication Nuclear Instruments & Methods in Physics Research A Abbreviated Journal Nucl. Instrum. Methods Phys. Res. A
Volume 985 Issue Pages (up) 164709 - 8pp
Keywords Silicon photomultiplier; Radiation detectors; Time-of-flight; Radiative capture; Total energy detector; Pulse-height weighting technique
Abstract Low efficiency total-energy detectors (TEDs) are one of the main tools for neutron capture cross section measurements utilizing the time-of-flight (TOF) technique. State-of-the-art TEDs are based on a C6D6 liquid-scintillation cell optically coupled to a fast photomultiplier tube. The large photomultiplier tube represents yet a significant contribution to the so-called neutron sensitivity background, which is one of the most conspicuous sources of uncertainty in this type of experiments. Here we report on the development of a first prototype of a TED based on a silicon-photomultiplier (SiPM) readout, thus resulting in a lightweight and much more compact detector. Apart from the envisaged improvement in neutron sensitivity, the new system uses low voltage (+28 V) and low current supply (-50 mA), which is more practical than the-kV supply required by conventional photomultipliers. One important difficulty hindering the earlier implementation of SiPM readout for this type of detector was the large capacitance for the output signal when all pixels of a SiPM array are summed together. The latter leads to long pulse rise and decay times, which are not suitable for time-of-flight experiments. In this work we demonstrate the feasibility of a Schottky-diode multiplexing readout approach, that allows one to preserve the excellent timing properties of SiPMs, hereby paving the way for their implementation in future neutron TOF experiments.
Address [Balibrea-Correa, J.; Lerendegui-Marco, J.; Calvo, D.; Caballero, L.; Babiano, V; Ladarescu, I; Redondo, M. Lopez; Tain, J. L.; Tolosa, A.; Domingo-Pardo, C.] Univ Valencia, Inst Fis Corpuscular, CSIC, Valencia, Spain, Email: dacaldia@ific.uv.es;
Corporate Author Thesis
Publisher Elsevier Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0168-9002 ISBN Medium
Area Expedition Conference
Notes WOS:000592358200019 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 4638
Permanent link to this record