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Llosa, G., Barrillon, P., Barrio, J., Bisogni, M. G., Cabello, J., Del Guerra, A., et al. (2013). High performance detector head for PET and PET/MR with continuous crystals and SiPMs. Nucl. Instrum. Methods Phys. Res. A, 702, 3–5.
Abstract: A high resolution PET detector head for small animal PET applications has been developed. The detector is composed of a 12 mm x 12 mm continuous LYSO crystal coupled to a 64-channel monolithic SiPM matrix from FBK-irst. Crystal thicknesses of 5 mm and 10 mm have been tested, both yielding an intrinsic spatial resolution around 0.7 mm FWHM with a position determination algorithm that can also provide depth-of-interaction information. The detectors have been tested in a rotating system that makes it possible to acquire tomographic data and reconstruct images of Na-22 sources. An image reconstruction method specifically adapted for continuous crystals has been employed. The Full Width at Half Maximum measured from a point source reconstructed with ML-EM was 0.7 mm with the 5 mm crystal and 0.8 mm with the 10 mm crystal.
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Llosa, G. (2015). Recent developments in photodetection for medical applications. Nucl. Instrum. Methods Phys. Res. A, 787, 353–357.
Abstract: The use of the most advanced technology in medical imaging results in the development of high performance detectors that can significantly improve the performance of the medical devices employed in hospitals. Scintillator crystals coupled to photodetectors remain to be essential detectors in terms of performance and cost for medical imaging applications in different imaging modalities. Recent advances in photodetectors result in an increase of the performance of the medical scanners. Solid state detectors can provide substantial performance improvement, but are more complex to integrate into clinical detectors due mainly to their higher cost. Solid state photodetectors (APDs, SiPMs) have made new detector concepts possible and have led to improvements in different imaging modalities. Recent advances in detectors for medical imaging are revised.
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Linhart, V., Burdette, D., Chessi, E., Cindro, V., Clinthorne, N. H., Cochran, E., et al. (2011). Spectroscopy study of imaging devices based on silicon Pixel Array Detector coupled to VATAGP7 read-out chips. J. Instrum., 6, C01092–8pp.
Abstract: Spectroscopic and timing response studies have been conducted on a detector module consisting of a silicon Pixel Array Detector bonded on two VATAGP7 read-out chips manufactured by Gamma-Medica Ideas using laboratory gamma sources and the internal calibration facilities (the calibration system of the read-out chips). The performed tests have proven that the chips have (i) non-linear calibration curves which can be approximated by power functions, (ii) capability to measure the energy of photons with energy resolution better than 2 keV (exact range and resolution depend on experimental setup), (iii) the internal calibration facility which provides 6 out of 16 available internal calibration charges within our region of interest (spanning the Compton edge of 511 keV photons). The peaks induced by the internal calibration facility are suitable for a fit of the calibration curves. However, they are not suitable for measurements of equivalent noise charge because their full width at half maximum varies with their amplitude. These facts indicate that the VATAGP7 chips are useful and precise tools for a wide variety of spectroscopic devices. We have also explored time walk of the module and peaking time of the spectroscopy signals provided by the chips. We have observed that (iv) the time walk is caused partly by the peaking time of the signals provided by the fast shaper of the chips and partly by the timing uncertainty related to the varying position of the photon interaction, (v) the peaking time of the spectroscopy signals provided by the chips increases with increasing pulse height.
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Koolen, B. B., Vidal-Sicart, S., Benlloch, J. M., & Olmos, R. A. V. (2014). Evaluating heterogeneity of primary tumor 18 F-FDG uptake in breast cancer with a dedicated breast PET ( MAMMI): a feasibility study based on correlation with PET/CT. Nucl. Med. Commun., 35(5), 446–452.
Abstract: PurposeThe aim of the study was to evaluate the heterogeneity of primary tumor F-18-fluorodeoxyglucose (F-18-FDG) uptake in breast cancer patients using a dedicated breast PET.Patients and methodsA positron emission tomography/computed tomography (PET/CT) of the thorax was performed 60 min after administration of 180-240 MBq of F-18-FDG in patients with breast cancer. Subsequently, 110 min after injection, a scan was taken with a dedicated high-resolution breast PET [MAMmography with Molecular Imaging (MAMMI)]. Both procedures were performed with the patients in the prone position. Four-point scores were used to compare the intensity (0: none; 1: mild; 2: moderate; 3: high) and heterogeneity (0: none; 1: mild; 2: moderate; 3: high) of F-18-FDG uptake between PET/CT and MAMMI images.ResultsThirty-five patients in whom the primary tumor was visualized on both scans were included in this analysis. The mean primary tumor size was 35.1 mm (range 10-108 mm). The mean intensity score was similar on both devices (2.4 for PET/CT and 2.3 for MAMMI; P=0.439), but the mean heterogeneity score on MAMMI images was significantly higher (PET/CT 1.9 vs. MAMMI 2.3; P=0.005). MAMMI showed a higher heterogeneity score in 11 (31%) of 35 patients, especially in tumors with moderate or high intensity. Significantly higher heterogeneity scores on both PET/CT and MAMMI were seen in large tumors (P=0.005 and 0.014, respectively) and in tumors with high intensity scores (P=0.012 and P<0.001, respectively).ConclusionHeterogeneous tumor F-18-FDG uptake in breast cancer is frequently observed, particularly in large tumors with intense F-18-FDG uptake. It is more often seen on MAMMI PET than on conventional PET/CT. Although the observed heterogeneity should be proven histopathologically, this finding offers a rationale for F-18-FDG-guided biopsies.
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Grkovski, M., Brzezinski, K., Cindro, V., Clinthorne, N. H., Kagan, H., Lacasta, C., et al. (2015). Evaluation of a high resolution silicon PET insert module. Nucl. Instrum. Methods Phys. Res. A, 788, 86–94.
Abstract: Conventional PET systems can be augmented with additional detectors placed in close proximity of the region of interest. We developed a high resolution PET insert module to evaluate the added benefit of such a combination. The insert module consists of two back-to-back 1 mm thick silicon sensors, each segmented into 1040 1 mm(2) pads arranged in a 40 by 26 array. A set of 16 VATAGP7.1 ASICs and a custom assembled data acquisition board were used to read out the signal from the insert module. Data were acquired in slice (20) geometry with a Jaszczak phantom (rod diameters of 12-4.8 mm) Filled with F-18-FDG and the images were reconstructed with ML-EM method. Both data with full and limited angular coverage from the insert module were considered and three types of coincidence events were combined. The ratio of high-resolution data that substantially improves quality of the reconstructed image for the region near the surface of the insert module was estimated to be about 4%. Results from our previous studies suggest that such ratio could be achieved at a moderate technological expense by using an equivalent of two insert modules (an effective sensor thickness of 4 mm).
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Gomez-Cadenas, J. J., Benlloch-Rodriguez, J. M., Ferrario, P., Monrabal, F., Rodriguez, J., & Toledo, J. F. (2016). Investigation of the coincidence resolving time performance of a PET scanner based on liquid xenon: a Monte Carlo study. J. Instrum., 11, P09011–18pp.
Abstract: The measurement of the time of flight of the two 511 keV gammas recorded in coincidence in a PET scanner provides an effective way of reducing the random background and therefore increases the scanner sensitivity, provided that the coincidence resolving time (CRT) of the gammas is sufficiently good. The best commercial PET-TOF system today (based in LYSO crystals and digital SiPMs), is the VEREOS of Philips, boasting a CRT of 316 ps (FWHM). In this paper we present a Monte Carlo investigation of the CRT performance of a PET scanner exploiting the scintillating properties of liquid xenon. We find that an excellent CRT of 70 ps (depending on the PDE of the sensor) can be obtained if the scanner is instrumented with silicon photomultipliers (SiPMs) sensitive to the ultraviolet light emitted by xenon. Alternatively, a CRT of 160 ps can be obtained instrumenting the scanner with (much cheaper) blue-sensitive SiPMs coated with a suitable wavelength shifter. These results show the excellent time of flight capabilities of a PET device based in liquid xenon.
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Gomez-Cadenas, J. J., Benlloch-Rodriguez, J. M., & Ferrario, P. (2016). Application of scintillating properties of liquid xenon and silicon photomultiplier technology to medical imaging. Spectroc. Acta Pt. B, 118, 6–13.
Abstract: We describe a new positron emission time-of-flight apparatus using liquid xenon. The detector is based in a liquid xenon scintillating cell. The cell shape and dimensions can be optimized depending on the intended application. In its simplest form, the liquid xenon scintillating cell is a box in which two faces are covered by silicon photomultipliers and the others by a reflecting material such as Teflon. It is a compact, homogenous and highly efficient detector which shares many of the desirable properties of monolithic crystals, with the added advantage of high yield and fast scintillation offered by liquid xenon. Our initial studies suggest that good energy and spatial resolution comparable with that achieved by lutetium oxyorthosilicate crystals can be obtained with a detector based in liquid xenon scintillating cells. In addition, the system can potentially achieve an excellent coincidence resolving time of better than 100 ps.
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Gomez-Cadenas, J. J., Benlloch-Rodriguez, J. M., & Ferrario, P. (2017). Monte Carlo study of the coincidence resolving time of a liquid xenon PET scanner, using Cherenkov radiation. J. Instrum., 12, P08023–13pp.
Abstract: In this paper we use detailed Monte Carlo simulations to demonstrate that liquid xenon (LXe) can be used to build a Cherenkov-based TOF-PET, with an intrinsic coincidence resolving time (CRT) in the vicinity of 10 ps. This extraordinary performance is due to three facts: a) the abundant emission of Cherenkov photons by liquid xenon; b) the fact that LXe is transparent to Cherenkov light; and c) the fact that the fastest photons in LXe have wavelengths higher than 300 nm, therefore making it possible to separate the detection of scintillation and Cherenkov light. The CRT in a Cherenkov LXe TOF-PET detector is, therefore, dominated by the resolution (time jitter) introduced by the photosensors and the electronics. However, we show that for sufficiently fast photosensors (e.g, an overall 40 ps jitter, which can be achieved by current micro-channel plate photomultipliers) the overall CRT varies between 30 and 55 ps, depending on the detection efficiency. This is still one order of magnitude better than commercial CRT devices and improves by a factor 3 the best CRT obtained with small laboratory prototypes.
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Gillam, J. E., Solevi, P., Oliver, J. F., Casella, C., Heller, M., Joram, C., et al. (2014). Sensitivity recovery for the AX-PET prototype using inter-crystal scattering events. Phys. Med. Biol., 59(15), 4065–4083.
Abstract: The development of novel detection devices and systems such as the AX-positron emission tomography (PET) demonstrator often introduce or increase the measurement of atypical coincidence events such as inter-crystal scattering (ICS). In more standard systems, ICS events often go undetected and the small measured fraction may be ignored. As the measured quantity of such events in the data increases, so too does the importance of considering them during image reconstruction. Generally, treatment of ICS events will attempt to determine which of the possible candidate lines of response (LoRs) correctly determine the annihilation photon trajectory. However, methods of assessment often have low success rates or are computationally demanding. In this investigation alternative approaches are considered. Experimental data was taken using the AX-PET prototype and a NEMA phantom. Three methods of ICS treatment were assessed-each of which considered all possible candidate LoRs during image reconstruction. Maximum likelihood expectation maximization was used in conjunction with both standard (line-like) and novel (V-like in this investigation) detection responses modeled within the system matrix. The investigation assumed that no information other than interaction locations was available to distinguish between candidates, yet the methods assessed all provided means by which such information could be included. In all cases it was shown that the signal to noise ratio is increased using ICS events. However, only one method, which used full modeling of the ICS response in the system matrix-the V-like model-provided enhancement in all figures of merit assessed in this investigation. Finally, the optimal method of ICS incorporation was demonstrated using data from two small animals measured using the AX-PET demonstrator.
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Etxebeste, A., Barrio, J., Bernabeu, J., Lacasta, C., Llosa, G., Muñoz, E., et al. (2019). Study of sensitivity and resolution for full ring PET prototypes based on continuous crystals and analytical modeling of the light distribution. Phys. Med. Biol., 64(3), 035015–17pp.
Abstract: Sensitivity and spatial resolution are the main parameters to maximize in the performance of a PET scanner. For this purpose, detectors consisting of a combination of continuous crystals optically coupled to segmented photodetectors have been employed. With the use of continuous crystals the sensitivity is increased with respect to the pixelated crystals. In addition, spatial resolution is no longer limited to the crystal size. The main drawback is the difficulty in determining the interaction position. In this work, we present the characterization of the performance of a full ring based on cuboid continuous crystals coupled to SiPMs. To this end, we have employed the simulations developed in a previous work for our experimental detector head. Sensitivity could be further enhanced by using tapered crystals. This enhancement is obtained by increasing the solid angle coverage, reducing the wedge-shaped gaps between contiguous detectors. The performance of the scanners based on both crystal geometries was characterized following NEMA NU 4-2008 standardized protocol in order to compare them. An average sensitivity gain over the entire axial field of view of 13.63% has been obtained with tapered geometry while similar performance of the spatial resolution has been proven with both scanners. The activity at which NECR and true peak occur is smaller and the peak value is greater for tapered crystals than for cuboid crystals. Moreover, a higher degree of homogeneity was obtained in the sensitivity map due to the tighter packing of the crystals, which reduces the gaps and results in a better recovery of homogeneous regions than for the cuboid configuration. Some of the results obtained, such as spatial resolution, depend on the interaction position estimation and may vary if other method is employed.
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