Abstract: Simple Summary There are no brachytherapy treatment planning systems (TPS) exclusively for the treatment of cervical tumours, so general-purpose TPSs are used. However, these treatments have some particular features concerning the treatment of other pathologies, especially in the case of exclusive use of MRI as an imaging modality and the presence of gynaecological applicators in combination with an interstitial part. That is why it is essential to review the latest versions of commercial TPSs to find the potential features to improve with the help of a group of experimented medical physicists and radiation oncologists. Furthermore, after reviewing the recent literature for advances applicable to cervical brachytherapy and through his own clinical experience, possible improvements are proposed to software providers for the development of new tools. Intracavitary brachytherapy (BT, Interventional Radiotherapy, IRT), plays an essential role in the curative intent of locally advanced cervical cancer, for which the conventional approach involves external beam radiotherapy with concurrent chemotherapy followed by BT. This work aims to review the different methodologies used by commercially available treatment planning systems (TPSs) in exclusive magnetic resonance imaging-based (MRI) cervix BT with interstitial component treatments. Practical aspects and improvements to be implemented into the TPSs are discussed. This review is based on the clinical expertise of a group of radiation oncologists and medical physicists and on interactive demos provided by the software manufacturers. The TPS versions considered include all the new tools currently in development for future commercial releases. The specialists from the supplier companies were asked to propose solutions to some of the challenges often encountered in a clinical environment through a questionnaire. The results include not only such answers but also comments by the authors that, in their opinion, could help solve the challenges covered in these questions. This study summarizes the possibilities offered nowadays by commercial TPSs, highlighting the absence of some useful tools that would notably improve the planning of MR-based interstitial component cervix brachytherapy.

Abstract: The properties of strange (K, (K) over bar and (K) over bar*) and open-charm (D, (D) over bar and D*) mesons in dense matter are studied using a unitary approach in coupled channels for meson-baryon scattering. In the strangeness sector, the interaction with nucleons always comes through vector-meson exchange, which is evaluated by chiral and hidden gauge Lagrangians. For the interaction of charmed mesons with nucleons we extend the SU(3) Weinberg-Tomozawa Lagrangian to incorporate spin-flavor symmetry and implement a suitable flavor symmetry breaking. The in-medium solution for the scattering amplitude accounts for Pauli blocking effects and meson self-energies. On one hand, we obtain the K, (K) over bar and (K) over bar* spectral functions in the nuclear medium and study their behaviour at finite density, temperature and momentum. We also make an estimate of the transparency ratio of the gamma A -> K+ K*(-) A' reaction, which we propose as a tool to detect in-medium modifications of the (K) over bar* meson. On the other hand, in the charm sector, several resonances with negative parity are generated dynamically by the s-wave interaction between pseudoscalar and vector meson multiplets with 1/2(+) and 3/2(+) baryons. The properties of these states in matter are analyzed and their influence on the open-charm meson spectral functions is studied. We finally discuss the possible formation of D-mesic nuclei at FAIR energies.