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Di Bari, P., King, S. F., & Hossain Rahat, M. (2024). Gravitational waves from phase transitions and cosmic strings in neutrino mass models with multiple majorons. J. High Energy Phys., 05(5), 068–31pp.
Abstract: We explore the origin of Majorana masses within the majoron model and how this can lead to the generation of a distinguishable primordial stochastic background of gravitational waves. We first show how in the simplest majoron model only a contribution from cosmic string can be within the reach of planned experiments. We then consider extensions containing multiple complex scalars, demonstrating how in this case a spectrum comprising contributions from both a strong first order phase transition and cosmic strings can naturally emerge. We show that the interplay between multiple scalar fields can amplify the phase transition signal, potentially leading to double peaks over the wideband sloped spectrum from cosmic strings. We also underscore the possibility of observing such a gravitational wave background to provide insights into the reheating temperature of the universe. We conclude highlighting how the model can be naturally combined with scenarios addressing the origin of matter of the universe, where baryogenesis occurs via leptogenesis and a right-handed neutrino plays the role of dark matter.
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Di Gregorio, E., Staelens, M., Hosseinkhah, N., Karimpoor, M., Liburd, J., Lim, L., et al. (2024). Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases. Nanomaterials, 14(13), 1093–21pp.
Abstract: In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition.
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Domcke, V., Ema, Y., & Sandner, S. (2024). Perturbatively including inhomogeneities in axion inflation. J. Cosmol. Astropart. Phys., 03(3), 019–24pp.
Abstract: Axion inflation, i.e. an axion-like inflaton coupled to an Abelian gauge field through a Chern-Simons interaction, comes with a rich and testable phenomenology. This is particularly true in the strong backreaction regime, where the gauge field production heavily impacts the axion dynamics. Lattice simulations have recently demonstrated the importance of accounting for inhomogeneities of the axion field in this regime. We propose a perturbative scheme to account for these inhomogeneities while maintaining high computational efficiency. Our goal is to accurately capture deviations from the homogeneous axion field approximation within the perturbative regime as well as self -consistently determine the onset of the nonperturbative regime.
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Domcke, V., Garcia-Cely, C., Lee, S. M., & Rodd, N. L. (2024). Symmetries and selection rules: optimising axion haloscopes for Gravitational Wave searches. J. High Energy Phys., 03(3), 128–51pp.
Abstract: In the presence of electromagnetic fields, both axions and gravitational waves (GWs) induce oscillating magnetic fields: a potentially detectable fingerprint of their presence. We demonstrate that the response is largely dictated by the symmetries of the instruments used to search for it. Focussing on low mass axion haloscopes, we derive selection rules that determine the parametric sensitivity of different detector geometries to axions and GWs, and which further reveal how to optimise the experimental geometry to maximise both signals. The formalism allows us to forecast the optimal sensitivity to GWs in the range of 100 kHz to 100 MHz for instruments such as ABRACADABRA, BASE, ADMX SLIC, SHAFT, WISPLC, and DMRadio.
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Easa, H., Gregoire, T., Stolarski, D., & Cosme, C. (2024). Baryogenesis and dark matter in multiple hidden sectors. Phys. Rev. D, 109(7), 075003–29pp.
Abstract: We explore a mechanism for producing the baryon asymmetry and dark matter in models with multiple hidden sectors that are Standard -Model -like but with varying Higgs mass parameters. If the field responsible for reheating the Standard Model and the exotic sectors carries an asymmetry, it can be converted into a baryon asymmetry using the standard sphaleron process. A hidden sector with positive Higgs mass squared can accommodate dark matter with its baryon asymmetry, and the larger abundance of dark matter relative to baryons is due to dark sphalerons being active all the way down the hidden sector QCD scale. This scenario predicts that dark matter is clustered in large dark nuclei and gives a lower bound on the effective relativistic degrees of freedom, Delta N eff greater than or similar to 0 .05 , which may be observable in the nextgeneration cosmic microwave background experiment CMB-S4.
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