Brzezinski, K., Oliver, J. F., Gillam, J., Rafecas, M., Studen, A., Grkovski, M., et al. (2016). Experimental evaluation of the resolution improvement provided by a silicon PET probe. J. Instrum., 11, P09016–13pp.
Abstract: A high-resolution PET system, which incorporates a silicon detector probe into a conventional PET scanner, has been proposed to obtain increased image quality in a limited region of interest. Detailed simulation studies have previously shown that the additional probe information improves the spatial resolution of the reconstructed image and increases lesion detectability, with no cost to other image quality measures. The current study expands on the previous work by using a laboratory prototype of the silicon PET-probe system to examine the resolution improvement in an experimental setting. Two different versions of the probe prototype were assessed, both consisting of a back-to-back pair of 1-mm thick silicon pad detectors, one arranged in 32 x 16 arrays of 1.4mm x 1.4mm pixels and the other in 40 x 26 arrays of 1.0mm x 1.0mm pixels. Each detector was read out by a set of VATAGP7 ASICs and a custom-designed data acquisition board which allowed trigger and data interfacing with the PET scanner, itself consisting of BGO block detectors segmented into 8 x 6 arrays of 6mm x 12mm x 30mm crystals. Limited-angle probe data was acquired from a group of Na-22 point-like sources in order to observe the maximum resolution achievable using the probe system. Data from a Derenzo-like resolution phantom was acquired, then scaled to obtain similar statistical quality as that of previous simulation studies. In this case, images were reconstructed using measurements of the PET ring alone and with the inclusion of the probe data. Images of the Na-22 source demonstrated a resolution of 1.5mm FWHM in the probe data, the PET ring resolution being approximately 6 mm. Profiles taken through the image of the Derenzo-like phantom showed a clear increase in spatial resolution. Improvements in peak-to-valley ratios of 50% and 38%, in the 4.8mm and 4.0mm phantom features respectively, were observed, while previously unresolvable 3.2mm features were brought to light by the addition of the probe. These results support the possibility of improving the image resolution of a clinical PET scanner using the silicon PET-probe.
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Gomez-Cadenas, J. J., Benlloch-Rodriguez, J. M., Ferrario, P., Monrabal, F., Rodriguez, J., & Toledo, J. F. (2016). Investigation of the coincidence resolving time performance of a PET scanner based on liquid xenon: a Monte Carlo study. J. Instrum., 11, P09011–18pp.
Abstract: The measurement of the time of flight of the two 511 keV gammas recorded in coincidence in a PET scanner provides an effective way of reducing the random background and therefore increases the scanner sensitivity, provided that the coincidence resolving time (CRT) of the gammas is sufficiently good. The best commercial PET-TOF system today (based in LYSO crystals and digital SiPMs), is the VEREOS of Philips, boasting a CRT of 316 ps (FWHM). In this paper we present a Monte Carlo investigation of the CRT performance of a PET scanner exploiting the scintillating properties of liquid xenon. We find that an excellent CRT of 70 ps (depending on the PDE of the sensor) can be obtained if the scanner is instrumented with silicon photomultipliers (SiPMs) sensitive to the ultraviolet light emitted by xenon. Alternatively, a CRT of 160 ps can be obtained instrumenting the scanner with (much cheaper) blue-sensitive SiPMs coated with a suitable wavelength shifter. These results show the excellent time of flight capabilities of a PET device based in liquid xenon.
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Moline, A., Schewtschenko, J. A., Palomares-Ruiz, S., Boehm, C., & Baugh, C. M. (2016). Isotropic extragalactic flux from dark matter annihilations: lessons from interacting dark matter scenarios. J. Cosmol. Astropart. Phys., 08(8), 069–23pp.
Abstract: The extragalactic gamma-ray and neutrino emission may have a contribution from dark matter (DM) annihilations. In the case of discrepancies between observations and standard predictions, one could infer the DM pair annihilation cross section into cosmic rays by studying the shape of the energy spectrum. So far all analyses of the extragalactic DM signal have assumed the standard cosmological model (ACDM) as the underlying theory. However, there are alternative DM scenarios where the number of low-mass objects is significantly suppressed. Therefore the characteristics of the gamma-ray and neutrino emission in these models may differ from ACDM as a result. Here we show that the extragalactic isotropic signal in these alternative models has a similar energy dependence to that in ACDM, but the overall normalisation is reduced. The similarities between the energy spectra combined with the flux suppression could lead one to misinterpret possible evidence for models beyond ACDM as being due to CDM particles annihilating with a much weaker cross section than expected.
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LHCb Collaboration(Aaij, R. et al), Garcia Martin, L. M., Martinez-Vidal, F., Oyanguren, A., Remon Alepuz, C., Ruiz Valls, P., et al. (2016). Measurement of the CKM angle gamma from a combination of LHCb results. J. High Energy Phys., 12(12), 087–59pp.
Abstract: A combination of measurements sensitive to the CKM angle gamma from LHCb is performed. The inputs are from analyses of time-integrated B+ -> DK+, B-0 -> DK*(0), B-0 -> DK+ pi(-) and B+ -> DK+ pi(+) pi(-) tree-level decays. In addition, results from a time-dependent analysis of B-s(0) -> (DsK +/-)-K--/+ decays are included. The combination yields = (72: 2(-7.3)(+6:8) 7 : 3)degrees, where the uncertainty includes systematic effects. The 95.5% confidence level interval is determined to be gamma is an element of [55.9, 85.2]degrees. A second combination is investigated, also including measurements from B+ -> DK+, B-0 -> DK*(0), B-0 -> DK+ pi(-) and B+ -> DK+ pi(+) pi decays, which yields compatible results.
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Bertone, G., Calore, F., Caron, S., Ruiz de Austri, R., Kim, J. S., Trotta, R., et al. (2016). Global analysis of the pMSSM in light of the Fermi GeV excess: prospects for the LHC Run-II and astroparticle experiments. J. Cosmol. Astropart. Phys., 04(4), 037–20pp.
Abstract: We present a new global fit of the 19-dimensional phenomenological Minimal Supersymmetric Standard Model (pMSSM-19) that complies with all the latest experimental results from dark matter indirect, direct and accelerator dark matter searches. We show that the model provides a satisfactory explanation of the excess of gamma rays from the Galactic centre observed by the Fermi Large Area Telescope, assuming that it is produced by the annihilation of neutralinos in the Milky Way halo. We identify two regions that pass all the constraints: the first corresponds to neutralinos with a mass similar to 80 – 100 GeV annihilating into WW with a branching ratio of 95%; the second to heavier neutralinos, with mass similar to 180 – 200 GeV annihilating into (l) over barl with a branching ratio of 87%. We show that neutralinos compatible with the Galactic centre GeV excess will soon be within the reach of LHC run-II – notably through searches for charginos and neutralinos, squarks and light smuons – and of Xenon1T, thanks to its unprecedented sensitivity to spin-dependent cross-section off neutrons.
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