Fletcher, E. M., Ballester, F., Beaulieu, L., Morrison, H., Poher, A., Rivard, M. J., et al. (2024). Generation and comparison of 3D dosimetric reference datasets for COMS eye plaque brachytherapy using model-based dose calculations. Med. Phys., 51, 694–706.
Abstract: PurposeA joint Working Group of the American Association of Physicists in Medicine (AAPM), the European Society for Radiotherapy and Oncology (ESTRO), and the Australasian Brachytherapy Group (ABG) was created to aid in the transition from the AAPM TG-43 dose calculation formalism, the current standard, to model-based dose calculations. This work establishes the first test cases for low-energy photon-emitting brachytherapy using model-based dose calculation algorithms (MBDCAs).Acquisition and Validation MethodsFive test cases are developed: (1) a single model 6711 125I brachytherapy seed in water, 13 seeds (2) individually and (3) in combination in water, (4) the full Collaborative Ocular Melanoma Study (COMS) 16-mm eye plaque in water, and (5) the full plaque in a realistic eye phantom. Calculations are done with four Monte Carlo (MC) codes and a research version of a commercial treatment planning system (TPS). For all test cases, local agreement of MC codes was within & SIM;2.5% and global agreement was & SIM;2% (4% for test case 5). MC agreement was within expected uncertainties. Local agreement of TPS with MC was within 5% for test case 1 and & SIM;20% for test cases 4 and 5, and global agreement was within 0.4% for test case 1 and 10% for test cases 4 and 5.Data Format and Usage NotesDose distributions for each set of MC and TPS calculations are available online () along with input files and all other information necessary to repeat the calculations.Potential ApplicationsThese data can be used to support commissioning of MBDCAs for low-energy brachytherapy as recommended by TGs 186 and 221 and AAPM Report 372. This work additionally lays out a sample framework for the development of test cases that can be extended to other applications beyond eye plaque brachytherapy.
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Figueroa, D. G., Pieroni, M., Ricciardone, A., & Simakachorn, P. (2024). Cosmological Background Interpretation of Pulsar Timing Array Data. Phys. Rev. Lett., 132(17), 171002–9pp.
Abstract: We discuss the interpretation of the detected signal by pulsar timing array (PTA) observations as a gravitational wave background of cosmological origin. We combine NANOGrav 15-years and EPTADR2new datasets and confront them against backgrounds from supermassive black hole binaries (SMBHBs), and cosmological signals from inflation, cosmic (super)strings, first-order phase transitions, Gaussian and non-Gaussian large scalar fluctuations, and audible axions. We find that scalar-induced, and to a lesser extent audible axion and cosmic superstring signals, provide a better fit than SMBHBs. These results depend, however, on modeling assumptions, so further data and analysis are needed to reach robust conclusions. Independently of the signal origin, the data strongly constrain the parameter space of cosmological signals, for example, setting an upper bound on primordial non-Gaussianity at PTA scales as jfnlj less than or similar to 2.34 at 95% C.L.
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Ferrer-Sanchez, A., Martin-Guerrero, J., Ruiz de Austri, R., Torres-Forne, A., & Font, J. A. (2024). Gradient-annihilated PINNs for solving Riemann problems: Application to relativistic hydrodynamics. Comput. Meth. Appl. Mech. Eng., 424, 116906–18pp.
Abstract: We present a novel methodology based on Physics-Informed Neural Networks (PINNs) for solving systems of partial differential equations admitting discontinuous solutions. Our method, called Gradient-Annihilated PINNs (GA-PINNs), introduces a modified loss function that forces the model to partially ignore high-gradients in the physical variables, achieved by introducing a suitable weighting function. The method relies on a set of hyperparameters that control how gradients are treated in the physical loss. The performance of our methodology is demonstrated by solving Riemann problems in special relativistic hydrodynamics, extending earlier studies with PINNs in the context of the classical Euler equations. The solutions obtained with the GA-PINN model correctly describe the propagation speeds of discontinuities and sharply capture the associated jumps. We use the relative l(2) error to compare our results with the exact solution of special relativistic Riemann problems, used as the reference ''ground truth'', and with the corresponding error obtained with a second-order, central, shock-capturing scheme. In all problems investigated, the accuracy reached by the GA-PINN model is comparable to that obtained with a shock-capturing scheme, achieving a performance superior to that of the baseline PINN algorithm in general. An additional benefit worth stressing is that our PINN-based approach sidesteps the costly recovery of the primitive variables from the state vector of conserved variables, a well-known drawback of grid-based solutions of the relativistic hydrodynamics equations. Due to its inherent generality and its ability to handle steep gradients, the GA-PINN methodology discussed in this paper could be a valuable tool to model relativistic flows in astrophysics and particle physics, characterized by the prevalence of discontinuous solutions.
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Ferreiro, A., Monin, S., & Torrenti, F. (2024). Physical scale adiabatic regularization in cosmological spacetimes. Phys. Rev. D, 109(4), 045015–16pp.
Abstract: We develop a new regularization method for the stress -energy tensor and the two -point function of free quantum scalar fields propagating in cosmological spacetimes. We proceed by extending the adiabatic regularization scheme with the introduction of two additional mass scales. By setting them to the order of the physical scale of the studied scenario, we obtain ultraviolet -regularized quantities that do not distort the power spectra amplitude at the infrared scales amplified by the expansion of the Universe. This is not ensured by the standard adiabatic approach. We also show how our proposed subtraction terms can be interpreted as a renormalization of coupling constants in the Einstein equations. We finally illustrate our proposed regularization method in two scenarios of cosmological interest: de Sitter inflation and geometric reheating.
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Ferrando Solera, S., Pich, A., & Vale Silva, L. (2024). Direct bounds on Left-Right gauge boson masses at LHC Run 2. J. High Energy Phys., 02(2), 027–39pp.
Abstract: While the third run of the Large Hadron Collider (LHC) is ongoing, the underlying theory that extends the Standard Model remains so far unknown. Left-Right Models (LRMs) introduce a new gauge sector, and can restore parity symmetry at high enough energies. If LRMs are indeed realized in nature, the mediators of the new weak force can be searched for in colliders via their direct production. We recast existing experimental limits from the LHC Run 2 and derive generic bounds on the masses of the heavy LRM gauge bosons. As a novelty, we discuss the dependence of the WR and ZR total width on the LRM scalar content, obtaining model-independent bounds within the specific realizations of the LRM scalar sectors analysed here. These bounds avoid the need to detail the spectrum of the scalar sector, and apply in the general case where no discrete symmetry is enforced. Moreover, we emphasize the impact on the WR production at LHC of general textures of the right-handed quark mixing matrix without manifest left-right symmetry. We find that the WR and ZR masses are constrained to lie above 2 TeV and 4 TeV, respectively.
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