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Albertus, C., Hernandez, E., & Nieves, J. (2011). Exclusive c -> s, d semileptonic decays of ground-state spin-1/2 doubly charmed baryons. Phys. Lett. B, 704(5), 499–509.
Abstract: We evaluate exclusive semileptonic decays of ground-state spin-1/2 doubly heavy charmed baryons driven by a c -> s, d transition at the quark level. Our results for the form factors are consistent with heavy quark spin symmetry constraints which are valid in the limit of an infinitely massive charm quark and near zero recoil. Only a few exclusive semileptonic decay channels have been theoretically analyzed before. For those cases we find that our results are in a reasonable agreement with previous calculations.
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Albertus, C., Hernandez, E., & Nieves, J. (2012). Exclusive c -> s, d semileptonic decays of ground-state spin-1/2 and spin-3/2 doubly heavy cb baryons. Phys. Rev. D, 85(9), 094035–21pp.
Abstract: We evaluate exclusive semileptonic decays of ground-state spin-1/2 and spin-3/2 doubly heavy cb baryons driven by a c --> s, d transition at the quark level. We check our results for the form factors against heavy quark spin symmetry constraints obtained in the limit of very large heavy quark masses and near zero recoil. Based on those constraints we make model-independent, though approximate, predictions for ratios of decay widths.
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Albertus, C., Hernandez, E., & Nieves, J. (2014). B -> rho semileptonic decays and vertical bar V-ub vertical bar. Phys. Rev. D, 90(1), 013017–11pp.
Abstract: We reevaluate the B -> rho l(+) nu(l) decay width as a full B. pi pi iota(+)nu iota four-particle decay, in which the two final pions are produced via an intermediate. meson. The decay width can be written as a convolution of the B -> rho l(+) nu(l) decay width, for an off-shell., with the.. pp line shape. This allows us to fully incorporate the effects of the finite. meson width and a better comparison with actual experiments. We use an Omn s representation to provide the dependence of the B.. semileptonic form factors on q2. The Omn s subtraction constants and the overall normalization parameter jVubj are fitted to light cone sum rules and lattice QCD theoretical form-factor calculations, in the low and high q2 regions, respectively, together to the CLEO, BABAR, and Belle experimental partial branching fraction distributions. The extracted value from this global fit is jVubj d3.40 +/- 0.15_ x 10-3, in agreement with jVubj extracted using all other inputs in Cabibbo-Kobayashi-Maskawa fits and the exclusive semileptonic B. p channel, but showing a clear disagreement with jVubj extracted from inclusive semileptonic b. u decays. As estimated by [U.-G. Mei beta ner andW. Wang, J. High Energy Phys. 01 (2014) 107], taking into account the. meson width effects and the actual acceptance of the experiments is essential to render the jVubj determinations from exclusive B. p and B.. decays totally compatible.
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Albertus, C., Hernandez, E., & Nieves, J. (2014). Exclusive c -> s, d Semileptonic Decays of Spin-1/2 and Spin-3/2 cb Baryons. Few-Body Syst., 55(8-10), 767–771.
Abstract: We present results for exclusive semileptonic decay widths of ground state spin-1/2 and spin-3/2 cb baryons corresponding to a c -> s, d transition at the quark level. The relevance of hyperfine mixing in spin-1/2 cb baryons is shown. Our form factors are compatible with heavy quark spin symmetry constraints obtained in the infinite heavy quark mass limit.
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Albiol, A., Albiol, F., Paredes, R., Plasencia-Martinez, J. M., Blanco Barrio, A., Garcia Santos, J. M., et al. (2022). A comparison of Covid-19 early detection between convolutional neural networks and radiologists. Insights Imaging, 13(1), 122–12pp.
Abstract: Background The role of chest radiography in COVID-19 disease has changed since the beginning of the pandemic from a diagnostic tool when microbiological resources were scarce to a different one focused on detecting and monitoring COVID-19 lung involvement. Using chest radiographs, early detection of the disease is still helpful in resource-poor environments. However, the sensitivity of a chest radiograph for diagnosing COVID-19 is modest, even for expert radiologists. In this paper, the performance of a deep learning algorithm on the first clinical encounter is evaluated and compared with a group of radiologists with different years of experience. Methods The algorithm uses an ensemble of four deep convolutional networks, Ensemble4Covid, trained to detect COVID-19 on frontal chest radiographs. The algorithm was tested using images from the first clinical encounter of positive and negative cases. Its performance was compared with five radiologists on a smaller test subset of patients. The algorithm's performance was also validated using the public dataset COVIDx. Results Compared to the consensus of five radiologists, the Ensemble4Covid model achieved an AUC of 0.85, whereas the radiologists achieved an AUC of 0.71. Compared with other state-of-the-art models, the performance of a single model of our ensemble achieved nonsignificant differences in the public dataset COVIDx. Conclusion The results show that the use of images from the first clinical encounter significantly drops the detection performance of COVID-19. The performance of our Ensemble4Covid under these challenging conditions is considerably higher compared to a consensus of five radiologists. Artificial intelligence can be used for the fast diagnosis of COVID-19.
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Albiol, A., Corbi, A., & Albiol, F. (2017). Automatic intensity windowing of mammographic images based on a perceptual metric. Med. Phys., 44(4), 1369–1378.
Abstract: Purpose: Initial auto-adjustment of the window level WL and width WW applied to mammographic images. The proposed intensity windowing (IW) method is based on the maximization of the mutual information (MI) between a perceptual decomposition of the original 12-bit sources and their screen displayed 8-bit version. Besides zoom, color inversion and panning operations, IW is the most commonly performed task in daily screening and has a direct impact on diagnosis and the time involved in the process. Methods: The authors present a human visual system and perception-based algorithm named GRAIL (Gabor-relying adjustment of image levels). GRAIL initially measures a mammogram's quality based on the MI between the original instance and its Gabor-filtered derivations. From this point on, the algorithm performs an automatic intensity windowing process that outputs the WL/WW that best displays each mammogram for screening. GRAIL starts with the default, high contrast, wide dynamic range 12-bit data, and then maximizes the graphical information presented in ordinary 8-bit displays. Tests have been carried out with several mammogram databases. They comprise correlations and an ANOVA analysis with the manual IW levels established by a group of radiologists. A complete MATLAB implementation of GRAIL is available at . Results: Auto-leveled images show superior quality both perceptually and objectively compared to their full intensity range and compared to the application of other common methods like global contrast stretching (GCS). The correlations between the human determined intensity values and the ones estimated by our method surpass that of GCS. The ANOVA analysis with the upper intensity thresholds also reveals a similar outcome. GRAIL has also proven to specially perform better with images that contain micro-calcifications and/or foreign X-ray-opaque elements and with healthy BI-RADS A-type mammograms. It can also speed up the initial screening time by a mean of 4.5 s per image. Conclusions: A novel methodology is introduced that enables a quality-driven balancing of the WL/WW of mammographic images. This correction seeks the representation that maximizes the amount of graphical information contained in each image. The presented technique can contribute to the diagnosis and the overall efficiency of the breast screening session by suggesting, at the beginning, an optimal and customized windowing setting for each mammogram.
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Albiol, F., Corbi, A., & Albiol, A. (2016). Geometrical Calibration of X-Ray Imaging With RGB Cameras for 3D Reconstruction. IEEE Trans. Med. Imaging, 35(8), 1952–1961.
Abstract: We present a methodology to recover the geometrical calibration of conventional X-ray settings with the help of an ordinary video camera and visible fiducials that are present in the scene. After calibration, equivalent points of interest can be easily identifiable with the help of the epipolar geometry. The same procedure also allows the measurement of real anatomic lengths and angles and obtains accurate 3D locations from image points. Our approach completely eliminates the need for X-ray-opaque reference marks (and necessary supporting frames) which can sometimes be invasive for the patient, occlude the radiographic picture, and end up projected outside the imaging sensor area in oblique protocols. Two possible frameworks are envisioned: a spatially shifting X-ray anode around the patient/object and a moving patient that moves/rotates while the imaging system remains fixed. As a proof of concept, experiences with a device under test (DUT), an anthropomorphic phantom and a real brachytherapy session have been carried out. The results show that it is possible to identify common points with a proper level of accuracy and retrieve three-dimensional locations, lengths and shapes with a millimetric level of precision. The presented approach is simple and compatible with both current and legacy widespread diagnostic X-ray imaging deployments and it can represent a good and inexpensive alternative to other radiological modalities like CT.
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Albiol, F., Corbi, A., & Albiol, A. (2017). 3D measurements in conventional X-ray imaging with RGB-D sensors. Med. Eng. Phys., 42, 73–79.
Abstract: A method for deriving 3D internal information in conventional X-ray settings is presented. It is based on the combination of a pair of radiographs from a patient and it avoids the use of X-ray-opaque fiducials and external reference structures. To achieve this goal, we augment an ordinary X-ray device with a consumer RGB-D camera. The patient' s rotation around the craniocaudal axis is tracked relative to this camera thanks to the depth information provided and the application of a modern surface-mapping algorithm. The measured spatial information is then translated to the reference frame of the X-ray imaging system. By using the intrinsic parameters of the diagnostic equipment, epipolar geometry, and X-ray images of the patient at different angles, 3D internal positions can be obtained. Both the RGB-D and Xray instruments are first geometrically calibrated to find their joint spatial transformation. The proposed method is applied to three rotating phantoms. The first two consist of an anthropomorphic head and a torso, which are filled with spherical lead bearings at precise locations. The third one is made of simple foam and has metal needles of several known lengths embedded in it. The results show that it is possible to resolve anatomical positions and lengths with a millimetric level of precision. With the proposed approach, internal 3D reconstructed coordinates and distances can be provided to the physician. It also contributes to reducing the invasiveness of ordinary X-ray environments and can replace other types of clinical explorations that are mainly aimed at measuring or geometrically relating elements that are present inside the patient's body.
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Albiol, F., Corbi, A., & Albiol, A. (2017). Evaluation of modern camera calibration techniques for conventional diagnostic X-ray imaging settings. Radiol. Phys. Technol., 10(1), 68–81.
Abstract: We explore three different alternatives for obtaining intrinsic and extrinsic parameters in conventional diagnostic X-ray frameworks: the direct linear transform (DLT), the Zhang method, and the Tsai approach. We analyze and describe the computational, operational, and mathematical background differences for these algorithms when they are applied to ordinary radiograph acquisition. For our study, we developed an initial 3D calibration frame with tin cross-shaped fiducials at specific locations. The three studied methods enable the derivation of projection matrices from 3D to 2D point correlations. We propose a set of metrics to compare the efficiency of each technique. One of these metrics consists of the calculation of the detector pixel density, which can be also included as part of the quality control sequence in general X-ray settings. The results show a clear superiority of the DLT approach, both in accuracy and operational suitability. We paid special attention to the Zhang calibration method. Although this technique has been extensively implemented in the field of computer vision, it has rarely been tested in depth in common radiograph production scenarios. Zhang's approach can operate on much simpler and more affordable 2D calibration frames, which were also tested in our research. We experimentally confirm that even three or four plane-image correspondences achieve accurate focal lengths.
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Albiol, F., Corbi, A., & Albiol, A. (2019). Densitometric Radiographic Imaging With Contour Sensors. IEEE Access, 7, 18902–18914.
Abstract: We present the technical/physical foundations of a new imaging technique that combines ordinary radiographic information (generated by conventional X-ray settings) with the patient's volume to derive densitometric images. Traditionally, these images provide quantitative information about tissues densities. In our approach, they graphically enhance either soft or bony regions. After measuring the patient's volume with contour recognition devices, the physical traversed lengths within it (as the Roentgen beam intersects the patient) are calculated and pixel-wise associated with the original radiograph (X). In order to derive this map of lengths (L), the camera equations of the X-ray system and the contour sensor are determined. The patient's surface is also translated to the point-of-view of the X-ray beam and all its entrance/exit points are sought with the help of ray-casting methods. The derived L is applied to X as a physical operation (subtraction), obtaining soft tissue-(D-S) or bone-enhanced (D'(B)) figures. In the D-S type, the contained graphical information can be linearly mapped to the average electronic density (traversed by the X-ray beam). This feature represents an interesting proof-of-concept of associating density data to radiographs, but most important, their intensity histogram is objectively compressed, i.e., the dynamic range is more shrunk (compared against the corresponding X). This leads to other advantages: improvement in the visibility of border/edge areas (high gradient), extended manual window level/width manipulations during screening, and immediate correction of underexposed X instances. In the D-B' type, high-density elements are highlighted and easier to discern. All these results can be achieved with low-energy beam exposures, saving costs and dose. Future work will deepen this clinical side of our research. In contrast with other image-based modifiers, the proposed method is grounded on the measurement of a physical entity: the span of the X-ray beam within a body while undertaking a radiographic examination.
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