Koolen, B. B., Vidal-Sicart, S., Benlloch, J. M., & Olmos, R. A. V. (2014). Evaluating heterogeneity of primary tumor 18 F-FDG uptake in breast cancer with a dedicated breast PET ( MAMMI): a feasibility study based on correlation with PET/CT. Nucl. Med. Commun., 35(5), 446–452.
Abstract: PurposeThe aim of the study was to evaluate the heterogeneity of primary tumor F-18-fluorodeoxyglucose (F-18-FDG) uptake in breast cancer patients using a dedicated breast PET.Patients and methodsA positron emission tomography/computed tomography (PET/CT) of the thorax was performed 60 min after administration of 180-240 MBq of F-18-FDG in patients with breast cancer. Subsequently, 110 min after injection, a scan was taken with a dedicated high-resolution breast PET [MAMmography with Molecular Imaging (MAMMI)]. Both procedures were performed with the patients in the prone position. Four-point scores were used to compare the intensity (0: none; 1: mild; 2: moderate; 3: high) and heterogeneity (0: none; 1: mild; 2: moderate; 3: high) of F-18-FDG uptake between PET/CT and MAMMI images.ResultsThirty-five patients in whom the primary tumor was visualized on both scans were included in this analysis. The mean primary tumor size was 35.1 mm (range 10-108 mm). The mean intensity score was similar on both devices (2.4 for PET/CT and 2.3 for MAMMI; P=0.439), but the mean heterogeneity score on MAMMI images was significantly higher (PET/CT 1.9 vs. MAMMI 2.3; P=0.005). MAMMI showed a higher heterogeneity score in 11 (31%) of 35 patients, especially in tumors with moderate or high intensity. Significantly higher heterogeneity scores on both PET/CT and MAMMI were seen in large tumors (P=0.005 and 0.014, respectively) and in tumors with high intensity scores (P=0.012 and P<0.001, respectively).ConclusionHeterogeneous tumor F-18-FDG uptake in breast cancer is frequently observed, particularly in large tumors with intense F-18-FDG uptake. It is more often seen on MAMMI PET than on conventional PET/CT. Although the observed heterogeneity should be proven histopathologically, this finding offers a rationale for F-18-FDG-guided biopsies.
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Korichi, A., Lauritsen, T., Wilson, A. N., Dudouet, J., Clement, E., Lalovic, N., et al. (2017). Performance of a gamma-ray tracking array: Characterizing the AGATA array using a Co-60 source. Nucl. Instrum. Methods Phys. Res. A, 872, 80–86.
Abstract: The AGATA (Advanced GAmma Tracking Array) tracking detector is being designed to far surpass the performance of the previous generation, Compton-suppressed arrays. In this paper, a characterization of AGATA is provided based on data from the second GSI campaign. Emphasis is placed on the proper corrections required to extract the absolute photopeak efficiency and peak-to-total ratio. The performance after tracking is extracted and GEANT4 simulations are used both to understand the results and to scale the measurements up to predicted values for the full 4 pi implementation of the device.
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Krzysiek, M. et al, Gadea, A., Huyuk, T., & Barrientos, D. (2014). Study of the soft dipole modes in Ce-140 via inelastic scattering of O-17. Phys. Scr., 89(5), 054016–6pp.
Abstract: The main aim of this study was a deeper understanding of the nuclear structure properties of the soft dipole modes in Ce-140, excited via inelastic scattering of weakly bound O-17 projectiles. An important aim was to investigate the 'splitting' of the PDR into two parts: a low-energy isoscalar component dominated by neutron-skin oscillations and a higher-energy component lying on the tail of the giant dipole resonance of a rather isovector character. This was already observed for this nucleus, investigated in (alpha, alpha') and (gamma,gamma') experiments. The experiment was performed at Laboratori Nazionali di Legnaro, Italy. Inelastic scattering of O-17 ion beam at 20 MeV A(-1) was used to excite the resonance modes in the Ce-140 target. Gamma-rays were registered by five triple clusters of AGATA-Demonstrator and nine large volume scintillators (LaBr3). The scattered O-17 ions were identified by two Delta E – E Si telescopes of the TRACE array mounted inside the scattering chamber. The telescopes consisted of two segmented Si-pad detectors, each of 60 pixels. Very preliminary data have shown a strong domination of the E1 transitions in the 'pygmy' region with a character more similar to the one obtained in alpha scattering experiment.
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Labiche, M. et al, Caballero, L., & Rubio, B. (2010). TIARA: A large solid angle silicon array for direct reaction studies with radioactive beams. Nucl. Instrum. Methods Phys. Res. A, 614(3), 439–448.
Abstract: A compact, quasi-4 pi position sensitive silicon array. TIARA, designed to study direct reactions induced by radioactive beams in inverse kinematics is described here. The Transfer and Inelastic All-angle Reaction Array (TIARA) consists of 8 resistive charge division detectors forming an octagonal barrel around the target and a set of double-sided silicon-strip annular detectors positioned at each end of the barrel. The detector was coupled to the gamma-ray array EXOGAM and the spectrometer VAMOS at the GANIL Laboratory to demonstrate the potential of such an apparatus with radioactive beams. The N-14(d,p)N-15 reaction, well known in direct kinematics, has been carried out in inverse kinematics for that purpose. The observation of the N-15 ground state and excited states at 7.16 and 7.86 MeV is presented here as well as the comparison of the measured proton angular distributions with DWBA calculations. Transferred l-values are in very good agreement with both theoretical calculations and previous experimental results obtained in direct kinematics.
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Lalovic, N., Louchart, C., Michelagnoli, C., Perez-Vidal, R. M., Ralet, D., Gerl, J., et al. (2016). Performance of the AGATA gamma-ray spectrometer in the PreSPEC set-up at GSI. Nucl. Instrum. Methods Phys. Res. A, 806, 258–266.
Abstract: In contemporary nuclear physics, the European Advanced GAmma Tracking Array (AGATA) represents a crucial detection system for cutting-edge nuclear structure studies. AGATA consists of highly segmented high-purity germanium crystals and uses the pulse-shape analysis technique to determine both the position and the energy of the y-ray interaction points in the crystals. It is the tracking algorithms that deploy this information and enable insight into the sequence of interactions, providing information on the full or partial absorption of the 7 ray. A series of dedicated performance measurements for an AGATA set-up comprising 21 crystals is described. This set-up was used within the recent PreSPEC-AGATA experimental campaign at the GSI Helmholtzzentrum fur Schwerionenforschung. Using the radioactive sources Co-56, Co-60 and Eu-152, absolute and normalized efficiencies and the peak-to-total of the array were measured. These quantities are discussed using different data analysis procedures. The quality of the pulse-shape analysis and the tracking algorithm are evaluated. The agreement between the experimental data and the Geant4 simulations is also investigated.
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