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Author  |
Penas, J.; Alejo, A.; Bembibre, A.; Apiñaniz, J.I.; Garcia-Garcia, E.; Guerrero, C.; Henares, J.L.; Hernandez-Palmero, I.; Mendez, C.; Millan-Callado, M.A.; Puyuelo-Valdes, P.; Seimetz, M.; Benlliure, J. |
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Title |
Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source |
Type |
Journal Article |
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Year |
2024 |
Publication |
Scientific Reports |
Abbreviated Journal |
Sci Rep |
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Volume |
14 |
Issue |
1 |
Pages |
11448 - 12pp |
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Abstract |
Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the first time the use of a high-repetition rate, ultra-intense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10-14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} B(p,n) 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Significant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-the-art technology (10 Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range. |
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Address |
[Penas, Juan; Alejo, Aaron; Bembibre, Adrian; Benlliure, Jose] Univ Santiago de Compostela, Inst Galego Fis Altas Enerxias IGFAE, Santiago De Compostela 15782, Spain, Email: j.benlliure@usc.es |
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Publisher |
Nature Portfolio |
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English |
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Edition |
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ISSN |
2045-2322 |
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Notes |
WOS:001228252900017 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
6143 |
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Author |
Rossi, R.R.; Sanchez Garcia, G.; Tortola, M. |
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Title |
Probing nuclear properties and neutrino physics with current and future CEνNS experiments |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
109 |
Issue |
9 |
Pages |
095044 - 17pp |
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Keywords |
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Abstract |
The recent observation of coherent elastic neutrino-nucleus scattering (CEvNS) with neutrinos from pion decay at rest (N-DAR) sources by the COHERENT Collaboration has raised interest in this process in the search for new physics. Unfortunately, current uncertainties in the determination of nuclear parameters relevant to those processes can hide new physics effects. This is not the case for processes involving lower-energy neutrino sources such as nuclear reactors. Note, however, that a CEvNS measurement with reactor neutrinos depends largely on a (still-missing) precise determination of the quenching factor at very low energies, making its observation more challenging. In the upcoming years, once this signal is confirmed, a combined analysis of N-DAR and reactor CEvNS experiments will be very useful to probe particle and nuclear physics, with a reduced dependence on nuclear uncertainties. In this work, we explore this idea by simultaneously testing the sensitivity of current and future CEvNS experiments to neutrino nonstandard interactions (NSIs) and the neutron root mean square (rms) radius, considering different neutrino sources as well as several detection materials. We show how the interplay between future reactor and accelerator CEvNS experiments can help to get robust constraints on the neutron rms and to break degeneracies between the NSI parameters. Our forecast could be used as a guide to optimize the experimental sensitivity to the parameters under study. |
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Address |
[Rossi, R. R.] Univ Estadual Campinas, Inst Fis Gleb Wataghin, BR-13083859 Campinas, SP, Brazil, Email: gsanchez@ific.uv.es; |
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Publisher |
Amer Physical Soc |
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English |
Summary Language |
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ISSN |
2470-0010 |
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Area |
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Conference |
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Notes |
WOS:001238451900005 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6149 |
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Author |
Servant, G.; Simakachorn, P. |
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Title |
Ultrahigh frequency primordial gravitational waves beyond the kHz: The case of cosmic strings |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
109 |
Issue |
10 |
Pages |
103538 - 24pp |
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Abstract |
We investigate gravitational -wave backgrounds (GWBs) of primordial origin that would manifest only at ultrahigh frequencies, from kilohertz to 100 gigahertz, and leave no signal at LIGO, the Einstein Telescope, the Cosmic Explorer, LISA, or pulsar -timing arrays. We focus on GWBs produced by cosmic strings and make predictions for the GW spectra scanning over high-energy scale (beyond 10 10 GeV) particle physics parameters. Signals from local string networks can easily be as large as the big bang nucleosynthesis/ cosmic microwave background bounds, with a characteristic strain as high as 10 – 26 in the 10 kHz band, offering prospects to probe grand unification physics in the 10 14 -10 17 GeV energy range. In comparison, GWB from axionic strings is suppressed (with maximal characteristic strain similar to 10 – 31 ) due to the early matter era induced by the associated heavy axions. We estimate the needed reach of hypothetical futuristic GW detectors to probe such GWB and, therefore, the corresponding high-energy physics processes. Beyond the information of the symmetry -breaking scale, the high -frequency spectrum encodes the microscopic structure of the strings through the position of the UV cutoffs associated with cusps and kinks, as well as potential information about friction forces on the string. The IR slope, on the other hand, reflects the physics responsible for the decay of the string network. We discuss possible strategies for reconstructing the scalar potential, particularly the scalar self -coupling, from the measurement of the UV cutoff of the GW spectrum. |
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Address |
[Servant, Geraldine] Deutsch Elektronen Synchrotron DESY, Notkestr 85, D-22607 Hamburg, Germany, Email: peera.simakachorn@ific.uv.es; |
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Corporate Author |
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Thesis |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
2470-0010 |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001238459100006 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6150 |
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