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Gimenez-Alventosa, V., Antunes, P. C. G., Vijande, J., Ballester, F., Perez-Calatayud, J., & Andreo, P. (2017). Collision-kerma conversion between dose-to-tissue and dose-to-water by photon energy-fluence corrections in low-energy brachytherapy. Phys. Med. Biol., 62(1), 146–164.
Abstract: The AAPM TG-43 brachytherapy dosimetry formalism, introduced in 1995, has become a standard for brachytherapy dosimetry worldwide; it implicitly assumes that charged-particle equilibrium (CPE) exists for the determination of absorbed dose to water at different locations, except in the vicinity of the source capsule. Subsequent dosimetry developments, based on Monte Carlo calculations or analytical solutions of transport equations, do not rely on the CPE assumption and determine directly the dose to different tissues. At the time of relating dose to tissue and dose to water, or vice versa, it is usually assumed that the photon fluence in water and in tissues are practically identical, so that the absorbed dose in the two media can be related by their ratio of mass energy-absorption coefficients. In this work, an efficient way to correlate absorbed dose to water and absorbed dose to tissue in brachytherapy calculations at clinically relevant distances for low-energy photon emitting seeds is proposed. A correction is introduced that is based on the ratio of the water-to-tissue photon energy-fluences. State-of-the art Monte Carlo calculations are used to score photon fluence differential in energy in water and in various human tissues (muscle, adipose and bone), which in all cases include a realistic modelling of low-energy brachytherapy sources in order to benchmark the formalism proposed. The energy-fluence based corrections given in this work are able to correlate absorbed dose to tissue and absorbed dose to water with an accuracy better than 0.5% in the most critical cases (e.g. bone tissue).
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ATLAS Collaboration(Adragna, P. et al), Castelo, J., Castillo Gimenez, V., Cuenca, C., Ferrer, A., Fullana, E., et al. (2010). Measurement of pion and proton response and longitudinal shower profiles up to 20 nuclear interaction lengths with the ATLAS Tile calorimeter. Nucl. Instrum. Methods Phys. Res. A, 615(2), 158–181.
Abstract: The response of pions and protons in the energy range of 20-180 GeV, produced at CERN's SPS H8 test-beam line in the ATLAS iron-scintillator Tile hadron calorimeter, has been measured. The test-beam configuration allowed the measurement of the longitudinal shower development for pions and protons up to 20 nuclear interaction lengths. It was found that pions penetrate deeper in the calorimeter than protons. However, protons induce showers that are wider laterally to the direction of the impinging particle. Including the measured total energy response, the pion-to-proton energy ratio and the resolution, all observations are consistent with a higher electromagnetic energy fraction in pion-induced showers. The data are compared with GEANT4 simulations using several hadronic physics lists. The measured longitudinal shower profiles are described by an analytical shower parametrization within an accuracy of 5-10%. The amount of energy leaking out behind the calorimeter is determined and parametrized as a function of the beam energy and the calorimeter depth. This allows for a leakage correction of test-beam results in the standard projective geometry.
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Campanario, F., & Kubocz, M. (2014). Higgs boson CP-properties of the gluonic contributions in Higgs plus three jet production via gluon fusion at the LHC. J. High Energy Phys., 10(10), 173–16pp.
Abstract: in high energy hadronic collisions, a general CP-violating Higgs boson Phi with accompanying jets can be efficiently produced via gluon fusion, which is mediated by heavy quark loops. In this article, we study the dominant sub-channel gg -> ggg Phi of the gluon fusion production process with triple real emission corrections at order alpha(5)(s). We go beyond the heavy top-quark approximation and include the full mass dependence of the top- and bottom-quark contributions. Furthermore, in a specific model we demonstrate the features of our program and show the impact of bottom-quark loop contributions in combination with large values of tan beta on differential distributions sensitive to CP-rneasurements of the Higgs boson.
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Vijande, J., Granero, D., Perez-Calatayud, J., & Ballester, F. (2013). Monte Carlo dosimetric study of the medium dose rate CSM40 source. Appl. Radiat. Isot., 82, 283–288.
Abstract: The Cs-137 medium dose rate (MDR) CSM40 source model (Eckert & Ziegler BEBIG, Germany) is in clinical use but no dosimetric dataset has been published. This study aims to obtain dosimetric data for the CSM40 source for its use in clinical practice as required by the American Association of Physicists in Medicine (AAPM) and the European Society for Radiotherapy and Oncology (ESTRO). Penelope2008 and Geant4 Monte Carlo codes were used to characterize this source dosimetrically. It was located in an unbounded water phantom with composition and mass density as recommended by AAPM and ESTRO. Due to the low photon energies of Cs-137, absorbed dose was approximated by collisional kerma. Additional simulations were performed to obtain the air-kerma strength, sic. Mass-energy absorption coefficients in water and air were consistently derived and used to calculate collisional kerma. Results performed with both radiation transport codes showed agreement typically within 0.05%. Dose rate constant, radial dose function and anisotropy function are provided for the CSM40 and compared with published data for other commercially available Cs-137 sources. An uncertainty analysis has been performed. The data provided by this study can be used as input data and verification in the treatment planning systems. (C) 2013 Elsevier Ltd. All rights reserved.
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AGATA Collaboration, Domingo-Pardo, C., Bazzacco, D., Doornenbal, P., Farnea, E., Gadea, A., et al. (2012). Conceptual design and performance study for the first implementation of AGATA at the in-flight RIB facility of GSI. Nucl. Instrum. Methods Phys. Res. A, 694, 297–312.
Abstract: The main objective of the Advanced GAmma Tracking Array (AGATA) is the investigation of the structure of exotic nuclei at the new generation of RIB facilities. As part of the preparatory phase for FAIR-NUSTAR, AGATA is going to be installed at the FRS fragmentation facility of the GSI centre for an experimental campaign to be performed in 2012 and 2013. Owing to its gamma-ray tracking capabilities and the envisaged enhancement in resolving power, a series of in-flight gamma-ray spectroscopy experiments are being planned. The present work describes the conceptual design of this first implementation of AGATA at GSI-FRS, and provides information about the expected performance figures. According to the characteristics of each particular experiment, it is foreseen that the target-array distance is adjusted in order to achieve the optimum compromise between detection efficiency and energy resolution, or to cover an specific angular range of the emitted electromagnetic radiation. Thus, a comprehensive Monte Carlo study of the detection sensitivity in terms of photopeak efficiency, resolution and peak-to-total ratio, as a function of the target-array distance is presented. Several configurations have been investigated, and MC-calculations indicate that a remarkable enhancement in resolving power can be achieved when double-cluster AGATA detectors are developed and implemented. Several experimental effects are also investigated. This concerns the impact of passive materials between the target and the array, the angular distribution of the detection efficiency and the influence of target thickness effects and transition lifetimes in the attainable detection sensitivity. A short overview on half-life measurements via lineshape effects utilizing AGATA is also presented. (C) 2012 Elsevier B.V. All rights reserved.
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