Abstract: In order to exploit the advantages of ion-beam therapy in a clinical setting, delivery verification techniques are necessary to detect deviations from the planned treatment. Efforts are currently oriented towards the development of devices for real-time range monitoring. Among the different detector concepts proposed, Compton cameras are employed to detect prompt gammas and represent a valid candidate for real-time range verification. We present the first on-beam test of MACACO, a Compton telescope (multi-layer Compton camera) based on lanthanum bromide crystals and silicon photo-multipliers. The Compton telescope was first characterized through measurements and Monte Carlo simulations. The detector linearity was measured employing Na-22 and Am-Be sources, obtaining about 10% deviation from linearity at 3.44 MeV. A spectral image reconstruction algorithm was tested on synthetic data. Point-like sources emitting gamma rays with energy between 2 and 7 MeV were reconstructed with 3-5 mm resolution. The two-layer Compton telescope was employed to measure radiation emitted from a beam of 150 MeV protons impinging on a cylindrical PMMA target. Bragg-peak shifts were achieved via adjustment of the PMMA target location and the resulting measurements used during image reconstruction. Reconstructed Bragg peak profiles proved sufficient to observe peak-location differences within 10 mm demonstrating the potential of the MACACO Compton Telescope as a monitoring device for ion-beam therapy.

Abstract: The precise connection between the theoretical T, CP, CPT asymmetries, in terms of transition probabilities between the filtered neutral meson B-d states, and the experimental asymmetries, in terms of the double decay rate intensities for Flavour-CP eigenstate decay products in a B-d-factory of entangled states, is established. This allows the identification of genuine Asymmetry Parameters in the time distribution of the asymmetries and their measurability by disentangling genuine and possible fake terms. We express the nine asymmetry parameters three different observables for each one of the three symmetries in terms of the ingredients of the Weisskopf-Wigner dynamical description of the entangled B-d-meson states and we obtain a global fit to their values from the BaBar collaboration experimental results. The possible fake terms are all compatible with zero and the information content of the nine asymmetry parameters is indeed different. The non -vanishing Delta l(c)(T) = 0.687 +/- 0.020 and Delta l(c)(CP) = 0.680 +/- 0.021 are impressive separate direct evidence of Time -Reversal -violation and CP-violation in these transitions and compatible with Standard Model expectations. An intriguing 2 sigma effect for the Re(theta) parameter responsible of CPT -violation appears which, interpreted as an upper limit, leads to vertical bar M (B) over baro (B) over baro vertical bar MBoBo < 4.0 x 10(-5) eV at 95% C.L. for the diagonal flavour terms of the mass matrix. It contributes to the CP-violating Delta l(c)(CP) asymmetry parameter in an unorthodox manner – in its cos(Delta M t) time dependence-, and it is accessible in facilities with non-entangled B-d's, like the LHCb experiment.