| |
Records |
Links |
|
Author  |
Etxebeste, A.; Dauvergne, D.; Fontana, M.; Letang, J.M.; Llosa, G.; Muñoz, E.; Oliver, J.F.; Testa, E.; Sarrut, D. |
|
| |
Title |
CCMod: a GATE module for Compton camera imaging simulation |
Type |
Journal Article |
| |
Year |
2020 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
|
| |
Volume |
65 |
Issue |
5 |
Pages |
055004 - 17pp |
|
| |
Keywords |
Monte Carlo; simulation; gamma imaging; Compton camera |
|
| |
Abstract |
Compton cameras are gamma-ray imaging systems which have been proposed for a wide variety of applications such as medical imaging, nuclear decommissioning or homeland security. In the design and optimization of such a system Monte Carlo simulations play an essential role. In this work, we propose a generic module to perform Monte Carlo simulations and analyses of Compton Camera imaging which is included in the open-source GATE/Geant4 platform. Several digitization stages have been implemented within the module to mimic the performance of the most commonly employed detectors (e.g. monolithic blocks, pixelated scintillator crystals, strip detectors...). Time coincidence sorter and sequence coincidence reconstruction are also available in order to aim at providing modules to facilitate the comparison and reproduction of the data taken with different prototypes. All processing steps may be performed during the simulation (on-the-fly mode) or as a post-process of the output files (offline mode). The predictions of the module have been compared with experimental data in terms of energy spectra, angular resolution, efficiency and back-projection image reconstruction. Consistent results within a 3-sigma interval were obtained for the energy spectra except for low energies where small differences arise. The angular resolution measure for incident photons of 1275 keV was also in good agreement between both data sets with a value close to 13 degrees. Moreover, with the aim of demonstrating the versatility of such a tool the performance of two different Compton camera designs was evaluated and compared. |
|
| |
Address |
[Etxebeste, A.; Letang, J. M.; Sarrut, D.] Univ Lyon 1, Univ Lyon, CREATIS, CNRS UMR5220,Inserm U1044,INSA Lyon, Lyon, France, Email: ane.etxebeste@creatis.insa-lyon.fr |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Iop Publishing Ltd |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0031-9155 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000519034800001 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
4321 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Llosa, G.; Trovato, M.; Barrio, J.; Etxebeste, A.; Muñoz, E.; Lacasta, C.; Oliver, J.F.; Rafecas, M.; Solaz, C.; Solevi, P. |
|
| |
Title |
First Images of a Three-layer compton Telescope prototype for Treatment Monitoring in hadron Therapy |
Type |
Journal Article |
| |
Year |
2016 |
Publication |
Frontiers in Oncology |
Abbreviated Journal |
Front. Oncol. |
|
| |
Volume |
6 |
Issue |
|
Pages |
14 - 6pp |
|
| |
Keywords |
Compton camera; Compton telescope; hadron therapy; treatment monitoring; LaBr3 |
|
| |
Abstract |
A Compton telescope for dose monitoring in hadron therapy is under development at IFIC. The system consists of three layers of LaBr3 crystals coupled to silicon photomulti-plier arrays. Na-22 sources have been successfully imaged reconstructing the data with an ML-EM code. Calibration and temperature stabilization are necessary for the prototype operation at low coincidence rates. A spatial resolution of 7.8 mm FWHM has been obtained in the first imaging tests. |
|
| |
Address |
[Llosa, Gabriela; Trovato, Marco; Barrio, John; Etxebeste, Ane; Munoz, Enrique; Lacasta, Carlos; Oliver, Josep F.; Rafecas, Magdalena; Solaz, Carles; Solevi, Paola] Inst Fis Corpuscular IFIC CSIC UVEG, Valencia, Spain, Email: gabriela.llosa@ific.uv.es |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Frontiers Media Sa |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
2234-943x |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000369799800001 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
no |
|
| |
Call Number |
IFIC @ elepoucu @ |
Serial |
2785 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Muñoz, E.; Barrientos, L.; Bernabeu, J.; Borja-Lloret, M.; Llosa, G.; Ros, A.; Roser, J.; Oliver, J.F. |
|
| |
Title |
A spectral reconstruction algorithm for two-plane Compton cameras |
Type |
Journal Article |
| |
Year |
2020 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
|
| |
Volume |
65 |
Issue |
2 |
Pages |
025011 - 17pp |
|
| |
Keywords |
Compton imaging; Compton camera; hadron therapy; image reconstruction |
|
| |
Abstract |
One factor limiting the current applicability extent of hadron therapy is the lack of a reliable method for real time treatment monitoring. The use of Compton imaging systems as monitors requires the correct reconstruction of the distribution of prompt gamma productions during patient irradiation. In order to extract the maximum information from all the measurable events, we implemented a spectral reconstruction method that assigns to all events a probability of being either partial or total energy depositions. The method, implemented in a list-mode maximum likelihood expectation maximization algorithm, generates a four dimensional image in the joint spatial-spectral domain, in which the voxels containing the emission positions and energies are obtained. The analytical model used for the system response function is also employed to derive an analytical expression for the sensitivity, which is calculated via Monte Carlo integration. The performance of the method is evaluated through reconstruction of various experimental and simulated sources with different spatial and energy distributions. The results show that the proposed method can recover the spectral and spatial information simultaneously, but only under the assumption of ideal measurements. The analysis of the Monte Carlo simulations has led to the identification of two important degradation sources: the mispositioning of the gamma interaction point and the missing energy recorded in the interaction. Both factors are related to the high energy transferred to the recoil electrons, which can travel far from the interaction point and even escape the detector. These effects prevent the direct application of the current method in more realistic scenarios. Nevertheless, experimental point-like sources have been accurately reconstructed and the spatial distributions and spectral emission of complex simulated phantoms can be identified. |
|
| |
Address |
[Munoz, Enrique; Barrientos, Luis; Bernabeu, Jose; Borja-Lloret, Marina; Llosa, Gabriela; Ros, Ana; Roser, Jorge; Oliver, Josep F.] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: Enrique.Munoz@ific.uv.es |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Iop Publishing Ltd |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0031-9155 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000520111400001 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
no |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
4332 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Muñoz, E.; Barrio, J.; Bemmerer, D.; Etxebeste, A.; Fiedler, F.; Hueso-Gonzalez, F.; Lacasta, C.; Oliver, J.F.; Romer, K.; Solaz, C.; Wagner, L.; Llosa, G. |
|
| |
Title |
Tests of MACACO Compton telescope with 4.44 MeV gamma rays |
Type |
Journal Article |
| |
Year |
2018 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
|
| |
Volume |
13 |
Issue |
|
Pages |
P05007 - 13pp |
|
| |
Keywords |
Compton imaging; Instrumentation for hadron therapy; Gamma detectors (scintillators, CZT, HPG, HgI etc); Photon detectors for UV, visible and IR photons (solid state) (PIN diodes, APDs, Si PMTs, G APDs, CCDs, EBCCDs, EMCCDs etc) |
|
| |
Abstract |
Hadron therapy offers the possibility of delivering a large amount of radiation dose to tumors with minimal absorption by the surrounding healthy tissue. In order to fully exploit the advantages of this technique, the use of real-time beam monitoring devices becomes mandatory. Compton imaging devices can be employed to map the distribution of prompt gamma emission during the treatment and thus assess its correct delivery. The Compton telescope prototype developed at IFIC-Valencia for this purpose is made of three layers of LaBr3 crystals coupled to silicon photomultipliers. The system has been tested in a 4.44 MeV gamma field at the 3 MV Tandetron accelerator at HZDR, Dresden. Images of the target with the system in three different positions separated by 10 mm were successfully reconstructed. This indicates the ability of MACACO for imaging the prompt gamma rays emitted at such energies. |
|
| |
Address |
[Munoz, E.; Barrio, J.; Etxebeste, A.; Lacasta, C.; Oliver, J. F.; Solaz, C.; Llosa, G.] Univ Valencia, CSIC, Inst Fis Corpuscular, Parque Cient,C Catedrat Jose Beltran 2, E-46980 Paterna, Valencia, Spain, Email: Enrique.Munoz@ific.uv.es |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Iop Publishing Ltd |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1748-0221 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000431716900001 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
3575 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Muñoz, E.; Barrio, J.; Bernabeu, J.; Etxebeste, A.; Lacasta, C.; Llosa, G.; Ros, A.; Roser, J.; Oliver, J.F. |
|
| |
Title |
Study and comparison of different sensitivity models for a two-plane Compton camera |
Type |
Journal Article |
| |
Year |
2018 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
|
| |
Volume |
63 |
Issue |
13 |
Pages |
135004 - 19pp |
|
| |
Keywords |
Compton camera imaging; MLEM; Monte Carlo simulations; image quality |
|
| |
Abstract |
Given the strong variations in the sensitivity of Compton cameras for the detection of events originating from different points in the field of view (FoV), sensitivity correction is often necessary in Compton image reconstruction. Several approaches for the calculation of the sensitivity matrix have been proposed in the literature. While most of these models are easily implemented and can be useful in many cases, they usually assume high angular coverage over the scattered photon, which is not the case for our prototype. In this work, we have derived an analytical model that allows us to calculate a detailed sensitivity matrix, which has been compared to other sensitivity models in the literature. Specifically, the proposed model describes the probability of measuring a useful event in a two-plane Compton camera, including the most relevant physical processes involved. The model has been used to obtain an expression for the system and sensitivity matrices for iterative image reconstruction. These matrices have been validated taking Monte Carlo simulations as a reference. In order to study the impact of the sensitivity, images reconstructed with our sensitivity model and with other models have been compared. Images have been reconstructed from several simulated sources, including point-like sources and extended distributions of activity, and also from experimental data measured with Na-22 sources. Results show that our sensitivity model is the best suited for our prototype. Although other models in the literature perform successfully in many scenarios, they are not applicable in all the geometrical configurations of interest for our system. In general, our model allows to effectively recover the intensity of point-like sources at different positions in the FoV and to reconstruct regions of homogeneous activity with minimal variance. Moreover, it can be employed for all Compton camera configurations, including those with low angular coverage over the scatterer. |
|
| |
Address |
[Munoz, Enrique; Barrio, John; Bernabeu, Jose; Etxebeste, Ane; Lacasta, Carlos; Llosa, Gabriela; Ros, Ana; Roser, Jorge; Oliver, Josep F.] Univ Valencia, CSIC, Inst Fis Corpuscular, IFIC, Valencia, Spain, Email: Enrique.Munoz@ific.uv.es |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Iop Publishing Ltd |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0031-9155 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:000436390800004 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
no |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
3639 |
|
| Permanent link to this record |
