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Peppa, V., Thomson, R. M., Enger, S. A., Fonseca, G. P., Lee, C. N., Lucero, J. N. E., et al. (2023). A MC-based anthropomorphic test case for commissioning model-based dose calculation in interstitial breast 192-Ir HDR brachytherapy. Med. Phys., 50(7), 4675–4687.
Abstract: PurposeTo provide the first clinical test case for commissioning of Ir-192 brachytherapy model-based dose calculation algorithms (MBDCAs) according to the AAPM TG-186 report workflow. Acquisition and Validation MethodsA computational patient phantom model was generated from a clinical multi-catheter Ir-192 HDR breast brachytherapy case. Regions of interest (ROIs) were contoured and digitized on the patient CT images and the model was written to a series of DICOM CT images using MATLAB. The model was imported into two commercial treatment planning systems (TPSs) currently incorporating an MBDCA. Identical treatment plans were prepared using a generic Ir-192 HDR source and the TG-43-based algorithm of each TPS. This was followed by dose to medium in medium calculations using the MBDCA option of each TPS. Monte Carlo (MC) simulation was performed in the model using three different codes and information parsed from the treatment plan exported in DICOM radiation therapy (RT) format. Results were found to agree within statistical uncertainty and the dataset with the lowest uncertainty was assigned as the reference MC dose distribution. Data Format and Usage NotesThe dataset is available online at ,. Files include the treatment plan for each TPS in DICOM RT format, reference MC dose data in RT Dose format, as well as a guide for database users and all files necessary to repeat the MC simulations. Potential ApplicationsThe dataset facilitates the commissioning of brachytherapy MBDCAs using TPS embedded tools and establishes a methodology for the development of future clinical test cases. It is also useful to non-MBDCA adopters for intercomparing MBDCAs and exploring their benefits and limitations, as well as to brachytherapy researchers in need of a dosimetric and/or a DICOM RT information parsing benchmark. Limitations include specificity in terms of radionuclide, source model, clinical scenario, and MBDCA version used for its preparation.
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Peñuelas, A., & Pich, A. (2017). Flavour alignment in multi-Higgs-doublet models. J. High Energy Phys., 12(12), 084–34pp.
Abstract: Extended electroweak scalar sectors containing several doublet multiplets require flavour-aligned Yukawa matrices to prevent the appearance at tree level of unwanted flavour-changing neutral-current transitions. We analyse the misalignment induced by one-loop quantum corrections and explore possible generalizations of the alignment condition and their compatibility with current experimental constraints. The hypothesis of flavour alignment at a high scale turns out to be consistent with all known phenomenological tests.
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Penas, J., Alejo, A., Bembibre, A., Apiñaniz, J. I., Garcia-Garcia, E., Guerrero, C., et al. (2024). Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source. Sci Rep, 14(1), 11448–12pp.
Abstract: Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the first time the use of a high-repetition rate, ultra-intense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10-14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} B(p,n) 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Significant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-the-art technology (10 Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range.
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Penalva, N., Hernandez, E., & Nieves, J. (2019). Further tests of lepton flavor universality from the charged lepton energy distribution in b -> c semileptonic decays: The case of Lambda(b) -> Lambda(c) l(v)over-bar(l). Phys. Rev. D, 100(11), 113007–11pp.
Abstract: In a general framework, valid for any H -> H' l(-)(v) over bar (l) semileptonic decay, we analyze the d(2)Gamma/(d omega d cos theta(l)) and d(2)Gamma/(d omega dE(l)) distributions, with omega being the product of the hadron four-velocities, theta(l) the angle made by the three-momenta of the charged lepton and the final hadron in the W- center of mass frame and E-l the charged lepton energy in the decaying hadron rest frame. Within the Standard Model (SM), d(2)Gamma/(d omega dE(l)) proportional to (c(0) (omega) c(1) (omega)E-l/M + c(2) (omega)E-l(2)/M-2), with M the initial hadron mass. We find that c(2) (omega) is independent of the lepton flavor and thus it is an ideal candidate to look for lepton flavor universality (LFU) violations. We also find a correlation between the a(2) (omega) structure function, which governs the (cos theta(l))(2) dependence of d(2)Gamma/(d omega d cos theta(l)), and c(2) (omega). Apart from trivial kinematical and mass factors, the ratio of a(2) (omega)/c(2) (omega) is a universal function that can be measured in any semileptonic decay, involving not only b -> c transitions. These two SM predictions can be used as new tests in the present search for signatures of LFU violations. We also generalize the formalism to account for some new physics (NP) terms, and show that neither c(2) nor a(2) are modified by left and right scalar NP terms, being however sensitive to left and right vector corrections. We also find that the a(2)/c(2) ratio is not modified by these latter NP contributions. Finally, and in order to illustrate our findings, we apply our general framework to the Lambda(b) -> Lambda(c)l (v) over bar (l) decay. We show that a measurement of c(2) (or a(2)) for tau decay would not only be a direct measurement of the possible existence of NP, but it would also allow to distinguish from NP fits to b -> c tau(v) over bar (tau) anomalies in the meson sector, which otherwise give the same total and differential d Gamma/d omega widths. We show that the same occurs for the other two terms, c(0) and c(1), that appear in d(2)Gamma/(d omega dE(l)), and for the cos theta(l) linear term of the angular distribution.
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Penalva, N., Hernandez, E., & Nieves, J. (2020). Hadron and lepton tensors in semileptonic decays including new physics. Phys. Rev. D, 101(11), 113004–24pp.
Abstract: We extend our general framework for semileptonic decay, originally introduced in N. Penalva et al. [Phys. Rev. D 100, 113007 (2019)], with the addition of new physics (NP) tensor terms. In this way, all the NP effective Hamiltonians that are considered in lepton flavor universality violation (LFUV) studies have now been included. Those are left and right vector and scalar NP Hamiltonians and the NP tensor one. Besides, we now also give general expressions that allow for complex Wilson coefficients. The scheme developed is totally general and it can be applied to any charged current semileptonic decay, involving any quark flavors or initial and final hadron states. We show that all the hadronic input, including NP effects, can be parametrized in terms of 16 Lorentz scalar structure functions, constructed out of the NP complex Wilson coefficients and the genuine hadronic responses, with the latter determined by the matrix elements of the involved hadron operators. In the second part of this work, we use this formalism to obtain the complete NP effects in the Ab Acr(/ semileptonic decay, where LFUV, if finally confirmed, is also expected to be seen. We- stress the relevance of the center of mass (CM) d2F/ (dwd cos 0i) and laboratory (LAB) d2F/(dwdE,) differential decay widths, with (o the product of the hadron four-velocities, Oe the angle made by the three -momenta of the charged lepton and the final hadron in the 11/- CM frame and the charged lepton energy in the decaying hadron rest frame. While models with very different strengths in the NP terms give the same differential d17 do) and total decay widths for this decay, they predict very different numerical results for some of the cos (.),, and E coefficient -functions that determine the above two distributions. Thus, the combined analysis of the CM d2F1(dcodcos0,,) and LAB d21'/(doidE,.) differential decay widths will help clarifying what kind of NP is a better candidate in order to explain LFUV.
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