Abstract: In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition.

Abstract: We explore quantum corrections of electrically charged black holes subject to vacuum polarization effects of fermion fields in QED. Solving this problem exactly is challenging so we restrict to perturbative corrections that one can obtain using the heat kernel expansion in the one -loop effective action for electrons. Starting from the corrections originally computed by Drummond and Hathrell, we solve the full semiclassical Einstein -Maxwell system of coupled equations to leading order in Planck 's constant and find a new electrically charged, static black hole solution. To probe these quantum corrections, we study electromagnetic and gravitational (axial) perturbations on this background and derive the coupled system of Regge-Wheeler master equations that govern the propagation of these waves. In the classical limit, our results agree with previous findings in the literature. We finally compare these results with those that one can obtain by working out the Euler-Heisenberg effective action. We find again a new electrically charged static black hole spacetime and derive the coupled system of Regge-Wheeler equations governing the propagation of axial electromagnetic and gravitational perturbations. Results are qualitatively similar in both cases. We briefly discuss some challenges found in the numerical computation of the quasinormal mode frequency spectra when quantum corrections are included.

Abstract: Lifetime measurements of low-lying excited states in the semimagic ( N = 50) nucleus 95 Rh have been performed by means of the fast -timing technique. The experiment was carried out using gamma -ray detector arrays consisting of LaBr 3 (Ce) scintillators and germanium detectors integrated into the DESPEC experimental setup commissioned for the Facility for Antiproton and Ion Research ( FAIR ) Phase -0, Darmstadt, Germany. The excited states in 95 Rh were populated primarily via the /3 decays of 95 Pd nuclei, produced in the projectile fragmentation of a 850 MeV / nucleon 124 Xe beam impinging on a 4 g / cm 2 9 Be target. The deduced electromagnetic E2 transition strengths for the gamma -ray cascade within the multiplet structure depopulating from the isomeric I pi = 21 / 2 + state are found to exhibit strong deviations from predictions of standard shell model calculations which feature approximately conserved seniority symmetry. In particular, the observation of a strongly suppressed E2 strength for the 13 / 2 + -> 9 / 2 + ground state transition cannot be explained by calculations employing standard interactions. This remarkable result may require revision of the nucleon-nucleon interactions employed in state-of-the-art theoretical model calculations, and might also point to the need for including three-body forces in the Hamiltonian.

Abstract: The Sun may capture asymmetric dark matter (DM), which can subsequently form bound-states through the radiative emission of a sub-GeV scalar. This process enables generation of scalars without requiring DM annihilation. In addition to DM capture on nucleons, the DM-scalar coupling responsible for bound-state formation also induces capture from self-scatterings of ambient DM particles with DM particles already captured, as well as with DM bound-states formed in-situ within the Sun. This scenario is studied in detail by solving Boltzmann equations numerically and analytically. In particular, we take into consideration that the DM self-capture rates require a treatment beyond the conventional Born approximation. We show that, thanks to DM scatterings on bound-states, the number of DM particles captured increases exponentially, leading to enhanced emission of relativistic scalars through bound-state formation, whose final decay products could be observable. We explore phenomenological signatures with the example that the scalar mediator decays to neutrinos. We find that the neutrino flux emitted can be comparable to atmospheric neutrino fluxes within the range of energies below one hundred MeV. Future facilities like Hyper-K, and direct DM detection experiments can further test such scenario.

Abstract: Searches for anomalous neutral triple gauge boson couplings (NTGCs) provide important tests for the gauge structure of the standard model. In SMEFT (“standard model effective field theory”) NTGCs appear only at the level of dimension-8 operators. While the phenomenology of these operators has been discussed extensively in the literature, renormalizable UV models that can generate these operators are scarce. In this work, we study a variety of extensions of the SM with heavy fermions and calculate their matching to d = 8 NTGC operators. We point out that the complete matching of UV models requires four different CP-conserving d = 8 operators and that the single CPC d = 8 operator, most commonly used by the experimental collaborations, does not describe all possible NTGC form factors. Despite stringent experimental constraints on NTGCs, limits on the scale of UV models are relatively weak, because their contributions are doubly suppressed (being d = 8 and 1-loop). We suggest a series of benchmark UV scenarios suitable for interpreting searches for NTGCs in the upcoming LHC runs, obtain their current limits and provide estimates for the expected sensitivity of the high-luminosity LHC.