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Author  |
Carrasco-Ribelles, L.A.; Pardo-Mas, J.R.; Tortajada, S.; Saez, C.; Valdivieso, B.; Garcia-Gomez, J.M. |
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Title |
Predicting morbidity by local similarities in multi-scale patient trajectories |
Type |
Journal Article |
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Year |
2021 |
Publication |
Journal of Biomedical Informatics |
Abbreviated Journal |
J. Biomed. Inform. |
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Volume |
120 |
Issue |
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Pages |
103837 - 9pp |
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Keywords |
Patient trajectory; Risk prediction; Local alignment; Dynamic programming; Diabetes; Cardiovascular disease |
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Abstract |
Patient Trajectories (PTs) are a method of representing the temporal evolution of patients. They can include information from different sources and be used in socio-medical or clinical domains. PTs have generally been used to generate and study the most common trajectories in, for instance, the development of a disease. On the other hand, healthcare predictive models generally rely on static snapshots of patient information. Only a few works about prediction in healthcare have been found that use PTs, and therefore benefit from their temporal dimension. All of them, however, have used PTs created from single-source information. Therefore, the use of longitudinal multi-scale data to build PTs and use them to obtain predictions about health conditions is yet to be explored. Our hypothesis is that local similarities on small chunks of PTs can identify similar patients concerning their future morbidities. The objectives of this work are (1) to develop a methodology to identify local similarities between PTs before the occurrence of morbidities to predict these on new query individuals; and (2) to validate this methodology on risk prediction of cardiovascular diseases (CVD) occurrence in patients with diabetes. We have proposed a novel formal definition of PTs based on sequences of longitudinal multi-scale data. Moreover, a dynamic programming methodology to identify local alignments on PTs for predicting future morbidities is proposed. Both the proposed methodology for PT definition and the alignment algorithm are generic to be applied on any clinical domain. We validated this solution for predicting CVD in patients with diabetes and we achieved a precision of 0.33, a recall of 0.72 and a specificity of 0.38. Therefore, the proposed solution in the diabetes use case can result of utmost utility to secondary screening. |
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Address |
[Carrasco-Ribelles, Lucia A.; Pardo-Mas, Jose Ramon; Saez, Carlos; Garcia-Gomez, Juan M.] Univ Politecn Valencia, Biomed Data Sci Lab BDSLAB, Inst Tecnol Informat & Comunicac ITACA, Camino Vera S-N, Valencia 46022, Spain, Email: lucarri@etsii.upv.es; |
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Publisher |
Academic Press Inc Elsevier Science |
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Language |
English |
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ISSN |
1532-0464 |
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Notes |
WOS:000683527500003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
4934 |
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Author |
Centelles Chulia, S.; Srivastava, R.; Vicente, A. |
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Title |
The inverse seesaw family: Dirac and Majorana |
Type |
Journal Article |
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Year |
2021 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
03 |
Issue |
3 |
Pages |
248 - 29pp |
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Keywords |
Beyond Standard Model; Neutrino Physics; Global Symmetries |
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Abstract |
After developing a general criterion for deciding which neutrino mass models belong to the category of inverse seesaw models, we apply it to obtain the Dirac analogue of the canonical Majorana inverse seesaw model. We then generalize the inverse seesaw model and obtain a class of inverse seesaw mechanisms both for Majorana and Dirac neutrinos. We further show that many of the models have double or multiple suppressions coming from tiny symmetry breaking “mu -parameters”. These models can be tested both in colliders and with the observation of lepton flavour violating processes. |
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Address |
[Centelles Chulia, Salvador; Vicente, Avelino] Univ Valencia, CSIC, Inst Fis Corpuscular, AHEP Grp, Parc Cientif Paterna,C Catedrat Jose Beltran 2, E-46980 Paterna, Valencia, Spain, Email: salcen@ific.uv.es; |
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Publisher |
Springer |
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English |
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ISSN |
1029-8479 |
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Notes |
WOS:000635241800001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4772 |
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Author |
Chala, M.; Titov, A. |
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Title |
Neutrino masses in the Standard Model effective field theory |
Type |
Journal Article |
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Year |
2021 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
104 |
Issue |
3 |
Pages |
035002 - 8pp |
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Keywords |
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Abstract |
We compute the leading-logarithmic correction to the neutrino mass matrix in the Standard Model effective field theory (SMEFT) to dimension seven. In the limit of negligible lepton and down-type quark Yukawa couplings, it receives contributions from the Weinberg dimension-five operator as well as from 11 dimension-six and five dimension-seven independent interactions. Two of the main implications we derive from this result are the following. First, we find dimension-seven operators which, despite violating lepton number, do not renormalize neutrino masses at one loop. And second, we demonstrate that the presence of dimension-six operators around the TeV scale can modify the Standard Model prediction by up to O(50%). Our result comprises also one step forward towards the renormalization of the SMEFT to order v(3)/Lambda(3). |
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Address |
[Chala, Mikael] Univ Granada, Dept Fis Teor & Cosmos, E-18071 Granada, Spain, Email: mikael.chala@ugr.es; |
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Publisher |
Amer Physical Soc |
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English |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
2470-0010 |
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Conference |
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Notes |
WOS:000681157900003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
4924 |
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Author |
Chianese, M.; Fiorillo, D.F.G.; Hajjar, R.; Miele, G.; Saviano, N. |
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Title |
Constraints on heavy decaying dark matter with current gamma-ray measurements |
Type |
Journal Article |
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Year |
2021 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
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Volume |
11 |
Issue |
11 |
Pages |
035 - 13pp |
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Keywords |
dark matter theory; ultra high energy photons and neutrinos |
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Abstract |
Among the several strategies for indirect searches of dark matter, a very promising one is to look for the gamma-rays from decaying dark matter. Here we use the most up-to-date upper bounds on the gamma-ray flux from 10(5) to 10(11) GeV, obtained from CASA-MIA, KASCADE, KASCADE-Grande, Pierre Auger Observatory, Telescope Array and EAS-MSU. We obtain global limits on dark matter lifetime in the range of masses in m(DM) = [10(7)-10(15)] GeV. We provide the bounds for a set of decay channels chosen as representatives. The constraints derived here are new and cover a region of the parameter space not yet explored. We compare our results with the projected constraints from future neutrino telescopes, in order to quantify the improvement that will be obtained by the complementary high-energy neutrino searches. |
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Address |
[Chianese, Marco; Fiorillo, Damiano F. G.; Miele, Gennaro] Univ Napoli Federico II, Dipartimento Fis Ettore Pancini, Complesso Univ Monte S Angelo, I-80126 Naples, Italy, Email: chianese@na.infn.it; |
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Thesis |
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Publisher |
IOP Publishing Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1475-7516 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000727716400012 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5051 |
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Author |
Cieri, L.; Sborlini, G.F.R. |
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Title |
Exploring QED Effects to Diphoton Production at Hadron Colliders |
Type |
Journal Article |
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Year |
2021 |
Publication |
Symmetry-Basel |
Abbreviated Journal |
Symmetry-Basel |
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Volume |
13 |
Issue |
6 |
Pages |
994 - 17pp |
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Keywords |
diphoton production; QCD corrections; NLO calculations; QED effects |
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Abstract |
In this article, we report phenomenological studies about the impact of O(alpha) corrections to diphoton production at hadron colliders. We explore the application of the Abelianized version of the qT-subtraction method to efficiently compute NLO QED contributions, taking advantage of the symmetries relating QCD and QED corrections. We analyze the experimental consequences due to the selection criteria and we find percent-level deviations for M-gamma gamma > 1TeV. An accurate description of the tail of the invariant mass distribution is very important for new physics searches which have the diphoton process as one of their main backgrounds. Moreover, we emphasize the importance of properly dealing with the observable photons by reproducing the experimental conditions applied to the event reconstruction. |
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Address |
[Cieri, Leandro] Ist Nazl Fis Nucl, Sez Firenze, I-50019 Sesto Fiorentino, Italy, Email: cieri@fi.infn.it; |
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Publisher |
Mdpi |
Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Editor |
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Notes |
WOS:000666940900001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4898 |
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