Muñoz, E., Ros, A., Borja-Lloret, M., Barrio, J., Dendooven, P., Oliver, J. F., et al. (2021). Proton range verification with MACACO II Compton camera enhanced by a neural network for event selection. Sci Rep, 11(1), 9325–12pp.
Abstract: The applicability extent of hadron therapy for tumor treatment is currently limited by the lack of reliable online monitoring techniques. An active topic of investigation is the research of monitoring systems based on the detection of secondary radiation produced during treatment. MACACO, a multi-layer Compton camera based on LaBr3 scintillator crystals and SiPMs, is being developed at IFIC-Valencia for this purpose. This work reports the results obtained from measurements of a 150 MeV proton beam impinging on a PMMA target. A neural network trained on Monte Carlo simulations is used for event selection, increasing the signal to background ratio before image reconstruction. Images of the measured prompt gamma distributions are reconstructed by means of a spectral reconstruction code, through which the 4.439 MeV spectral line is resolved. Images of the emission distribution at this energy are reconstructed, allowing calculation of the distal fall-off and identification of target displacements of 3 mm.
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Muñoz, E., Barrio, J., Etxebeste, A., Ortega, P. G., Lacasta, C., Oliver, J. F., et al. (2017). Performance evaluation of MACACO: a multilayer Compton camera. Phys. Med. Biol., 62(18), 7321–7341.
Abstract: Compton imaging devices have been proposed and studied for a wide range of applications. We have developed a Compton camera prototype which can be operated with two or three detector layers based on monolithic lanthanum bromide (LaBr3) crystals coupled to silicon photomultipliers (SiPMs), to be used for proton range verification in hadron therapy. In this work, we present the results obtained with our prototype in laboratory tests with radioactive sources and in simulation studies. Images of a Na-22 and an Y-88 radioactive sources have been successfully reconstructed. The full width half maximum of the reconstructed images is below 4 mm for a Na-22 source at a distance of 5 cm.
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Muñoz, E., Barrio, J., Bernabeu, J., Etxebeste, A., Lacasta, C., Llosa, G., et al. (2018). Study and comparison of different sensitivity models for a two-plane Compton camera. Phys. Med. Biol., 63(13), 135004–19pp.
Abstract: Given the strong variations in the sensitivity of Compton cameras for the detection of events originating from different points in the field of view (FoV), sensitivity correction is often necessary in Compton image reconstruction. Several approaches for the calculation of the sensitivity matrix have been proposed in the literature. While most of these models are easily implemented and can be useful in many cases, they usually assume high angular coverage over the scattered photon, which is not the case for our prototype. In this work, we have derived an analytical model that allows us to calculate a detailed sensitivity matrix, which has been compared to other sensitivity models in the literature. Specifically, the proposed model describes the probability of measuring a useful event in a two-plane Compton camera, including the most relevant physical processes involved. The model has been used to obtain an expression for the system and sensitivity matrices for iterative image reconstruction. These matrices have been validated taking Monte Carlo simulations as a reference. In order to study the impact of the sensitivity, images reconstructed with our sensitivity model and with other models have been compared. Images have been reconstructed from several simulated sources, including point-like sources and extended distributions of activity, and also from experimental data measured with Na-22 sources. Results show that our sensitivity model is the best suited for our prototype. Although other models in the literature perform successfully in many scenarios, they are not applicable in all the geometrical configurations of interest for our system. In general, our model allows to effectively recover the intensity of point-like sources at different positions in the FoV and to reconstruct regions of homogeneous activity with minimal variance. Moreover, it can be employed for all Compton camera configurations, including those with low angular coverage over the scatterer.
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Muñoz, E., Barrio, J., Bemmerer, D., Etxebeste, A., Fiedler, F., Hueso-Gonzalez, F., et al. (2018). Tests of MACACO Compton telescope with 4.44 MeV gamma rays. J. Instrum., 13, P05007–13pp.
Abstract: Hadron therapy offers the possibility of delivering a large amount of radiation dose to tumors with minimal absorption by the surrounding healthy tissue. In order to fully exploit the advantages of this technique, the use of real-time beam monitoring devices becomes mandatory. Compton imaging devices can be employed to map the distribution of prompt gamma emission during the treatment and thus assess its correct delivery. The Compton telescope prototype developed at IFIC-Valencia for this purpose is made of three layers of LaBr3 crystals coupled to silicon photomultipliers. The system has been tested in a 4.44 MeV gamma field at the 3 MV Tandetron accelerator at HZDR, Dresden. Images of the target with the system in three different positions separated by 10 mm were successfully reconstructed. This indicates the ability of MACACO for imaging the prompt gamma rays emitted at such energies.
Keywords: Compton imaging; Instrumentation for hadron therapy; Gamma detectors (scintillators, CZT, HPG, HgI etc); Photon detectors for UV, visible and IR photons (solid state) (PIN diodes, APDs, Si PMTs, G APDs, CCDs, EBCCDs, EMCCDs etc)
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Muñoz, E., Barrientos, L., Bernabeu, J., Borja-Lloret, M., Llosa, G., Ros, A., et al. (2020). A spectral reconstruction algorithm for two-plane Compton cameras. Phys. Med. Biol., 65(2), 025011–17pp.
Abstract: One factor limiting the current applicability extent of hadron therapy is the lack of a reliable method for real time treatment monitoring. The use of Compton imaging systems as monitors requires the correct reconstruction of the distribution of prompt gamma productions during patient irradiation. In order to extract the maximum information from all the measurable events, we implemented a spectral reconstruction method that assigns to all events a probability of being either partial or total energy depositions. The method, implemented in a list-mode maximum likelihood expectation maximization algorithm, generates a four dimensional image in the joint spatial-spectral domain, in which the voxels containing the emission positions and energies are obtained. The analytical model used for the system response function is also employed to derive an analytical expression for the sensitivity, which is calculated via Monte Carlo integration. The performance of the method is evaluated through reconstruction of various experimental and simulated sources with different spatial and energy distributions. The results show that the proposed method can recover the spectral and spatial information simultaneously, but only under the assumption of ideal measurements. The analysis of the Monte Carlo simulations has led to the identification of two important degradation sources: the mispositioning of the gamma interaction point and the missing energy recorded in the interaction. Both factors are related to the high energy transferred to the recoil electrons, which can travel far from the interaction point and even escape the detector. These effects prevent the direct application of the current method in more realistic scenarios. Nevertheless, experimental point-like sources have been accurately reconstructed and the spatial distributions and spectral emission of complex simulated phantoms can be identified.
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Mostajeran, M., Sorolla, E., Rakova, E., & Gimeno, B. (2024). Space charge and two-sheet model in multipactor. Eur. Phys. J. Plus, 139(3), 256–13pp.
Abstract: The electron cloud populated by a multipactor within two emissive parallel plates was modeled by two thin sheets of charge, and for the first time the equations of the particle motion for this two-sheet system were derived taking into account space charge effects. The electron population growth in multipacting process was then simulated with the code developed on the base of these equations. It was found that the mutual repulsion between the sheets, i.e., space charge effects, results in the increasing of charge in one of the sheets and the loss of charge in the other due to the different growth rates. This process eventually comes to the saturation of one sheet and the dissappearence of the other.
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Mosbech, M. R., Boehm, C., Hannestad, S., Mena, O., Stadler, J., & Wong, Y. Y. Y. (2021). The full Boltzmann hierarchy for dark matter-massive neutrino interactions. J. Cosmol. Astropart. Phys., 03(3), 066–31pp.
Abstract: The impact of dark matter-neutrino interactions on the measurement of the cosmological parameters has been investigated in the past in the context of massless neutrinos exclusively. Here we revisit the role of a neutrino-dark matter coupling in light of ongoing cosmological tensions by implementing the full Boltzmann hierarchy for three massive neutrinos. Our tightest 95% CL upper limit on the strength of the interactions, parameterized via u(chi) = sigma(0)/sigma(Th) (m(chi)/100GeV)(-1), is u(chi) <= 3.34 . 10(-4), arising from a combination of Planck TTTEEE data, Planck lensing data and SDSS BAO data. This upper bound is, as expected, slightly higher than previous results for interacting massless neutrinos, due to the correction factor associated with neutrino masses. We find that these interactions significantly relax the lower bounds on the value of sigma 8 that is inferred in the context of Lambda CDM from the Planck data, leading to agreement within 1-2 sigma with weak lensing estimates of sigma 8, as those from KiDS1000. However, the presence of these interactions barely affects the value of the Hubble constant H-0.
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Moretti, F., Del Prete, M., & Montani, G. (2023). Linear analysis of the gravitational beam-plasma instability. Eur. Phys. J. C, 83(6), 486–16pp.
Abstract: We investigate the well-known phenomenon of the beam-plasma instability in the gravitational sector when a fast population of particles interacts with the massive scalar mode of a Horndeski theory of gravity, resulting in linear growth of the latter amplitude. Following the approach used in the standard electromagnetic case, we start from the dielectric representation of the gravitational plasma, as introduced in a previous analysis of the Landau damping for the scalar Horndeski mode. We then set up the modified Vlasov-Einstein equation, using a Dirac delta function to describe the fast beam distribution. We thus provide an analytical expression for the dispersion relation, and we demonstrate the existence of a nonzero growth rate for the linear evolution of the Horndeski scalar mode. A numerical investigation is then performed with a trapezoidal beam distribution function, which confirms the analytical results and allows us to demonstrate how the growth rate decreases as the beam spread increases.
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Moretti, F., Bombacigno, F., & Montani, G. (2020). Gravitational Landau damping for massive scalar modes. Eur. Phys. J. C, 80(12), 1203–9pp.
Abstract: We establish the possibility of Landau damping for gravitational scalar waves which propagate in a non-collisional gas of particles. In particular, under the hypothesis of homogeneity and isotropy, we describe the medium at the equilibrium with a Juttner-Maxwell distribution, and we analytically determine the damping rate from the Vlasov equation. We find that damping occurs only if the phase velocity of the wave is subluminal throughout the propagation within the medium. Finally, we investigate relativistic media in cosmological settings by adopting numerical techniques.
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Moretti, F., Bombacigno, F., & Montani, G. (2021). The Role of Longitudinal Polarizations in Horndeski and Macroscopic Gravity: Introducing Gravitational Plasmas. Universe, 7(12), 496–28pp.
Abstract: We discuss some general and relevant features of longitudinal gravitational modes in Horndeski gravity and their interaction with matter media. Adopting a gauge-invariant formulation, we clarify how massive scalar and vector fields can induce additional transverse and longitudinal excitations, resulting in breathing, vector, and longitudinal polarizations. We review, then, the interaction of standard gravitational waves with a molecular medium, outlining the emergence of effective massive gravitons, induced by the net quadrupole moment due to molecule deformation. Finally, we investigate the interaction of the massive mode in Horndeski gravity with a noncollisional medium, showing that Landau damping phenomenon can occur in the gravitational sector as well. That allows us to introduce the concept of “gravitational plasma”, where inertial forces associated with the background field play the role of cold ions in electromagnetic plasma.
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