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Valdes-Cortez, C., Niatsetski, Y., Perez-Calatayud, J., Ballester, F., & Vijande, J. (2022). A Monte Carlo study of the relative biological effectiveness in surface brachytherapy. Med. Phys., 49, 5576–5588.
Abstract: Purpose This work aims to simulate clustered DNA damage from ionizing radiation and estimate the relative biological effectiveness (RBE) for radionuclide (rBT)- and electronic (eBT)-based surface brachytherapy through a hybrid Monte Carlo (MC) approach, using realistic models of the sources and applicators. Methods Damage from ionizing radiation has been studied using the Monte Carlo Damage Simulation algorithm using as input the primary electron fluence simulated using a state-of-the-art MC code, PENELOPE-2018. Two Ir-192 rBT applicators, Valencia and Leipzig, one Co-60 source with a Freiburg Flap applicator (reference source), and two eBT systems, Esteya and INTRABEAM, have been included in this study implementing full realizations of their geometries as disclosed by the manufacturer. The role played by filtration and tube kilovoltage has also been addressed. Results For rBT, an RBE value of about 1.01 has been found for the applicators and phantoms considered. In the case of eBT, RBE values for the Esteya system show an almost constant RBE value of about 1.06 for all depths and materials. For INTRABEAM, variations in the range of 1.12-1.06 are reported depending on phantom composition and depth. Modifications in the Esteya system, filtration, and tube kilovoltage give rise to variations in the same range. Conclusions Current clinical practice does not incorporate biological effects in surface brachytherapy. Therefore, the same absorbed dose is administered to the patients independently on the particularities of the rBT or eBT system considered. The almost constant RBE values reported for rBT support that assumption regardless of the details of the patient geometry, the presence of a flattening filter in the applicator design, or even significant modifications in the photon energy spectra above 300 keV. That is not the case for eBT, where a clear dependence on the eBT system and the characteristics of the patient geometry are reported. A complete study specific for each eBT system, including detailed applicator characteristics (size, shape, filtering, among others) and common anatomical locations, should be performed before adopting an existing RBE value.
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Valdes-Cortez, C., Mansour, I., Rivard, M. J., Ballester, F., Mainegra-Hing, E., Thomson, R. M., et al. (2021). A study of Type B uncertainties associated with the photoelectric effect in low-energy Monte Carlo simulations. Phys. Med. Biol., 66(10), 105014–14pp.
Abstract: Purpose. To estimate Type B uncertainties in absorbed-dose calculations arising from the different implementations in current state-of-the-art Monte Carlo (MC) codes of low-energy photon cross-sections (<200 keV). Methods. MC simulations are carried out using three codes widely used in the low-energy domain: PENELOPE-2018, EGSnrc, and MCNP. Three dosimetry-relevant quantities are considered: mass energy-absorption coefficients for water, air, graphite, and their respective ratios; absorbed dose; and photon-fluence spectra. The absorbed dose and the photon-fluence spectra are scored in a spherical water phantom of 15 cm radius. Benchmark simulations using similar cross-sections have been performed. The differences observed between these quantities when different cross-sections are considered are taken to be a good estimator for the corresponding Type B uncertainties. Results. A conservative Type B uncertainty for the absorbed dose (k = 2) of 1.2%-1.7% (<50 keV), 0.6%-1.2% (50-100 keV), and 0.3% (100-200 keV) is estimated. The photon-fluence spectrum does not present clinically relevant differences that merit considering additional Type B uncertainties except for energies below 25 keV, where a Type B uncertainty of 0.5% is obtained. Below 30 keV, mass energy-absorption coefficients show Type B uncertainties (k = 2) of about 1.5% (water and air), and 2% (graphite), diminishing in all materials for larger energies and reaching values about 1% (40-50 keV) and 0.5% (50-75 keV). With respect to their ratios, the only significant Type B uncertainties are observed in the case of the water-to-graphite ratio for energies below 30 keV, being about 0.7% (k = 2). Conclusions. In contrast with the intermediate (about 500 keV) or high (about 1 MeV) energy domains, Type B uncertainties due to the different cross-sections implementation cannot be considered subdominant with respect to Type A uncertainties or even to other sources of Type B uncertainties (tally volume averaging, manufacturing tolerances, etc). Therefore, the values reported here should be accommodated within the uncertainty budget in low-energy photon dosimetry studies.
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Valdes-Cortez, C., Ballester, F., Vijande, J., Gimenez, V., Gimenez-Alventosa, V., Perez-Calatayud, J., et al. (2020). Depth-dose measurement corrections for the surface electronic brachytherapy beams of an Esteya(R) unit: a Monte Carlo study. Phys. Med. Biol., 65(24), 245026–12pp.
Abstract: Three different correction factors for measurements with the parallel-plate ionization chamber PTW T34013 on the Esteya electronic brachytherapy unit have been investigated. This chamber type is recommended by AAPM TG-253 for depth-dose measurements in the 69.5 kV x-ray beam generated by the Esteya unit. Monte Carlo simulations using the PENELOPE-2018 system were performed to determine the absorbed dose deposited in water and in the chamber sensitive volume at different depths with a Type A uncertainty smaller than 0.1%. Chamber-to-chamber differences have been explored performing measurements using three different chambers. The range of conical applicators available, from 10 to 30 mm in diameter, has been explored. Using a depth-independent global chamber perturbation correction factor without a shift of the effective point of measurement yielded differences between the absorbed dose to water and the corrected absorbed dose in the sensitive volume of the chamber of up to 1% and 0.6% for the 10 mm and 30 mm applicators, respectively. Calculations using a depth-dependent perturbation factor, including or excluding a shift of the effective point of measurement, resulted in depth-dose differences of about +/- 0.5% or less for both applicators. The smallest depth-dose differences were obtained when a shift of the effective point of measurement was implemented, being displaced 0.4 mm towards the center of the sensitive volume of the chamber. The correction factors were obtained with combined uncertainties of 0.4% (k = 2). Uncertainties due to chamber-to-chamber differences are found to be lower than 2%. The results emphasize the relevance of carrying out detailed Monte Carlo studies for each electronic brachytherapy device and ionization chamber used for its dosimetry.
Keywords: electronic brachytherapy; eBT; dosimetry; ionization chamber; Monte Carlo
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Valderrama, M., Crepon, B., Botella-Soler, V., Martinerie, J., Hasboun, D., Alvarado-Rojas, C., et al. (2012). Human Gamma Oscillations during Slow Wave Sleep. PLoS One, 7(4), e33477–14pp.
Abstract: Neocortical local field potentials have shown that gamma oscillations occur spontaneously during slow-wave sleep (SWS). At the macroscopic EEG level in the human brain, no evidences were reported so far. In this study, by using simultaneous scalp and intracranial EEG recordings in 20 epileptic subjects, we examined gamma oscillations in cerebral cortex during SWS. We report that gamma oscillations in low (30-50 Hz) and high (60-120 Hz) frequency bands recurrently emerged in all investigated regions and their amplitudes coincided with specific phases of the cortical slow wave. In most of the cases, multiple oscillatory bursts in different frequency bands from 30 to 120 Hz were correlated with positive peaks of scalp slow waves (“IN-phase'' pattern), confirming previous animal findings. In addition, we report another gamma pattern that appears preferentially during the negative phase of the slow wave (”ANTI-phase'' pattern). This new pattern presented dominant peaks in the high gamma range and was preferentially expressed in the temporal cortex. Finally, we found that the spatial coherence between cortical sites exhibiting gamma activities was local and fell off quickly when computed between distant sites. Overall, these results provide the first human evidences that gamma oscillations can be observed in macroscopic EEG recordings during sleep. They support the concept that these high-frequency activities might be associated with phasic increases of neural activity during slow oscillations. Such patterned activity in the sleeping brain could play a role in off-line processing of cortical networks.
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Valcarce, A., Vijande, J., Richard, J. M., & Garcilazo, H. (2018). Stability of Heavy Tetraquarks. Few-Body Syst., 59(2), 9–7pp.
Abstract: We discuss the stability of tetraquark systems with two different masses. After some reminders about the stability of very asymmetric QQ (q) over bar(q) over bar tetraquarks, we demonstrate that in the all-heavy limit q -> Q, the system becomes unstable for standard color-additive models. We also analyze the consequences of symmetry breaking for Qq (Q) over bar(q) over bar configurations: we find a kind of metastability between the lowest threshold Q (Q) over bar + q (q) over bar and the highest one, Q (q) over bar + (Q) over barq, and we calculate the width of the resonance. Our results are consistent with the experimental observation of narrow hadrons lying well above their lowest decay threshold.
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Valcarce, A., Garcilazo, H., & Vijande, J. (2014). Heavy baryon spectroscopy with relativistic kinematics. Phys. Lett. B, 733, 288–295.
Abstract: We present a comparative Faddeev study of heavy baryon spectroscopy with nonrelativistic and relativistic kinematics. We show results for different standard hyperfine interactions with both kinematics in an attempt to learn about the light quark dynamics. We highlight the properties of particular states accessible in nowadays laboratories that would help in discriminating between different dynamical models. The advance in the knowledge of light quark dynamics is a key tool for the understanding of the existence of exotic hadrons.
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Vague, J., Melgarejo, J. C., Boria, V. E., Guglielmi, M., Moreno, R., Reglero, M., et al. (2019). Experimental Validation of Multipactor Effect for Ferrite Materials Used in L- and S-Band Nonreciprocal Microwave Components. IEEE Trans. Microw. Theory Tech., 67(6), 2151–2161.
Abstract: This paper reports on the experimental measurement of power threshold levels for the multipactor effect between samples of ferrite material typically used in the practical implementation of L-and S-band circulators and isolators. For this purposes, a new family of wideband, nonreciprocal rectangular waveguide structures loaded with ferrites has been designed with a full-wave electromagnetic simulation tool. The design also includes the required magnetostatic field biasing circuits. The multipactor breakdown power levels have also been predicted with an accurate electron tracking code using measured values for the secondary electron yield (SEY) coefficient. The measured results agree well with simulations, thereby fully validating the experimental campaign.
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Vagnozzi, S., Visinelli, L., Mena, O., & Mota, D. F. (2020). Do we have any hope of detecting scattering between dark energy and baryons through cosmology? Mon. Not. Roy. Astron. Soc., 493(1), 1139–1152.
Abstract: We consider the possibility that dark energy and baryons might scatter off each other. The type of interaction we consider leads to a pure momentum exchange, and does not affect the background evolution of the expansion history. We parametrize this interaction in an effective way at the level of Boltzmann equations. We compute the effect of dark energy-baryon scattering on cosmological observables, focusing on the cosmic microwave background (CMB) temperature anisotropy power spectrum and the matter power spectrum. Surprisingly, we find that even huge dark energy-baryon cross-sections sigma(xb) similar to O(b), which are generically excluded by non-cosmological probes such as collider searches or precision gravity tests, only leave an insignificant imprint on the observables considered. In the case of the CMB temperature power spectrum, the only imprint consists in a sub-per cent enhancement or depletion of power (depending whether or not the dark energy equation of state lies above or below -1) at very low multipoles, which is thus swamped by cosmic variance. These effects are explained in terms of differences in how gravitational potentials decay in the presence of a dark energy-baryon scattering, which ultimately lead to an increase or decrease in the late-time integrated Sachs-Wolfe power. Even smaller related effects are imprinted on the matter power spectrum. The imprints on the CMB are not expected to be degenerate with the effects due to altering the dark energy sound speed. We conclude that, while strongly appealing, the prospects for a direct detection of dark energy through cosmology do not seem feasible when considering realistic dark energy-baryon cross-sections. As a caveat, our results hold to linear order in perturbation theory.
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Vagnozzi, S., Giusarma, E., Mena, O., Freese, K., Gerbino, M., Ho, S., et al. (2017). Unveiling nu secrets with cosmological data: Neutrino masses and mass hierarchy. Phys. Rev. D, 96(12), 123503–26pp.
Abstract: Using some of the latest cosmological data sets publicly available, we derive the strongest bounds in the literature on the sum of the three active neutrino masses, M-nu, within the assumption of a background flat Lambda CDM cosmology. In the most conservative scheme, combining Planck cosmic microwave background temperature anisotropies and baryon acoustic oscillations (BAO) data, as well as the up-to-date constraint on the optical depth to reionization (tau), the tightest 95% confidence level upper bound we find is M-nu < 0.151 eV. The addition of Planck high-l polarization data, which, however, might still be contaminated by systematics, further tightens the bound to M-nu < 0.118 eV. A proper model comparison treatment shows that the two aforementioned combinations disfavor the inverted hierarchy at similar to 64% C.L. and similar to 71% C.L., respectively. In addition, we compare the constraining power of measurements of the full- shape galaxy power spectrum versus the BAO signature, from the BOSS survey. Even though the latest BOSS full-shape measurements cover a larger volume and benefit from smaller error bars compared to previous similar measurements, the analysis method commonly adopted results in their constraining power still being less powerful than that of the extracted BAO signal. Our work uses only cosmological data; imposing the constraint M-nu > 0.06 eV from oscillations data would raise the quoted upper bounds by O(0.1 sigma) and would not affect our conclusions.
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Vagnozzi, S., Di Valentino, E., Gariazzo, S., Melchiorri, A., Mena, O., & Silk, J. (2021). The galaxy power spectrum take on spatial curvature and cosmic concordance. Phys. Dark Universe, 33, 100851–17pp.
Abstract: The concordance of the ACDM cosmological model in light of current observations has been the subject of an intense debate in recent months. The 2018 Planck Cosmic Microwave Background (CMB) temperature anisotropy power spectrum measurements appear at face value to favour a spatially closed Universe with curvature parameter Omega(K) < 0. This preference disappears if Baryon Acoustic Oscillation (BAO) measurements are combined with Planck data to break the geometrical degeneracy, although the reliability of this combination has been questioned due to the strong tension present between the two datasets when assuming a curved Universe. Here, we approach this issue from yet another point of view, using measurements of the full-shape (FS) galaxy power spectrum, P(k), from the Baryon Oscillation Spectroscopic Survey DR12 CMASS sample. By combining Planck data with FS measurements, we break the geometrical degeneracy and find Omega(K) = 0.0023 +/- 0.0028. This constrains the Universe to be spatially flat to sub-percent precision, in excellent agreement with results obtained using BAO measurements. However, as with BAO, the overall increase in the best-fit chi(2) suggests a similar level of tension between Planck and P(k) under the assumption of a curved Universe. While the debate on spatial curvature and the concordance between cosmological datasets remains open, our results provide new perspectives on the issue, highlighting the crucial role of FS measurements in the era of precision cosmology.
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