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Studen, A., Burdette, D., Chesi, E., Cindro, V., Clinthorne, N. H., Cochran, E., et al. (2010). Timing performance of the silicon PET insert probe. Radiat. Prot. Dosim., 139(1-3), 199–203.
Abstract: Simulation indicates that PET image could be improved by upgrading a conventional ring with a probe placed close to the imaged object. In this paper, timing issues related to a PET probe using high-resistivity silicon as a detector material are addressed. The final probe will consist of several (four to eight) 1-mm thick layers of silicon detectors, segmented into 1 x 1 mm(2) pads, each pad equivalent to an independent p + nn+ diode. A proper matching of events in silicon with events of the external ring can be achieved with a good timing resolution. To estimate the timing performance, measurements were performed on a simplified model probe, consisting of a single 1-mm thick detector with 256 square pads (1.4 mm side), coupled with two VATAGP7s, application-specific integrated circuits. The detector material and electronics are the same that will be used for the final probe. The model was exposed to 511 keV annihilation photons from an Na-22 source, and a scintillator (LYSO)-PMT assembly was used as a timing reference. Results were compared with the simulation, consisting of four parts: (i) GEANT4 implemented realistic tracking of electrons excited by annihilation photon interactions in silicon, (ii) calculation of propagation of secondary ionisation (electron-hole pairs) in the sensor, (iii) estimation of the shape of the current pulse induced on surface electrodes and (iv) simulation of the first electronics stage. A very good agreement between the simulation and the measurements were found. Both indicate reliable performance of the final probe at timing windows down to 20 ns.
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Studen, A., Brzezinski, K., Chesi, E., Cindro, V., Clinthorne, N. H., Cochran, E., et al. (2013). Silicon detectors for combined MR-PET and MR-SPECT imaging. Nucl. Instrum. Methods Phys. Res. A, 702, 88–90.
Abstract: Silicon based devices can extend PET-MR and SPECT-MR imaging to applications, where their advantages in performance outweigh benefits of high statistical counts. Silicon is in many ways an excellent detector material with numerous advantages, among others: excellent energy and spatial resolution, mature processing technology, large signal to noise ratio, relatively low price, availability, versatility and malleability. The signal in silicon is also immune to effects of magnetic field at the level normally used in MR devices. Tests in fields up to 7 T were performed in a study to determine effects of magnetic field on positron range in a silicon PET device. The curvature of positron tracks in direction perpendicular to the field's orientation shortens the distance between emission and annihilation point of the positron. The effect can be fully appreciated for a rotation of the sample for a fixed field direction, compressing range in all dimensions. A popular Ga-68 source was used showing a factor of 2 improvement in image noise compared to zero field operation. There was also a little increase in noise as the reconstructed resolution varied between 2.5 and 1.5 mm. A speculative applications can be recognized in both emission modalities, SPECT and PET. Compton camera is a subspecies of SPECT, where a silicon based scatter as a MR compatible part could inserted into the MR bore and the secondary detector could operate in less constrained environment away from the magnet. Introducing a Compton camera also relaxes requirements of the radiotracers used, extending the range of conceivable photon energies beyond 140.5 keV of the Tc-99m. In PET, one could exploit the compressed sub-millimeter range of positrons in the magnetic field. To exploit the advantage, detectors with spatial resolution commensurate to the effect must be used with silicon being an excellent candidate. Measurements performed outside of the MR achieving spatial resolution below 1 mm are reported.
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Strege, C., Bertone, G., Feroz, F., Fornasa, M., Ruiz de Austri, R., & Trotta, R. (2013). Global fits of the cMSSM and NUHM including the LHC Higgs discovery and new XENON100 constraints. J. Cosmol. Astropart. Phys., 04(4), 013–40pp.
Abstract: We present global fits of the constrained Minimal Supersymmetric Standard Model (cMSSM) and the Non-Universal Higgs Model (NUHM), including the most recent CMS constraint on the Higgs boson mass, 5.8 fb(-1) integrated luminosity null Supersymmetry searches by ATLAS, the new LHCb measurement of B R ((B) over bar (s) -> mu(+) mu(-)) and the 7-year WMAP dark matter relic abundance determination. We include the latest dark matter constraints from the XENON100 experiment, marginalising over astrophysical and particle physics uncertainties. We present Bayesian posterior and profile likelihood maps of the highest resolution available today, obtained from up to 350M points. We find that the new constraint on the Higgs boson mass has a dramatic impact, ruling out large regions of previously favoured cMSSM and NUHM parameter space. In the cMSSM, light sparticles and predominantly gaugino-like dark matter with a mass of a few hundred GeV are favoured. The NUHM exhibits a strong preference for heavier sparticle masses and a Higgsino-like neutralino with a mass of 1 TeV. The future ton-scale XENON1T direct detection experiment will probe large portions of the currently favoured cMSSM and NUHM parameter space. The LHC operating at 14 TeV collision energy will explore the favoured regions in the cMSSM, while most of the regions favoured in the NUHM will remain inaccessible. Our best-fit points achieve a satisfactory quality-of-fit, with p-values ranging from 0.21 to 0.35, so that none of the two models studied can be presently excluded at any meaningful significance level.
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Strege, C., Bertone, G., Cerdeño, D. G., Fornasa, M., Ruiz de Austri, R., & Trotta, R. (2012). Updated global fits of the cMSSM including the latest LHC SUSY and Higgs searches and XENON100 data. J. Cosmol. Astropart. Phys., 03(3), 030–22pp.
Abstract: We present new global fits of the constrained Minimal Supersymmetric Standard Model (cMSSM), including LHC 1/fb integrated luminosity SUSY exclusion limits, recent LHC 5/fb constraints on the mass of the Higgs boson and XENON100 direct detection data. Our analysis fully takes into account astrophysical and hadronic uncertainties that enter the analysis when translating direct detection limits into constraints on the cMSSM parameter space. We provide results for both a Bayesian and a Frequentist statistical analysis. We find that LHC 2011 constraints in combination with XENON100 data can rule out a significant portion of the cMSSM parameter space. Our results further emphasise the complementarity of collider experiments and direct detection searches in constraining extensions of Standard Model physics. The LHC 2011 exclusion limit strongly impacts on low-mass regions of cMSSM parameter space, such as the stau co-annihilation region, while direct detection data can rule out regions of high SUSY masses, such as the Focus-Point region, which is unreachable for the LHC in the near future. We show that, in addition to XENON100 data, the experimental constraint on the anomalous magnetic moment of the muon plays a dominant role in disfavouring large scalar and gaugino masses. We find that, should the LHC 2011 excess hinting towards a Higgs boson at 126 GeV be confirmed, currently favoured regions of the cMSSM parameter space will be robustly ruled out from both a Bayesian and a profile likelihood statistical perspective.
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Strege, C., Bertone, G., Besjes, G. J., Caron, S., Ruiz de Austri, R., Strubig, A., et al. (2014). Profile likelihood maps of a 15-dimensional MSSM. J. High Energy Phys., 09(9), 081–59pp.
Abstract: We present statistically convergent profile likelihood maps obtained via global fits of a phenomenological Minimal Supersymmetric Standard Model with 15 free parameters (the MSSM-15), based on over 250M points. We derive constraints on the model parameters from direct detection limits on dark matter, the Planck relic density measurement and data from accelerator searches. We provide a detailed analysis of the rich phenomenology of this model, and determine the SUSY mass spectrum and dark matter properties that are preferred by current experimental constraints. We evaluate the impact of the measurement of the anomalous magnetic moment of the muon (g – 2) on our results, and provide an analysis of scenarios in which the lightest neutralino is a subdominant component of the dark matter. The MSSM-15 parameters are relatively weakly constrained by current data sets, with the exception of the parameters related to dark matter phenomenology (M-1, M-2, mu), which are restricted to the sub-TeV regime, mainly due to the relic density constraint. The mass of the lightest neutralino is found to be < 1.5TeV at 99% C.L., but can extend up to 3 TeV when excluding the g – 2 constraint from the analysis. Low-mass bino-like neutralinos are strongly favoured, with spin-independent scattering cross-sections extending to very small values, similar to 10(-20) pb. ATLAS SUSY null searches strongly impact on this mass range, and thus rule out a region of parameter space that is outside the reach of any current or future direct detection experiment. The best-fit point obtained after inclusion of all data corresponds to a squark mass of 2.3 TeV, a gluino mass of 2.1 TeV and a 130 GeV neutralino with a spin-independent cross-section of 2.4 x 10(-10) pb, which is within the reach of future multi-ton scale direct detection experiments and of the upcoming LHC run at increased centre-of-mass energy.
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